P0C862 (C1T9A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement C1q and tumor necrosis factor-related protein 9A

Alternative name(s):
Complement C1q and tumor necrosis factor-related protein 9

Gene names

Name:	C1QTNF9
Synonyms:	C1QTNF9A
ORF Names:	UNQ6503/PRO21380

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways By similarity.
Subunit structure	Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex By similarity. Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B. Ref.1
Subcellular location	Secreted By similarity Ref.1.
Tissue specificity	Expressed predominantly in adipose tissue. Ref.1
Sequence similarities	Contains 1 C1q domain. Contains 3 collagen-like domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Collagen Repeat Signal
Molecular function	Hormone
PTM	Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 333	314	Complement C1q and tumor necrosis factor-related protein 9A		PRO_0000291751
Regions
	Domain	24 – 82	59	Collagen-like 1
	Domain	95 – 154	60	Collagen-like 2
	Domain	155 – 191	37	Collagen-like 3
	Domain	197 – 333	137	C1q
Amino acid modifications
	Modified residue	31	1	4-hydroxyproline By similarity
	Modified residue	34	1	4-hydroxyproline By similarity
	Modified residue	40	1	4-hydroxyproline By similarity
	Modified residue	58	1	4-hydroxyproline By similarity
	Modified residue	61	1	4-hydroxyproline By similarity
	Modified residue	64	1	4-hydroxyproline By similarity
	Modified residue	73	1	5-hydroxylysine By similarity
	Modified residue	127	1	5-hydroxylysine By similarity
	Modified residue	151	1	4-hydroxyproline By similarity
	Modified residue	160	1	4-hydroxyproline By similarity
	Modified residue	175	1	4-hydroxyproline By similarity
	Glycosylation	73	1	O-linked (Gal...) By similarity
	Glycosylation	127	1	O-linked (Gal...) By similarity
Natural variations
	Natural variant	6	1	L → F. Corresponds to variant rs1974332 [ dbSNP | Ensembl ].		VAR_059148
	Natural variant	219	1	M → V. Ref.2 Ref.3 Ref.4 Corresponds to variant rs3751357 [ dbSNP | Ensembl ].		VAR_032840
	Natural variant	301	1	V → M. Ref.3 Corresponds to variant rs4589405 [ dbSNP | Ensembl ].		VAR_032841

Sequences

	Sequence		Length	Mass (Da)
	P0C862 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: F2EBF303B034E307	FASTA	333	34,681
	10 20 30 40 50 60 MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGR 70 80 90 100 110 120 PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP 130 140 150 160 170 180 QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI 190 200 210 220 230 240 RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDMP IKFDKILYNE FNHYDTAAGK 250 260 270 280 290 300 FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTKDAY MSSEDQASGG IVLQLKLGDE 310 320 330 VWLQVTGGER FNGLFADEDD DTTFTGFLLF SSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members." Peterson J.M., Wei Z., Wong G.W. Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed: 19666007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY. Tissue: Hippocampus.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-219 AND MET-301.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358145 mRNA. Translation: AAQ88512.1. AL359736 Genomic DNA. Translation: CAH72292.1. AL359736 Genomic DNA. Translation: CAH72293.1. BC040438 mRNA. Translation: AAH40438.1.
IPI	IPI00552240.
RefSeq	NP_848635.2. NM_178540.3.
UniGene	Hs.362854.
3D structure databases
ProteinModelPortal	P0C862.
SMR	P0C862. Positions 28-109, 197-332.
ModBase	Search...
Protein-protein interaction databases
STRING	P0C862.
Polymorphism databases
DMDM	205686199.
Proteomic databases
PRIDE	P0C862.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332018; ENSP00000333737; ENSG00000240654. ENST00000382071; ENSP00000371503; ENSG00000240654.
GeneID	338872.
KEGG	hsa:338872.
Organism-specific databases
CTD	338872.
GeneCards	GC13P024881.
HGNC	HGNC:28732. C1QTNF9.
MIM	614285. gene.
neXtProt	NX_P0C862.
PharmGKB	PA145008937.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05639.
GeneTree	ENSGT00590000082736.
HOVERGEN	HBG108220.
InParanoid	P0C862.
OMA	GMRGWKG.
OrthoDB	EOG4D7Z64.
Gene expression databases
ArrayExpress	P0C862.
Bgee	P0C862.
CleanEx	HS_C1QTNF9.
Genevestigator	P0C862.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 3 hits. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

C1T9A_HUMAN

Accession

Primary (citable) accession number: P0C862
Secondary accession number(s): A2A3T6 , Q0VGC5, Q5VX65, Q5VX66, Q8IUU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.