P0C869 (PA24B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic phospholipase A2 beta
Short name=cPLA2-beta
EC=3.1.1.4

Alternative name(s):
Phospholipase A2 group IVB

Gene names

Name:

PLA2G4B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	781 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Ref.1 Ref.2 Ref.3
Catalytic activity	Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Enzyme regulation	Stimulated by cytosolic Ca2+. Ref.1 Ref.2
Subcellular location	Cytoplasm › cytosol Ref.3. Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note: Translocates to membrane vesicles in a calcium-dependent fashion. Ref.3
Tissue specificity	Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. Ref.1 Ref.2 Ref.3
Domain	The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ By similarity.
Sequence similarities	Contains 1 C2 domain. Contains 1 PLA2c domain.
Caution	Most tissues also express read-through transcripts from this gene into the upstream gene (JMJD7), some of which may encode fusion proteins.
Biophysicochemical properties	Kinetic parameters: Vmax=7.9 pmol/min/mg enzyme (isoform 5) Ref.1 Vmax=3.6 pmol/min/µg enzyme with cAMP as substrate (isoform 4) Vmax=140 nmol/min/µg enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5) Vmax=1.6 nmol/min/µg enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3) Vmax=2.1 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5) Vmax=0.6 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5) Vmax=0.8 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3) Vmax=0.3 nmol/min/µg enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3)
Sequence caution	The sequence BAD92387.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Cytoplasm Endosome Membrane Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arachidonic acid metabolic process Non-traceable author statement Ref.1. Source: UniProtKB calcium-mediated signaling Non-traceable author statement Ref.1. Source: UniProtKB glycerophospholipid catabolic process Inferred from direct assay Ref.1. Source: UniProtKB inflammatory response Non-traceable author statement Ref.1. Source: UniProtKB parturition Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	cytosol Inferred from direct assay Ref.2. Source: UniProtKB early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Traceable author statement Ref.1. Source: UniProtKB mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Non-traceable author statement Ref.1. Source: UniProtKB calcium-dependent phospholipase A2 activity Inferred from direct assay Ref.1. Source: UniProtKB calcium-dependent phospholipid binding Non-traceable author statement Ref.1. Source: UniProtKB lysophospholipase activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P0C869-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P0C869-7)

Also known as: beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MAV → MAEAALEAVR...KVVDEEAMEK
     650-662: QLQLLGRFCQEQG → GSGGHPRRRQLGR
     663-781: Missing.

Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

Isoform 3 (identifier: P0C869-8)

Also known as: beta3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MAV → MAEAALEAVR...KVVDEEAMEK
     641-765: Missing.

Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

Isoform 4 (identifier: P0C869-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: P0C869-6)

Also known as: Beta1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MAV → MAEAALEAVR...KVVDEEAMEK

Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 781	781	Cytosolic phospholipase A2 beta		PRO_0000247021
Regions
	Domain	1 – 97	97	C2
	Domain	246 – 781	536	PLA2c
Sites
	Active site	335	1	Nucleophile By similarity
	Active site	615	1	Proton acceptor By similarity
Natural variations
	Alternative sequence	1 – 299	299	Missing in isoform 4.		VSP_019871
	Alternative sequence	1 – 3	3	MAV → MAEAALEAVRSELREFPAAA RELCVPLAVPYLDKPPTPLH FYRDWVCPNRPCIIRNALQH WPALQKWSLPYFRATVGSTE VSVAVTPDGYADAVRGDRFM MPAERRLPLSFVLDVLEGRA QHPGVLYVQKQCSNLPSELP QLLPDLESHVPWASEALGKM PDAVNFWLGEAAAVTSLHKD HYENLYCVVSGEKHFLFHPP SDRPFIPYELYTPATYQLTE EGTFKVVDEEAMEK in isoform 2, isoform 3 and isoform 5.		VSP_039387
	Alternative sequence	641 – 765	125	Missing in isoform 3.		VSP_039388
	Alternative sequence	650 – 662	13	QLQLL…CQEQG → GSGGHPRRRQLGR in isoform 2.		VSP_039389
	Alternative sequence	663 – 781	119	Missing in isoform 2.		VSP_039390
	Natural variant	191	1	R → C. Ref.4 Corresponds to variant rs3816533 [ dbSNP | Ensembl ].		VAR_027047
	Natural variant	239	1	M → I. Corresponds to variant rs2290552 [ dbSNP | Ensembl ].		VAR_027048
	Natural variant	391	1	R → H. Corresponds to variant rs34807597 [ dbSNP | Ensembl ].		VAR_034365
	Natural variant	591	1	T → I. Corresponds to variant rs36126315 [ dbSNP | Ensembl ].		VAR_060082
Experimental info
	Mutagenesis	335	1	S → A: Abolishes enzyme activity. Ref.1
	Mutagenesis	417	1	H → A: No effect. Ref.1
	Mutagenesis	615	1	D → A: Abolishes enzyme activity. Ref.1
	Mutagenesis	632	1	R → A: Abolishes enzyme activity. Ref.1
	Sequence conflict	138	1	L → F in AAD32135. Ref.2
	Sequence conflict	162	1	Q → P in ABF69195. Ref.3
	Sequence conflict	162	1	Q → P in ABF69196. Ref.3
	Sequence conflict	438	1	A → V in ABF69195. Ref.3
	Sequence conflict	517	1	S → P in ABF69195. Ref.3
	Sequence conflict	575	1	R → C in BAG61401. Ref.4
	Sequence conflict	723	1	G → E in BAG61401. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: 4C5C6861E7BAB1B8	FASTA	781	87,978
	10 20 30 40 50 60 MAVAEVSRTC LLTVRVLQAH RLPSKDLVTP SDCYVTLWLP TACSHRLQTR TVKNSSSPVW 70 80 90 100 110 120 NQSFHFRIHR QLKNVMELKV FDQDLVTGDD PVLSVLFDAG TLRAGEFRRE SFSLSPQGEG 130 140 150 160 170 180 RLEVEFRLQS LADRGEWLVS NGVLVARELS CLHVQLEETG DQKSSEHRVQ LVVPGSCEGP 190 200 210 220 230 240 QEASVGTGTF RFHCPACWEQ ELSIRLQDAP EEQLKAPLSA LPSGQVVRLV FPTSQEPLMR 250 260 270 280 290 300 VELKKEAGLR ELAVRLGFGP CAEEQAFLSR RKQVVAAALR QALQLDGDLQ EDEIPVVAIM 310 320 330 340 350 360 ATGGGIRAMT SLYGQLAGLK ELGLLDCVSY ITGASGSTWA LANLYEDPEW SQKDLAGPTE 370 380 390 400 410 420 LLKTQVTKNK LGVLAPSQLQ RYRQELAERA RLGYPSCFTN LWALINEALL HDEPHDHKLS 430 440 450 460 470 480 DQREALSHGQ NPLPIYCALN TKGQSLTTFE FGEWCEFSPY EVGFPKYGAF IPSELFGSEF 490 500 510 520 530 540 FMGQLMKRLP ESRICFLEGI WSNLYAANLQ DSLYWASEPS QFWDRWVRNQ ANLDKEQVPL 550 560 570 580 590 600 LKIEEPPSTA GRIAEFFTDL LTWRPLAQAT HNFLRGLHFH KDYFQHPHFS TWKATTLDGL 610 620 630 640 650 660 PNQLTPSEPH LCLLDVGYLI NTSCLPLLQP TRDVDLILSL DYNLHGAFQQ LQLLGRFCQE 670 680 690 700 710 720 QGIPFPPISP SPEEQLQPRE CHTFSDPTCP GAPAVLHFPL VSDSFREYSA PGVRRTPEEA 730 740 750 760 770 780 AAGEVNLSSS DSPYHYTKVT YSQEDVDKLL HLTHYNVCNN QEQLLEALRQ AVQRRRQRRP H
