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Protein

Proline-rich protein 29

Gene

PRR29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 29
Gene namesi
Name:PRR29
Synonyms:C17orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25673. PRR29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Proline-rich protein 29PRO_0000344468Add
BLAST

Proteomic databases

PaxDbiP0C7W0.
PRIDEiP0C7W0.

Expressioni

Gene expression databases

BgeeiP0C7W0.
CleanExiHS_C17orf72.
ExpressionAtlasiP0C7W0. baseline and differential.
GenevestigatoriP0C7W0.

Organism-specific databases

HPAiHPA051264.

Interactioni

Protein-protein interaction databases

BioGridi124935. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP0C7W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi73 – 16694Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG28023.
GeneTreeiENSGT00390000002000.
HOGENOMiHOG000111941.
HOVERGENiHBG107756.
InParanoidiP0C7W0.
OMAiHHYLPCP.
OrthoDBiEOG74XS8P.

Family and domain databases

InterProiIPR027904. DUF4587.
[Graphical view]
PfamiPF15248. DUF4587. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C7W0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL
60 70 80 90 100
MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV
110 120 130 140 150
REKGPLVFHH HYLPYLMPSP GALLPWPAPF FPTPACQPYL QDVPRIQHCP
160 170 180
ASREREVRAV PPPPPPSATG TVGADVPPAS DYYDAESLL
Length:189
Mass (Da):20,715
Last modified:February 6, 2013 - v2
Checksum:i1110D9410668AD7C
GO
Isoform 2 (identifier: P0C7W0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-189: VRAVPPPPPPSATGTVGADVPPASDYYDAESLL → TTMMPRASYE...SWTGRICAVV

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):26,083
Checksum:i6FEDE51C9AA13183
GO
Isoform 3 (identifier: P0C7W0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-98: VYLEVPQEEPEEEEEEM → ESCAPTPTPQCHRDCGC
     99-189: Missing.

Note: No experimental confirmation available.

Show »
Length:98
Mass (Da):10,435
Checksum:i32B699C855AF48C9
GO
Isoform 4 (identifier: P0C7W0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-28: Missing.

Note: No experimental confirmation available.

Show »
Length:182
Mass (Da):19,843
Checksum:i4E95DE87606A402F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451R → S in BAG51052 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241T → S.1 Publication
Corresponds to variant rs62070903 [ dbSNP | Ensembl ].
VAR_069055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 287Missing in isoform 4. 1 PublicationVSP_046997
Alternative sequencei82 – 9817VYLEV…EEEEM → ESCAPTPTPQCHRDCGC in isoform 3. 1 PublicationVSP_045344Add
BLAST
Alternative sequencei99 – 18991Missing in isoform 3. 1 PublicationVSP_045345Add
BLAST
Alternative sequencei157 – 18933VRAVP…AESLL → TTMMPRASYEDRPRPWELHQ LPALDTAPEPPPAPLLSTPR CPWLAVLLTPSTSARPSSPG EISPCPTPMSSWTGRICAVV in isoform 2. 1 PublicationVSP_045346Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021786 mRNA. Translation: BAG51052.1.
AK302960 mRNA. Translation: BAG64111.1.
AK304254 mRNA. Translation: BAG65120.1.
DB037384 mRNA. No translation available.
AC005803 Genomic DNA. No translation available.
CCDSiCCDS54157.1. [P0C7W0-2]
CCDS54158.1. [P0C7W0-1]
CCDS54159.1. [P0C7W0-3]
CCDS58586.1. [P0C7W0-4]
RefSeqiNP_001157729.1. NM_001164257.1. [P0C7W0-1]
NP_001177958.1. NM_001191029.1. [P0C7W0-2]
NP_001177959.1. NM_001191030.1. [P0C7W0-4]
NP_001177960.1. NM_001191031.1. [P0C7W0-3]
UniGeneiHs.708161.

Genome annotation databases

EnsembliENST00000412177; ENSP00000400986; ENSG00000224383. [P0C7W0-1]
ENST00000425164; ENSP00000396936; ENSG00000224383. [P0C7W0-2]
ENST00000577953; ENSP00000463279; ENSG00000224383. [P0C7W0-3]
ENST00000579184; ENSP00000462097; ENSG00000224383. [P0C7W0-4]
GeneIDi92340.
KEGGihsa:92340.
UCSCiuc002jdt.4. human. [P0C7W0-1]
uc010wpv.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021786 mRNA. Translation: BAG51052.1.
AK302960 mRNA. Translation: BAG64111.1.
AK304254 mRNA. Translation: BAG65120.1.
DB037384 mRNA. No translation available.
AC005803 Genomic DNA. No translation available.
CCDSiCCDS54157.1. [P0C7W0-2]
CCDS54158.1. [P0C7W0-1]
CCDS54159.1. [P0C7W0-3]
CCDS58586.1. [P0C7W0-4]
RefSeqiNP_001157729.1. NM_001164257.1. [P0C7W0-1]
NP_001177958.1. NM_001191029.1. [P0C7W0-2]
NP_001177959.1. NM_001191030.1. [P0C7W0-4]
NP_001177960.1. NM_001191031.1. [P0C7W0-3]
UniGeneiHs.708161.

3D structure databases

ProteinModelPortaliP0C7W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124935. 1 interaction.

Proteomic databases

PaxDbiP0C7W0.
PRIDEiP0C7W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412177; ENSP00000400986; ENSG00000224383. [P0C7W0-1]
ENST00000425164; ENSP00000396936; ENSG00000224383. [P0C7W0-2]
ENST00000577953; ENSP00000463279; ENSG00000224383. [P0C7W0-3]
ENST00000579184; ENSP00000462097; ENSG00000224383. [P0C7W0-4]
GeneIDi92340.
KEGGihsa:92340.
UCSCiuc002jdt.4. human. [P0C7W0-1]
uc010wpv.2. human.

Organism-specific databases

CTDi92340.
GeneCardsiGC17P062075.
HGNCiHGNC:25673. PRR29.
HPAiHPA051264.
neXtProtiNX_P0C7W0.
PharmGKBiPA142672220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28023.
GeneTreeiENSGT00390000002000.
HOGENOMiHOG000111941.
HOVERGENiHBG107756.
InParanoidiP0C7W0.
OMAiHHYLPCP.
OrthoDBiEOG74XS8P.

Miscellaneous databases

GenomeRNAii92340.
NextBioi35536420.

Gene expression databases

BgeeiP0C7W0.
CleanExiHS_C17orf72.
ExpressionAtlasiP0C7W0. baseline and differential.
GenevestigatoriP0C7W0.

Family and domain databases

InterProiIPR027904. DUF4587.
[Graphical view]
PfamiPF15248. DUF4587. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT SER-24.
    Tissue: Embryo and Testis.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRR29_HUMAN
AccessioniPrimary (citable) accession number: P0C7W0
Secondary accession number(s): B3KMP0
, B4DZJ9, B4E2F8, E9PGL5, J3QKX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 6, 2013
Last modified: January 7, 2015
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.