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P0C7Q6

- S35G6_HUMAN

UniProt

P0C7Q6 - S35G6_HUMAN

Protein

Solute carrier family 35 member G6

Gene

SLC35G6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member G6
    Alternative name(s):
    Acyl-malonyl-condensing enzyme 1-like protein 3
    Transmembrane protein 21B
    Gene namesi
    Name:SLC35G6
    Synonyms:AMAC1L3, TMEM21B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:31351. SLC35G6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134919830.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Solute carrier family 35 member G6PRO_0000342676Add
    BLAST

    Proteomic databases

    PaxDbiP0C7Q6.

    Expressioni

    Tissue specificityi

    Expressed in placenta and testis.1 Publication

    Gene expression databases

    BgeeiP0C7Q6.
    CleanExiHS_AMAC1L3.
    GenevestigatoriP0C7Q6.

    Organism-specific databases

    HPAiCAB012226.
    CAB016388.
    CAB022311.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000396523.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C7Q6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 174126EamA 1Add
    BLAST
    Domaini272 – 32554EamA 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the SLC35G solute transporter family.Curated
    Contains 2 EamA domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85890.
    HOGENOMiHOG000033917.
    HOVERGENiHBG080671.
    InParanoidiP0C7Q6.
    OMAiNLSCERE.
    OrthoDBiEOG7BGHKM.
    PhylomeDBiP0C7Q6.
    TreeFamiTF331838.

    Family and domain databases

    InterProiIPR000620. DMT.
    [Graphical view]
    PfamiPF00892. EamA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C7Q6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP    50
    AGFVGPLSHM AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI 100
    RGRAYFYALL NVLSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE 150
    SQGLSGYDWC GLLGSILGLI IIVGPGLWTL QEGITGVYTA LGYGQAFVGG 200
    LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV LQPPVLPSDL 250
    PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM 300
    LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE 338
    Length:338
    Mass (Da):35,103
    Last modified:July 1, 2008 - v1
    Checksum:i5E5E5D10245050C3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511A → T.
    Corresponds to variant rs3760422 [ dbSNP | Ensembl ].
    VAR_044335
    Natural varianti251 – 2511P → L.
    Corresponds to variant rs4491591 [ dbSNP | Ensembl ].
    VAR_044336
    Natural varianti263 – 2631A → T.
    Corresponds to variant rs7209977 [ dbSNP | Ensembl ].
    VAR_059581

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113189 Genomic DNA. No translation available.
    CCDSiCCDS45603.1.
    RefSeqiNP_001096084.1. NM_001102614.1.
    UniGeneiHs.632234.

    Genome annotation databases

    EnsembliENST00000412468; ENSP00000396523; ENSG00000259224.
    GeneIDi643664.
    KEGGihsa:643664.
    UCSCiuc010cmj.1. human.

    Polymorphism databases

    DMDMi193806690.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113189 Genomic DNA. No translation available.
    CCDSi CCDS45603.1.
    RefSeqi NP_001096084.1. NM_001102614.1.
    UniGenei Hs.632234.

    3D structure databases

    ProteinModelPortali P0C7Q6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000396523.

    Protein family/group databases

    TCDBi 2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

    Polymorphism databases

    DMDMi 193806690.

    Proteomic databases

    PaxDbi P0C7Q6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412468 ; ENSP00000396523 ; ENSG00000259224 .
    GeneIDi 643664.
    KEGGi hsa:643664.
    UCSCi uc010cmj.1. human.

    Organism-specific databases

    CTDi 643664.
    GeneCardsi GC17P007386.
    HGNCi HGNC:31351. SLC35G6.
    HPAi CAB012226.
    CAB016388.
    CAB022311.
    neXtProti NX_P0C7Q6.
    PharmGKBi PA134919830.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85890.
    HOGENOMi HOG000033917.
    HOVERGENi HBG080671.
    InParanoidi P0C7Q6.
    OMAi NLSCERE.
    OrthoDBi EOG7BGHKM.
    PhylomeDBi P0C7Q6.
    TreeFami TF331838.

    Miscellaneous databases

    NextBioi 115206.
    PROi P0C7Q6.

    Gene expression databases

    Bgeei P0C7Q6.
    CleanExi HS_AMAC1L3.
    Genevestigatori P0C7Q6.

    Family and domain databases

    InterProi IPR000620. DMT.
    [Graphical view ]
    Pfami PF00892. EamA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Emergence of primate genes by retrotransposon-mediated sequence transduction."
      Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.

    Entry informationi

    Entry nameiS35G6_HUMAN
    AccessioniPrimary (citable) accession number: P0C7Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3