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P0C7U2

- ASA2C_HUMAN

UniProt

P0C7U2 - ASA2C_HUMAN

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Protein

Putative neutral ceramidase C

Gene

ASAH2C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid.By similarity

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei196 – 1961NucleophileBy similarity

GO - Molecular functioni

  1. ceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. sphingolipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiREACT_116105. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neutral ceramidase C (EC:3.5.1.23)
Alternative name(s):
N-acylsphingosine amidohydrolase 2C
Non-lysosomal ceramidase C
Gene namesi
Name:ASAH2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23457. ASAH2C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Putative neutral ceramidase CPRO_0000343742Add
BLAST

Proteomic databases

PaxDbiP0C7U2.
PRIDEiP0C7U2.

PTM databases

PhosphoSiteiP0C7U2.

Expressioni

Gene expression databases

BgeeiP0C7U2.
CleanExiHS_ASAH2C.
GenevestigatoriP0C7U2.

Structurei

3D structure databases

ProteinModelPortaliP0C7U2.
SMRiP0C7U2. Positions 13-620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni612 – 62211Required for correct folding and localizationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the neutral ceramidase family.Curated

Phylogenomic databases

eggNOGiNOG316089.
HOGENOMiHOG000209915.
HOVERGENiHBG080870.
InParanoidiP0C7U2.
OMAiVRTDSDW.
OrthoDBiEOG7WQ7RQ.
PhylomeDBiP0C7U2.
TreeFamiTF300786.

Family and domain databases

InterProiIPR006823. Ceramidase_alk.
[Graphical view]
PANTHERiPTHR12670. PTHR12670. 1 hit.
PfamiPF04734. Ceramidase_alk. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7U2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSEKSSEWR SDVLNRLQSK YGSLYRRDNV ILSGTHTHSG PAGYFQYTVF
60 70 80 90 100
VIASEGFSNQ TFQHMVTGIL KSIDIAHTNM KPGKIFINKG NVDGVQINRS
110 120 130 140 150
PYSYLQNPQS ERARYSSNTD KEMIVLKMVD LNGDDLGLIS WFAIHPVSMN
160 170 180 190 200
NSNHLVNSDN VGYASYLLEQ EKNKGYLPGQ GPFVAAFSSS NLGDVSPNIL
210 220 230 240 250
GPRCINTGES CDNANSTCPI GGPSMCIAKG PGQDMFDSTQ IIGRAMYQRA
260 270 280 290 300
KELYASASQE VTGPLASAHQ WVDMTDVTVW LNSTHASKTC KPALGYSFAA
310 320 330 340 350
GTIDGVGGLN FTQGKTEGDP FWDTIRDQIL GKPSEEIKEC HKPKPILLHT
360 370 380 390 400
GELSKPHPWH PDIVDVQIIT LGSLAITAIP GEFTTMSGRR LREAVQAEFA
410 420 430 440 450
SHGMQNMTVV ISGLCNVYTH YITTYEEYQA QRYEAASTIY GPHTLSAYIQ
460 470 480 490 500
LFRNLAKAIA TDTVANLSRG PEPPFFKQLI VPLIPSIVDR APKGRTFGDV
510 520 530 540 550
LQPAKPEYRV GEVAEVIFVG ANPKNSVQNQ NHQTFLTVEK YEATSTSWQI
560 570 580 590 600
VCNDASWETR FYWHKGLLGL SNATVEWHIP DTAQPGIYRI RYFGHNRKQD
610 620
ILKPAVILSF EGTSPAFEVV TI
Length:622
Mass (Da):68,749
Last modified:July 22, 2008 - v1
Checksum:i2FB96681179A7D4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954360 Genomic DNA. No translation available.

Polymorphism databases

DMDMi206557840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954360 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P0C7U2.
SMRi P0C7U2. Positions 13-620.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P0C7U2.

Polymorphism databases

DMDMi 206557840.

Proteomic databases

PaxDbi P0C7U2.
PRIDEi P0C7U2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC10M047999.
HGNCi HGNC:23457. ASAH2C.
neXtProti NX_P0C7U2.
PharmGKBi PA134984054.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316089.
HOGENOMi HOG000209915.
HOVERGENi HBG080870.
InParanoidi P0C7U2.
OMAi VRTDSDW.
OrthoDBi EOG7WQ7RQ.
PhylomeDBi P0C7U2.
TreeFami TF300786.

Enzyme and pathway databases

Reactomei REACT_116105. Glycosphingolipid metabolism.

Miscellaneous databases

NextBioi 21547581.
PROi P0C7U2.

Gene expression databases

Bgeei P0C7U2.
CleanExi HS_ASAH2C.
Genevestigatori P0C7U2.

Family and domain databases

InterProi IPR006823. Ceramidase_alk.
[Graphical view ]
PANTHERi PTHR12670. PTHR12670. 1 hit.
Pfami PF04734. Ceramidase_alk. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiASA2C_HUMAN
AccessioniPrimary (citable) accession number: P0C7U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In contrast to other mammalian members of the family, ASAH2C has no predicted transmembrane domain.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3