Reviewed,
UniProtKB/Swiss-Prot P0C7U2 (ASA2C_HUMAN)
Last modified
October 13, 2009.
Version 13.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative neutral ceramidase C EC=3.5.1.23 Alternative name(s): N-acylsphingosine amidohydrolase 2C Non-lysosomal ceramidase C | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 622 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid By similarity. |
| Catalytic activity | N-acylsphingosine + H2O = a carboxylate + sphingosine. |
| Sequence similarities | Belongs to the neutral ceramidase family. |
| Caution | In contrast to other mammalian members of the family, ASAH2C has no predicted transmembrane domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid metabolism Sphingolipid metabolism |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | sphingolipid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ceramidase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AL954360 Genomic DNA. No translation available. | |
| IPI | IPI00472292. |
| RefSeq | XP_932179.1. |
| UniGene | Hs.537110 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P0C7U2. |
Proteomic databases | |
| PRIDE | P0C7U2. |
Genome annotation databases | |
| Ensembl | ENST00000420079; ENSP00000392320; ENSG00000072444; Homo sapiens. [Genome view] ENST00000426610; ENSP00000399947; ENSG00000072444; Homo sapiens. [Genome view] |
| GeneID | 653365. |
| KEGG | hsa:653365. |
Organism-specific databases | |
| CTD | 653365. |
| GeneCards | GC10M047523. |
| HGNC | HGNC:23457. ASAH2C. |
| GenAtlas | Search... |
Gene expression databases | |
| CleanEx | HS_ASAH2C. |
| Genevestigator | P0C7U2. |
Family and domain databases | |
| InterPro | IPR006823. Ceramidase_alk. [Graphical view] |
| PANTHER | PTHR12670. Ceramidase_alk. 1 hit. |
| Pfam | PF04734. Ceramidase_alk. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ASA2C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P0C7U2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

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