SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C7U2

- ASA2C_HUMAN

UniProt

P0C7U2 - ASA2C_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative neutral ceramidase C
Gene
ASAH2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid By similarity.

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei196 – 1961Nucleophile By similarity

GO - Molecular functioni

  1. ceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. sphingolipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiREACT_116105. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neutral ceramidase C (EC:3.5.1.23)
Alternative name(s):
N-acylsphingosine amidohydrolase 2C
Non-lysosomal ceramidase C
Gene namesi
Name:ASAH2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23457. ASAH2C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Putative neutral ceramidase C
PRO_0000343742Add
BLAST

Proteomic databases

PaxDbiP0C7U2.
PRIDEiP0C7U2.

PTM databases

PhosphoSiteiP0C7U2.

Expressioni

Gene expression databases

BgeeiP0C7U2.
CleanExiHS_ASAH2C.
GenevestigatoriP0C7U2.

Structurei

3D structure databases

ProteinModelPortaliP0C7U2.
SMRiP0C7U2. Positions 13-620.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni612 – 62211Required for correct folding and localization By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG316089.
HOGENOMiHOG000209915.
HOVERGENiHBG080870.
InParanoidiP0C7U2.
OMAiVRTDSDW.
OrthoDBiEOG7WQ7RQ.
PhylomeDBiP0C7U2.
TreeFamiTF300786.

Family and domain databases

InterProiIPR006823. Ceramidase_alk.
[Graphical view]
PANTHERiPTHR12670. PTHR12670. 1 hit.
PfamiPF04734. Ceramidase_alk. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7U2-1 [UniParc]FASTAAdd to Basket

« Hide

MDSEKSSEWR SDVLNRLQSK YGSLYRRDNV ILSGTHTHSG PAGYFQYTVF    50
VIASEGFSNQ TFQHMVTGIL KSIDIAHTNM KPGKIFINKG NVDGVQINRS 100
PYSYLQNPQS ERARYSSNTD KEMIVLKMVD LNGDDLGLIS WFAIHPVSMN 150
NSNHLVNSDN VGYASYLLEQ EKNKGYLPGQ GPFVAAFSSS NLGDVSPNIL 200
GPRCINTGES CDNANSTCPI GGPSMCIAKG PGQDMFDSTQ IIGRAMYQRA 250
KELYASASQE VTGPLASAHQ WVDMTDVTVW LNSTHASKTC KPALGYSFAA 300
GTIDGVGGLN FTQGKTEGDP FWDTIRDQIL GKPSEEIKEC HKPKPILLHT 350
GELSKPHPWH PDIVDVQIIT LGSLAITAIP GEFTTMSGRR LREAVQAEFA 400
SHGMQNMTVV ISGLCNVYTH YITTYEEYQA QRYEAASTIY GPHTLSAYIQ 450
LFRNLAKAIA TDTVANLSRG PEPPFFKQLI VPLIPSIVDR APKGRTFGDV 500
LQPAKPEYRV GEVAEVIFVG ANPKNSVQNQ NHQTFLTVEK YEATSTSWQI 550
VCNDASWETR FYWHKGLLGL SNATVEWHIP DTAQPGIYRI RYFGHNRKQD 600
ILKPAVILSF EGTSPAFEVV TI 622
Length:622
Mass (Da):68,749
Last modified:July 22, 2008 - v1
Checksum:i2FB96681179A7D4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954360 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000426610; ENSP00000399947; ENSG00000072444.

Polymorphism databases

DMDMi206557840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954360 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P0C7U2.
SMRi P0C7U2. Positions 13-620.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P0C7U2.

Polymorphism databases

DMDMi 206557840.

Proteomic databases

PaxDbi P0C7U2.
PRIDEi P0C7U2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000426610 ; ENSP00000399947 ; ENSG00000072444 .

Organism-specific databases

GeneCardsi GC10M047999.
HGNCi HGNC:23457. ASAH2C.
neXtProti NX_P0C7U2.
PharmGKBi PA134984054.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316089.
HOGENOMi HOG000209915.
HOVERGENi HBG080870.
InParanoidi P0C7U2.
OMAi VRTDSDW.
OrthoDBi EOG7WQ7RQ.
PhylomeDBi P0C7U2.
TreeFami TF300786.

Enzyme and pathway databases

Reactomei REACT_116105. Glycosphingolipid metabolism.

Miscellaneous databases

NextBioi 21547581.
PROi P0C7U2.

Gene expression databases

Bgeei P0C7U2.
CleanExi HS_ASAH2C.
Genevestigatori P0C7U2.

Family and domain databases

InterProi IPR006823. Ceramidase_alk.
[Graphical view ]
PANTHERi PTHR12670. PTHR12670. 1 hit.
Pfami PF04734. Ceramidase_alk. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiASA2C_HUMAN
AccessioniPrimary (citable) accession number: P0C7U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In contrast to other mammalian members of the family, ASAH2C has no predicted transmembrane domain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi