Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 253

Gene

TMEM253

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 253
Gene namesi
Name:TMEM253
Synonyms:C14orf176, C14orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000232070.8
HGNCiHGNC:32545 TMEM253
neXtProtiNX_P0C7T8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232070
PharmGKBiPA143485392

Polymorphism and mutation databases

BioMutaiTMEM253
DMDMi206557836

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437221 – 217Transmembrane protein 253Add BLAST217

Proteomic databases

PaxDbiP0C7T8
PRIDEiP0C7T8

PTM databases

PhosphoSitePlusiP0C7T8

Expressioni

Gene expression databases

BgeeiENSG00000232070
CleanExiHS_C14orf176
ExpressionAtlasiP0C7T8 baseline and differential

Organism-specific databases

HPAiHPA052329
HPA065092

Interactioni

Protein-protein interaction databases

BioGridi568735, 2 interactors
IntActiP0C7T8, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP0C7T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS6R Eukaryota
ENOG410Z6FW LUCA
GeneTreeiENSGT00400000023212
HOGENOMiHOG000111833
HOVERGENiHBG107734
InParanoidiP0C7T8
OMAiKLQHWAR
OrthoDBiEOG091G0SDH
PhylomeDBiP0C7T8
TreeFamiTF354003

Family and domain databases

InterProiView protein in InterPro
IPR038874 TMEM253
PANTHERiPTHR37359 PTHR37359, 1 hit

Sequencei

Sequence statusi: Complete.

P0C7T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA
60 70 80 90 100
VSVACLNSDC HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN
110 120 130 140 150
TFNLILGFIV VVVEVMKTAL GPAPTASSQH AGLLVLELSA EAFTLGGVLV
160 170 180 190 200
SVHALFLLSQ RKPGCCRSQS LHYQELQEGF SELEEVPGLE NGPTVASTGA
210
NERVGQREQT RAALLPP
Length:217
Mass (Da):23,522
Last modified:July 22, 2008 - v1
Checksum:iC6964904189C64F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161668 Genomic DNA No translation available.
CCDSiCCDS53884.1
RefSeqiNP_001140155.1, NM_001146683.1
XP_006720296.1, XM_006720233.3
XP_011535380.1, XM_011537078.2
XP_011535381.1, XM_011537079.1
UniGeneiHs.540107

Genome annotation databases

EnsembliENST00000418511; ENSP00000453962; ENSG00000232070
ENST00000556585; ENSP00000451229; ENSG00000232070
GeneIDi643382
KEGGihsa:643382
UCSCiuc010tlo.2 human

Similar proteinsi

Entry informationi

Entry nameiTM253_HUMAN
AccessioniPrimary (citable) accession number: P0C7T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health