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P0C7W0

- PRR29_HUMAN

UniProt

P0C7W0 - PRR29_HUMAN

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Protein
Proline-rich protein 29
Gene
PRR29, C17orf72
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 29
Gene namesi
Name:PRR29
Synonyms:C17orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25673. PRR29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Proline-rich protein 29
PRO_0000344468Add
BLAST

Proteomic databases

PaxDbiP0C7W0.
PRIDEiP0C7W0.

Expressioni

Gene expression databases

ArrayExpressiP0C7W0.
BgeeiP0C7W0.
CleanExiHS_C17orf72.
GenevestigatoriP0C7W0.

Organism-specific databases

HPAiHPA051264.

Interactioni

Protein-protein interaction databases

BioGridi124935. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP0C7W0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi73 – 16694Pro-rich
Add
BLAST

Phylogenomic databases

eggNOGiNOG28023.
HOGENOMiHOG000111941.
HOVERGENiHBG107756.
OMAiHHYLPCP.
OrthoDBiEOG74XS8P.

Family and domain databases

InterProiIPR027904. DUF4587.
[Graphical view]
PfamiPF15248. DUF4587. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P0C7W0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL    50
MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV 100
REKGPLVFHH HYLPYLMPSP GALLPWPAPF FPTPACQPYL QDVPRIQHCP 150
ASREREVRAV PPPPPPSATG TVGADVPPAS DYYDAESLL 189
Length:189
Mass (Da):20,715
Last modified:February 6, 2013 - v2
Checksum:i1110D9410668AD7C
GO
Isoform 2 (identifier: P0C7W0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-189: VRAVPPPPPPSATGTVGADVPPASDYYDAESLL → TTMMPRASYE...SWTGRICAVV

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):26,083
Checksum:i6FEDE51C9AA13183
GO
Isoform 3 (identifier: P0C7W0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-98: VYLEVPQEEPEEEEEEM → ESCAPTPTPQCHRDCGC
     99-189: Missing.

Note: No experimental confirmation available.

Show »
Length:98
Mass (Da):10,435
Checksum:i32B699C855AF48C9
GO
Isoform 4 (identifier: P0C7W0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-28: Missing.

Note: No experimental confirmation available.

Show »
Length:182
Mass (Da):19,843
Checksum:i4E95DE87606A402F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241T → S.1 Publication
Corresponds to variant rs62070903 [ dbSNP | Ensembl ].
VAR_069055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 287Missing in isoform 4.
VSP_046997
Alternative sequencei82 – 9817VYLEV…EEEEM → ESCAPTPTPQCHRDCGC in isoform 3.
VSP_045344Add
BLAST
Alternative sequencei99 – 18991Missing in isoform 3.
VSP_045345Add
BLAST
Alternative sequencei157 – 18933VRAVP…AESLL → TTMMPRASYEDRPRPWELHQ LPALDTAPEPPPAPLLSTPR CPWLAVLLTPSTSARPSSPG EISPCPTPMSSWTGRICAVV in isoform 2.
VSP_045346Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451R → S in BAG51052. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021786 mRNA. Translation: BAG51052.1.
AK302960 mRNA. Translation: BAG64111.1.
AK304254 mRNA. Translation: BAG65120.1.
DB037384 mRNA. No translation available.
AC005803 Genomic DNA. No translation available.
CCDSiCCDS54157.1. [P0C7W0-2]
CCDS54158.1. [P0C7W0-1]
CCDS54159.1. [P0C7W0-3]
CCDS58586.1. [P0C7W0-4]
RefSeqiNP_001157729.1. NM_001164257.1. [P0C7W0-1]
NP_001177958.1. NM_001191029.1. [P0C7W0-2]
NP_001177959.1. NM_001191030.1. [P0C7W0-4]
NP_001177960.1. NM_001191031.1. [P0C7W0-3]
UniGeneiHs.708161.

Genome annotation databases

EnsembliENST00000412177; ENSP00000400986; ENSG00000224383. [P0C7W0-1]
ENST00000425164; ENSP00000396936; ENSG00000224383. [P0C7W0-2]
ENST00000577953; ENSP00000463279; ENSG00000224383. [P0C7W0-3]
ENST00000579184; ENSP00000462097; ENSG00000224383. [P0C7W0-4]
GeneIDi92340.
KEGGihsa:92340.
UCSCiuc002jdt.4. human. [P0C7W0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021786 mRNA. Translation: BAG51052.1 .
AK302960 mRNA. Translation: BAG64111.1 .
AK304254 mRNA. Translation: BAG65120.1 .
DB037384 mRNA. No translation available.
AC005803 Genomic DNA. No translation available.
CCDSi CCDS54157.1. [P0C7W0-2 ]
CCDS54158.1. [P0C7W0-1 ]
CCDS54159.1. [P0C7W0-3 ]
CCDS58586.1. [P0C7W0-4 ]
RefSeqi NP_001157729.1. NM_001164257.1. [P0C7W0-1 ]
NP_001177958.1. NM_001191029.1. [P0C7W0-2 ]
NP_001177959.1. NM_001191030.1. [P0C7W0-4 ]
NP_001177960.1. NM_001191031.1. [P0C7W0-3 ]
UniGenei Hs.708161.

3D structure databases

ProteinModelPortali P0C7W0.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124935. 1 interaction.

Proteomic databases

PaxDbi P0C7W0.
PRIDEi P0C7W0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412177 ; ENSP00000400986 ; ENSG00000224383 . [P0C7W0-1 ]
ENST00000425164 ; ENSP00000396936 ; ENSG00000224383 . [P0C7W0-2 ]
ENST00000577953 ; ENSP00000463279 ; ENSG00000224383 . [P0C7W0-3 ]
ENST00000579184 ; ENSP00000462097 ; ENSG00000224383 . [P0C7W0-4 ]
GeneIDi 92340.
KEGGi hsa:92340.
UCSCi uc002jdt.4. human. [P0C7W0-1 ]

Organism-specific databases

CTDi 92340.
GeneCardsi GC17P062075.
HGNCi HGNC:25673. PRR29.
HPAi HPA051264.
neXtProti NX_P0C7W0.
PharmGKBi PA142672220.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28023.
HOGENOMi HOG000111941.
HOVERGENi HBG107756.
OMAi HHYLPCP.
OrthoDBi EOG74XS8P.

Miscellaneous databases

ChiTaRSi C17orf72. human.
NextBioi 35536420.

Gene expression databases

ArrayExpressi P0C7W0.
Bgeei P0C7W0.
CleanExi HS_C17orf72.
Genevestigatori P0C7W0.

Family and domain databases

InterProi IPR027904. DUF4587.
[Graphical view ]
Pfami PF15248. DUF4587. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT SER-24.
    Tissue: Embryo and Testis.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRR29_HUMAN
AccessioniPrimary (citable) accession number: P0C7W0
Secondary accession number(s): B3KMP0
, B4DZJ9, B4E2F8, E9PGL5, J3QKX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 6, 2013
Last modified: July 9, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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