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P0C869

- PA24B_HUMAN

UniProt

P0C869 - PA24B_HUMAN

Protein

Cytosolic phospholipase A2 beta

Gene

PLA2G4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.3 Publications

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.3 Publications

    Enzyme regulationi

    Stimulated by cytosolic Ca2+.2 Publications

    Kineticsi

      Vmax=7.9 pmol/min/mg enzyme (isoform 5)1 Publication

      Vmax=3.6 pmol/min/µg enzyme with cAMP as substrate (isoform 4)1 Publication

      Vmax=140 nmol/min/µg enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5)1 Publication

      Vmax=1.6 nmol/min/µg enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3)1 Publication

      Vmax=2.1 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5)1 Publication

      Vmax=0.6 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5)1 Publication

      Vmax=0.8 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3)1 Publication

      Vmax=0.3 nmol/min/µg enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3)1 Publication

      Sites

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Active sitei335 – 3351NucleophileBy similarity
      Active sitei615 – 6151Proton acceptorBy similarity

      GO - Molecular functioni

      1. calcium-dependent phospholipase A2 activity Source: UniProtKB
      2. calcium-dependent phospholipid binding Source: UniProtKB
      3. calcium ion binding Source: UniProtKB
      4. lysophospholipase activity Source: UniProtKB

      GO - Biological processi

      1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
      2. arachidonic acid metabolic process Source: UniProtKB
      3. calcium-mediated signaling Source: UniProtKB
      4. cellular protein metabolic process Source: Reactome
      5. endoplasmic reticulum unfolded protein response Source: Reactome
      6. glycerophospholipid biosynthetic process Source: Reactome
      7. glycerophospholipid catabolic process Source: UniProtKB
      8. inflammatory response Source: UniProtKB
      9. parturition Source: UniProtKB
      10. phosphatidic acid biosynthetic process Source: Reactome
      11. phosphatidylcholine acyl-chain remodeling Source: Reactome
      12. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
      13. phosphatidylglycerol acyl-chain remodeling Source: Reactome
      14. phosphatidylserine acyl-chain remodeling Source: Reactome
      15. phospholipid metabolic process Source: Reactome
      16. small molecule metabolic process Source: Reactome

      Keywords - Molecular functioni

      Hydrolase

      Keywords - Biological processi

      Lipid degradation, Lipid metabolism

      Keywords - Ligandi

      Calcium, Metal-binding

      Enzyme and pathway databases

      ReactomeiREACT_120829. Acyl chain remodelling of PC.
      REACT_120906. Synthesis of PA.
      REACT_120977. Hydrolysis of LPC.
      REACT_121324. Acyl chain remodelling of PG.
      REACT_121369. Acyl chain remodelling of PE.
      REACT_121384. Acyl chain remodelling of PS.
      REACT_18273. XBP1(S) activates chaperone genes.

      Names & Taxonomyi

      Protein namesi
      Recommended name:
      Cytosolic phospholipase A2 beta (EC:3.1.1.4)
      Short name:
      cPLA2-beta
      Alternative name(s):
      Phospholipase A2 group IVB
      Gene namesi
      Name:PLA2G4B
      OrganismiHomo sapiens (Human)
      Taxonomic identifieri9606 [NCBI]
      Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      ProteomesiUP000005640: Chromosome 15

      Organism-specific databases

      HGNCiHGNC:9036. PLA2G4B.

      Subcellular locationi

      Cytoplasmcytosol 1 Publication
      Isoform 3 : Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein
      Note: Translocates to membrane vesicles in a calcium-dependent fashion.

      GO - Cellular componenti

      1. cytosol Source: UniProtKB
      2. early endosome membrane Source: UniProtKB-SubCell
      3. extracellular region Source: UniProtKB
      4. mitochondrial inner membrane Source: Reactome

      Keywords - Cellular componenti

      Cytoplasm, Endosome, Membrane, Mitochondrion

      Pathology & Biotechi

      Mutagenesis

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Mutagenesisi335 – 3351S → A: Abolishes enzyme activity. 1 Publication
      Mutagenesisi417 – 4171H → A: No effect. 1 Publication
      Mutagenesisi615 – 6151D → A: Abolishes enzyme activity. 1 Publication
      Mutagenesisi632 – 6321R → A: Abolishes enzyme activity. 1 Publication

      Organism-specific databases

      PharmGKBiPA165479070.

