Reviewed, UniProtKB/Swiss-Prot P0C7Q5 (AMCL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein AMAC1L1
Alternative name(s):
    Acyl-malonyl-condensing enzyme 1-like protein 1

Gene names

Name:

AMAC1L1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Miscellaneous	The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the AMAC1L3 gene in the primate lineage.
Sequence similarities	Contains 2 DUF6 domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Protein AMAC1L1		PRO_0000342675
Regions
	Transmembrane	37 – 57	21	Potential
	Transmembrane	160 – 180	21	Potential
	Transmembrane	190 – 210	21	Potential
	Transmembrane	221 – 241	21	Potential
	Transmembrane	250 – 270	21	Potential
	Transmembrane	281 – 301	21	Potential
	Transmembrane	305 – 325	21	Potential
	Domain	49 – 174	126	DUF6 1
	Domain	272 – 325	54	DUF6 2
Natural variations
	Natural variant	104	1	T → A: dbSNP rs8087447.		VAR_061556

Sequences

	Sequence		Length	Mass (Da)
	P0C7Q5-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: E99932C4BE7683D9	FASTA	338	35,378
	10 20 30 40 50 60 MAGSHPYFNL PDSTHPSPPS TPPSLHWHQR CQPSDATNGL LVALLGGGLP AGFVGPLSRM 70 80 90 100 110 120 AYQASNLPSL ELVICRCLFH LPIALLLKLR GDPLLGPPDI RGRTCFCALL NVLNIGCAYS 130 140 150 160 170 180 AVQVVPTGNA ATVRKHSSTV CSAILTLCLE SQVLSGYDWC GLLGSILGLI IIVGPGLWTL 190 200 210 220 230 240 QEGTTGVYTG LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV 250 260 270 280 290 300 LQSPVLPSDL LSWSCVGAVG ILTLVSFTCV GYAVTKAHPA LVCAVLHSEV VMALILQYFM 310 320 330 LHETVAPSDI MGAGVVLGSI AIITARNLIC ERTGKVEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Emergence of primate genes by retrotransposon-mediated sequence transduction." Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A. Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed: 17101974] [Abstract] Cited for: GENE EVOLUTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP001120 Genomic DNA. No translation available.
IPI	IPI00141042.
RefSeq	XP_934053.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P0C7Q5.
Genome annotation databases
Ensembl	ENST00000424015; ENSP00000408366; ENSG00000236396; Homo sapiens. [Genome view]
GeneID	646000.
Organism-specific databases
CTD	646000.
GeneCards	GC18P011603.
HGNC	HGNC:31043. AMAC1L1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG505905.
InParanoid	P0C7Q5.
Gene expression databases
Genevestigator	P0C7Q5.
Family and domain databases
InterPro	IPR000620. DUF6_TM. [Graphical view]
Pfam	PF00892. DUF6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	118259.

Entry information

Entry name

AMCL1_HUMAN

Accession

Primary (citable) accession number: P0C7Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 15, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.