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Protein

DDB1- and CUL4-associated factor 8-like protein 2

Gene

DCAF8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiP0C7V8.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 8-like protein 2
Alternative name(s):
WD repeat-containing protein 42C
Gene namesi
Name:DCAF8L2
Synonyms:WDR42C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189186.10.
HGNCiHGNC:31811. DCAF8L2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189186.

Polymorphism and mutation databases

BioMutaiDCAF8L2.
DMDMi519668665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444621 – 631DDB1- and CUL4-associated factor 8-like protein 2Add BLAST631

Proteomic databases

EPDiP0C7V8.
MaxQBiP0C7V8.
PaxDbiP0C7V8.
PeptideAtlasiP0C7V8.
PRIDEiP0C7V8.

PTM databases

iPTMnetiP0C7V8.
PhosphoSitePlusiP0C7V8.

Expressioni

Gene expression databases

BgeeiENSG00000189186.
CleanExiHS_WDR42C.
ExpressionAtlasiP0C7V8. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi131438. 15 interactors.
STRINGi9606.ENSP00000462745.

Structurei

3D structure databases

ProteinModelPortaliP0C7V8.
SMRiP0C7V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati226 – 265WD 1Add BLAST40
Repeati269 – 310WD 2Add BLAST42
Repeati316 – 356WD 3Add BLAST41
Repeati364 – 404WD 4Add BLAST41
Repeati420 – 459WD 5Add BLAST40
Repeati467 – 507WD 6Add BLAST41
Repeati511 – 550WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 178Glu-richAdd BLAST74

Sequence similaritiesi

Belongs to the WD repeat DCAF8 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOVERGENiHBG053807.
InParanoidiP0C7V8.
OMAiDHDGRAH.
OrthoDBiEOG091G056C.
TreeFamiTF326071.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 3 hits.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQEGSTDG LPDLGTESLF SSPEEQSGAV AATEASSDID IATSELSVTV
60 70 80 90 100
TGDGSDSRDG GFPNDASTEN RSSDQESASE DIELESLEDF EHFLMSGESL
110 120 130 140 150
FHYPLVGEEE TEREEEDEEI QEEGGEEEEE EEEEEEEEEE EEEEEEEQPR
160 170 180 190 200
AGPQGSGGNH EQYSLEEDQA LEEWVSSETS ALPRPRWQVV TALHQRQLGS
210 220 230 240 250
RPRFVYEACG ARAFVQRFRL QYRLADHVGC VNTVHFNQRG TRLASSGDDL
260 270 280 290 300
KVIVWDWVRQ RPVLNFESGH TNNVFQAKFL PNCGDSTLAM CARDGQVRVA
310 320 330 340 350
ELINASYFNN TKCVAQHRGP AHKLALEPDS PYKFLTSGED AVVFTIDLRQ
360 370 380 390 400
DRPASKVVVT RENDKKVGLY TITVNPANTY QFAVGGQDQF VRIYDQRKID
410 420 430 440 450
KKENNGVLKK FTPHHLVNCD FPTNITCVVY SHDGTELLAS YNDDDIYLFN
460 470 480 490 500
SSHSDGAQYS KRFKGHRNNT TVKGVNFYGP RSEFVVSGSD CGHIFFWEKS
510 520 530 540 550
SCQIIQFLKG SREGTINCLE PHPYLPVLAC SGLDHDVKIW TPTAKAATEL
560 570 580 590 600
TGLKKVIKKN KWERDEDSLH HGSLFDQYML WFLLRHVTQR GRHQDWRSGE
610 620 630
AEFPDEESDE SSSTSETSEE EVQDRVQCMP S
Length:631
Mass (Da):71,191
Last modified:June 26, 2013 - v2
Checksum:i04C398AEE033EB3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145 – 147Missing in AAI57860 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045620345T → A. Corresponds to variant dbSNP:rs5926895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157859 mRNA. Translation: AAI57860.1.
AC006210 Genomic DNA. No translation available.
AC079902 Genomic DNA. No translation available.
AC107613 Genomic DNA. No translation available.
CCDSiCCDS59162.1.
RefSeqiNP_001130005.1. NM_001136533.1.
UniGeneiHs.720885.

Genome annotation databases

EnsembliENST00000451261; ENSP00000462745; ENSG00000189186.
ENST00000545306; ENSP00000479800; ENSG00000189186.
GeneIDi347442.
KEGGihsa:347442.
UCSCiuc011mjy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDC8L2_HUMAN
AccessioniPrimary (citable) accession number: P0C7V8
Secondary accession number(s): B2RXH9, J3KT06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 26, 2013
Last modified: September 27, 2017
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families