      PTM / Processingi

      Molecule processing

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Chaini1 – 781781Cytosolic phospholipase A2 betaPRO_0000247021Add
      BLAST

      Proteomic databases

      MaxQBiP0C869.
      PaxDbiP0C869.
      PRIDEiP0C869.

      PTM databases

      PhosphoSiteiP0C869.

      Expressioni

      Tissue specificityi

      Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.3 Publications

      Gene expression databases

      BgeeiP0C869.
      GenevestigatoriP0C869.

      Organism-specific databases

      HPAiHPA005726.

      Interactioni

      Protein-protein interaction databases

      BioGridi936685. 4 interactions.
      IntActiP0C869. 2 interactions.
      STRINGi9606.ENSP00000396045.

      Structurei

      3D structure databases

      ProteinModelPortaliP0C869.
      SMRiP0C869. Positions 8-777.
      ModBaseiSearch...
      MobiDBiSearch...

      Family & Domainsi

      Domains and Repeats

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Domaini1 – 9797C2PROSITE-ProRule annotationAdd
      BLAST
      Domaini246 – 781536PLA2cPROSITE-ProRule annotationAdd
      BLAST

      Domaini

      The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ By similarity.By similarity

      Sequence similaritiesi

      Contains 1 C2 domain.PROSITE-ProRule annotation
      Contains 1 PLA2c domain.PROSITE-ProRule annotation

      Phylogenomic databases

      eggNOGiNOG239428.
      HOVERGENiHBG080412.
      InParanoidiP0C869.
      KOiK16342.
      OrthoDBiEOG70CR62.
      PhylomeDBiP0C869.
      TreeFamiTF325228.

      Family and domain databases

      Gene3Di2.60.40.150. 1 hit.
      InterProiIPR016035. Acyl_Trfase/lysoPLipase.
      IPR000008. C2_dom.
      IPR002642. LysoPLipase_cat_dom.
      [Graphical view]
      PfamiPF00168. C2. 1 hit.
      PF01735. PLA2_B. 1 hit.
      [Graphical view]
      SMARTiSM00239. C2. 1 hit.
      SM00022. PLAc. 1 hit.
      [Graphical view]
      SUPFAMiSSF49562. SSF49562. 1 hit.
      SSF52151. SSF52151. 1 hit.
      PROSITEiPS50004. C2. 1 hit.
      PS51210. PLA2C. 1 hit.
      [Graphical view]

      Sequences (5)i

      Sequence statusi: Complete.

      This entry describes 5 isoformsi produced by alternative splicing. Align

      Isoform 1 (identifier: P0C869-1) [UniParc]FASTAAdd to Basket

      This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

      « Hide

      MAVAEVSRTC LLTVRVLQAH RLPSKDLVTP SDCYVTLWLP TACSHRLQTR    50
      TVKNSSSPVW NQSFHFRIHR QLKNVMELKV FDQDLVTGDD PVLSVLFDAG 100
      TLRAGEFRRE SFSLSPQGEG RLEVEFRLQS LADRGEWLVS NGVLVARELS 150
      CLHVQLEETG DQKSSEHRVQ LVVPGSCEGP QEASVGTGTF RFHCPACWEQ 200
      ELSIRLQDAP EEQLKAPLSA LPSGQVVRLV FPTSQEPLMR VELKKEAGLR 250
      ELAVRLGFGP CAEEQAFLSR RKQVVAAALR QALQLDGDLQ EDEIPVVAIM 300
      ATGGGIRAMT SLYGQLAGLK ELGLLDCVSY ITGASGSTWA LANLYEDPEW 350
      SQKDLAGPTE LLKTQVTKNK LGVLAPSQLQ RYRQELAERA RLGYPSCFTN 400
      LWALINEALL HDEPHDHKLS DQREALSHGQ NPLPIYCALN TKGQSLTTFE 450
      FGEWCEFSPY EVGFPKYGAF IPSELFGSEF FMGQLMKRLP ESRICFLEGI 500
      WSNLYAANLQ DSLYWASEPS QFWDRWVRNQ ANLDKEQVPL LKIEEPPSTA 550
      GRIAEFFTDL LTWRPLAQAT HNFLRGLHFH KDYFQHPHFS TWKATTLDGL 600
      PNQLTPSEPH LCLLDVGYLI NTSCLPLLQP TRDVDLILSL DYNLHGAFQQ 650
      LQLLGRFCQE QGIPFPPISP SPEEQLQPRE CHTFSDPTCP GAPAVLHFPL 700
      VSDSFREYSA PGVRRTPEEA AAGEVNLSSS DSPYHYTKVT YSQEDVDKLL 750
      HLTHYNVCNN QEQLLEALRQ AVQRRRQRRP H 781
      Length:781
      Mass (Da):87,978
      Last modified:July 13, 2010 - v2
      Checksum:i4C5C6861E7BAB1B8
      GO
      Isoform 2 (identifier: P0C869-7) [UniParc]FASTAAdd to Basket

