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Protein

Transmembrane protein 253

Gene

TMEM253

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31867-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 253
Gene namesi
Name:TMEM253
Synonyms:C14orf176, C14orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:32545. TMEM253.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232070.
PharmGKBiPA143485392.

Polymorphism and mutation databases

BioMutaiTMEM253.
DMDMi206557836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437221 – 217Transmembrane protein 253Add BLAST217

Proteomic databases

PaxDbiP0C7T8.
PRIDEiP0C7T8.

PTM databases

PhosphoSitePlusiP0C7T8.

Expressioni

Gene expression databases

BgeeiENSG00000232070.
CleanExiHS_C14orf176.
ExpressionAtlasiP0C7T8. baseline and differential.

Organism-specific databases

HPAiHPA052329.
HPA065092.

Interactioni

Protein-protein interaction databases

BioGridi568735. 2 interactors.
IntActiP0C7T8. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0C7T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS6R. Eukaryota.
ENOG410Z6FW. LUCA.
GeneTreeiENSGT00400000023212.
HOGENOMiHOG000111833.
HOVERGENiHBG107734.
InParanoidiP0C7T8.
OMAiKLQHWAR.
OrthoDBiEOG091G0SDH.
PhylomeDBiP0C7T8.
TreeFamiTF354003.

Sequencei

Sequence statusi: Complete.

P0C7T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA
60 70 80 90 100
VSVACLNSDC HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN
110 120 130 140 150
TFNLILGFIV VVVEVMKTAL GPAPTASSQH AGLLVLELSA EAFTLGGVLV
160 170 180 190 200
SVHALFLLSQ RKPGCCRSQS LHYQELQEGF SELEEVPGLE NGPTVASTGA
210
NERVGQREQT RAALLPP
Length:217
Mass (Da):23,522
Last modified:July 22, 2008 - v1
Checksum:iC6964904189C64F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161668 Genomic DNA. No translation available.
CCDSiCCDS53884.1.
RefSeqiNP_001140155.1. NM_001146683.1.
XP_006720296.1. XM_006720233.3.
XP_011535380.1. XM_011537078.2.
XP_011535381.1. XM_011537079.1.
UniGeneiHs.540107.

Genome annotation databases

EnsembliENST00000418511; ENSP00000453962; ENSG00000232070.
ENST00000556585; ENSP00000451229; ENSG00000232070.
GeneIDi643382.
KEGGihsa:643382.
UCSCiuc010tlo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161668 Genomic DNA. No translation available.
CCDSiCCDS53884.1.
RefSeqiNP_001140155.1. NM_001146683.1.
XP_006720296.1. XM_006720233.3.
XP_011535380.1. XM_011537078.2.
XP_011535381.1. XM_011537079.1.
UniGeneiHs.540107.

3D structure databases

ProteinModelPortaliP0C7T8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi568735. 2 interactors.
IntActiP0C7T8. 2 interactors.

PTM databases

PhosphoSitePlusiP0C7T8.

Polymorphism and mutation databases

BioMutaiTMEM253.
DMDMi206557836.

Proteomic databases

PaxDbiP0C7T8.
PRIDEiP0C7T8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418511; ENSP00000453962; ENSG00000232070.
ENST00000556585; ENSP00000451229; ENSG00000232070.
GeneIDi643382.
KEGGihsa:643382.
UCSCiuc010tlo.2. human.

Organism-specific databases

CTDi643382.
GeneCardsiTMEM253.
HGNCiHGNC:32545. TMEM253.
HPAiHPA052329.
HPA065092.
neXtProtiNX_P0C7T8.
OpenTargetsiENSG00000232070.
PharmGKBiPA143485392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS6R. Eukaryota.
ENOG410Z6FW. LUCA.
GeneTreeiENSGT00400000023212.
HOGENOMiHOG000111833.
HOVERGENiHBG107734.
InParanoidiP0C7T8.
OMAiKLQHWAR.
OrthoDBiEOG091G0SDH.
PhylomeDBiP0C7T8.
TreeFamiTF354003.

Enzyme and pathway databases

BioCyciZFISH:G66-31867-MONOMER.

Miscellaneous databases

GenomeRNAii643382.
PROiP0C7T8.

Gene expression databases

BgeeiENSG00000232070.
CleanExiHS_C14orf176.
ExpressionAtlasiP0C7T8. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTM253_HUMAN
AccessioniPrimary (citable) accession number: P0C7T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.