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Protein

Conantokin-E

Gene
N/A
Organism
Conus ermineus (Atlantic fish-hunting cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit, followed by NR2A/GRIN2A, NR2C/GRIN2C, and NR2D/GRIN2D subunits.By similarity

Miscellaneous

Calcium facilitates disulfide bond formation of the synthetic peptide.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-E
Short name:
Con-E
OrganismiConus ermineus (Atlantic fish-hunting cone)
Taxonomic identifieri55423 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri3533. Conantokin-E precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 24Sequence analysisAdd BLAST›24
PropeptideiPRO_000035312525 – 72By similarityAdd BLAST48
PeptideiPRO_000035312673 – 96Conantokin-EAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei754-carboxyglutamateBy similarity1
Modified residuei764-carboxyglutamateBy similarity1
Modified residuei824-carboxyglutamateBy similarity1
Disulfide bondi83 ↔ 96Curated
Modified residuei864-carboxyglutamateBy similarity1
Modified residuei954-carboxyglutamateBy similarity1

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

ProteinModelPortaliP0C8D9.
SMRiP0C8D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is C-C.Curated

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005918. Conantokin_CS.
PROSITEiView protein in PROSITE
PS60025. CONANTOKIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLVPLVTFHL ILGMGTLDHG GALTERRSAD ATALKPEPVL LQKSDARSTD
60 70 80 90
DNDKDRLTQM KRILKKRGNK ARGEEEHSKY QECLREIRVN NVQQEC
Length:96
Mass (Da):10,896
Last modified:November 4, 2008 - v1
Checksum:iBEC114988156ABDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Similar proteinsi

Entry informationi

Entry nameiCKE_CONER
AccessioniPrimary (citable) accession number: P0C8D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: November 22, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families