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Protein

Olfactory receptor 56A5

Gene

OR56A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A5
Gene namesi
Name:OR56A5
Synonyms:OR56A5P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14792. OR56A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6713CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10012ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14625CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 20336ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 24622CytoplasmicSequence analysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini268 – 2769ExtracellularSequence analysis
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 31316CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32447.

Polymorphism and mutation databases

BioMutaiOR56A5.
DMDMi206557833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 56A5PRO_0000343673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi100 ↔ 182PROSITE-ProRule annotation
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP0C7T3.
PeptideAtlasiP0C7T3.
PRIDEiP0C7T3.

PTM databases

PhosphoSiteiP0C7T3.

Expressioni

Gene expression databases

ExpressionAtlasiP0C7T3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliP0C7T3.
SMRiP0C7T3. Positions 24-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074576.
HOVERGENiHBG017625.
InParanoidiP0C7T3.
KOiK04257.
OMAiRYCAGHI.
PhylomeDBiP0C7T3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPSNNSTS PVFEFFLICF PSFQSWQHWL SLPLSLLFLL AMGANATLLI
60 70 80 90 100
TIYLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC
110 120 130 140 150
FLQVFIMNSF LTMESCTFMI MAYDRYVAIC KPLQYSSIIT DQFVARAAIF
160 170 180 190 200
VVARNGLLTM PIPILSSRLR YCAGHIIKNC ICTNVSVSKL SCDDITLNQS
210 220 230 240 250
YQFVIGWTLL GSDLILIVLS YFFILKTVLR IKGEGDMAKA LGTCGSHFIL
260 270 280 290 300
ILFFTTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK
310
EIKQGIQNLL RRL
Length:313
Mass (Da):35,317
Last modified:July 22, 2008 - v1
Checksum:i8E4CE42666CEC833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025016 Genomic DNA. No translation available.
CCDSiCCDS73248.1.
RefSeqiNP_001139505.1. NM_001146033.1.
UniGeneiHs.719888.

Genome annotation databases

EnsembliENST00000532411; ENSP00000481594; ENSG00000188691.
GeneIDi390084.
KEGGihsa:390084.
UCSCiuc010qzu.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025016 Genomic DNA. No translation available.
CCDSiCCDS73248.1.
RefSeqiNP_001139505.1. NM_001146033.1.
UniGeneiHs.719888.

3D structure databases

ProteinModelPortaliP0C7T3.
SMRiP0C7T3. Positions 24-310.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP0C7T3.

Polymorphism and mutation databases

BioMutaiOR56A5.
DMDMi206557833.

Proteomic databases

EPDiP0C7T3.
PeptideAtlasiP0C7T3.
PRIDEiP0C7T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532411; ENSP00000481594; ENSG00000188691.
GeneIDi390084.
KEGGihsa:390084.
UCSCiuc010qzu.2. human.

Organism-specific databases

CTDi390084.
GeneCardsiOR56A5.
HGNCiHGNC:14792. OR56A5.
neXtProtiNX_P0C7T3.
PharmGKBiPA32447.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074576.
HOVERGENiHBG017625.
InParanoidiP0C7T3.
KOiK04257.
OMAiRYCAGHI.
PhylomeDBiP0C7T3.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii390084.
PROiP0C7T3.

Gene expression databases

ExpressionAtlasiP0C7T3. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiO56A5_HUMAN
AccessioniPrimary (citable) accession number: P0C7T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.