Reviewed, UniProtKB/Swiss-Prot P0C862 (C1QT9_HUMAN)

Names and origin

Protein names

Recommended name:
    Complement C1q tumor necrosis factor-related protein 9

Gene names

Name:	C1QTNF9
ORF Names:	UNQ6503/PRO21380

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 C1q domain. Contains 3 collagen-like domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Collagen Repeat Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 333	314	Complement C1q tumor necrosis factor-related protein 9		PRO_0000291751
Regions
	Domain	24 – 82	59	Collagen-like 1
	Domain	95 – 154	60	Collagen-like 2
	Domain	155 – 191	37	Collagen-like 3
	Domain	197 – 333	137	C1q
Natural variations
	Natural variant	6	1	L → F: dbSNP rs1974332.		VAR_059148
	Natural variant	219	1	M → V: dbSNP rs3751357. Ref.1 Ref.2 Ref.3		VAR_032840
	Natural variant	301	1	V → M: dbSNP rs4589405. Ref.2		VAR_032841

Sequences

	Sequence		Length	Mass (Da)
	P0C862-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: F2EBF303B034E307	FASTA	333	34,681
	10 20 30 40 50 60 MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGR 70 80 90 100 110 120 PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP 130 140 150 160 170 180 QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI 190 200 210 220 230 240 RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDMP IKFDKILYNE FNHYDTAAGK 250 260 270 280 290 300 FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTKDAY MSSEDQASGG IVLQLKLGDE 310 320 330 VWLQVTGGER FNGLFADEDD DTTFTGFLLF SSP

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-219 AND MET-301.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY358145 mRNA. Translation: AAQ88512.1. AL359736 Genomic DNA. Translation: CAH72292.1. AL359736 Genomic DNA. Translation: CAH72293.1. BC040438 mRNA. Translation: AAH40438.1.
IPI	IPI00552240.
RefSeq	NP_848635.2.
UniGene	Hs.362854
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P0C862.
Genome annotation databases
Ensembl	ENST00000332018; ENSP00000333737; ENSG00000240654; Homo sapiens. [Genome view] ENST00000382071; ENSP00000371503; ENSG00000240654; Homo sapiens. [Genome view]
GeneID	338872.
KEGG	hsa:338872.
Organism-specific databases
CTD	338872.
GeneCards	GC13P023779.
HGNC	HGNC:28732. C1QTNF9.
GenAtlas	Search...
Phylogenomic databases
OMA	CHVAGVY
Gene expression databases
ArrayExpress	P0C862.
Bgee	P0C862.
CleanEx	HS_C1QTNF9.
Genevestigator	P0C862.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 3 hits. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C1QT9_HUMAN

Accession

Primary (citable) accession number: P0C862
Secondary accession number(s): A2A3T6 , Q0VGC5, Q5VX65, Q5VX66, Q8IUU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	November 24, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.