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Protein

Phosphoinositide-interacting protein

Gene

PIRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide-interacting protein
Gene namesi
Name:PIRT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:37239. PIRT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiPIRT.
DMDMi308153473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Phosphoinositide-interacting proteinPRO_0000347060Add
BLAST

Proteomic databases

PaxDbiP0C851.
PRIDEiP0C851.

PTM databases

PhosphoSiteiP0C851.

Expressioni

Gene expression databases

BgeeiP0C851.
GenevisibleiP0C851. HS.

Organism-specific databases

HPAiHPA042337.

Interactioni

Subunit structurei

Interacts with TRPV1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000462046.

Structurei

3D structure databases

ProteinModelPortaliP0C851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40976.
GeneTreeiENSGT00390000016891.
HOGENOMiHOG000082413.
HOVERGENiHBG106144.
InParanoidiP0C851.
OMAiQKSVFFQ.
OrthoDBiEOG718KF5.
PhylomeDBiP0C851.
TreeFamiTF328608.

Family and domain databases

InterProiIPR028068. PIRT.
[Graphical view]
PfamiPF15099. PIRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMETLPKVL EVDEKSPEAK DLLPSQTASS LCISSRSESV WTTTPRSNWE
60 70 80 90 100
IYRKPIVIMS VGGAILLFGV VITCLAYTLK LSDKSLSILK MVGPGFLSLG
110 120 130
LMMLVCGLVW VPIIKKKQKH RQKSNFLRSL KSFFLTR
Length:137
Mass (Da):15,334
Last modified:October 5, 2010 - v2
Checksum:i588C1AA13A5BDD05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299808 mRNA. Translation: BAH13134.1.
DC332889 mRNA. No translation available.
AC015908 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW89989.1.
CCDSiCCDS45614.1.
RefSeqiNP_001094857.1. NM_001101387.1.
UniGeneiHs.553909.

Genome annotation databases

EnsembliENST00000580256; ENSP00000462046; ENSG00000233670.
GeneIDi644139.
KEGGihsa:644139.
UCSCiuc010col.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299808 mRNA. Translation: BAH13134.1.
DC332889 mRNA. No translation available.
AC015908 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW89989.1.
CCDSiCCDS45614.1.
RefSeqiNP_001094857.1. NM_001101387.1.
UniGeneiHs.553909.

3D structure databases

ProteinModelPortaliP0C851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000462046.

PTM databases

PhosphoSiteiP0C851.

Polymorphism and mutation databases

BioMutaiPIRT.
DMDMi308153473.

Proteomic databases

PaxDbiP0C851.
PRIDEiP0C851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000580256; ENSP00000462046; ENSG00000233670.
GeneIDi644139.
KEGGihsa:644139.
UCSCiuc010col.3. human.

Organism-specific databases

CTDi644139.
GeneCardsiGC17M010725.
HGNCiHGNC:37239. PIRT.
HPAiHPA042337.
MIMi612068. gene.
neXtProtiNX_P0C851.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40976.
GeneTreeiENSGT00390000016891.
HOGENOMiHOG000082413.
HOVERGENiHBG106144.
InParanoidiP0C851.
OMAiQKSVFFQ.
OrthoDBiEOG718KF5.
PhylomeDBiP0C851.
TreeFamiTF328608.

Miscellaneous databases

GenomeRNAii644139.
NextBioi115894.
PROiP0C851.
SOURCEiSearch...

Gene expression databases

BgeeiP0C851.
GenevisibleiP0C851. HS.

Family and domain databases

InterProiIPR028068. PIRT.
[Graphical view]
PfamiPF15099. PIRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain and Hippocampus.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPIRT_HUMAN
AccessioniPrimary (citable) accession number: P0C851
Secondary accession number(s): B7Z648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 5, 2010
Last modified: June 24, 2015
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.