	Isoform 2 (beta2) [UniParc]. Checksum: 0A7C3BE752C48F55	FASTA	893	100,516
	10 20 30 40 50 60 MAEAALEAVR SELREFPAAA RELCVPLAVP YLDKPPTPLH FYRDWVCPNR PCIIRNALQH 70 80 90 100 110 120 WPALQKWSLP YFRATVGSTE VSVAVTPDGY ADAVRGDRFM MPAERRLPLS FVLDVLEGRA 130 140 150 160 170 180 QHPGVLYVQK QCSNLPSELP QLLPDLESHV PWASEALGKM PDAVNFWLGE AAAVTSLHKD 190 200 210 220 230 240 HYENLYCVVS GEKHFLFHPP SDRPFIPYEL YTPATYQLTE EGTFKVVDEE AMEKAEVSRT 250 260 270 280 290 300 CLLTVRVLQA HRLPSKDLVT PSDCYVTLWL PTACSHRLQT RTVKNSSSPV WNQSFHFRIH 310 320 330 340 350 360 RQLKNVMELK VFDQDLVTGD DPVLSVLFDA GTLRAGEFRR ESFSLSPQGE GRLEVEFRLQ 370 380 390 400 410 420 SLADRGEWLV SNGVLVAREL SCLHVQLEET GDQKSSEHRV QLVVPGSCEG PQEASVGTGT 430 440 450 460 470 480 FRFHCPACWE QELSIRLQDA PEEQLKAPLS ALPSGQVVRL VFPTSQEPLM RVELKKEAGL 490 500 510 520 530 540 RELAVRLGFG PCAEEQAFLS RRKQVVAAAL RQALQLDGDL QEDEIPVVAI MATGGGIRAM 550 560 570 580 590 600 TSLYGQLAGL KELGLLDCVS YITGASGSTW ALANLYEDPE WSQKDLAGPT ELLKTQVTKN 610 620 630 640 650 660 KLGVLAPSQL QRYRQELAER ARLGYPSCFT NLWALINEAL LHDEPHDHKL SDQREALSHG 670 680 690 700 710 720 QNPLPIYCAL NTKGQSLTTF EFGEWCEFSP YEVGFPKYGA FIPSELFGSE FFMGQLMKRL 730 740 750 760 770 780 PESRICFLEG IWSNLYAANL QDSLYWASEP SQFWDRWVRN QANLDKEQVP LLKIEEPPST 790 800 810 820 830 840 AGRIAEFFTD LLTWRPLAQA THNFLRGLHF HKDYFQHPHF STWKATTLDG LPNQLTPSEP 850 860 870 880 890 HLCLLDVGYL INTSCLPLLQ PTRDVDLILS LDYNLHGAFQ GSGGHPRRRQ LGR
	Isoform 3 (beta3) [UniParc]. Checksum: 4C5CC6D084F2DF99	FASTA	887	100,094
	10 20 30 40 50 60 MAEAALEAVR SELREFPAAA RELCVPLAVP YLDKPPTPLH FYRDWVCPNR PCIIRNALQH 70 80 90 100 110 120 WPALQKWSLP YFRATVGSTE VSVAVTPDGY ADAVRGDRFM MPAERRLPLS FVLDVLEGRA 130 140 150 160 170 180 QHPGVLYVQK QCSNLPSELP QLLPDLESHV PWASEALGKM PDAVNFWLGE AAAVTSLHKD 190 200 210 220 230 240 HYENLYCVVS GEKHFLFHPP SDRPFIPYEL YTPATYQLTE EGTFKVVDEE AMEKAEVSRT 250 260 270 280 290 300 CLLTVRVLQA HRLPSKDLVT PSDCYVTLWL PTACSHRLQT RTVKNSSSPV WNQSFHFRIH 310 320 330 340 350 360 RQLKNVMELK VFDQDLVTGD DPVLSVLFDA GTLRAGEFRR ESFSLSPQGE GRLEVEFRLQ 370 380 390 400 410 420 SLADRGEWLV SNGVLVAREL SCLHVQLEET GDQKSSEHRV QLVVPGSCEG PQEASVGTGT 430 440 450 460 470 480 FRFHCPACWE QELSIRLQDA PEEQLKAPLS ALPSGQVVRL VFPTSQEPLM RVELKKEAGL 490 500 510 520 530 540 RELAVRLGFG PCAEEQAFLS RRKQVVAAAL RQALQLDGDL QEDEIPVVAI MATGGGIRAM 550 560 570 580 590 600 TSLYGQLAGL KELGLLDCVS YITGASGSTW ALANLYEDPE WSQKDLAGPT ELLKTQVTKN 610 620 630 640 650 660 KLGVLAPSQL QRYRQELAER ARLGYPSCFT NLWALINEAL LHDEPHDHKL SDQREALSHG 670 680 690 700 710 720 QNPLPIYCAL NTKGQSLTTF EFGEWCEFSP YEVGFPKYGA FIPSELFGSE FFMGQLMKRL 730 740 750 760 770 780 PESRICFLEG IWSNLYAANL QDSLYWASEP SQFWDRWVRN QANLDKEQVP LLKIEEPPST 790 800 810 820 830 840 AGRIAEFFTD LLTWRPLAQA THNFLRGLHF HKDYFQHPHF STWKATTLDG LPNQLTPSEP 850 860 870 880 HLCLLDVGYL INTSCLPLLQ PTRDVDLILS LEALRQAVQR RRQRRPH