      Also known as: beta2

      The sequence of this isoform differs from the canonical sequence as follows:
           1-3: MAV → MAEAALEAVR...KVVDEEAMEK
           650-662: QLQLLGRFCQEQG → GSGGHPRRRQLGR
           663-781: Missing.

      Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

      Show »
      Length:893
      Mass (Da):100,516
      Checksum:i0A7C3BE752C48F55
      GO
      Isoform 3 (identifier: P0C869-8) [UniParc]FASTAAdd to Basket

      Also known as: beta3

      The sequence of this isoform differs from the canonical sequence as follows:
           1-3: MAV → MAEAALEAVR...KVVDEEAMEK
           641-765: Missing.

      Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

      Show »
      Length:887
      Mass (Da):100,094
      Checksum:i4C5CC6D084F2DF99
      GO
      Isoform 4 (identifier: P0C869-4) [UniParc] [UniParc]FASTAAdd to Basket

      The sequence of this isoform differs from the canonical sequence as follows:
           1-299: Missing.

      Note: No experimental confirmation available.

      Show »
      Length:482
      Mass (Da):54,679
      Checksum:iEB8FC2F2EB2AE258
      GO
      Isoform 5 (identifier: P0C869-6) [UniParc]FASTAAdd to Basket

      Also known as: Beta1

      The sequence of this isoform differs from the canonical sequence as follows:
           1-3: MAV → MAEAALEAVR...KVVDEEAMEK

      Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

      Show »
      Length:1,012
      Mass (Da):114,121
      Checksum:i989EDB4AD3CF19DD
      GO

      Sequence cautioni

      The sequence BAD92387.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

      Experimental Info

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Sequence conflicti138 – 1381L → F in AAD32135. (PubMed:10358058)Curated
      Sequence conflicti162 – 1621Q → P in ABF69195. (PubMed:16617059)Curated
      Sequence conflicti162 – 1621Q → P in ABF69196. (PubMed:16617059)Curated
      Sequence conflicti438 – 4381A → V in ABF69195. (PubMed:16617059)Curated
      Sequence conflicti517 – 5171S → P in ABF69195. (PubMed:16617059)Curated
      Sequence conflicti575 – 5751R → C in BAG61401. (PubMed:14702039)Curated
      Sequence conflicti723 – 7231G → E in BAG61401. (PubMed:14702039)Curated

      Natural variant

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Natural varianti191 – 1911R → C.1 Publication
      Corresponds to variant rs3816533 [ dbSNP | Ensembl ].
      VAR_027047
      Natural varianti239 – 2391M → I.
      Corresponds to variant rs2290552 [ dbSNP | Ensembl ].
      VAR_027048
      Natural varianti391 – 3911R → H.
      Corresponds to variant rs34807597 [ dbSNP | Ensembl ].
      VAR_034365
      Natural varianti591 – 5911T → I.
      Corresponds to variant rs36126315 [ dbSNP | Ensembl ].
      VAR_060082

