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Protein

Cytosolic phospholipase A2 beta

Gene

Pla2g4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A (By similarity).By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Enzyme regulationi

Stimulated by cytosolic Ca2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei333 – 3331NucleophileBy similarity
Active sitei613 – 6131Proton acceptorBy similarity

GO - Molecular functioni

  • calcium-dependent phospholipase A2 activity Source: MGI
  • lysophospholipase activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • phospholipase A2 activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic phospholipase A2 beta (EC:3.1.1.4)
Short name:
cPLA2-beta
Alternative name(s):
Phospholipase A2 group IVB
Gene namesi
Name:Pla2g4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384819. Pla2g4b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Cytosolic phospholipase A2 betaPRO_0000247022Add
BLAST

Proteomic databases

MaxQBiP0C871.
PaxDbiP0C871.
PRIDEiP0C871.

PTM databases

iPTMnetiP0C871.
PhosphoSiteiP0C871.

Expressioni

Gene expression databases

BgeeiENSMUSG00000098488.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000118458.

Structurei

3D structure databases

ProteinModelPortaliP0C871.
SMRiP0C871. Positions 10-153, 225-775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 102102C2PROSITE-ProRule annotationAdd
BLAST
Domaini245 – 782538PLA2cPROSITE-ProRule annotationAdd
BLAST

Domaini

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
KOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOGENOMiHOG000231788.
HOVERGENiHBG080412.
InParanoidiP0C871.
KOiK16342.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAKVPETCL LTVRVLRASG LPSKDLVTSS DCYVTLNLPT ASSHTLQTRT
60 70 80 90 100
VKNSRNPVWN QNFHFRIHRQ LKNVMELKVF DHDLVTRDDP VLSVLFDVGT
110 120 130 140 150
LQIGTQRQSF SLGTQEKGCL EVEFRLQTLT DCEEQLISNG IVVARELSCL
160 170 180 190 200
HVELKRTGDP KRSERKVQLV VAGACEGPQD ASAGTGSFHF HYPACWEQEL
210 220 230 240 250
NVHLQDDPHE QLKVPLRTLP SSQLVRLVFP TSQEPLMRLE LKKEEGPKEL
260 270 280 290 300
AVRLGCGPCP EEQAFLSKRK QVVAAALKKA LQLDQDLHED EIPVIAVMAT
310 320 330 340 350
GGGIRAMTSL YGQLAGLQEL GLLDCISYIT GASGSTWALA NLYEDPEWSQ
360 370 380 390 400
KDLAGPTEVL KTQVTKSKLG ALAPSQLWRY RQELAERARL GHPTCFTNLW
410 420 430 440 450
ALINEALLHD KPHEHKLSDQ REALSRGQNP LPIYCALNSK EQGLSTFDFG
460 470 480 490 500
EWCEFSPYEV GFPKYGAFIS SELFGSEFFM GRLVKQLPES RICFLEGIWS
510 520 530 540 550
NLFAASLQDS LYWSSEPSQF WDRWAQDQAN LDKEQVPHLK IAEPPTMAGR
560 570 580 590 600
IAELFTDLLT KRPLAHATHN FTRGLHFHKD YFQNSHFSAW KASKLDRLPN
610 620 630 640 650
QLTPTEPHLC LLDVGYLINT SCPPLLQPTR DVDLILSLDY NLYGAFQQLQ
660 670 680 690 700
LLSRFCQEQG IPFPSISPSP EEQRQPQECH LFCDPAQPEA PAVLHFPLVN
710 720 730 740 750
DSFQDYSAPG VPRTSEEKAA GEVNLSSSDS PYHYTKVTYS QEDVDKLLRL
760 770 780
THYNICNNQD RLREAMHQAV QRRRKRKQFR PE
Length:782
Mass (Da):88,448
Last modified:September 2, 2008 - v1
Checksum:iBD803A02439F6846
GO

Sequence cautioni

The sequence CAM22684 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751M → I in BC098210 (PubMed:15489334).Curated
Sequence conflicti79 – 791V → A in BC098210 (PubMed:15489334).Curated
Sequence conflicti605 – 6051T → A in AAH42758 (PubMed:15489334).Curated
Sequence conflicti617 – 6171L → F in AAH42758 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833774 Genomic DNA. Translation: CAM22684.1. Sequence problems.
BC042758 mRNA. Translation: AAH42758.1.
BC098210 mRNA. No translation available.
RefSeqiNP_663353.3. NM_145378.3.
UniGeneiMm.41467.

Genome annotation databases

GeneIDi211429.
KEGGimmu:211429.
UCSCiuc008luz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833774 Genomic DNA. Translation: CAM22684.1. Sequence problems.
BC042758 mRNA. Translation: AAH42758.1.
BC098210 mRNA. No translation available.
RefSeqiNP_663353.3. NM_145378.3.
UniGeneiMm.41467.

3D structure databases

ProteinModelPortaliP0C871.
SMRiP0C871. Positions 10-153, 225-775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000118458.

PTM databases

iPTMnetiP0C871.
PhosphoSiteiP0C871.

Proteomic databases

MaxQBiP0C871.
PaxDbiP0C871.
PRIDEiP0C871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi211429.
KEGGimmu:211429.
UCSCiuc008luz.2. mouse.

Organism-specific databases

CTDi100137049.
MGIiMGI:2384819. Pla2g4b.

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
KOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOGENOMiHOG000231788.
HOVERGENiHBG080412.
InParanoidiP0C871.
KOiK16342.

Miscellaneous databases

PROiP0C871.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000098488.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA24B_MOUSE
AccessioniPrimary (citable) accession number: P0C871
Secondary accession number(s): A2AP62
, Q4QQM1, Q80VV8, Q91W88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.