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Protein

Zinc finger protein 688

Gene

ZNF688

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri183 – 20523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 688
Gene namesi
Name:ZNF688
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30489. ZNF688.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670487.

Polymorphism and mutation databases

BioMutaiZNF688.
DMDMi205636136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Zinc finger protein 688PRO_0000234007Add
BLAST

Proteomic databases

MaxQBiP0C7X2.
PaxDbiP0C7X2.
PRIDEiP0C7X2.

Expressioni

Gene expression databases

BgeeiP0C7X2.
CleanExiHS_ZNF688.
ExpressionAtlasiP0C7X2. baseline and differential.
GenevisibleiP0C7X2. HS.

Organism-specific databases

HPAiHPA048922.

Interactioni

Protein-protein interaction databases

BioGridi126996. 1 interaction.
IntActiP0C7X2. 2 interactions.
STRINGi9606.ENSP00000223459.

Structurei

3D structure databases

ProteinModelPortaliP0C7X2.
SMRiP0C7X2. Positions 179-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri183 – 20523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP0C7X2.
KOiK09228.
OMAiELVKHNP.
OrthoDBiEOG73JKWC.
PhylomeDBiP0C7X2.
TreeFamiTF339643.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C7X2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPPAPLLA PRPGETRPGC RKPGTVSFAD VAVYFSPEEW GCLRPAQRAL
60 70 80 90 100
YRDVMQETYG HLGALGFPGP KPALISWMEQ ESEAWSPAAQ DPEKGERLGG
110 120 130 140 150
ARRGDVPNRK EEEPEEVPRA KGPRKAPVKE SPEVLVERNP DPAISVAPAR
160 170 180 190 200
AQPPKNAAWD PTTGAQPPAP IPSMDAQAGQ RRHVCTDCGR RFTYPSLLVS
210 220 230 240 250
HRRMHSGERP FPCPECGMRF KRKFAVEAHQ WIHRSCSGGR RGRRPGIRAV
260 270
PRAPVRGDRD PPVLFRHYPD IFEECG
Length:276
Mass (Da):30,575
Last modified:July 22, 2008 - v1
Checksum:i11D583A6D671CBFE
GO
Isoform 2 (identifier: P0C7X2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MAPPPAPLLA...QETYGHLGAL → MPRSPLRSSL...IGRCVLRVQR

Show »
Length:262
Mass (Da):28,905
Checksum:i6478F38218E22066
GO

Sequence cautioni

The sequence AAC31673.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: ZNF688 and ZNF785.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531P → A in BM011208 (Ref. 5) Curated
Sequence conflicti193 – 1931T → S in BM011208 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311S → I.
Corresponds to variant rs33997546 [ dbSNP | Ensembl ].
VAR_052896

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565MAPPP…HLGAL → MPRSPLRSSLSTEASGPRGP FKCPASPRPITAQLLPGSSP IIGRCVLRVQR in isoform 2. 1 PublicationVSP_046955Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122680 mRNA. Translation: BAG53663.1.
AC002310 Genomic DNA. Translation: AAC31673.1. Sequence problems.
CH471192 Genomic DNA. Translation: EAW52233.1.
CH471192 Genomic DNA. Translation: EAW52235.1.
BC018997 mRNA. Translation: AAH18997.1.
BM011208 mRNA. No translation available.
CCDSiCCDS10684.1. [P0C7X2-1]
CCDS42151.1. [P0C7X2-5]
RefSeqiNP_001019854.1. NM_001024683.1. [P0C7X2-5]
NP_660314.1. NM_145271.3. [P0C7X2-1]
UniGeneiHs.301463.
Hs.513509.

Genome annotation databases

EnsembliENST00000223459; ENSP00000223459; ENSG00000229809. [P0C7X2-1]
ENST00000563276; ENSP00000455227; ENSG00000229809. [P0C7X2-5]
GeneIDi146542.
KEGGihsa:146542.
UCSCiuc002dyt.4. human. [P0C7X2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122680 mRNA. Translation: BAG53663.1.
AC002310 Genomic DNA. Translation: AAC31673.1. Sequence problems.
CH471192 Genomic DNA. Translation: EAW52233.1.
CH471192 Genomic DNA. Translation: EAW52235.1.
BC018997 mRNA. Translation: AAH18997.1.
BM011208 mRNA. No translation available.
CCDSiCCDS10684.1. [P0C7X2-1]
CCDS42151.1. [P0C7X2-5]
RefSeqiNP_001019854.1. NM_001024683.1. [P0C7X2-5]
NP_660314.1. NM_145271.3. [P0C7X2-1]
UniGeneiHs.301463.
Hs.513509.

3D structure databases

ProteinModelPortaliP0C7X2.
SMRiP0C7X2. Positions 179-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126996. 1 interaction.
IntActiP0C7X2. 2 interactions.
STRINGi9606.ENSP00000223459.

Polymorphism and mutation databases

BioMutaiZNF688.
DMDMi205636136.

Proteomic databases

MaxQBiP0C7X2.
PaxDbiP0C7X2.
PRIDEiP0C7X2.

Protocols and materials databases

DNASUi146542.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223459; ENSP00000223459; ENSG00000229809. [P0C7X2-1]
ENST00000563276; ENSP00000455227; ENSG00000229809. [P0C7X2-5]
GeneIDi146542.
KEGGihsa:146542.
UCSCiuc002dyt.4. human. [P0C7X2-1]

Organism-specific databases

CTDi146542.
GeneCardsiZNF688.
HGNCiHGNC:30489. ZNF688.
HPAiHPA048922.
neXtProtiNX_P0C7X2.
PharmGKBiPA142670487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP0C7X2.
KOiK09228.
OMAiELVKHNP.
OrthoDBiEOG73JKWC.
PhylomeDBiP0C7X2.
TreeFamiTF339643.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii146542.
NextBioi85389.
PROiP0C7X2.

Gene expression databases

BgeeiP0C7X2.
CleanExiHS_ZNF688.
ExpressionAtlasiP0C7X2. baseline and differential.
GenevisibleiP0C7X2. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell and Brain.
  5. The MGC Project Team
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-215 (ISOFORM 2).

Entry informationi

Entry nameiZN688_HUMAN
AccessioniPrimary (citable) accession number: P0C7X2
Secondary accession number(s): A8MV39
, B3KV51, O75701, Q8IW91, Q8WV14, Q96MN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.