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P0C7T8 (TM253_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 253
Gene names
Name:TMEM253
Synonyms:C14orf176, C14orf95
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Transmembrane protein 253
PRO_0000343722

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane138 – 15821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P0C7T8 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: C6964904189C64F2

FASTA21723,522
        10         20         30         40         50         60 
MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA VSVACLNSDC 

        70         80         90        100        110        120 
HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN TFNLILGFIV VVVEVMKTAL 

       130        140        150        160        170        180 
GPAPTASSQH AGLLVLELSA EAFTLGGVLV SVHALFLLSQ RKPGCCRSQS LHYQELQEGF 

       190        200        210 
SELEEVPGLE NGPTVASTGA NERVGQREQT RAALLPP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL161668 Genomic DNA. No translation available.
CCDSCCDS53884.1.
RefSeqNP_001140155.1. NM_001146683.1.
XP_006720296.1. XM_006720233.1.
UniGeneHs.540107.

3D structure databases

ProteinModelPortalP0C7T8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid568735. 2 interactions.
IntActP0C7T8. 2 interactions.

PTM databases

PhosphoSiteP0C7T8.

Polymorphism databases

DMDM206557836.

Proteomic databases

PRIDEP0C7T8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000418511; ENSP00000453962; ENSG00000232070.
ENST00000556585; ENSP00000451229; ENSG00000232070.
GeneID643382.
KEGGhsa:643382.
UCSCuc010tlo.2. human.

Organism-specific databases

CTD643382.
GeneCardsGC14P021567.
HGNCHGNC:32545. TMEM253.
HPAHPA052329.
neXtProtNX_P0C7T8.
PharmGKBPA143485392.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG115990.
HOGENOMHOG000111833.
HOVERGENHBG107734.
OMAPEMISSE.
PhylomeDBP0C7T8.
TreeFamTF354003.

Gene expression databases

BgeeP0C7T8.
CleanExHS_C14orf176.
GenevestigatorP0C7T8.

Family and domain databases

ProtoNetSearch...

Other

NextBio114850.

Entry information

Entry nameTM253_HUMAN
AccessionPrimary (citable) accession number: P0C7T8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM