Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 35 member G6

Gene

SLC35G6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33732-MONOMER.

Protein family/group databases

TCDBi2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G6
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 3
Transmembrane protein 21B
Gene namesi
Name:SLC35G6
Synonyms:AMAC1L3, TMEM21B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:31351. SLC35G6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi643664.
OpenTargetsiENSG00000259224.
PharmGKBiPA134919830.

Polymorphism and mutation databases

BioMutaiSLC35G6.
DMDMi193806690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426761 – 338Solute carrier family 35 member G6Add BLAST338

Proteomic databases

PaxDbiP0C7Q6.
PRIDEiP0C7Q6.

PTM databases

iPTMnetiP0C7Q6.
PhosphoSitePlusiP0C7Q6.

Expressioni

Tissue specificityi

Expressed in placenta and testis.1 Publication

Gene expression databases

BgeeiENSG00000259224.
CleanExiHS_AMAC1L3.
GenevisibleiP0C7Q6. HS.

Structurei

3D structure databases

ProteinModelPortaliP0C7Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 174EamA 1Add BLAST126
Domaini272 – 325EamA 2Add BLAST54

Sequence similaritiesi

Belongs to the SLC35G solute transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWA. Eukaryota.
ENOG410YABU. LUCA.
GeneTreeiENSGT00730000110996.
HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiP0C7Q6.
OMAiCVSYAVT.
OrthoDBiEOG091G070D.
PhylomeDBiP0C7Q6.
TreeFamiTF331838.

Sequencei

Sequence statusi: Complete.

P0C7Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP
60 70 80 90 100
AGFVGPLSHM AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI
110 120 130 140 150
RGRAYFYALL NVLSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE
160 170 180 190 200
SQGLSGYDWC GLLGSILGLI IIVGPGLWTL QEGITGVYTA LGYGQAFVGG
210 220 230 240 250
LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV LQPPVLPSDL
260 270 280 290 300
PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM
310 320 330
LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE
Length:338
Mass (Da):35,103
Last modified:July 1, 2008 - v1
Checksum:i5E5E5D10245050C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04433551A → T.Corresponds to variant rs3760422dbSNPEnsembl.1
Natural variantiVAR_044336251P → L.Corresponds to variant rs4491591dbSNPEnsembl.1
Natural variantiVAR_059581263A → T.Corresponds to variant rs7209977dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113189 Genomic DNA. No translation available.
CCDSiCCDS45603.1.
RefSeqiNP_001096084.1. NM_001102614.1.
UniGeneiHs.632234.

Genome annotation databases

EnsembliENST00000412468; ENSP00000396523; ENSG00000259224.
GeneIDi643664.
KEGGihsa:643664.
UCSCiuc010cmj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113189 Genomic DNA. No translation available.
CCDSiCCDS45603.1.
RefSeqiNP_001096084.1. NM_001102614.1.
UniGeneiHs.632234.

3D structure databases

ProteinModelPortaliP0C7Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiP0C7Q6.
PhosphoSitePlusiP0C7Q6.

Polymorphism and mutation databases

BioMutaiSLC35G6.
DMDMi193806690.

Proteomic databases

PaxDbiP0C7Q6.
PRIDEiP0C7Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412468; ENSP00000396523; ENSG00000259224.
GeneIDi643664.
KEGGihsa:643664.
UCSCiuc010cmj.2. human.

Organism-specific databases

CTDi643664.
DisGeNETi643664.
GeneCardsiSLC35G6.
HGNCiHGNC:31351. SLC35G6.
neXtProtiNX_P0C7Q6.
OpenTargetsiENSG00000259224.
PharmGKBiPA134919830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEWA. Eukaryota.
ENOG410YABU. LUCA.
GeneTreeiENSGT00730000110996.
HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiP0C7Q6.
OMAiCVSYAVT.
OrthoDBiEOG091G070D.
PhylomeDBiP0C7Q6.
TreeFamiTF331838.

Enzyme and pathway databases

BioCyciZFISH:G66-33732-MONOMER.

Miscellaneous databases

PROiP0C7Q6.

Gene expression databases

BgeeiENSG00000259224.
CleanExiHS_AMAC1L3.
GenevisibleiP0C7Q6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiS35G6_HUMAN
AccessioniPrimary (citable) accession number: P0C7Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.