P0C7U1 (ASA2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative inactive neutral ceramidase B

Alternative name(s):
ASAH2-like protein
Putative inactive N-acylsphingosine amidohydrolase 2B
Putative inactive non-lysosomal ceramidase B

Gene names

Name:	ASAH2B
Synonyms:	ASAH2L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitous. Expression is reduced with increasing age and in late-onset Alzheimer disease (LOAD) patients. This reduction is even more pronounced in patients with an affected mother. Ref.2
Miscellaneous	ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome 10. It has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus other putative translation start site that might lead to several potential ORFs.
Sequence similarities	Belongs to the neutral ceramidase family.
Caution	In contrast to other members of the family, ASAH2B has no predicted transmembrane domain, and lacks the active site, suggesting that it may be catalytically inactive.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Putative inactive neutral ceramidase B		PRO_0000343741

Sequences

	Sequence		Length	Mass (Da)
	P0C7U1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: AB59B4F728F82D66	FASTA	165	19,025
	10 20 30 40 50 60 MRQHRQFMDR THYLLTFSSS ETLLRLLLRI VDRAPKGRTF GDVLQPAKPE YRVGEVAEVI 70 80 90 100 110 120 FVGANPKNSV QNQTHQTFLT VEKYEATSTS WQIVCNDASW ETRFYWHKGL LGLSNATVEW 130 140 150 160 HIPDTAQPGI YRIRYFGHNR KQDILKPAVI LSFEGTSPAF EVVTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease." Avramopoulos D., Wang R., Valle D., Fallin M.D., Bassett S.S. Neurogenetics 8:111-120(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL589794 Genomic DNA. No translation available.
IPI	IPI00513980.
RefSeq	NP_001072984.1. NM_001079516.2.
UniGene	Hs.710005.
3D structure databases
ProteinModelPortal	P0C7U1.
ModBase	Search...
PTM databases
PhosphoSite	P0C7U1.
Proteomic databases
PaxDb	P0C7U1.
PRIDE	P0C7U1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374006; ENSP00000363118; ENSG00000204147.
GeneID	653308.
KEGG	hsa:653308.
UCSC	uc001jjg.3. human.
Organism-specific databases
CTD	653308.
GeneCards	GC10P052499.
HGNC	HGNC:23456. ASAH2B.
HPA	HPA051862.
MIM	610987. gene.
neXtProt	NX_P0C7U1.
PharmGKB	PA134977109.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316089.
HOGENOM	HOG000034083.
HOVERGEN	HBG105868.
InParanoid	P0C7U1.
Gene expression databases
ArrayExpress	P0C7U1.
Bgee	P0C7U1.
CleanEx	HS_ASAH2B.
Genevestigator	P0C7U1.
Family and domain databases
InterPro	IPR006823. Ceramidase_alk. [Graphical view]
PANTHER	PTHR12670. PTHR12670. 1 hit.
Pfam	PF04734. Ceramidase_alk. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	123060.
SOURCE	Search...

Entry information

Entry name

ASA2B_HUMAN

Accession

Primary (citable) accession number: P0C7U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.