	Isoform 4 [UniParc] [UniParc]. Checksum: EB8FC2F2EB2AE258	FASTA	482	54,679
	10 20 30 40 50 60 MATGGGIRAM TSLYGQLAGL KELGLLDCVS YITGASGSTW ALANLYEDPE WSQKDLAGPT 70 80 90 100 110 120 ELLKTQVTKN KLGVLAPSQL QRYRQELAER ARLGYPSCFT NLWALINEAL LHDEPHDHKL 130 140 150 160 170 180 SDQREALSHG QNPLPIYCAL NTKGQSLTTF EFGEWCEFSP YEVGFPKYGA FIPSELFGSE 190 200 210 220 230 240 FFMGQLMKRL PESRICFLEG IWSNLYAANL QDSLYWASEP SQFWDRWVRN QANLDKEQVP 250 260 270 280 290 300 LLKIEEPPST AGRIAEFFTD LLTWRPLAQA THNFLRGLHF HKDYFQHPHF STWKATTLDG 310 320 330 340 350 360 LPNQLTPSEP HLCLLDVGYL INTSCLPLLQ PTRDVDLILS LDYNLHGAFQ QLQLLGRFCQ 370 380 390 400 410 420 EQGIPFPPIS PSPEEQLQPR ECHTFSDPTC PGAPAVLHFP LVSDSFREYS APGVRRTPEE 430 440 450 460 470 480 AAAGEVNLSS SDSPYHYTKV TYSQEDVDKL LHLTHYNVCN NQEQLLEALR QAVQRRRQRR PH
	Isoform 5 (Beta1) [UniParc]. Checksum: 989EDB4AD3CF19DD	FASTA	1,012	114,121
	10 20 30 40 50 60 MAEAALEAVR SELREFPAAA RELCVPLAVP YLDKPPTPLH FYRDWVCPNR PCIIRNALQH 70 80 90 100 110 120 WPALQKWSLP YFRATVGSTE VSVAVTPDGY ADAVRGDRFM MPAERRLPLS FVLDVLEGRA 130 140 150 160 170 180 QHPGVLYVQK QCSNLPSELP QLLPDLESHV PWASEALGKM PDAVNFWLGE AAAVTSLHKD 190 200 210 220 230 240 HYENLYCVVS GEKHFLFHPP SDRPFIPYEL YTPATYQLTE EGTFKVVDEE AMEKAEVSRT 250 260 270 280 290 300 CLLTVRVLQA HRLPSKDLVT PSDCYVTLWL PTACSHRLQT RTVKNSSSPV WNQSFHFRIH 310 320 330 340 350 360 RQLKNVMELK VFDQDLVTGD DPVLSVLFDA GTLRAGEFRR ESFSLSPQGE GRLEVEFRLQ 370 380 390 400 410 420 SLADRGEWLV SNGVLVAREL SCLHVQLEET GDQKSSEHRV QLVVPGSCEG PQEASVGTGT 430 440 450 460 470 480 FRFHCPACWE QELSIRLQDA PEEQLKAPLS ALPSGQVVRL VFPTSQEPLM RVELKKEAGL 490 500 510 520 530 540 RELAVRLGFG PCAEEQAFLS RRKQVVAAAL RQALQLDGDL QEDEIPVVAI MATGGGIRAM 550 560 570 580 590 600 TSLYGQLAGL KELGLLDCVS YITGASGSTW ALANLYEDPE WSQKDLAGPT ELLKTQVTKN 610 620 630 640 650 660 KLGVLAPSQL QRYRQELAER ARLGYPSCFT NLWALINEAL LHDEPHDHKL SDQREALSHG 670 680 690 700 710 720 QNPLPIYCAL NTKGQSLTTF EFGEWCEFSP YEVGFPKYGA FIPSELFGSE FFMGQLMKRL 730 740 750 760 770 780 PESRICFLEG IWSNLYAANL QDSLYWASEP SQFWDRWVRN QANLDKEQVP LLKIEEPPST 790 800 810 820 830 840 AGRIAEFFTD LLTWRPLAQA THNFLRGLHF HKDYFQHPHF STWKATTLDG LPNQLTPSEP 850 860 870 880 890 900 HLCLLDVGYL INTSCLPLLQ PTRDVDLILS LDYNLHGAFQ QLQLLGRFCQ EQGIPFPPIS 910 920 930 940 950 960 PSPEEQLQPR ECHTFSDPTC PGAPAVLHFP LVSDSFREYS APGVRRTPEE AAAGEVNLSS 970 980 990 1000 1010 SDSPYHYTKV TYSQEDVDKL LHLTHYNVCN NQEQLLEALR QAVQRRRQRR PH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2." Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D. J. Biol. Chem. 274:8823-8831(1999) [PubMed: 10085124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-335; HIS-417; ASP-615 AND ARG-632.
