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P0C7T8

- TM253_HUMAN

UniProt

P0C7T8 - TM253_HUMAN

Protein

Transmembrane protein 253

Gene

TMEM253

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 253
    Gene namesi
    Name:TMEM253
    Synonyms:C14orf176, C14orf95
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:32545. TMEM253.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485392.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Transmembrane protein 253PRO_0000343722Add
    BLAST

    Proteomic databases

    PRIDEiP0C7T8.

    PTM databases

    PhosphoSiteiP0C7T8.

    Expressioni

    Gene expression databases

    BgeeiP0C7T8.
    CleanExiHS_C14orf176.
    GenevestigatoriP0C7T8.

    Organism-specific databases

    HPAiHPA052329.

    Interactioni

    Protein-protein interaction databases

    BioGridi568735. 2 interactions.
    IntActiP0C7T8. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C7T8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG115990.
    HOGENOMiHOG000111833.
    HOVERGENiHBG107734.
    OMAiPEMISSE.
    PhylomeDBiP0C7T8.
    TreeFamiTF354003.

    Sequencei

    Sequence statusi: Complete.

    P0C7T8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA    50
    VSVACLNSDC HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN 100
    TFNLILGFIV VVVEVMKTAL GPAPTASSQH AGLLVLELSA EAFTLGGVLV 150
    SVHALFLLSQ RKPGCCRSQS LHYQELQEGF SELEEVPGLE NGPTVASTGA 200
    NERVGQREQT RAALLPP 217
    Length:217
    Mass (Da):23,522
    Last modified:July 22, 2008 - v1
    Checksum:iC6964904189C64F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161668 Genomic DNA. No translation available.
    CCDSiCCDS53884.1.
    RefSeqiNP_001140155.1. NM_001146683.1.
    XP_006720296.1. XM_006720233.1.
    UniGeneiHs.540107.

    Genome annotation databases

    EnsembliENST00000418511; ENSP00000453962; ENSG00000232070.
    ENST00000556585; ENSP00000451229; ENSG00000232070.
    GeneIDi643382.
    KEGGihsa:643382.
    UCSCiuc010tlo.2. human.

    Polymorphism databases

    DMDMi206557836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL161668 Genomic DNA. No translation available.
    CCDSi CCDS53884.1.
    RefSeqi NP_001140155.1. NM_001146683.1.
    XP_006720296.1. XM_006720233.1.
    UniGenei Hs.540107.

    3D structure databases

    ProteinModelPortali P0C7T8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 568735. 2 interactions.
    IntActi P0C7T8. 2 interactions.

    PTM databases

    PhosphoSitei P0C7T8.

    Polymorphism databases

    DMDMi 206557836.

    Proteomic databases

    PRIDEi P0C7T8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000418511 ; ENSP00000453962 ; ENSG00000232070 .
    ENST00000556585 ; ENSP00000451229 ; ENSG00000232070 .
    GeneIDi 643382.
    KEGGi hsa:643382.
    UCSCi uc010tlo.2. human.

    Organism-specific databases

    CTDi 643382.
    GeneCardsi GC14P021567.
    HGNCi HGNC:32545. TMEM253.
    HPAi HPA052329.
    neXtProti NX_P0C7T8.
    PharmGKBi PA143485392.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG115990.
    HOGENOMi HOG000111833.
    HOVERGENi HBG107734.
    OMAi PEMISSE.
    PhylomeDBi P0C7T8.
    TreeFami TF354003.

    Miscellaneous databases

    NextBioi 114850.

    Gene expression databases

    Bgeei P0C7T8.
    CleanExi HS_C14orf176.
    Genevestigatori P0C7T8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTM253_HUMAN
    AccessioniPrimary (citable) accession number: P0C7T8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM

    External Data

    Dasty 3