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P0C7Q6

- S35G6_HUMAN

UniProt

P0C7Q6 - S35G6_HUMAN

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Protein
Solute carrier family 35 member G6
Gene
SLC35G6, AMAC1L3, TMEM21B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G6
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 3
Transmembrane protein 21B
Gene namesi
Name:SLC35G6
Synonyms:AMAC1L3, TMEM21B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:31351. SLC35G6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Transmembranei105 – 12521Helical; Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST
Transmembranei281 – 30121Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Solute carrier family 35 member G6
PRO_0000342676Add
BLAST

Proteomic databases

PaxDbiP0C7Q6.

Expressioni

Tissue specificityi

Expressed in placenta and testis.1 Publication

Gene expression databases

BgeeiP0C7Q6.
CleanExiHS_AMAC1L3.
GenevestigatoriP0C7Q6.

Organism-specific databases

HPAiCAB012226.
CAB016388.
CAB022311.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396523.

Structurei

3D structure databases

ProteinModelPortaliP0C7Q6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 174126EamA 1
Add
BLAST
Domaini272 – 32554EamA 2
Add
BLAST

Sequence similaritiesi

Contains 2 EamA domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85890.
HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiP0C7Q6.
OMAiNLSCERE.
OrthoDBiEOG7BGHKM.
PhylomeDBiP0C7Q6.
TreeFamiTF331838.

Family and domain databases

InterProiIPR000620. DMT.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7Q6-1 [UniParc]FASTAAdd to Basket

« Hide

MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP    50
AGFVGPLSHM AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI 100
RGRAYFYALL NVLSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE 150
SQGLSGYDWC GLLGSILGLI IIVGPGLWTL QEGITGVYTA LGYGQAFVGG 200
LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV LQPPVLPSDL 250
PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM 300
LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE 338
Length:338
Mass (Da):35,103
Last modified:July 1, 2008 - v1
Checksum:i5E5E5D10245050C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511A → T.
Corresponds to variant rs3760422 [ dbSNP | Ensembl ].
VAR_044335
Natural varianti251 – 2511P → L.
Corresponds to variant rs4491591 [ dbSNP | Ensembl ].
VAR_044336
Natural varianti263 – 2631A → T.
Corresponds to variant rs7209977 [ dbSNP | Ensembl ].
VAR_059581

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC113189 Genomic DNA. No translation available.
CCDSiCCDS45603.1.
RefSeqiNP_001096084.1. NM_001102614.1.
UniGeneiHs.632234.

Genome annotation databases

EnsembliENST00000412468; ENSP00000396523; ENSG00000259224.
GeneIDi643664.
KEGGihsa:643664.
UCSCiuc010cmj.1. human.

Polymorphism databases

DMDMi193806690.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC113189 Genomic DNA. No translation available.
CCDSi CCDS45603.1.
RefSeqi NP_001096084.1. NM_001102614.1.
UniGenei Hs.632234.

3D structure databases

ProteinModelPortali P0C7Q6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000396523.

Protein family/group databases

TCDBi 2.A.7.28.6. the drug/metabolite transporter (dmt) superfamily.

Polymorphism databases

DMDMi 193806690.

Proteomic databases

PaxDbi P0C7Q6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412468 ; ENSP00000396523 ; ENSG00000259224 .
GeneIDi 643664.
KEGGi hsa:643664.
UCSCi uc010cmj.1. human.

Organism-specific databases

CTDi 643664.
GeneCardsi GC17P007386.
HGNCi HGNC:31351. SLC35G6.
HPAi CAB012226.
CAB016388.
CAB022311.
neXtProti NX_P0C7Q6.
PharmGKBi PA134919830.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85890.
HOGENOMi HOG000033917.
HOVERGENi HBG080671.
InParanoidi P0C7Q6.
OMAi NLSCERE.
OrthoDBi EOG7BGHKM.
PhylomeDBi P0C7Q6.
TreeFami TF331838.

Miscellaneous databases

NextBioi 115206.
PROi P0C7Q6.

Gene expression databases

Bgeei P0C7Q6.
CleanExi HS_AMAC1L3.
Genevestigatori P0C7Q6.

Family and domain databases

InterProi IPR000620. DMT.
[Graphical view ]
Pfami PF00892. EamA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Emergence of primate genes by retrotransposon-mediated sequence transduction."
    Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.

Entry informationi

Entry nameiS35G6_HUMAN
AccessioniPrimary (citable) accession number: P0C7Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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