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Protein

JmjC domain-containing protein 7

Gene

JMJD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
JmjC domain-containing protein 7
Alternative name(s):
Jumonji domain-containing protein 7
Gene namesi
Name:JMJD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:34397. JMJD7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392530.

Polymorphism and mutation databases

BioMutaiJMJD7.
DMDMi205783894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316JmjC domain-containing protein 7PRO_0000349374Add
BLAST

Proteomic databases

EPDiP0C870.
MaxQBiP0C870.
PaxDbiP0C870.
PeptideAtlasiP0C870.
PRIDEiP0C870.

PTM databases

iPTMnetiP0C870.
PhosphoSiteiP0C870.

Expressioni

Gene expression databases

BgeeiP0C870.
CleanExiHS_JMJD7.
ExpressionAtlasiP0C870. baseline and differential.
GenevisibleiP0C870. HS.

Organism-specific databases

HPAiHPA005726.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VAC14Q08AM63EBI-9090173,EBI-2107455

Protein-protein interaction databases

BioGridi936684. 1 interaction.
IntActiP0C870. 2 interactions.
STRINGi9606.ENSP00000380467.

Structurei

3D structure databases

ProteinModelPortaliP0C870.
SMRiP0C870. Positions 1-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 307180JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2508. Eukaryota.
ENOG410YDQ9. LUCA.
GeneTreeiENSGT00840000130020.
HOGENOMiHOG000264513.
HOVERGENiHBG054447.
InParanoidiP0C870.
KOiK19219.
OMAiCIIRNAF.
OrthoDBiEOG7PS1FP.
PhylomeDBiP0C870.
TreeFamiTF329946.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAALEAVR SELREFPAAA RELCVPLAVP YLDKPPTPLH FYRDWVCPNR
60 70 80 90 100
PCIIRNALQH WPALQKWSLP YFRATVGSTE VSVAVTPDGY ADAVRGDRFM
110 120 130 140 150
MPAERRLPLS FVLDVLEGRA QHPGVLYVQK QCSNLPSELP QLLPDLESHV
160 170 180 190 200
PWASEALGKM PDAVNFWLGE AAAVTSLHKD HYENLYCVVS GEKHFLFHPP
210 220 230 240 250
SDRPFIPYEL YTPATYQLTE EGTFKVVDEE AMEKVPWIPL DPLAPDLARY
260 270 280 290 300
PSYSQAQALR CTVRAGEMLY LPALWFHHVQ QSQGCIAVNF WYDMEYDLKY
310
SYFQLLDSLT KASGLD
Length:316
Mass (Da):35,932
Last modified:September 2, 2008 - v1
Checksum:i3C2DFDAD12BBC4E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281A → G.
Corresponds to variant rs7174710 [ dbSNP | Ensembl ].
VAR_027046
Natural varianti160 – 1601M → V.1 Publication
VAR_069392

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289833 mRNA. Translation: BAF82522.1.
AK290051 mRNA. Translation: BAF82740.1.
BC025290 mRNA. Translation: AAH25290.1.
BC139899 mRNA. Translation: AAI39900.1.
CCDSiCCDS45240.1.
RefSeqiNP_001108104.1. NM_001114632.1.
UniGeneiHs.198161.

Genome annotation databases

EnsembliENST00000397299; ENSP00000380467; ENSG00000243789.
GeneIDi100137047.
KEGGihsa:100137047.
UCSCiuc001zon.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289833 mRNA. Translation: BAF82522.1.
AK290051 mRNA. Translation: BAF82740.1.
BC025290 mRNA. Translation: AAH25290.1.
BC139899 mRNA. Translation: AAI39900.1.
CCDSiCCDS45240.1.
RefSeqiNP_001108104.1. NM_001114632.1.
UniGeneiHs.198161.

3D structure databases

ProteinModelPortaliP0C870.
SMRiP0C870. Positions 1-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi936684. 1 interaction.
IntActiP0C870. 2 interactions.
STRINGi9606.ENSP00000380467.

PTM databases

iPTMnetiP0C870.
PhosphoSiteiP0C870.

Polymorphism and mutation databases

BioMutaiJMJD7.
DMDMi205783894.

Proteomic databases

EPDiP0C870.
MaxQBiP0C870.
PaxDbiP0C870.
PeptideAtlasiP0C870.
PRIDEiP0C870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397299; ENSP00000380467; ENSG00000243789.
GeneIDi100137047.
KEGGihsa:100137047.
UCSCiuc001zon.3. human.

Organism-specific databases

CTDi100137047.
GeneCardsiJMJD7.
HGNCiHGNC:34397. JMJD7.
HPAiHPA005726.
neXtProtiNX_P0C870.
PharmGKBiPA162392530.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2508. Eukaryota.
ENOG410YDQ9. LUCA.
GeneTreeiENSGT00840000130020.
HOGENOMiHOG000264513.
HOVERGENiHBG054447.
InParanoidiP0C870.
KOiK19219.
OMAiCIIRNAF.
OrthoDBiEOG7PS1FP.
PhylomeDBiP0C870.
TreeFamiTF329946.

Miscellaneous databases

GenomeRNAii100137047.
PROiP0C870.

Gene expression databases

BgeeiP0C870.
CleanExiHS_JMJD7.
ExpressionAtlasiP0C870. baseline and differential.
GenevisibleiP0C870. HS.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: VARIANT VAL-160.

Entry informationi

Entry nameiJMJD7_HUMAN
AccessioniPrimary (citable) accession number: P0C870
Secondary accession number(s): A5D6V5
, O95712, Q59GF9, Q8TB10, Q9UKV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 6, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This sequence was first thought to be an alternatively spliced isoform of PLA2G4B. It is derived from JMJD7 which is located upstream of PLA2G4B. Most tissues also express read-through transcripts from JMJD7 into the downstream PLA2G4B gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.