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Protein

Probable palmitoyltransferase ZDHHC11B

Gene

ZDHHC11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC11B (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 11B
Short name:
DHHC-11B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:32962. ZDHHC11B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206077.

Polymorphism and mutation databases

DMDMi206557841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437471 – 371Probable palmitoyltransferase ZDHHC11BAdd BLAST371

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP0C7U3.
PeptideAtlasiP0C7U3.
PRIDEiP0C7U3.

PTM databases

iPTMnetiP0C7U3.
PhosphoSitePlusiP0C7U3.

Expressioni

Gene expression databases

BgeeiENSG00000206077.
CleanExiHS_ZDHHC11B.
ExpressionAtlasiP0C7U3. baseline and differential.

Organism-specific databases

HPAiHPA057886.
HPA069008.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000442373.

Structurei

3D structure databases

ProteinModelPortaliP0C7U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 175DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOVERGENiHBG059666.
InParanoidiP0C7U3.
PhylomeDBiP0C7U3.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRSGSQCS VTPEAIRNNE ELVLPPRISR VNGWSLPLHY FRVVTWAVFV
60 70 80 90 100
GLSLATFRIF IPLLPHSWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV
110 120 130 140 150
RLMKNYSQPM PLFDRSKHAH VIQNQFCHLC KVTVNKKTKH CISCNKCVSG
160 170 180 190 200
FDHHCKWINN CVGSRNYWFF FSTVASATAG MLCLIAILLY VLVQYLVNPR
210 220 230 240 250
VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIRMLV LLLDLLGLVQ
260 270 280 290 300
LGQLLIFHIY LKAKKMTTFE YLINTRKEES SKHQAVRKDP YVQMDKGFLQ
310 320 330 340 350
QGAGALGSSA QGVKAKSSLL IYKCPCHFCT SVNQDGDSKA QEADDAPSTS
360 370
TLGLQQETTE PMKTDSAESE D
Length:371
Mass (Da):41,895
Last modified:July 22, 2008 - v1
Checksum:i8B3222AB3F1717CF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05297642R → Q. Corresponds to variant dbSNP:rs1809933Ensembl.1
Natural variantiVAR_052977200R → G. Corresponds to variant dbSNP:rs634901Ensembl.1
Natural variantiVAR_061990228V → L. Corresponds to variant dbSNP:rs3817063Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026740 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000382776; ENSP00000445280; ENSG00000206077.
UCSCiuc063bxc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZH11B_HUMAN
AccessioniPrimary (citable) accession number: P0C7U3
Secondary accession number(s): A6NHR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families