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P0C862 (C1T9A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q and tumor necrosis factor-related protein 9A
Alternative name(s):
Complement C1q and tumor necrosis factor-related protein 9
Gene names
Name:C1QTNF9
Synonyms:C1QTNF9A
ORF Names:UNQ6503/PRO21380
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways By similarity.

Subunit structure

Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex By similarity. Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B. Ref.1

Subcellular location

Secreted By similarity Ref.1.

Tissue specificity

Expressed predominantly in adipose tissue. Ref.1

Sequence similarities

Contains 1 C1q domain.

Contains 3 collagen-like domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCollagen
Repeat
Signal
   Molecular functionHormone
   PTMGlycoprotein
Hydroxylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 333314Complement C1q and tumor necrosis factor-related protein 9A
PRO_0000291751

Regions

Domain24 – 8259Collagen-like 1
Domain95 – 15460Collagen-like 2
Domain155 – 19137Collagen-like 3
Domain197 – 333137C1q

Amino acid modifications

Modified residue3114-hydroxyproline By similarity
Modified residue3414-hydroxyproline By similarity
Modified residue4014-hydroxyproline By similarity
Modified residue5814-hydroxyproline By similarity
Modified residue6114-hydroxyproline By similarity
Modified residue6414-hydroxyproline By similarity
Modified residue7315-hydroxylysine By similarity
Modified residue12715-hydroxylysine By similarity
Modified residue15114-hydroxyproline By similarity
Modified residue16014-hydroxyproline By similarity
Modified residue17514-hydroxyproline By similarity
Glycosylation731O-linked (Gal...) By similarity
Glycosylation1271O-linked (Gal...) By similarity

Natural variations

Natural variant61L → F.
Corresponds to variant rs1974332 [ dbSNP | Ensembl ].
VAR_059148
Natural variant2191M → V. Ref.2 Ref.3 Ref.4
Corresponds to variant rs3751357 [ dbSNP | Ensembl ].
VAR_032840
Natural variant3011V → M. Ref.3
Corresponds to variant rs4589405 [ dbSNP | Ensembl ].
VAR_032841

Sequences

Sequence LengthMass (Da)Tools
P0C862 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: F2EBF303B034E307

FASTA33334,681
        10         20         30         40         50         60 
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGR 

        70         80         90        100        110        120 
PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP 

       130        140        150        160        170        180 
QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI 

       190        200        210        220        230        240 
RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDMP IKFDKILYNE FNHYDTAAGK 

       250        260        270        280        290        300 
FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTKDAY MSSEDQASGG IVLQLKLGDE 

       310        320        330 
VWLQVTGGER FNGLFADEDD DTTFTGFLLF SSP 

« Hide

References

« Hide 'large scale' references
[1]"CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
Peterson J.M., Wei Z., Wong G.W.
Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
Tissue: Hippocampus.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-219 AND MET-301.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358145 mRNA. Translation: AAQ88512.1.
AL359736 Genomic DNA. Translation: CAH72292.1.
AL359736 Genomic DNA. Translation: CAH72293.1.
BC040438 mRNA. Translation: AAH40438.1.
RefSeqNP_848635.2. NM_178540.3.
UniGeneHs.362854.

3D structure databases

ProteinModelPortalP0C862.
SMRP0C862. Positions 113-151, 201-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0C862. 17 interactions.

Polymorphism databases

DMDM205686199.

Proteomic databases

PaxDbP0C862.
PRIDEP0C862.

Protocols and materials databases

DNASU338872.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332018; ENSP00000333737; ENSG00000240654.
ENST00000382071; ENSP00000371503; ENSG00000240654.
GeneID338872.
KEGGhsa:338872.
UCSCuc001upj.3. human.

Organism-specific databases

CTD338872.
GeneCardsGC13P024881.
H-InvDBHIX0079546.
HGNCHGNC:28732. C1QTNF9.
MIM614285. gene.
neXtProtNX_P0C862.
PharmGKBPA145008937.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidP0C862.
OMASSQDTCR.
OrthoDBEOG70ZZPW.
PhylomeDBP0C862.
TreeFamTF334029.

Gene expression databases

BgeeP0C862.
CleanExHS_C1QTNF9.
GenevestigatorP0C862.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi338872.
NextBio97187.
PROP0C862.
SOURCESearch...

Entry information

Entry nameC1T9A_HUMAN
AccessionPrimary (citable) accession number: P0C862
Secondary accession number(s): A2A3T6 expand/collapse secondary AC list , Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM