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P0C7Q6 (S35G6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member G6
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 3
Transmembrane protein 21B
Gene names
Name:SLC35G6
Synonyms:AMAC1L3, TMEM21B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in placenta and testis. Ref.2

Miscellaneous

This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.

Sequence similarities

Belongs to the SLC35G solute transporter family.

Contains 2 EamA domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Solute carrier family 35 member G6
PRO_0000342676

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane67 – 8721Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane310 – 33021Helical; Potential
Domain49 – 174126EamA 1
Domain272 – 32554EamA 2

Natural variations

Natural variant511A → T.
Corresponds to variant rs3760422 [ dbSNP | Ensembl ].
VAR_044335
Natural variant2511P → L.
Corresponds to variant rs4491591 [ dbSNP | Ensembl ].
VAR_044336
Natural variant2631A → T.
Corresponds to variant rs7209977 [ dbSNP | Ensembl ].
VAR_059581

Sequences

Sequence LengthMass (Da)Tools
P0C7Q6 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 5E5E5D10245050C3

FASTA33835,103
        10         20         30         40         50         60 
MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP AGFVGPLSHM 

        70         80         90        100        110        120 
AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGRAYFYALL NVLSIGCAYS 

       130        140        150        160        170        180 
AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGSILGLI IIVGPGLWTL 

       190        200        210        220        230        240 
QEGITGVYTA LGYGQAFVGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV 

       250        260        270        280        290        300 
LQPPVLPSDL PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM 

       310        320        330 
LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Emergence of primate genes by retrotransposon-mediated sequence transduction."
Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC113189 Genomic DNA. No translation available.
CCDSCCDS45603.1.
RefSeqNP_001096084.1. NM_001102614.1.
UniGeneHs.632234.

3D structure databases

ProteinModelPortalP0C7Q6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000396523.

Protein family/group databases

TCDB2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

Polymorphism databases

DMDM193806690.

Proteomic databases

PaxDbP0C7Q6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412468; ENSP00000396523; ENSG00000259224.
GeneID643664.
KEGGhsa:643664.
UCSCuc010cmj.1. human.

Organism-specific databases

CTD643664.
GeneCardsGC17P007386.
HGNCHGNC:31351. SLC35G6.
HPACAB012226.
CAB016388.
CAB022311.
neXtProtNX_P0C7Q6.
PharmGKBPA134919830.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85890.
HOGENOMHOG000033917.
HOVERGENHBG080671.
InParanoidP0C7Q6.
OMANLSCERE.
OrthoDBEOG7BGHKM.
PhylomeDBP0C7Q6.
TreeFamTF331838.

Gene expression databases

BgeeP0C7Q6.
CleanExHS_AMAC1L3.
GenevestigatorP0C7Q6.

Family and domain databases

InterProIPR000620. DMT.
[Graphical view]
PfamPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio115206.
PROP0C7Q6.

Entry information

Entry nameS35G6_HUMAN
AccessionPrimary (citable) accession number: P0C7Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM