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P0C7U2 (ASA2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative neutral ceramidase C

EC=3.5.1.23
Alternative name(s):
N-acylsphingosine amidohydrolase 2C
Non-lysosomal ceramidase C
Gene names
Name:ASAH2C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Sequence similarities

Belongs to the neutral ceramidase family.

Caution

In contrast to other mammalian members of the family, ASAH2C has no predicted transmembrane domain.

Ontologies

Keywords
   Biological processLipid metabolism
Sphingolipid metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsphingolipid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionceramidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622Putative neutral ceramidase C
PRO_0000343742

Regions

Region612 – 62211Required for correct folding and localization By similarity

Sites

Active site1961Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C7U2 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 2FB96681179A7D4C

FASTA62268,749
        10         20         30         40         50         60 
MDSEKSSEWR SDVLNRLQSK YGSLYRRDNV ILSGTHTHSG PAGYFQYTVF VIASEGFSNQ 

        70         80         90        100        110        120 
TFQHMVTGIL KSIDIAHTNM KPGKIFINKG NVDGVQINRS PYSYLQNPQS ERARYSSNTD 

       130        140        150        160        170        180 
KEMIVLKMVD LNGDDLGLIS WFAIHPVSMN NSNHLVNSDN VGYASYLLEQ EKNKGYLPGQ 

       190        200        210        220        230        240 
GPFVAAFSSS NLGDVSPNIL GPRCINTGES CDNANSTCPI GGPSMCIAKG PGQDMFDSTQ 

       250        260        270        280        290        300 
IIGRAMYQRA KELYASASQE VTGPLASAHQ WVDMTDVTVW LNSTHASKTC KPALGYSFAA 

       310        320        330        340        350        360 
GTIDGVGGLN FTQGKTEGDP FWDTIRDQIL GKPSEEIKEC HKPKPILLHT GELSKPHPWH 

       370        380        390        400        410        420 
PDIVDVQIIT LGSLAITAIP GEFTTMSGRR LREAVQAEFA SHGMQNMTVV ISGLCNVYTH 

       430        440        450        460        470        480 
YITTYEEYQA QRYEAASTIY GPHTLSAYIQ LFRNLAKAIA TDTVANLSRG PEPPFFKQLI 

       490        500        510        520        530        540 
VPLIPSIVDR APKGRTFGDV LQPAKPEYRV GEVAEVIFVG ANPKNSVQNQ NHQTFLTVEK 

       550        560        570        580        590        600 
YEATSTSWQI VCNDASWETR FYWHKGLLGL SNATVEWHIP DTAQPGIYRI RYFGHNRKQD 

       610        620 
ILKPAVILSF EGTSPAFEVV TI 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954360 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP0C7U2.
SMRP0C7U2. Positions 13-620.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP0C7U2.

Polymorphism databases

DMDM206557840.

Proteomic databases

PaxDbP0C7U2.
PRIDEP0C7U2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000426610; ENSP00000399947; ENSG00000072444.

Organism-specific databases

GeneCardsGC10M047999.
HGNCHGNC:23457. ASAH2C.
neXtProtNX_P0C7U2.
PharmGKBPA134984054.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316089.
HOGENOMHOG000209915.
HOVERGENHBG080870.
InParanoidP0C7U2.
OMASSCFEIG.
OrthoDBEOG7WQ7RQ.
PhylomeDBP0C7U2.
TreeFamTF300786.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

BgeeP0C7U2.
CleanExHS_ASAH2C.
GenevestigatorP0C7U2.

Family and domain databases

InterProIPR006823. Ceramidase_alk.
[Graphical view]
PANTHERPTHR12670. PTHR12670. 1 hit.
PfamPF04734. Ceramidase_alk. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio21547581.
PROP0C7U2.

Entry information

Entry nameASA2C_HUMAN
AccessionPrimary (citable) accession number: P0C7U2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM