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Protein

Potassium channel toxin gamma-KTx 1.8

Gene
N/A
Organism
Centruroides elegans (Bark scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks in a reversible manner human and rat Kv11.1/KCNH2/ERG1 potassium channels. Also completely and irreversibly blocks rat Kv11.2/KCNH6/ERG2 and human Kv11.3/KCNH7/ERG3 channels.1 Publication

Miscellaneous

Does not affect human Kv11.2/KCNH6/ERG2.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin gamma-KTx 1.81 Publication
Alternative name(s):
CeErgTx5Curated
Short name:
CeErg51 Publication
OrganismiCentruroides elegans (Bark scorpion)
Taxonomic identifieri217897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003524911 – 42Potassium channel toxin gamma-KTx 1.81 PublicationAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 23By similarity
Disulfide bondi11 ↔ 34By similarity
Disulfide bondi20 ↔ 39By similarity
Disulfide bondi24 ↔ 41By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

SMRiP0C893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Has the CSalpha/beta fold, which comprises one or two short alpha helices connected to anti-parallel beta-sheets stabilized by three or four disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the ergtoxin family. Gamma-KTx 1 subfamily.Curated

Keywords - Domaini

Knottin

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR012622. Ergtoxin.
IPR003614. Scorpion_toxin-like.
PfamiView protein in Pfam
PF08086. Toxin_17. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD736966. Ergtoxin. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS60026. ERGTX. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
DRDSCIDKSR CSKYGYYQEC QDCCKKAGHN GGTCMFFKCK CA
Length:42
Mass (Da):4,782
Last modified:October 14, 2008 - v1
Checksum:i9BE5F5145BF93360
GO

Mass spectrometryi

Molecular mass is 4775.0 Da from positions 1 - 42. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKGX18_CENEL
AccessioniPrimary (citable) accession number: P0C893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: May 10, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families