P0C7U3 (ZH11B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable palmitoyltransferase ZDHHC11B
EC=2.3.1.-

Alternative name(s):
Zinc finger DHHC domain-containing protein 11B
Short name=DHHC-11B

Gene names

Name:

ZDHHC11B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Probable palmitoyltransferase ZDHHC11B		PRO_0000343747
Regions
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	216 – 236	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
	Zinc finger	125 – 175	51	DHHC-type
Natural variations
	Natural variant	42	1	R → Q. Corresponds to variant rs1809933 [ dbSNP | Ensembl ].		VAR_052976
	Natural variant	200	1	R → G. Corresponds to variant rs634901 [ dbSNP | Ensembl ].		VAR_052977
	Natural variant	228	1	V → L. Corresponds to variant rs3817063 [ dbSNP | Ensembl ].		VAR_061990

Sequences

	Sequence		Length	Mass (Da)
	P0C7U3 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 8B3222AB3F1717CF	FASTA	371	41,895
	10 20 30 40 50 60 MDTRSGSQCS VTPEAIRNNE ELVLPPRISR VNGWSLPLHY FRVVTWAVFV GLSLATFRIF 70 80 90 100 110 120 IPLLPHSWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV RLMKNYSQPM PLFDRSKHAH 130 140 150 160 170 180 VIQNQFCHLC KVTVNKKTKH CISCNKCVSG FDHHCKWINN CVGSRNYWFF FSTVASATAG 190 200 210 220 230 240 MLCLIAILLY VLVQYLVNPR VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIRMLV 250 260 270 280 290 300 LLLDLLGLVQ LGQLLIFHIY LKAKKMTTFE YLINTRKEES SKHQAVRKDP YVQMDKGFLQ 310 320 330 340 350 360 QGAGALGSSA QGVKAKSSLL IYKCPCHFCT SVNQDGDSKA QEADDAPSTS TLGLQQETTE 370 PMKTDSAESE D

References

[1]

"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC026740 Genomic DNA. No translation available.
IPI	IPI00984840.
3D structure databases
ProteinModelPortal	P0C7U3.
ModBase	Search...
PTM databases
PhosphoSite	P0C7U3.
Polymorphism databases
DMDM	206557841.
Proteomic databases
PaxDb	P0C7U3.
PRIDE	P0C7U3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382776; ENSP00000445280; ENSG00000206077.
Organism-specific databases
GeneCards	GC05M000710.
HGNC	HGNC:32962. ZDHHC11B.
neXtProt	NX_P0C7U3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5273.
HOVERGEN	HBG059666.
Gene expression databases
ArrayExpress	P0C7U3.
Bgee	P0C7U3.
CleanEx	HS_ZDHHC11B.
Genevestigator	P0C7U3.
Family and domain databases
InterPro	IPR001594. Znf_DHHC_palmitoyltrfase. [Graphical view]
Pfam	PF01529. zf-DHHC. 1 hit. [Graphical view]
PROSITE	PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZH11B_HUMAN

Accession

Primary (citable) accession number: P0C7U3
Secondary accession number(s): A6NHR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.