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Protein

Putative solute carrier family 35 member G4

Gene

SLC35G4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Protein family/group databases

TCDBi2.A.7.28.4. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative solute carrier family 35 member G4
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 1
Gene namesi
Name:SLC35G4
Synonyms:AMAC1L1, SLC35G4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31043. SLC35G4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875980.

Polymorphism and mutation databases

DMDMi193806689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Putative solute carrier family 35 member G4PRO_0000342675Add
BLAST

Proteomic databases

PRIDEiP0C7Q5.

Structurei

3D structure databases

ProteinModelPortaliP0C7Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 174126EamA 1Add
BLAST
Domaini272 – 32554EamA 2Add
BLAST

Sequence similaritiesi

Belongs to the SLC35G solute transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiP0C7Q5.
PhylomeDBiP0C7Q5.

Sequencei

Sequence statusi: Complete.

P0C7Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSHPYFNL PDSTHPSPPS TPPSLHWHQR CQPSDATNGL LVALLGGGLP
60 70 80 90 100
AGFVGPLSRM AYQASNLPSL ELVICRCLFH LPIALLLKLR GDPLLGPPDI
110 120 130 140 150
RGRTCFCALL NVLNIGCAYS AVQVVPTGNA ATVRKHSSTV CSAILTLCLE
160 170 180 190 200
SQVLSGYDWC GLLGSILGLI IIVGPGLWTL QEGTTGVYTG LGYVQAFLGG
210 220 230 240 250
LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV LQSPVLPSDL
260 270 280 290 300
LSWSCVGAVG ILTLVSFTCV GYAVTKAHPA LVCAVLHSEV VMALILQYFM
310 320 330
LHETVAPSDI MGAGVVLGSI AIITARNLIC ERTGKVEE
Length:338
Mass (Da):35,378
Last modified:July 1, 2008 - v1
Checksum:iE99932C4BE7683D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041T → A.
Corresponds to variant rs8087447 [ dbSNP | Ensembl ].
VAR_061556

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001120 Genomic DNA. No translation available.
RefSeqiNP_001269229.1. NM_001282300.1.

Genome annotation databases

GeneIDi646000.
KEGGihsa:646000.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001120 Genomic DNA. No translation available.
RefSeqiNP_001269229.1. NM_001282300.1.

3D structure databases

ProteinModelPortaliP0C7Q5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.7.28.4. the drug/metabolite transporter (dmt) superfamily.

Polymorphism and mutation databases

DMDMi193806689.

Proteomic databases

PRIDEiP0C7Q5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi646000.
KEGGihsa:646000.

Organism-specific databases

CTDi646000.
GeneCardsiSLC35G4.
HGNCiHGNC:31043. SLC35G4.
neXtProtiNX_P0C7Q5.
PharmGKBiPA134875980.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiP0C7Q5.
PhylomeDBiP0C7Q5.

Miscellaneous databases

GenomeRNAii646000.
PROiP0C7Q5.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Emergence of primate genes by retrotransposon-mediated sequence transduction."
    Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE EVOLUTION.

Entry informationi

Entry nameiS35G4_HUMAN
AccessioniPrimary (citable) accession number: P0C7Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. The intronless gene encoding this protein has arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage. There is no evidence for transcription (PubMed:17101974).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.