Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Conantokin-P

Gene
N/A
Organism
Conus purpurascens (Purple cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit, followed by NR2A/GRIN2A, NR2C/GRIN2C, and NR2D/GRIN2D subunits.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.Curated
Calcium facilitates disulfide bond formation of the synthetic peptide.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-P
Short name:
Con-P
OrganismiConus purpurascens (Purple cone)
Taxonomic identifieri41690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri3531. Conantokin-P precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000035313027 – 80By similarityAdd BLAST54
PeptideiPRO_000035313181 – 104Conantokin-PAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei834-carboxyglutamate1 Publication1
Modified residuei844-carboxyglutamate1 Publication1
Modified residuei904-carboxyglutamate1 Publication1
Disulfide bondi91 ↔ 104Curated
Modified residuei944-carboxyglutamate1 Publication1
Modified residuei1034-carboxyglutamate1 Publication1

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

ProteinModelPortaliP0C8E3.
SMRiP0C8E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005918. Conantokin_CS.
PROSITEiView protein in PROSITE
PS60025. CONANTOKIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYTYLYLL VPLVTFHLIL STGTLAHGGT LTERRSTDTT ALKPEPVLLQ
60 70 80 90 100
KSDARSTDDN DKDRLTQMKR ILKKRGNKAR GEEEHSKYQE CLREIRVNKV

QQEC
Length:104
Mass (Da):12,033
Last modified:November 4, 2008 - v1
Checksum:iC6364066BBC1D04B
GO

Similar proteinsi

Entry informationi

Entry nameiCKP_CONPU
AccessioniPrimary (citable) accession number: P0C8E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: November 22, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families