SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C7U1

- ASA2B_HUMAN

UniProt

P0C7U1 - ASA2B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative inactive neutral ceramidase B
Gene
ASAH2B, ASAH2L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive neutral ceramidase B
Alternative name(s):
ASAH2-like protein
Putative inactive N-acylsphingosine amidohydrolase 2B
Putative inactive non-lysosomal ceramidase B
Gene namesi
Name:ASAH2B
Synonyms:ASAH2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23456. ASAH2B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Putative inactive neutral ceramidase B
PRO_0000343741Add
BLAST

Proteomic databases

PaxDbiP0C7U1.
PRIDEiP0C7U1.

PTM databases

PhosphoSiteiP0C7U1.

Expressioni

Tissue specificityi

Ubiquitous. Expression is reduced with increasing age and in late-onset Alzheimer disease (LOAD) patients. This reduction is even more pronounced in patients with an affected mother.1 Publication

Gene expression databases

BgeeiP0C7U1.
CleanExiHS_ASAH2B.
GenevestigatoriP0C7U1.

Organism-specific databases

HPAiHPA051862.

Interactioni

Protein-protein interaction databases

BioGridi575684. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP0C7U1.
SMRiP0C7U1. Positions 30-163.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG316089.
HOGENOMiHOG000034083.
HOVERGENiHBG105868.
InParanoidiP0C7U1.
OrthoDBiEOG7WQ7RQ.
PhylomeDBiP0C7U1.

Family and domain databases

InterProiIPR006823. Ceramidase_alk.
[Graphical view]
PANTHERiPTHR12670. PTHR12670. 1 hit.
PfamiPF04734. Ceramidase_alk. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7U1-1 [UniParc]FASTAAdd to Basket

« Hide

MRQHRQFMDR THYLLTFSSS ETLLRLLLRI VDRAPKGRTF GDVLQPAKPE    50
YRVGEVAEVI FVGANPKNSV QNQTHQTFLT VEKYEATSTS WQIVCNDASW 100
ETRFYWHKGL LGLSNATVEW HIPDTAQPGI YRIRYFGHNR KQDILKPAVI 150
LSFEGTSPAF EVVTI 165
Length:165
Mass (Da):19,025
Last modified:July 22, 2008 - v1
Checksum:iAB59B4F728F82D66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589794 Genomic DNA. No translation available.
CCDSiCCDS31203.1.
RefSeqiNP_001072984.1. NM_001079516.2.
XP_006718015.1. XM_006717952.1.
UniGeneiHs.710005.

Genome annotation databases

EnsembliENST00000374006; ENSP00000363118; ENSG00000204147.
GeneIDi653308.
KEGGihsa:653308.
UCSCiuc001jjg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589794 Genomic DNA. No translation available.
CCDSi CCDS31203.1.
RefSeqi NP_001072984.1. NM_001079516.2.
XP_006718015.1. XM_006717952.1.
UniGenei Hs.710005.

3D structure databases

ProteinModelPortali P0C7U1.
SMRi P0C7U1. Positions 30-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 575684. 1 interaction.

PTM databases

PhosphoSitei P0C7U1.

Proteomic databases

PaxDbi P0C7U1.
PRIDEi P0C7U1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374006 ; ENSP00000363118 ; ENSG00000204147 .
GeneIDi 653308.
KEGGi hsa:653308.
UCSCi uc001jjg.4. human.

Organism-specific databases

CTDi 653308.
GeneCardsi GC10P052499.
HGNCi HGNC:23456. ASAH2B.
HPAi HPA051862.
MIMi 610987. gene.
neXtProti NX_P0C7U1.
PharmGKBi PA134977109.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316089.
HOGENOMi HOG000034083.
HOVERGENi HBG105868.
InParanoidi P0C7U1.
OrthoDBi EOG7WQ7RQ.
PhylomeDBi P0C7U1.

Miscellaneous databases

GeneWikii ASAH2B.
NextBioi 123060.
PROi P0C7U1.
SOURCEi Search...

Gene expression databases

Bgeei P0C7U1.
CleanExi HS_ASAH2B.
Genevestigatori P0C7U1.

Family and domain databases

InterProi IPR006823. Ceramidase_alk.
[Graphical view ]
PANTHERi PTHR12670. PTHR12670. 1 hit.
Pfami PF04734. Ceramidase_alk. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease."
    Avramopoulos D., Wang R., Valle D., Fallin M.D., Bassett S.S.
    Neurogenetics 8:111-120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiASA2B_HUMAN
AccessioniPrimary (citable) accession number: P0C7U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome 10. It has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus other putative translation start site that might lead to several potential ORFs.

Caution

In contrast to other members of the family, ASAH2B has no predicted transmembrane domain, and lacks the active site, suggesting that it may be catalytically inactive.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi