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P0C7W0

- PRR29_HUMAN

UniProt

P0C7W0 - PRR29_HUMAN

Protein

Proline-rich protein 29

Gene

PRR29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (06 Feb 2013)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-rich protein 29
    Gene namesi
    Name:PRR29
    Synonyms:C17orf72
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25673. PRR29.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Proline-rich protein 29PRO_0000344468Add
    BLAST

    Proteomic databases

    PaxDbiP0C7W0.
    PRIDEiP0C7W0.

    Expressioni

    Gene expression databases

    ArrayExpressiP0C7W0.
    BgeeiP0C7W0.
    CleanExiHS_C17orf72.
    GenevestigatoriP0C7W0.

    Organism-specific databases

    HPAiHPA051264.

    Interactioni

    Protein-protein interaction databases

    BioGridi124935. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C7W0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi73 – 16694Pro-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG28023.
    HOGENOMiHOG000111941.
    HOVERGENiHBG107756.
    OMAiHHYLPCP.
    OrthoDBiEOG74XS8P.

    Family and domain databases

    InterProiIPR027904. DUF4587.
    [Graphical view]
    PfamiPF15248. DUF4587. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P0C7W0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL    50
    MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV 100
    REKGPLVFHH HYLPYLMPSP GALLPWPAPF FPTPACQPYL QDVPRIQHCP 150
    ASREREVRAV PPPPPPSATG TVGADVPPAS DYYDAESLL 189
    Length:189
    Mass (Da):20,715
    Last modified:February 6, 2013 - v2
    Checksum:i1110D9410668AD7C
    GO
    Isoform 2 (identifier: P0C7W0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         157-189: VRAVPPPPPPSATGTVGADVPPASDYYDAESLL → TTMMPRASYE...SWTGRICAVV

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):26,083
    Checksum:i6FEDE51C9AA13183
    GO
    Isoform 3 (identifier: P0C7W0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-98: VYLEVPQEEPEEEEEEM → ESCAPTPTPQCHRDCGC
         99-189: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:98
    Mass (Da):10,435
    Checksum:i32B699C855AF48C9
    GO
    Isoform 4 (identifier: P0C7W0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-28: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:182
    Mass (Da):19,843
    Checksum:i4E95DE87606A402F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451R → S in BAG51052. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241T → S.1 Publication
    Corresponds to variant rs62070903 [ dbSNP | Ensembl ].
    VAR_069055

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 287Missing in isoform 4. 1 PublicationVSP_046997
    Alternative sequencei82 – 9817VYLEV…EEEEM → ESCAPTPTPQCHRDCGC in isoform 3. 1 PublicationVSP_045344Add
    BLAST
    Alternative sequencei99 – 18991Missing in isoform 3. 1 PublicationVSP_045345Add
    BLAST
    Alternative sequencei157 – 18933VRAVP…AESLL → TTMMPRASYEDRPRPWELHQ LPALDTAPEPPPAPLLSTPR CPWLAVLLTPSTSARPSSPG EISPCPTPMSSWTGRICAVV in isoform 2. 1 PublicationVSP_045346Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021786 mRNA. Translation: BAG51052.1.
    AK302960 mRNA. Translation: BAG64111.1.
    AK304254 mRNA. Translation: BAG65120.1.
    DB037384 mRNA. No translation available.
    AC005803 Genomic DNA. No translation available.
    CCDSiCCDS54157.1. [P0C7W0-2]
    CCDS54158.1. [P0C7W0-1]
    CCDS54159.1. [P0C7W0-3]
    CCDS58586.1. [P0C7W0-4]
    RefSeqiNP_001157729.1. NM_001164257.1. [P0C7W0-1]
    NP_001177958.1. NM_001191029.1. [P0C7W0-2]
    NP_001177959.1. NM_001191030.1. [P0C7W0-4]
    NP_001177960.1. NM_001191031.1. [P0C7W0-3]
    UniGeneiHs.708161.

    Genome annotation databases

    EnsembliENST00000412177; ENSP00000400986; ENSG00000224383. [P0C7W0-1]
    ENST00000425164; ENSP00000396936; ENSG00000224383. [P0C7W0-2]
    ENST00000577953; ENSP00000463279; ENSG00000224383. [P0C7W0-3]
    ENST00000579184; ENSP00000462097; ENSG00000224383. [P0C7W0-4]
    GeneIDi92340.
    KEGGihsa:92340.
    UCSCiuc002jdt.4. human. [P0C7W0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021786 mRNA. Translation: BAG51052.1 .
    AK302960 mRNA. Translation: BAG64111.1 .
    AK304254 mRNA. Translation: BAG65120.1 .
    DB037384 mRNA. No translation available.
    AC005803 Genomic DNA. No translation available.
    CCDSi CCDS54157.1. [P0C7W0-2 ]
    CCDS54158.1. [P0C7W0-1 ]
    CCDS54159.1. [P0C7W0-3 ]
    CCDS58586.1. [P0C7W0-4 ]
    RefSeqi NP_001157729.1. NM_001164257.1. [P0C7W0-1 ]
    NP_001177958.1. NM_001191029.1. [P0C7W0-2 ]
    NP_001177959.1. NM_001191030.1. [P0C7W0-4 ]
    NP_001177960.1. NM_001191031.1. [P0C7W0-3 ]
    UniGenei Hs.708161.

    3D structure databases

    ProteinModelPortali P0C7W0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124935. 1 interaction.

    Proteomic databases

    PaxDbi P0C7W0.
    PRIDEi P0C7W0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412177 ; ENSP00000400986 ; ENSG00000224383 . [P0C7W0-1 ]
    ENST00000425164 ; ENSP00000396936 ; ENSG00000224383 . [P0C7W0-2 ]
    ENST00000577953 ; ENSP00000463279 ; ENSG00000224383 . [P0C7W0-3 ]
    ENST00000579184 ; ENSP00000462097 ; ENSG00000224383 . [P0C7W0-4 ]
    GeneIDi 92340.
    KEGGi hsa:92340.
    UCSCi uc002jdt.4. human. [P0C7W0-1 ]

    Organism-specific databases

    CTDi 92340.
    GeneCardsi GC17P062075.
    HGNCi HGNC:25673. PRR29.
    HPAi HPA051264.
    neXtProti NX_P0C7W0.
    PharmGKBi PA142672220.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28023.
    HOGENOMi HOG000111941.
    HOVERGENi HBG107756.
    OMAi HHYLPCP.
    OrthoDBi EOG74XS8P.

    Miscellaneous databases

    ChiTaRSi C17orf72. human.
    NextBioi 35536420.

    Gene expression databases

    ArrayExpressi P0C7W0.
    Bgeei P0C7W0.
    CleanExi HS_C17orf72.
    Genevestigatori P0C7W0.

    Family and domain databases

    InterProi IPR027904. DUF4587.
    [Graphical view ]
    Pfami PF15248. DUF4587. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT SER-24.
      Tissue: Embryo and Testis.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPRR29_HUMAN
    AccessioniPrimary (citable) accession number: P0C7W0
    Secondary accession number(s): B3KMP0
    , B4DZJ9, B4E2F8, E9PGL5, J3QKX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: February 6, 2013
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3