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P0C851

- PIRT_HUMAN

UniProt

P0C851 - PIRT_HUMAN

Protein

Phosphoinositide-interacting protein

Gene

PIRT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide-interacting protein
    Gene namesi
    Name:PIRT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:37239. PIRT.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 137137Phosphoinositide-interacting proteinPRO_0000347060Add
    BLAST

    Proteomic databases

    PaxDbiP0C851.
    PRIDEiP0C851.

    PTM databases

    PhosphoSiteiP0C851.

    Expressioni

    Gene expression databases

    BgeeiP0C851.
    GenevestigatoriP0C851.

    Organism-specific databases

    HPAiHPA042337.

    Interactioni

    Subunit structurei

    Interacts with TRPV1.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000408936.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C851.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40976.
    HOGENOMiHOG000082413.
    HOVERGENiHBG106144.
    OMAiLKMIGPA.
    OrthoDBiEOG718KF5.
    PhylomeDBiP0C851.
    TreeFamiTF328608.

    Family and domain databases

    InterProiIPR028068. PIRT.
    [Graphical view]
    PfamiPF15099. PIRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMETLPKVL EVDEKSPEAK DLLPSQTASS LCISSRSESV WTTTPRSNWE    50
    IYRKPIVIMS VGGAILLFGV VITCLAYTLK LSDKSLSILK MVGPGFLSLG 100
    LMMLVCGLVW VPIIKKKQKH RQKSNFLRSL KSFFLTR 137
    Length:137
    Mass (Da):15,334
    Last modified:October 5, 2010 - v2
    Checksum:i588C1AA13A5BDD05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299808 mRNA. Translation: BAH13134.1.
    DC332889 mRNA. No translation available.
    AC015908 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW89989.1.
    CCDSiCCDS45614.1.
    RefSeqiNP_001094857.1. NM_001101387.1.
    UniGeneiHs.553909.

    Genome annotation databases

    EnsembliENST00000580256; ENSP00000462046; ENSG00000233670.
    GeneIDi644139.
    KEGGihsa:644139.
    UCSCiuc010col.3. human.

    Polymorphism databases

    DMDMi308153473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299808 mRNA. Translation: BAH13134.1 .
    DC332889 mRNA. No translation available.
    AC015908 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW89989.1 .
    CCDSi CCDS45614.1.
    RefSeqi NP_001094857.1. NM_001101387.1.
    UniGenei Hs.553909.

    3D structure databases

    ProteinModelPortali P0C851.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000408936.

    PTM databases

    PhosphoSitei P0C851.

    Polymorphism databases

    DMDMi 308153473.

    Proteomic databases

    PaxDbi P0C851.
    PRIDEi P0C851.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000580256 ; ENSP00000462046 ; ENSG00000233670 .
    GeneIDi 644139.
    KEGGi hsa:644139.
    UCSCi uc010col.3. human.

    Organism-specific databases

    CTDi 644139.
    GeneCardsi GC17M010725.
    HGNCi HGNC:37239. PIRT.
    HPAi HPA042337.
    MIMi 612068. gene.
    neXtProti NX_P0C851.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40976.
    HOGENOMi HOG000082413.
    HOVERGENi HBG106144.
    OMAi LKMIGPA.
    OrthoDBi EOG718KF5.
    PhylomeDBi P0C851.
    TreeFami TF328608.

    Miscellaneous databases

    NextBioi 115894.
    PROi P0C851.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C851.
    Genevestigatori P0C851.

    Family and domain databases

    InterProi IPR028068. PIRT.
    [Graphical view ]
    Pfami PF15099. PIRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain and Hippocampus.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPIRT_HUMAN
    AccessioniPrimary (citable) accession number: P0C851
    Secondary accession number(s): B7Z648
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-3 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3