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Protein

Protein ELFN1

Gene

ELFN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
  • synapse organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ELFN1
Alternative name(s):
Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1
Protein phosphatase 1 regulatory subunit 28
Gene namesi
Name:ELFN1
Synonyms:PPP1R28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33154. ELFN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 418391ExtracellularSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Topological domaini440 – 828389CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendrite Source: UniProtKB
  • excitatory synapse Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiELFN1.
DMDMi519668666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 828801Protein ELFN1PRO_0000343738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis
Modified residuei461 – 4611PhosphoserineCombined sources
Modified residuei645 – 6451PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP0C7U0.
MaxQBiP0C7U0.
PaxDbiP0C7U0.
PRIDEiP0C7U0.

PTM databases

iPTMnetiP0C7U0.
PhosphoSiteiP0C7U0.

Expressioni

Gene expression databases

BgeeiP0C7U0.
CleanExiHS_ELFN1.
GenevisibleiP0C7U0. HS.

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi134291. 1 interaction.
IntActiP0C7U0. 2 interactions.
STRINGi9606.ENSP00000456548.

Structurei

3D structure databases

ProteinModelPortaliP0C7U0.
SMRiP0C7U0. Positions 35-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 8222LRR 1Add
BLAST
Repeati85 – 10622LRR 2Add
BLAST
Repeati109 – 13022LRR 3Add
BLAST
Repeati133 – 15422LRR 4Add
BLAST
Repeati157 – 17822LRR 5Add
BLAST
Domaini190 – 25263LRRCTAdd
BLAST
Domaini312 – 39988Fibronectin type-IIIAdd
BLAST
Repeati318 – 34225LRR 6Add
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.Curated
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHCP. Eukaryota.
ENOG4110NB3. LUCA.
GeneTreeiENSGT00790000122963.
HOVERGENiHBG056941.
InParanoidiP0C7U0.
KOiK17567.
OMAiYHNLSYS.
OrthoDBiEOG7WDN1Z.
TreeFamiTF332887.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C7U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGWGALW VCVAAATLLH AGGLARADCW LIEGDKGFVW LAICSQNQPP
60 70 80 90 100
YEAIPQQINS TIVDLRLNEN RIRSVQYASL SRFGNLTYLN LTKNEIGYIE
110 120 130 140 150
DGAFSGQFNL QVLQLGYNRL RNLTEGMLRG LGKLEYLYLQ ANLIEVVMAS
160 170 180 190 200
SFWECPNIVN IDLSMNRIQQ LNSGTFAGLA KLSVCELYSN PFYCSCELLG
210 220 230 240 250
FLRWLAAFTN ATQTYDRMQC ESPPVYSGYY LLGQGRRGHR SILSKLQSVC
260 270 280 290 300
TEDSYAAEVV GPPRPASGRS QPGRSPPPPP PPEPSDMPCA DDECFSGDGT
310 320 330 340 350
TPLVALPTLA TQAEARPLIK VKQLTQNSAT ITVQLPSPFH RMYTLEHFNN
360 370 380 390 400
SKASTVSRLT KAQEEIRLTN LFTLTNYTYC VVSTSAGLRH NHTCLTICLP
410 420 430 440 450
RLPSPPGPVP SPSTATHYIM TILGCLFGMV LVLGAVYYCL RRRRRQEEKH
460 470 480 490 500
KKAASAAAAG SLKKTIIELK YGPELEAPGL APLSQGPLLG PEAVTRIPYL
510 520 530 540 550
PAAGEVEQYK LVESADTPKA SKGSYMEVRT GDPPERRDCE LGRPGPDSQS
560 570 580 590 600
SVAEISTIAK EVDKVNQIIN NCIDALKSES TSFQGVKSGP VSVAEPPLVL
610 620 630 640 650
LSEPLAAKHG FLAPGYKDAF GHSLQRHHSV EAAGPPRAST SSSGSVRSPR
660 670 680 690 700
AFRAEAVGVH KAAAAEAKYI EKGSPAADAI LTVTPAAAVL RAEAEKGRQY
710 720 730 740 750
GEHRHSYPGS HPAEPPAPPG PPPPPPHEGL GRKASILEPL TRPRPRDLAY
760 770 780 790 800
SQLSPQYHSL SYSSSPEYTC RASQSIWERF RLSRRRHKEE EEFMAAGHAL
810 820
RKKVQFAKDE DLHDILDYWK GVSAQHKS
Length:828
Mass (Da):90,477
Last modified:June 26, 2013 - v2
Checksum:i3AE4837E93E2BA54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074389 Genomic DNA. No translation available.
CCDSiCCDS59046.1.
RefSeqiNP_001122108.1. NM_001128636.2.
XP_006715788.1. XM_006715725.2.
XP_006715789.1. XM_006715726.2.
XP_006715790.1. XM_006715727.2.
XP_011513699.1. XM_011515397.1.
XP_011513700.1. XM_011515398.1.
XP_011513701.1. XM_011515399.1.
XP_011513702.1. XM_011515400.1.
XP_011513703.1. XM_011515401.1.
UniGeneiHs.42896.

