P0C7V8 (DC8L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DDB1- and CUL4-associated factor 8-like protein 2

Alternative name(s):
WD repeat-containing protein 42C

Gene names

Name:	DCAF8L2
Synonyms:	WDR42C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the WD repeat DCAF8 family. Contains 7 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 602	602	DDB1- and CUL4-associated factor 8-like protein 2		PRO_0000344462
Regions
	Repeat	197 – 236	40	WD 1
	Repeat	240 – 281	42	WD 2
	Repeat	287 – 327	41	WD 3
	Repeat	335 – 375	41	WD 4
	Repeat	391 – 430	40	WD 5
	Repeat	438 – 478	41	WD 6
	Repeat	482 – 521	40	WD 7
	Compositional bias	76 – 149	74	Glu-rich
Natural variations
	Natural variant	316	1	T → A. Corresponds to variant rs5926895 [ dbSNP | Ensembl ].		VAR_045620

Sequences

	Sequence		Length	Mass (Da)
	P0C7V8 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 51BEA03C519CE8B3	FASTA	602	67,911
	10 20 30 40 50 60 MSHQEGSTDG LPDLGTESLF SSPEEQSGAV AATEASSDID IATSELSVTV TGDGSDSRDG 70 80 90 100 110 120 GFPNDASTEN RSSDQESASE DIELESLEDF EHFLMREEEE EEEEEEEEEE EEEEEEEEQP 130 140 150 160 170 180 RAGPQGSGGN HEQYSLEEDQ ALEEWVSSET SALPRPRWQV VTALHQRQLG SRPRFVYEAC 190 200 210 220 230 240 GARAFVQRFR LQYRLADHVG CVNTVHFNQR GTRLASSGDD LKVIVWDWVR QRPVLNFESG 250 260 270 280 290 300 HTNNVFQAKF LPNCGDSTLA MCARDGQVRV AELINASYFN NTKCVAQHRG PAHKLALEPD 310 320 330 340 350 360 SPYKFLTSGE DAVVFTIDLR QDRPASKVVV TRENDKKVGL YTITVNPANT YQFAVGGQDQ 370 380 390 400 410 420 FVRIYDQRKI DKKENNGVLK KFTPHHLVNC DFPTNITCVV YSHDGTELLA SYNDDDIYLF 430 440 450 460 470 480 NSSHSDGAQY SKRFKGHRNN TTVKGVNFYG PRSEFVVSGS DCGHIFFWEK SSCQIIQFLK 490 500 510 520 530 540 GSREGTINCL EPHPYLPVLA CSGLDHDVKI WTPTAKAATE LTGLKKVIKK NKWERDEDSL 550 560 570 580 590 600 HHGSLFDQYM LWFLLRHVTQ RGRHQDWRSG EAEFPDEESD ESSSTSETSE EEVQDRVQCM PS

References

[1]

"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC107613 Genomic DNA. No translation available.
IPI	IPI00232818.
UniGene	Hs.720885.
3D structure databases
ProteinModelPortal	P0C7V8.
SMR	P0C7V8. Positions 188-424.
ModBase	Search...
Polymorphism databases
DMDM	206557849.
Proteomic databases
PRIDE	P0C7V8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC0XP027764.
HGNC	HGNC:31811. DCAF8L2.
neXtProt	NX_P0C7V8.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG053807.
PhylomeDB	P0C7V8.
Gene expression databases
CleanEx	HS_WDR42C.
Genevestigator	P0C7V8.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DC8L2_HUMAN

Accession

Primary (citable) accession number: P0C7V8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.