      Alternative sequence

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Alternative sequencei1 – 299299Missing in isoform 4. 1 PublicationVSP_019871Add
      BLAST
      Alternative sequencei1 – 33MAV → MAEAALEAVRSELREFPAAA RELCVPLAVPYLDKPPTPLH FYRDWVCPNRPCIIRNALQH WPALQKWSLPYFRATVGSTE VSVAVTPDGYADAVRGDRFM MPAERRLPLSFVLDVLEGRA QHPGVLYVQKQCSNLPSELP QLLPDLESHVPWASEALGKM PDAVNFWLGEAAAVTSLHKD HYENLYCVVSGEKHFLFHPP SDRPFIPYELYTPATYQLTE EGTFKVVDEEAMEK in isoform 2, isoform 3 and isoform 5. 3 PublicationsVSP_039387
      Alternative sequencei641 – 765125Missing in isoform 3. 1 PublicationVSP_039388Add
      BLAST
      Alternative sequencei650 – 66213QLQLL…CQEQG → GSGGHPRRRQLGR in isoform 2. 1 PublicationVSP_039389Add
      BLAST
      Alternative sequencei663 – 781119Missing in isoform 2. 1 PublicationVSP_039390Add
      BLAST

      Sequence databases

      Select the link destinations:
      EMBL
      GenBank
      DDBJ
      Links Updated
      AF065215 mRNA. Translation: AAC78836.1.
      AF121908 mRNA. Translation: AAD32135.1.
      DQ523799 mRNA. Translation: ABF69195.1.
      DQ523800 mRNA. Translation: ABF69196.1.
      AK299419 mRNA. Translation: BAG61401.1.
      AB209150 mRNA. Translation: BAD92387.1. Different initiation.
      AC020659 Genomic DNA. No translation available.
      CCDSiCCDS45241.1.
      RefSeqiNP_001108105.1. NM_001114633.1. [P0C869-1]
      NP_001185517.1. NM_001198588.1. [P0C869-7]
      NP_005081.1. NM_005090.3. [P0C869-6]
      UniGeneiHs.198161.

      Genome annotation databases

      EnsembliENST00000452633; ENSP00000396045; ENSG00000243708. [P0C869-1]
      ENST00000458483; ENSP00000416610; ENSG00000243708. [P0C869-1]
      GeneIDi100137049.
      8681.
      KEGGihsa:100137049.
      hsa:8681.
      UCSCiuc001zoo.4. human. [P0C869-6]
      uc001zoq.4. human.
      uc010bcn.3. human. [P0C869-7]

      Polymorphism databases

      DMDMi300669659.

      Keywords - Coding sequence diversityi

      Alternative splicing, Polymorphism

      Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBL
      GenBank
      DDBJ
      Links Updated
      AF065215 mRNA. Translation: AAC78836.1 .
      AF121908 mRNA. Translation: AAD32135.1 .
      DQ523799 mRNA. Translation: ABF69195.1 .
      DQ523800 mRNA. Translation: ABF69196.1 .
      AK299419 mRNA. Translation: BAG61401.1 .
      AB209150 mRNA. Translation: BAD92387.1 . Different initiation.
      AC020659 Genomic DNA. No translation available.
      CCDSi CCDS45241.1.
      RefSeqi NP_001108105.1. NM_001114633.1. [P0C869-1 ]
      NP_001185517.1. NM_001198588.1. [P0C869-7 ]
      NP_005081.1. NM_005090.3. [P0C869-6 ]
      UniGenei Hs.198161.

      3D structure databases

      ProteinModelPortali P0C869.
      SMRi P0C869. Positions 8-777.
      ModBasei Search...
      MobiDBi Search...

      Protein-protein interaction databases

      BioGridi 936685. 4 interactions.
      IntActi P0C869. 2 interactions.
      STRINGi 9606.ENSP00000396045.

      Chemistry

      BindingDBi P0C869.
      ChEMBLi CHEMBL4136.

      PTM databases

      PhosphoSitei P0C869.

      Polymorphism databases

      DMDMi 300669659.

      Proteomic databases

      MaxQBi P0C869.
      PaxDbi P0C869.
      PRIDEi P0C869.

      Protocols and materials databases

      DNASUi 8681.
      Structural Biology Knowledgebase Search...

