P0C7T8 (TM253_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 253

Gene names

Name:	TMEM253
Synonyms:	C14orf176, C14orf95

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Transmembrane protein 253		PRO_0000343722
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P0C7T8 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: C6964904189C64F2	FASTA	217	23,522
	10 20 30 40 50 60 MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA VSVACLNSDC 70 80 90 100 110 120 HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN TFNLILGFIV VVVEVMKTAL 130 140 150 160 170 180 GPAPTASSQH AGLLVLELSA EAFTLGGVLV SVHALFLLSQ RKPGCCRSQS LHYQELQEGF 190 200 210 SELEEVPGLE NGPTVASTGA NERVGQREQT RAALLPP

References

[1]

"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL161668 Genomic DNA. No translation available.
IPI	IPI00888890.
RefSeq	NP_001140155.1. NM_001146683.1.
UniGene	Hs.540107.
3D structure databases
ProteinModelPortal	P0C7T8.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0C7T8. 2 interactions.
PTM databases
PhosphoSite	P0C7T8.
Polymorphism databases
DMDM	206557836.
Proteomic databases
PRIDE	P0C7T8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000418511; ENSP00000453962; ENSG00000232070. ENST00000556585; ENSP00000451229; ENSG00000232070.
GeneID	643382.
KEGG	hsa:643382.
UCSC	uc010tlo.2. human.
Organism-specific databases
CTD	643382.
GeneCards	GC14P021569.
HGNC	HGNC:32545. TMEM253.
HPA	HPA052329.
neXtProt	NX_P0C7T8.
PharmGKB	PA143485392.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG115990.
HOGENOM	HOG000111833.
HOVERGEN	HBG107734.
OMA	KLQHWAR.
OrthoDB	EOG4QC16Q.
Gene expression databases
ArrayExpress	P0C7T8.
Bgee	P0C7T8.
CleanEx	HS_C14orf176.
Genevestigator	P0C7T8.
Family and domain databases
ProtoNet	Search...
Other
NextBio	114850.

Entry information

Entry name

TM253_HUMAN

Accession

Primary (citable) accession number: P0C7T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.