P0C7Q6 (S35G6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member G6

Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 3
Transmembrane protein 21B

Gene names

Name:	SLC35G6
Synonyms:	AMAC1L3, TMEM21B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in placenta and testis. Ref.2
Miscellaneous	This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.
Sequence similarities	Belongs to the SLC35G solute transporter family. Contains 2 DUF6 domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Solute carrier family 35 member G6		PRO_0000342676
Regions
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	255 – 275	21	Helical; Potential
	Transmembrane	281 – 301	21	Helical; Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Domain	49 – 174	126	DUF6 1
	Domain	272 – 325	54	DUF6 2
Natural variations
	Natural variant	51	1	A → T. Corresponds to variant rs3760422 [ dbSNP | Ensembl ].		VAR_044335
	Natural variant	251	1	P → L. Corresponds to variant rs4491591 [ dbSNP | Ensembl ].		VAR_044336
	Natural variant	263	1	A → T. Corresponds to variant rs7209977 [ dbSNP | Ensembl ].		VAR_059581

Sequences

	Sequence		Length	Mass (Da)
	P0C7Q6 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 5E5E5D10245050C3	FASTA	338	35,103
	10 20 30 40 50 60 MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP AGFVGPLSHM 70 80 90 100 110 120 AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGRAYFYALL NVLSIGCAYS 130 140 150 160 170 180 AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGSILGLI IIVGPGLWTL 190 200 210 220 230 240 QEGITGVYTA LGYGQAFVGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV 250 260 270 280 290 300 LQPPVLPSDL PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM 310 320 330 LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Emergence of primate genes by retrotransposon-mediated sequence transduction." Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A. Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed: 17101974] [Abstract] Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC113189 Genomic DNA. No translation available.
IPI	IPI00334736.
RefSeq	NP_001096084.1. NM_001102614.1.
UniGene	Hs.632234.
3D structure databases
ProteinModelPortal	P0C7Q6.
ModBase	Search...
Protein-protein interaction databases
STRING	P0C7Q6.
Polymorphism databases
DMDM	193806690.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000412468; ENSP00000396523; ENSG00000181222.
GeneID	643664.
KEGG	hsa:643664.
UCSC	uc010cmj.1. human.
Organism-specific databases
CTD	643664.
HGNC	HGNC:31351. SLC35G6.
HPA	CAB012226. CAB016388. CAB022311.
neXtProt	NX_P0C7Q6.
PharmGKB	PA134919830.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17469.
GeneTree	ENSGT00510000048315.
HOGENOM	HBG505905.
HOVERGEN	HBG080671.
InParanoid	P0C7Q6.
OMA	LQEGITG.
OrthoDB	EOG4K0QPB.
Gene expression databases
Bgee	P0C7Q6.
CleanEx	HS_AMAC1L3.
Genevestigator	P0C7Q6.
Family and domain databases
InterPro	IPR000620. DMT. [Graphical view]
Pfam	PF00892. EamA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	115206.

Entry information

Entry name

S35G6_HUMAN

Accession

Primary (citable) accession number: P0C7Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.