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Protein

Putative signal peptidase complex catalytic subunit SEC11B

Gene

SEC11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative component of some signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Putative signal peptidase complex catalytic subunit SEC11B (EC:3.4.21.89)
Alternative name(s):
SEC11 homolog B
SEC11-like protein 2
Gene namesi
Name:SEC11B
Synonyms:SEC11L2, SPCS4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31884. SEC11B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini25 – 166ExtracellularSequence analysisAdd BLAST142

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi206557848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444611 – 166Putative signal peptidase complex catalytic subunit SEC11BAdd BLAST166

Proteomic databases

EPDiP0C7V7.
MaxQBiP0C7V7.
PeptideAtlasiP0C7V7.
PRIDEiP0C7V7.

PTM databases

iPTMnetiP0C7V7.
PhosphoSitePlusiP0C7V7.

Expressioni

Gene expression databases

CleanExiHS_SEC11B.

Structurei

3D structure databases

ProteinModelPortaliP0C7V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP0C7V7.

Family and domain databases

InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKWRLYYQV LNFGMIVSSA LMIWKGLMVI TGSESPIVLL SGSMEPAFHR
60 70 80 90 100
GYLLFLTNRV EDPIRVGEIA VLRIEGRKIP IVHRVLKIHE KQNGHIKFLT
110 120 130 140 150
KGDNNAVDDR GLYKQDQHWL EKKDVVGRAR GFVPYIGIGT SLMNDYPKHK
160
YEVLFLLGLF VLVHRE
Length:166
Mass (Da):19,160
Last modified:July 22, 2008 - v1
Checksum:i64C26E8B71A2BF00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091076 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091076 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP0C7V7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0C7V7.
PhosphoSitePlusiP0C7V7.

Polymorphism and mutation databases

DMDMi206557848.

Proteomic databases

EPDiP0C7V7.
MaxQBiP0C7V7.
PeptideAtlasiP0C7V7.
PRIDEiP0C7V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiSEC11B.
HGNCiHGNC:31884. SEC11B.
neXtProtiNX_P0C7V7.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP0C7V7.

Gene expression databases

CleanExiHS_SEC11B.

Family and domain databases

InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC11B_HUMAN
AccessioniPrimary (citable) accession number: P0C7V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.