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P0C7U2

- ASA2C_HUMAN

UniProt

P0C7U2 - ASA2C_HUMAN

Protein

Putative neutral ceramidase C

Gene

ASAH2C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid.By similarity

    Catalytic activityi

    N-acylsphingosine + H2O = a carboxylate + sphingosine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei196 – 1961NucleophileBy similarity

    GO - Molecular functioni

    1. ceramidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sphingolipid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_116105. Glycosphingolipid metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative neutral ceramidase C (EC:3.5.1.23)
    Alternative name(s):
    N-acylsphingosine amidohydrolase 2C
    Non-lysosomal ceramidase C
    Gene namesi
    Name:ASAH2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23457. ASAH2C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984054.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Putative neutral ceramidase CPRO_0000343742Add
    BLAST

    Proteomic databases

    PaxDbiP0C7U2.
    PRIDEiP0C7U2.

    PTM databases

    PhosphoSiteiP0C7U2.

    Expressioni

    Gene expression databases

    BgeeiP0C7U2.
    CleanExiHS_ASAH2C.
    GenevestigatoriP0C7U2.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C7U2.
    SMRiP0C7U2. Positions 13-620.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni612 – 62211Required for correct folding and localizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the neutral ceramidase family.Curated

    Phylogenomic databases

    eggNOGiNOG316089.
    HOGENOMiHOG000209915.
    HOVERGENiHBG080870.
    InParanoidiP0C7U2.
    OMAiVRTDSDW.
    OrthoDBiEOG7WQ7RQ.
    PhylomeDBiP0C7U2.
    TreeFamiTF300786.

    Family and domain databases

    InterProiIPR006823. Ceramidase_alk.
    [Graphical view]
    PANTHERiPTHR12670. PTHR12670. 1 hit.
    PfamiPF04734. Ceramidase_alk. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C7U2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSEKSSEWR SDVLNRLQSK YGSLYRRDNV ILSGTHTHSG PAGYFQYTVF    50
    VIASEGFSNQ TFQHMVTGIL KSIDIAHTNM KPGKIFINKG NVDGVQINRS 100
    PYSYLQNPQS ERARYSSNTD KEMIVLKMVD LNGDDLGLIS WFAIHPVSMN 150
    NSNHLVNSDN VGYASYLLEQ EKNKGYLPGQ GPFVAAFSSS NLGDVSPNIL 200
    GPRCINTGES CDNANSTCPI GGPSMCIAKG PGQDMFDSTQ IIGRAMYQRA 250
    KELYASASQE VTGPLASAHQ WVDMTDVTVW LNSTHASKTC KPALGYSFAA 300
    GTIDGVGGLN FTQGKTEGDP FWDTIRDQIL GKPSEEIKEC HKPKPILLHT 350
    GELSKPHPWH PDIVDVQIIT LGSLAITAIP GEFTTMSGRR LREAVQAEFA 400
    SHGMQNMTVV ISGLCNVYTH YITTYEEYQA QRYEAASTIY GPHTLSAYIQ 450
    LFRNLAKAIA TDTVANLSRG PEPPFFKQLI VPLIPSIVDR APKGRTFGDV 500
    LQPAKPEYRV GEVAEVIFVG ANPKNSVQNQ NHQTFLTVEK YEATSTSWQI 550
    VCNDASWETR FYWHKGLLGL SNATVEWHIP DTAQPGIYRI RYFGHNRKQD 600
    ILKPAVILSF EGTSPAFEVV TI 622
    Length:622
    Mass (Da):68,749
    Last modified:July 22, 2008 - v1
    Checksum:i2FB96681179A7D4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954360 Genomic DNA. No translation available.

    Polymorphism databases

    DMDMi206557840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954360 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali P0C7U2.
    SMRi P0C7U2. Positions 13-620.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P0C7U2.

    Polymorphism databases

    DMDMi 206557840.

    Proteomic databases

    PaxDbi P0C7U2.
    PRIDEi P0C7U2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC10M047999.
    HGNCi HGNC:23457. ASAH2C.
    neXtProti NX_P0C7U2.
    PharmGKBi PA134984054.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316089.
    HOGENOMi HOG000209915.
    HOVERGENi HBG080870.
    InParanoidi P0C7U2.
    OMAi VRTDSDW.
    OrthoDBi EOG7WQ7RQ.
    PhylomeDBi P0C7U2.
    TreeFami TF300786.

    Enzyme and pathway databases

    Reactomei REACT_116105. Glycosphingolipid metabolism.

    Miscellaneous databases

    NextBioi 21547581.
    PROi P0C7U2.

    Gene expression databases

    Bgeei P0C7U2.
    CleanExi HS_ASAH2C.
    Genevestigatori P0C7U2.

    Family and domain databases

    InterProi IPR006823. Ceramidase_alk.
    [Graphical view ]
    PANTHERi PTHR12670. PTHR12670. 1 hit.
    Pfami PF04734. Ceramidase_alk. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiASA2C_HUMAN
    AccessioniPrimary (citable) accession number: P0C7U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    In contrast to other mammalian members of the family, ASAH2C has no predicted transmembrane domain.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3