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P0C7T8

- TM253_HUMAN

UniProt

P0C7T8 - TM253_HUMAN

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Protein

Transmembrane protein 253

Gene
TMEM253, C14orf176, C14orf95
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 253
Gene namesi
Name:TMEM253
Synonyms:C14orf176, C14orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:32545. TMEM253.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Reviewed predictionAdd
BLAST
Transmembranei96 – 11621Helical; Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Transmembrane protein 253PRO_0000343722Add
BLAST

Proteomic databases

PRIDEiP0C7T8.

PTM databases

PhosphoSiteiP0C7T8.

Expressioni

Gene expression databases

BgeeiP0C7T8.
CleanExiHS_C14orf176.
GenevestigatoriP0C7T8.

Organism-specific databases

HPAiHPA052329.

Interactioni

Protein-protein interaction databases

BioGridi568735. 2 interactions.
IntActiP0C7T8. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0C7T8.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG115990.
HOGENOMiHOG000111833.
HOVERGENiHBG107734.
OMAiPEMISSE.
PhylomeDBiP0C7T8.
TreeFamiTF354003.

Sequencei

Sequence statusi: Complete.

P0C7T8-1 [UniParc]FASTAAdd to Basket

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MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA    50
VSVACLNSDC HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN 100
TFNLILGFIV VVVEVMKTAL GPAPTASSQH AGLLVLELSA EAFTLGGVLV 150
SVHALFLLSQ RKPGCCRSQS LHYQELQEGF SELEEVPGLE NGPTVASTGA 200
NERVGQREQT RAALLPP 217
Length:217
Mass (Da):23,522
Last modified:July 22, 2008 - v1
Checksum:iC6964904189C64F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161668 Genomic DNA. No translation available.
CCDSiCCDS53884.1.
RefSeqiNP_001140155.1. NM_001146683.1.
XP_006720296.1. XM_006720233.1.
UniGeneiHs.540107.

Genome annotation databases

EnsembliENST00000418511; ENSP00000453962; ENSG00000232070.
ENST00000556585; ENSP00000451229; ENSG00000232070.
GeneIDi643382.
KEGGihsa:643382.
UCSCiuc010tlo.2. human.

Polymorphism databases

DMDMi206557836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL161668 Genomic DNA. No translation available.
CCDSi CCDS53884.1.
RefSeqi NP_001140155.1. NM_001146683.1.
XP_006720296.1. XM_006720233.1.
UniGenei Hs.540107.

3D structure databases

ProteinModelPortali P0C7T8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 568735. 2 interactions.
IntActi P0C7T8. 2 interactions.

PTM databases

PhosphoSitei P0C7T8.

Polymorphism databases

DMDMi 206557836.

Proteomic databases

PRIDEi P0C7T8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000418511 ; ENSP00000453962 ; ENSG00000232070 .
ENST00000556585 ; ENSP00000451229 ; ENSG00000232070 .
GeneIDi 643382.
KEGGi hsa:643382.
UCSCi uc010tlo.2. human.

Organism-specific databases

CTDi 643382.
GeneCardsi GC14P021567.
HGNCi HGNC:32545. TMEM253.
HPAi HPA052329.
neXtProti NX_P0C7T8.
PharmGKBi PA143485392.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG115990.
HOGENOMi HOG000111833.
HOVERGENi HBG107734.
OMAi PEMISSE.
PhylomeDBi P0C7T8.
TreeFami TF354003.

Miscellaneous databases

NextBioi 114850.

Gene expression databases

Bgeei P0C7T8.
CleanExi HS_C14orf176.
Genevestigatori P0C7T8.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM253_HUMAN
AccessioniPrimary (citable) accession number: P0C7T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

External Data

Dasty 3

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