      Genome annotation databases

      Ensembli ENST00000452633 ; ENSP00000396045 ; ENSG00000243708 . [P0C869-1 ]
      ENST00000458483 ; ENSP00000416610 ; ENSG00000243708 . [P0C869-1 ]
      GeneIDi 100137049.
      8681.
      KEGGi hsa:100137049.
      hsa:8681.
      UCSCi uc001zoo.4. human. [P0C869-6 ]
      uc001zoq.4. human.
      uc010bcn.3. human. [P0C869-7 ]

      Organism-specific databases

      CTDi 100137049.
      8681.
      GeneCardsi GC15P042129.
      HGNCi HGNC:9036. PLA2G4B.
      HPAi HPA005726.
      MIMi 606088. gene.
      neXtProti NX_P0C869.
      PharmGKBi PA165479070.
      GenAtlasi Search...

      Phylogenomic databases

      eggNOGi NOG239428.
      HOVERGENi HBG080412.
      InParanoidi P0C869.
      KOi K16342.
      OrthoDBi EOG70CR62.
      PhylomeDBi P0C869.
      TreeFami TF325228.

      Enzyme and pathway databases

      Reactomei REACT_120829. Acyl chain remodelling of PC.
      REACT_120906. Synthesis of PA.
      REACT_120977. Hydrolysis of LPC.
      REACT_121324. Acyl chain remodelling of PG.
      REACT_121369. Acyl chain remodelling of PE.
      REACT_121384. Acyl chain remodelling of PS.
      REACT_18273. XBP1(S) activates chaperone genes.

      Miscellaneous databases

      GeneWikii PLA2G4B.
      NextBioi 20774774.
      PROi P0C869.
      SOURCEi Search...

      Gene expression databases

      Bgeei P0C869.
      Genevestigatori P0C869.

      Family and domain databases

      Gene3Di 2.60.40.150. 1 hit.
      InterProi IPR016035. Acyl_Trfase/lysoPLipase.
      IPR000008. C2_dom.
      IPR002642. LysoPLipase_cat_dom.
      [Graphical view ]
      Pfami PF00168. C2. 1 hit.
      PF01735. PLA2_B. 1 hit.
      [Graphical view ]
      SMARTi SM00239. C2. 1 hit.
      SM00022. PLAc. 1 hit.
      [Graphical view ]
      SUPFAMi SSF49562. SSF49562. 1 hit.
      SSF52151. SSF52151. 1 hit.
      PROSITEi PS50004. C2. 1 hit.
      PS51210. PLA2C. 1 hit.
      [Graphical view ]
      ProtoNeti Search...

      Publicationsi

      1. "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
        Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
        J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-335; HIS-417; ASP-615 AND ARG-632.
      2. "Molecular characterization of cytosolic phospholipase A2-beta."
        Song C., Chang X.J., Bean K.M., Proia M.S., Knopf J.L., Kriz R.W.
        J. Biol. Chem. 274:17063-17067(1999) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, TISSUE SPECIFICITY.
      3. "Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes."
        Ghosh M., Loper R., Gelb M.H., Leslie C.C.
        J. Biol. Chem. 281:16615-16624(2006) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
        Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
        , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
        Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-191.
        Tissue: Tongue.
      5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
        Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
        Tissue: Brain.
      6. "Analysis of the DNA sequence and duplication history of human chromosome 15."
        Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
        , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
        Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

      Entry informationi

      Entry nameiPA24B_HUMAN
      AccessioniPrimary (citable) accession number: P0C869
      Secondary accession number(s): B4DRT9
      , O95712, Q19KD5, Q19KD6, Q59GF9, Q8TB10, Q9UKV7
      Entry historyi
      Integrated into UniProtKB/Swiss-Prot: September 2, 2008
      Last sequence update: July 13, 2010
      Last modified: October 1, 2014
      This is version 63 of the entry and version 2 of the sequence. [Complete history]
      Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Reference proteome

      Documents

      1. Human chromosome 15
        Human chromosome 15: entries, gene names and cross-references to MIM
      2. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
      3. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      4. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      5. SIMILARITY comments
        Index of protein domains and families

      External Data

      Dasty 3