UniProtKB - P0C893 (KGX18_CENEL)
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Protein
Potassium channel toxin gamma-KTx 1.8
Gene
N/A
Organism
Centruroides elegans (Bark scorpion)
Status
Functioni
Blocks in a reversible manner human and rat Kv11.1/KCNH2/ERG1 potassium channels. Also completely and irreversibly blocks rat Kv11.2/KCNH6/ERG2 and human Kv11.3/KCNH7/ERG3 channels.1 Publication
Miscellaneous
Does not affect human Kv11.2/KCNH6/ERG2.1 Publication
GO - Molecular functioni
- potassium channel inhibitor activity Source: InterPro
GO - Biological processi
- defense response Source: InterPro
- pathogenesis Source: InterPro
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin gamma-KTx 1.81 PublicationAlternative name(s): CeErgTx5Curated Short name: CeErg51 Publication |
| Organismi | Centruroides elegans (Bark scorpion) |
| Taxonomic identifieri | 217897 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
- Secreted 1 Publication
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000352491 | 1 – 42 | Potassium channel toxin gamma-KTx 1.81 PublicationAdd BLAST | 42 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 5 ↔ 23 | By similarity | ||
| Disulfide bondi | 11 ↔ 34 | By similarity | ||
| Disulfide bondi | 20 ↔ 39 | By similarity | ||
| Disulfide bondi | 24 ↔ 41 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Family & Domainsi
Domaini
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Has the CSalpha/beta fold, which comprises one or two short alpha helices connected to anti-parallel beta-sheets stabilized by three or four disulfide bonds.By similarity
Sequence similaritiesi
Keywords - Domaini
KnottinFamily and domain databases
| Gene3Di | 3.30.30.10. 1 hit. |
| InterProi | View protein in InterPro IPR012622. Ergtoxin. IPR003614. Scorpion_toxin-like. |
| Pfami | View protein in Pfam PF08086. Toxin_17. 1 hit. |
| ProDomi | View protein in ProDom or Entries sharing at least one domain PD736966. Ergtoxin. 1 hit. |
| SUPFAMi | SSF57095. SSF57095. 1 hit. |
| PROSITEi | View protein in PROSITE PS60026. ERGTX. 1 hit. |
Sequencei
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KGX18_CENEL | |
| Accessioni | P0C893Primary (citable) accession number: P0C893 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
| Last sequence update: | October 14, 2008 | |
| Last modified: | May 10, 2017 | |
| This is version 20 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
