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P0C862

- C1T9A_HUMAN

UniProt

P0C862 - C1T9A_HUMAN

Protein

Complement C1q and tumor necrosis factor-related protein 9A

Gene

C1QTNF9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways By similarity.By similarity

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q and tumor necrosis factor-related protein 9A
    Alternative name(s):
    Complement C1q and tumor necrosis factor-related protein 9
    Gene namesi
    Name:C1QTNF9
    Synonyms:C1QTNF9A
    ORF Names:UNQ6503/PRO21380
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:28732. C1QTNF9.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145008937.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 333314Complement C1q and tumor necrosis factor-related protein 9APRO_0000291751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 3114-hydroxyprolineBy similarity
    Modified residuei34 – 3414-hydroxyprolineBy similarity
    Modified residuei40 – 4014-hydroxyprolineBy similarity
    Modified residuei58 – 5814-hydroxyprolineBy similarity
    Modified residuei61 – 6114-hydroxyprolineBy similarity
    Modified residuei64 – 6414-hydroxyprolineBy similarity
    Modified residuei73 – 7315-hydroxylysineBy similarity
    Glycosylationi73 – 731O-linked (Gal...)By similarity
    Modified residuei127 – 12715-hydroxylysineBy similarity
    Glycosylationi127 – 1271O-linked (Gal...)By similarity
    Modified residuei151 – 15114-hydroxyprolineBy similarity
    Modified residuei160 – 16014-hydroxyprolineBy similarity
    Modified residuei175 – 17514-hydroxyprolineBy similarity

    Keywords - PTMi

    Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiP0C862.
    PRIDEiP0C862.

    Expressioni

    Tissue specificityi

    Expressed predominantly in adipose tissue.1 Publication

    Gene expression databases

    BgeeiP0C862.
    CleanExiHS_C1QTNF9.
    GenevestigatoriP0C862.

    Interactioni

    Subunit structurei

    Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex By similarity. Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B.By similarity1 Publication

    Protein-protein interaction databases

    IntActiP0C862. 17 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C862.
    SMRiP0C862. Positions 201-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 8259Collagen-like 1Add
    BLAST
    Domaini95 – 15460Collagen-like 2Add
    BLAST
    Domaini155 – 19137Collagen-like 3Add
    BLAST
    Domaini197 – 333137C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 3 collagen-like domains.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiP0C862.
    OMAiCYLEINC.
    OrthoDBiEOG70ZZPW.
    PhylomeDBiP0C862.
    TreeFamiTF334029.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 3 hits.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C862-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG    50
    DKGDAGEPGR PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH 100
    GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL 150
    PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP 200
    KSAFTVGLTV LSKFPSSDMP IKFDKILYNE FNHYDTAAGK FTCHIAGVYY 250
    FTYHITVFSR NVQVSLVKNG VKILHTKDAY MSSEDQASGG IVLQLKLGDE 300
    VWLQVTGGER FNGLFADEDD DTTFTGFLLF SSP 333
    Length:333
    Mass (Da):34,681
    Last modified:September 2, 2008 - v1
    Checksum:iF2EBF303B034E307
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61L → F.
    Corresponds to variant rs1974332 [ dbSNP | Ensembl ].
    VAR_059148
    Natural varianti219 – 2191M → V.3 Publications
    Corresponds to variant rs3751357 [ dbSNP | Ensembl ].
    VAR_032840
    Natural varianti301 – 3011V → M.1 Publication
    Corresponds to variant rs4589405 [ dbSNP | Ensembl ].
    VAR_032841

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358145 mRNA. Translation: AAQ88512.1.
    AL359736 Genomic DNA. Translation: CAH72292.1.
    AL359736 Genomic DNA. Translation: CAH72293.1.
    BC040438 mRNA. Translation: AAH40438.1.
    CCDSiCCDS9306.1.
    RefSeqiNP_848635.2. NM_178540.3.
    UniGeneiHs.362854.

    Genome annotation databases

    EnsembliENST00000332018; ENSP00000333737; ENSG00000240654.
    ENST00000382071; ENSP00000371503; ENSG00000240654.
    GeneIDi338872.
    KEGGihsa:338872.
    UCSCiuc001upj.3. human.

    Polymorphism databases

    DMDMi205686199.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358145 mRNA. Translation: AAQ88512.1 .
    AL359736 Genomic DNA. Translation: CAH72292.1 .
    AL359736 Genomic DNA. Translation: CAH72293.1 .
    BC040438 mRNA. Translation: AAH40438.1 .
    CCDSi CCDS9306.1.
    RefSeqi NP_848635.2. NM_178540.3.
    UniGenei Hs.362854.

    3D structure databases

    ProteinModelPortali P0C862.
    SMRi P0C862. Positions 201-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0C862. 17 interactions.

    Polymorphism databases

    DMDMi 205686199.

    Proteomic databases

    PaxDbi P0C862.
    PRIDEi P0C862.

    Protocols and materials databases

    DNASUi 338872.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332018 ; ENSP00000333737 ; ENSG00000240654 .
    ENST00000382071 ; ENSP00000371503 ; ENSG00000240654 .
    GeneIDi 338872.
    KEGGi hsa:338872.
    UCSCi uc001upj.3. human.

    Organism-specific databases

    CTDi 338872.
    GeneCardsi GC13P024881.
    H-InvDB HIX0079546.
    HGNCi HGNC:28732. C1QTNF9.
    MIMi 614285. gene.
    neXtProti NX_P0C862.
    PharmGKBi PA145008937.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi P0C862.
    OMAi CYLEINC.
    OrthoDBi EOG70ZZPW.
    PhylomeDBi P0C862.
    TreeFami TF334029.

    Miscellaneous databases

    GenomeRNAii 338872.
    NextBioi 97187.
    PROi P0C862.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C862.
    CleanExi HS_C1QTNF9.
    Genevestigatori P0C862.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 3 hits.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
      Peterson J.M., Wei Z., Wong G.W.
      Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
      Tissue: Hippocampus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-219 AND MET-301.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.

    Entry informationi

    Entry nameiC1T9A_HUMAN
    AccessioniPrimary (citable) accession number: P0C862
    Secondary accession number(s): A2A3T6
    , Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3