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P0C7W0 (PRR29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline-rich protein 29
Gene names
Name:PRR29
Synonyms:C17orf72
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P0C7W0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P0C7W0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     157-189: VRAVPPPPPPSATGTVGADVPPASDYYDAESLL → TTMMPRASYE...SWTGRICAVV
Note: No experimental confirmation available.
Isoform 3 (identifier: P0C7W0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     82-98: VYLEVPQEEPEEEEEEM → ESCAPTPTPQCHRDCGC
     99-189: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: P0C7W0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     22-28: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Proline-rich protein 29
PRO_0000344468

Regions

Compositional bias73 – 16694Pro-rich

Natural variations

Alternative sequence22 – 287Missing in isoform 4.
VSP_046997
Alternative sequence82 – 9817VYLEV…EEEEM → ESCAPTPTPQCHRDCGC in isoform 3.
VSP_045344
Alternative sequence99 – 18991Missing in isoform 3.
VSP_045345
Alternative sequence157 – 18933VRAVP…AESLL → TTMMPRASYEDRPRPWELHQ LPALDTAPEPPPAPLLSTPR CPWLAVLLTPSTSARPSSPG EISPCPTPMSSWTGRICAVV in isoform 2.
VSP_045346
Natural variant241T → S. Ref.1
Corresponds to variant rs62070903 [ dbSNP | Ensembl ].
VAR_069055

Experimental info

Sequence conflict1451R → S in BAG51052. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2013. Version 2.
Checksum: 1110D9410668AD7C

FASTA18920,715
        10         20         30         40         50         60 
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL MMLQNAQMHQ 

        70         80         90        100        110        120 
LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV REKGPLVFHH HYLPYLMPSP 

       130        140        150        160        170        180 
GALLPWPAPF FPTPACQPYL QDVPRIQHCP ASREREVRAV PPPPPPSATG TVGADVPPAS 


DYYDAESLL 

« Hide

Isoform 2 [UniParc].

Checksum: 6FEDE51C9AA13183
Show »

FASTA23626,083
Isoform 3 [UniParc].

Checksum: 32B699C855AF48C9
Show »

FASTA9810,435
Isoform 4 [UniParc].

Checksum: 4E95DE87606A402F
Show »

FASTA18219,843

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT SER-24.
Tissue: Embryo and Testis.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK021786 mRNA. Translation: BAG51052.1.
AK302960 mRNA. Translation: BAG64111.1.
AK304254 mRNA. Translation: BAG65120.1.
DB037384 mRNA. No translation available.
AC005803 Genomic DNA. No translation available.
CCDSCCDS54157.1. [P0C7W0-2]
CCDS54158.1. [P0C7W0-1]
CCDS54159.1. [P0C7W0-3]
CCDS58586.1. [P0C7W0-4]
RefSeqNP_001157729.1. NM_001164257.1. [P0C7W0-1]
NP_001177958.1. NM_001191029.1. [P0C7W0-2]
NP_001177959.1. NM_001191030.1. [P0C7W0-4]
NP_001177960.1. NM_001191031.1. [P0C7W0-3]
UniGeneHs.708161.

3D structure databases

ProteinModelPortalP0C7W0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124935. 1 interaction.

Proteomic databases

PaxDbP0C7W0.
PRIDEP0C7W0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412177; ENSP00000400986; ENSG00000224383. [P0C7W0-1]
ENST00000425164; ENSP00000396936; ENSG00000224383. [P0C7W0-2]
ENST00000577953; ENSP00000463279; ENSG00000224383. [P0C7W0-3]
ENST00000579184; ENSP00000462097; ENSG00000224383. [P0C7W0-4]
GeneID92340.
KEGGhsa:92340.
UCSCuc002jdt.4. human. [P0C7W0-1]

Organism-specific databases

CTD92340.
GeneCardsGC17P062075.
HGNCHGNC:25673. PRR29.
HPAHPA051264.
neXtProtNX_P0C7W0.
PharmGKBPA142672220.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28023.
HOGENOMHOG000111941.
HOVERGENHBG107756.
OMAHHYLPCP.
OrthoDBEOG74XS8P.

Gene expression databases

ArrayExpressP0C7W0.
BgeeP0C7W0.
CleanExHS_C17orf72.
GenevestigatorP0C7W0.

Family and domain databases

InterProIPR027904. DUF4587.
[Graphical view]
PfamPF15248. DUF4587. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC17orf72. human.
NextBio35536420.

Entry information

Entry namePRR29_HUMAN
AccessionPrimary (citable) accession number: P0C7W0
Secondary accession number(s): B3KMP0 expand/collapse secondary AC list , B4DZJ9, B4E2F8, E9PGL5, J3QKX4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 6, 2013
Last modified: July 9, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM