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Protein

Complement C1q and tumor necrosis factor-related protein 9A

Gene

C1QTNF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity).By similarity

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9A
Alternative name(s):
Complement C1q and tumor necrosis factor-related protein 9
Gene namesi
Name:C1QTNF9
Synonyms:C1QTNF9A
ORF Names:UNQ6503/PRO21380
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:28732. C1QTNF9.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 333314Complement C1q and tumor necrosis factor-related protein 9APRO_0000291751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 3114-hydroxyprolineBy similarity
Modified residuei34 – 3414-hydroxyprolineBy similarity
Modified residuei40 – 4014-hydroxyprolineBy similarity
Modified residuei58 – 5814-hydroxyprolineBy similarity
Modified residuei61 – 6114-hydroxyprolineBy similarity
Modified residuei64 – 6414-hydroxyprolineBy similarity
Modified residuei73 – 7315-hydroxylysineBy similarity
Glycosylationi73 – 731O-linked (Gal...)By similarity
Modified residuei127 – 12715-hydroxylysineBy similarity
Glycosylationi127 – 1271O-linked (Gal...)By similarity
Modified residuei151 – 15114-hydroxyprolineBy similarity
Modified residuei160 – 16014-hydroxyprolineBy similarity
Modified residuei175 – 17514-hydroxyprolineBy similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP0C862.
PRIDEiP0C862.

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue.1 Publication

Gene expression databases

BgeeiP0C862.
CleanExiHS_C1QTNF9.
GenevestigatoriP0C862.

Interactioni

Subunit structurei

Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex (By similarity). Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B.By similarity1 Publication

Protein-protein interaction databases

BioGridi130809. 15 interactions.
IntActiP0C862. 17 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0C862.
SMRiP0C862. Positions 201-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8259Collagen-like 1Add
BLAST
Domaini95 – 15460Collagen-like 2Add
BLAST
Domaini155 – 19137Collagen-like 3Add
BLAST
Domaini197 – 333137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 3 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiP0C862.
OMAiCTQGYPG.
OrthoDBiEOG70ZZPW.
PhylomeDBiP0C862.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C862-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGR PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH
110 120 130 140 150
GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL
160 170 180 190 200
PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP
210 220 230 240 250
KSAFTVGLTV LSKFPSSDMP IKFDKILYNE FNHYDTAAGK FTCHIAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKILHTKDAY MSSEDQASGG IVLQLKLGDE
310 320 330
VWLQVTGGER FNGLFADEDD DTTFTGFLLF SSP
Length:333
Mass (Da):34,681
Last modified:September 2, 2008 - v1
Checksum:iF2EBF303B034E307
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → F.
Corresponds to variant rs1974332 [ dbSNP | Ensembl ].
VAR_059148
Natural varianti219 – 2191M → V.3 Publications
Corresponds to variant rs3751357 [ dbSNP | Ensembl ].
VAR_032840
Natural varianti301 – 3011V → M.1 Publication
Corresponds to variant rs4589405 [ dbSNP | Ensembl ].
VAR_032841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358145 mRNA. Translation: AAQ88512.1.
AL359736 Genomic DNA. Translation: CAH72292.1.
AL359736 Genomic DNA. Translation: CAH72293.1.
BC040438 mRNA. Translation: AAH40438.1.
CCDSiCCDS9306.1.
RefSeqiNP_848635.2. NM_178540.3.
UniGeneiHs.362854.

Genome annotation databases

EnsembliENST00000332018; ENSP00000333737; ENSG00000240654.
ENST00000382071; ENSP00000371503; ENSG00000240654.
GeneIDi338872.
KEGGihsa:338872.
UCSCiuc001upj.3. human.

Polymorphism databases

DMDMi205686199.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358145 mRNA. Translation: AAQ88512.1.
AL359736 Genomic DNA. Translation: CAH72292.1.
AL359736 Genomic DNA. Translation: CAH72293.1.
BC040438 mRNA. Translation: AAH40438.1.
CCDSiCCDS9306.1.
RefSeqiNP_848635.2. NM_178540.3.
UniGeneiHs.362854.

3D structure databases

ProteinModelPortaliP0C862.
SMRiP0C862. Positions 201-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130809. 15 interactions.
IntActiP0C862. 17 interactions.

Polymorphism databases

DMDMi205686199.

Proteomic databases

PaxDbiP0C862.
PRIDEiP0C862.

Protocols and materials databases

DNASUi338872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332018; ENSP00000333737; ENSG00000240654.
ENST00000382071; ENSP00000371503; ENSG00000240654.
GeneIDi338872.
KEGGihsa:338872.
UCSCiuc001upj.3. human.

Organism-specific databases

CTDi338872.
GeneCardsiGC13P024881.
H-InvDBHIX0079546.
HGNCiHGNC:28732. C1QTNF9.
MIMi614285. gene.
neXtProtiNX_P0C862.
PharmGKBiPA145008937.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiP0C862.
OMAiCTQGYPG.
OrthoDBiEOG70ZZPW.
PhylomeDBiP0C862.
TreeFamiTF334029.

Miscellaneous databases

GenomeRNAii338872.
NextBioi97187.
PROiP0C862.
SOURCEiSearch...

Gene expression databases

BgeeiP0C862.
CleanExiHS_C1QTNF9.
GenevestigatoriP0C862.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 3 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
    Peterson J.M., Wei Z., Wong G.W.
    Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
    Tissue: Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-219 AND MET-301.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-219.

Entry informationi

Entry nameiC1T9A_HUMAN
AccessioniPrimary (citable) accession number: P0C862
Secondary accession number(s): A2A3T6
, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.