Genome annotation databases

EnsembliENST00000424383; ENSP00000456548; ENSG00000225968.
ENST00000561626; ENSP00000457193; ENSG00000225968.
GeneIDi392617.
KEGGihsa:392617.
UCSCiuc010ksg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074389 Genomic DNA. No translation available.
CCDSiCCDS59046.1.
RefSeqiNP_001122108.1. NM_001128636.2.
XP_006715788.1. XM_006715725.2.
XP_006715789.1. XM_006715726.2.
XP_006715790.1. XM_006715727.2.
XP_011513699.1. XM_011515397.1.
XP_011513700.1. XM_011515398.1.
XP_011513701.1. XM_011515399.1.
XP_011513702.1. XM_011515400.1.
XP_011513703.1. XM_011515401.1.
UniGeneiHs.42896.

3D structure databases

ProteinModelPortaliP0C7U0.
SMRiP0C7U0. Positions 35-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134291. 1 interaction.
IntActiP0C7U0. 2 interactions.
STRINGi9606.ENSP00000456548.

PTM databases

iPTMnetiP0C7U0.
PhosphoSiteiP0C7U0.

Polymorphism and mutation databases

BioMutaiELFN1.
DMDMi519668666.

Proteomic databases

EPDiP0C7U0.
MaxQBiP0C7U0.
PaxDbiP0C7U0.
PRIDEiP0C7U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424383; ENSP00000456548; ENSG00000225968.
ENST00000561626; ENSP00000457193; ENSG00000225968.
GeneIDi392617.
KEGGihsa:392617.
UCSCiuc010ksg.2. human.

Organism-specific databases

CTDi392617.
GeneCardsiELFN1.
HGNCiHGNC:33154. ELFN1.
MIMi614964. gene.
neXtProtiNX_P0C7U0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHCP. Eukaryota.
ENOG4110NB3. LUCA.
GeneTreeiENSGT00790000122963.
HOVERGENiHBG056941.
InParanoidiP0C7U0.
KOiK17567.
OMAiYHNLSYS.
OrthoDBiEOG7WDN1Z.
TreeFamiTF332887.

Miscellaneous databases

GenomeRNAii392617.
NextBioi105323.
PROiP0C7U0.
SOURCEiSearch...

Gene expression databases

BgeeiP0C7U0.
CleanExiHS_ELFN1.
GenevisibleiP0C7U0. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Docking motif-guided mapping of the interactome of protein phosphatase-1."
    Hendrickx A., Beullens M., Ceulemans H., Den Abt T., Van Eynde A., Nicolaescu E., Lesage B., Bollen M.
    Chem. Biol. 16:365-371(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PPP1CA.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiELFN1_HUMAN
AccessioniPrimary (citable) accession number: P0C7U0
Secondary accession number(s): H3BS57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 26, 2013
Last modified: May 11, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.