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Protein

Coiled-coil domain-containing protein 172

Gene

CCDC172

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30880-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 172
Gene namesi
Name:CCDC172
Synonyms:C10orf96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:30524. CCDC172.

Pathology & Biotechi

Organism-specific databases

DisGeNETi374355.
OpenTargetsiENSG00000182645.
PharmGKBiPA134867240.

Polymorphism and mutation databases

BioMutaiCCDC172.
DMDMi206557852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003445131 – 258Coiled-coil domain-containing protein 172Add BLAST258

Proteomic databases

MaxQBiP0C7W6.
PaxDbiP0C7W6.
PRIDEiP0C7W6.

PTM databases

iPTMnetiP0C7W6.
PhosphoSitePlusiP0C7W6.

Expressioni

Gene expression databases

BgeeiENSG00000182645.
CleanExiHS_C10orf96.
GenevisibleiP0C7W6. HS.

Organism-specific databases

HPAiHPA037955.
HPA037956.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCTN2Q135613EBI-2548868,EBI-715074
FAM13CQ8NE313EBI-2548868,EBI-751248
HDDC3Q8N4P33EBI-2548868,EBI-750003
ISCUQ9H1K13EBI-2548868,EBI-1047335
SH2D4AQ9H7883EBI-2548868,EBI-747035
SMARCE1Q969G33EBI-2548868,EBI-455078
TCHPQ9BT925EBI-2548868,EBI-740781
TEAD4D3DUQ63EBI-2548868,EBI-10176734
TXNDC9O145303EBI-2548868,EBI-707554

Protein-protein interaction databases

BioGridi131893. 17 interactors.
IntActiP0C7W6. 17 interactors.
MINTiMINT-8417611.
STRINGi9606.ENSP00000329860.

Structurei

3D structure databases

ProteinModelPortaliP0C7W6.
SMRiP0C7W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 90Sequence analysisAdd BLAST78
Coiled coili123 – 191Sequence analysisAdd BLAST69
Coiled coili226 – 256Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the CCDC172 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWRG. Eukaryota.
ENOG4112A44. LUCA.
GeneTreeiENSGT00390000005203.
HOGENOMiHOG000111699.
HOVERGENiHBG106901.
InParanoidiP0C7W6.
OMAiEAICTTK.
OrthoDBiEOG091G0OD3.
PhylomeDBiP0C7W6.
TreeFamiTF333231.

Family and domain databases

InterProiIPR029618. CCDC172.
[Graphical view]
PANTHERiPTHR22419:SF2. PTHR22419:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLESLFQHI IFTEHQAEES RRLMREVRSE ITRCREKIKK ATEELNEEKI
60 70 80 90 100
KLESKVQQFF EKSFFLQLLK AHENALEKQY SEITNHRNML LQTFEAIKKQ
110 120 130 140 150
MIEEEDKFIK EITDFNNDYE ITKKRELLMK ENVKIEISDL ENQANMLKSE
160 170 180 190 200
MKSMEHDSSQ LNELQKQKSE LIQELFTLQR KLKVFEDEEN ESICTTKYLE
210 220 230 240 250
AEKIKISEKP QNDTECLRLK KELELYKEDD MESVYEALQT EIEFLELTLA

QKDLQESK
Length:258
Mass (Da):31,035
Last modified:July 22, 2008 - v1
Checksum:i9CFC9C42B13486B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA. No translation available.
BC044830 mRNA. Translation: AAH44830.1.
CCDSiCCDS31291.1.
RefSeqiNP_940917.1. NM_198515.2.
XP_016871695.1. XM_017016206.1.
UniGeneiHs.233407.

Genome annotation databases

EnsembliENST00000333254; ENSP00000329860; ENSG00000182645.
GeneIDi374355.
KEGGihsa:374355.
UCSCiuc001lck.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA. No translation available.
BC044830 mRNA. Translation: AAH44830.1.
CCDSiCCDS31291.1.
RefSeqiNP_940917.1. NM_198515.2.
XP_016871695.1. XM_017016206.1.
UniGeneiHs.233407.

3D structure databases

ProteinModelPortaliP0C7W6.
SMRiP0C7W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131893. 17 interactors.
IntActiP0C7W6. 17 interactors.
MINTiMINT-8417611.
STRINGi9606.ENSP00000329860.

PTM databases

iPTMnetiP0C7W6.
PhosphoSitePlusiP0C7W6.

Polymorphism and mutation databases

BioMutaiCCDC172.
DMDMi206557852.

Proteomic databases

MaxQBiP0C7W6.
PaxDbiP0C7W6.
PRIDEiP0C7W6.

Protocols and materials databases

DNASUi374355.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333254; ENSP00000329860; ENSG00000182645.
GeneIDi374355.
KEGGihsa:374355.
UCSCiuc001lck.3. human.

Organism-specific databases

CTDi374355.
DisGeNETi374355.
GeneCardsiCCDC172.
HGNCiHGNC:30524. CCDC172.
HPAiHPA037955.
HPA037956.
neXtProtiNX_P0C7W6.
OpenTargetsiENSG00000182645.
PharmGKBiPA134867240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWRG. Eukaryota.
ENOG4112A44. LUCA.
GeneTreeiENSGT00390000005203.
HOGENOMiHOG000111699.
HOVERGENiHBG106901.
InParanoidiP0C7W6.
OMAiEAICTTK.
OrthoDBiEOG091G0OD3.
PhylomeDBiP0C7W6.
TreeFamiTF333231.

Enzyme and pathway databases

BioCyciZFISH:G66-30880-MONOMER.

Miscellaneous databases

GenomeRNAii374355.
PROiP0C7W6.

Gene expression databases

BgeeiENSG00000182645.
CleanExiHS_C10orf96.
GenevisibleiP0C7W6. HS.

Family and domain databases

InterProiIPR029618. CCDC172.
[Graphical view]
PANTHERiPTHR22419:SF2. PTHR22419:SF2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCC172_HUMAN
AccessioniPrimary (citable) accession number: P0C7W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.