P0C856 (UREG1_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreG 1

Gene names

Name:	ureG1
Ordered Locus Names:	BruAb1_0299

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG By similarity. HAMAP MF_01389
Subunit structure	Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01389.
Sequence similarities	Belongs to the UreG family.

Ontologies

Keywords
Biological process	Nickel insertion
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Urease accessory protein UreG 1 HAMAP MF_01389		PRO_0000347354
Regions
	Nucleotide binding	14 – 21	8	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C856 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 39FF82812CA4FDE2	FASTA	208	22,705
	10 20 30 40 50 60 MTQKNGPLRV GIGGPVGSGK TTLTEKLCKA MRDKYSVAVI TNDIYTQEDA LILARRQALS 70 80 90 100 110 120 EDRIIGVETG GCPHTAIRED ASINLQAVVE MTRRFPDLDV VFIESGGDNL AATFSPDLAD 130 140 150 160 170 180 LTLYVISVCQ GEEIPRKGGP GITRSDFLVI NKSDLAPYVH VDLEVMEADA MRMRAKRPFG 190 200 FTDLHRGKGV QEIIDFIVEN GGLEPRSN

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX73702.1.
PIR	AC3458.
RefSeq	YP_221063.1. NC_006932.1.
3D structure databases
ProteinModelPortal	P0C856.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3340616.
GenomeReviews	Gene locus BruAb1_0299 in contig AE017223_GR.
KEGG	bmb:BruAb1_0299.
PATRIC	17822178. VBIBruAbo15061_0327.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG364734.
OMA	PFIFTNL.
PhylomeDB	P0C856.
ProtClustDB	CLSK864148.
Family and domain databases
HAMAP	MF_01389. UreG. [Tree]
InterPro	IPR003495. Cbl_biosynth_CobW-like. IPR012202. NiFe-hyd/urease_mat_GTPase. IPR004400. Urease_accessory_UreG. [Graphical view]
KO	K03189.
Pfam	PF02492. cobW. 1 hit. [Graphical view]
PIRSF	PIRSF005624. Ni-bind_GTPase. 1 hit.
TIGRFAMs	TIGR00101. UreG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UREG1_BRUAB

Accession

Primary (citable) accession number: P0C856
Secondary accession number(s): Q57F82, Q93T78

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program