[2]	"Molecular characterization of cytosolic phospholipase A2-beta." Song C., Chang X.J., Bean K.M., Proia M.S., Knopf J.L., Kriz R.W. J. Biol. Chem. 274:17063-17067(1999) [PubMed: 10358058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
[3]	"Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes." Ghosh M., Loper R., Gelb M.H., Leslie C.C. J. Biol. Chem. 281:16615-16624(2006) [PubMed: 16617059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-191. Tissue: Tongue.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[6]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF065215 mRNA. Translation: AAC78836.1. AF121908 mRNA. Translation: AAD32135.1. DQ523799 mRNA. Translation: ABF69195.1. DQ523800 mRNA. Translation: ABF69196.1. AK299419 mRNA. Translation: BAG61401.1. AB209150 mRNA. Translation: BAD92387.1. Different initiation. AC020659 Genomic DNA. No translation available.
IPI	IPI00413939. IPI00783406. IPI00783975. IPI00925427. IPI00969053.
RefSeq	NP_001108105.1. NM_001114633.1. NP_001185517.1. NM_001198588.1. NP_005081.1. NM_005090.3.
UniGene	Hs.198161.
3D structure databases
ProteinModelPortal	P0C869.
SMR	P0C869. Positions 4-777.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0C869. 2 interactions.
STRING	P0C869.
PTM databases
PhosphoSite	P0C869.
Polymorphism databases
DMDM	300669659.
Proteomic databases
PRIDE	P0C869.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342159; ENSP00000342785; ENSG00000168970. ENST00000382448; ENSP00000371886; ENSG00000168970. ENST00000452633; ENSP00000396045; ENSG00000243708. ENST00000458483; ENSP00000416610; ENSG00000168970.
GeneID	100137049. 8681.
KEGG	hsa:100137049. hsa:8681.
Organism-specific databases
CTD	100137049. 8681.
GeneCards	GC15P042122. GC15P042129.
HGNC	HGNC:9036. PLA2G4B.
HPA	HPA005726.
MIM	606088. gene.
neXtProt	NX_P0C869.
PharmGKB	PA165479070.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074489.
HOVERGEN	HBG080412.
InParanoid	P0C869.
OrthoDB	EOG4RR6GJ.
Enzyme and pathway databases
Reactome	REACT_15380. Diabetes pathways.
Gene expression databases
ArrayExpress	P0C869.
Bgee	P0C869.
Genevestigator	P0C869.
GermOnline	ENSG00000168970. Homo sapiens.
Family and domain databases
InterPro	IPR016035. Acyl_Trfase/lysoPLipase. IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR002642. LysoPLipase_cat_dom. [Graphical view]
KO	K01047.
Pfam	PF00168. C2. 1 hit. PF01735. PLA2_B. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00022. PLAc. 1 hit. [Graphical view]
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS51210. PLA2C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	32561.
SOURCE	Search...

Entry information

Entry name

PA24B_HUMAN

Accession

Primary (citable) accession number: P0C869
Secondary accession number(s): B4DRT9 , O95712, Q19KD5, Q19KD6, Q59GF9, Q8TB10, Q9UKV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 13, 2010
Last modified:	January 25, 2012
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.