Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Complement C1q and tumor necrosis factor-related protein 9A

Gene

C1QTNF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity).By similarity

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:G66-31735-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9A
Alternative name(s):
Complement C1q and tumor necrosis factor-related protein 9
Gene namesi
Name:C1QTNF9
Synonyms:C1QTNF9A
ORF Names:UNQ6503/PRO21380
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:28732. C1QTNF9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000240654.
PharmGKBiPA145008937.

Polymorphism and mutation databases

BioMutaiC1QTNF9.
DMDMi205686199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029175120 – 333Complement C1q and tumor necrosis factor-related protein 9AAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314-hydroxyprolineBy similarity1
Modified residuei344-hydroxyprolineBy similarity1
Modified residuei404-hydroxyprolineBy similarity1
Modified residuei584-hydroxyprolineBy similarity1
Modified residuei614-hydroxyprolineBy similarity1
Modified residuei644-hydroxyprolineBy similarity1
Modified residuei735-hydroxylysineBy similarity1
Glycosylationi73O-linked (Gal...)By similarity1
Modified residuei1275-hydroxylysineBy similarity1
Glycosylationi127O-linked (Gal...)By similarity1
Modified residuei1514-hydroxyprolineBy similarity1
Modified residuei1604-hydroxyprolineBy similarity1
Modified residuei1754-hydroxyprolineBy similarity1

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiP0C862.
PaxDbiP0C862.
PeptideAtlasiP0C862.
PRIDEiP0C862.

PTM databases

iPTMnetiP0C862.
PhosphoSitePlusiP0C862.

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000240654.
CleanExiHS_C1QTNF9.
GenevisibleiP0C862. HS.

Organism-specific databases

HPAiHPA056632.

Interactioni

Subunit structurei

Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex (By similarity). Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-5654640,EBI-5654640
C1QTNF9BB2RNN32EBI-5654640,EBI-10828035

Protein-protein interaction databases

BioGridi130809. 15 interactors.
IntActiP0C862. 19 interactors.
STRINGi9606.ENSP00000333737.

Structurei

3D structure databases

ProteinModelPortaliP0C862.
SMRiP0C862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 82Collagen-like 1Add BLAST59
Domaini95 – 154Collagen-like 2Add BLAST60
Domaini155 – 191Collagen-like 3Add BLAST37
Domaini197 – 333C1qPROSITE-ProRule annotationAdd BLAST137

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 3 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE67. Eukaryota.
ENOG4112BCC. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiP0C862.
OMAiCTQGYPG.
OrthoDBiEOG091G0L3Y.
PhylomeDBiP0C862.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGR PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH
110 120 130 140 150
GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL
160 170 180 190 200
PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP
210 220 230 240 250
KSAFTVGLTV LSKFPSSDMP IKFDKILYNE FNHYDTAAGK FTCHIAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKILHTKDAY MSSEDQASGG IVLQLKLGDE
310 320 330
VWLQVTGGER FNGLFADEDD DTTFTGFLLF SSP
Length:333
Mass (Da):34,681
Last modified:September 2, 2008 - v1
Checksum:iF2EBF303B034E307
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0591486L → F.Corresponds to variant rs1974332dbSNPEnsembl.1
Natural variantiVAR_032840219M → V.3 PublicationsCorresponds to variant rs3751357dbSNPEnsembl.1
Natural variantiVAR_032841301V → M.1 PublicationCorresponds to variant rs4589405dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358145 mRNA. Translation: AAQ88512.1.
AL359736 Genomic DNA. Translation: CAH72292.1.
AL359736 Genomic DNA. Translation: CAH72293.1.
BC040438 mRNA. Translation: AAH40438.1.
CCDSiCCDS9306.1.
RefSeqiNP_001290066.1. NM_001303137.1.
NP_001290067.1. NM_001303138.1.
NP_848635.2. NM_178540.4.
UniGeneiHs.362854.

Genome annotation databases

EnsembliENST00000332018; ENSP00000333737; ENSG00000240654.
ENST00000382071; ENSP00000371503; ENSG00000240654.
GeneIDi338872.
KEGGihsa:338872.
UCSCiuc001upj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358145 mRNA. Translation: AAQ88512.1.
AL359736 Genomic DNA. Translation: CAH72292.1.
AL359736 Genomic DNA. Translation: CAH72293.1.
BC040438 mRNA. Translation: AAH40438.1.
CCDSiCCDS9306.1.
RefSeqiNP_001290066.1. NM_001303137.1.
NP_001290067.1. NM_001303138.1.
NP_848635.2. NM_178540.4.
UniGeneiHs.362854.

3D structure databases

ProteinModelPortaliP0C862.
SMRiP0C862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130809. 15 interactors.
IntActiP0C862. 19 interactors.
STRINGi9606.ENSP00000333737.

PTM databases

iPTMnetiP0C862.
PhosphoSitePlusiP0C862.

Polymorphism and mutation databases

BioMutaiC1QTNF9.
DMDMi205686199.

Proteomic databases

MaxQBiP0C862.
PaxDbiP0C862.
PeptideAtlasiP0C862.
PRIDEiP0C862.

Protocols and materials databases

DNASUi338872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332018; ENSP00000333737; ENSG00000240654.
ENST00000382071; ENSP00000371503; ENSG00000240654.
GeneIDi338872.
KEGGihsa:338872.
UCSCiuc001upj.4. human.

Organism-specific databases

CTDi338872.
GeneCardsiC1QTNF9.
H-InvDBHIX0079546.
HGNCiHGNC:28732. C1QTNF9.
HPAiHPA056632.
MIMi614285. gene.
neXtProtiNX_P0C862.
OpenTargetsiENSG00000240654.
PharmGKBiPA145008937.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE67. Eukaryota.
ENOG4112BCC. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiP0C862.
OMAiCTQGYPG.
OrthoDBiEOG091G0L3Y.
PhylomeDBiP0C862.
TreeFamiTF334029.

Enzyme and pathway databases

BioCyciZFISH:G66-31735-MONOMER.

Miscellaneous databases

GenomeRNAii338872.
PROiP0C862.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240654.
CleanExiHS_C1QTNF9.
GenevisibleiP0C862. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1T9A_HUMAN
AccessioniPrimary (citable) accession number: P0C862
Secondary accession number(s): A2A3T6
, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.