P0C7P4 (UCRIL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cytochrome b-c1 complex subunit Rieske-like protein 1

Alternative name(s):
Ubiquinol-cytochrome c reductase Rieske iron-sulfur subunit pseudogene 1

Gene names

Name:	UQCRFS1P1
Synonyms:	UQCRFSL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Cofactor	Binds 1 2Fe-2S cluster.
Sequence similarities	Contains 1 Rieske domain.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from direct assay. Source: HPA
Molecular_function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Putative cytochrome b-c1 complex subunit Rieske-like protein 1		PRO_0000342402
Regions
	Domain	196 – 281	86	Rieske
Sites
	Metal binding	226	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	228	1	Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
	Metal binding	245	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	248	1	Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Amino acid modifications
	Disulfide bond	231 ↔ 247		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C7P4 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 00B1D0656BE89054	FASTA	283	30,815
	10 20 30 40 50 60 MQQIYTVKEI RSVAARSGPF APVLSATSRG VAGALRPLVQ ATVPATPEQP VLDLKRPFLS 70 80 90 100 110 120 RESLSGQAVR RPLVASVGLN VPASVCYSHT DIKVPDFSEY RRLEVLDSTK SSRESTEARK 130 140 150 160 170 180 GFSYLVTGVT TVGVAYAAKN AVTQFVSSMS ASADVLALAK IEIKLSDIPE GKNMAFKWRG 190 200 210 220 230 240 KPLFVRHRTQ KEIKQEAAVE LSQLRDPQHD LDRVKKPEWV ILIGVCTHLG CVPIANAGDF 250 260 270 280 GGYYCPCHGS HYDASGRIRL GPATLNLEVP TYEFTSDDMV IVG

References

[1]

"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-283. Tissue: Neuroblastoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z82206 Genomic DNA. No translation available. CR592425 mRNA. No translation available.
IPI	IPI00889196.
3D structure databases
ProteinModelPortal	P0C7P4.
ModBase	Search...
Polymorphism databases
DMDM	193806571.
2D gel databases
UCD-2DPAGE	P0C7P4.
Proteomic databases
PaxDb	P0C7P4.
PRIDE	P0C7P4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC22P040273.
HGNC	HGNC:12588. UQCRFS1P1.
HPA	HPA041863.
neXtProt	NX_P0C7P4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0723.
HOGENOM	HOG000255193.
HOVERGEN	HBG001040.
InParanoid	P0C7P4.
OrthoDB	EOG4VMFG4.
Gene expression databases
Genevestigator	P0C7P4.
Family and domain databases
Gene3D	1.20.5.270. 1 hit. 2.102.10.10. 1 hit.
InterPro	IPR011070. Globular_prot_asu/bsu. IPR017941. Rieske_2Fe-2S. IPR014349. Rieske_Fe-S_prot. IPR005805. Rieske_Fe-S_prot_C. IPR015248. Ubiqinol_cyt_c_Rdtase_N. IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su. IPR004192. Ubiquinol_cyt_Rdtase_TM. [Graphical view]
PANTHER	PTHR10134. PTHR10134. 1 hit.
Pfam	PF00355. Rieske. 1 hit. PF09165. Ubiq-Cytc-red_N. 1 hit. PF02921. UCR_TM. 1 hit. [Graphical view]
PRINTS	PR00162. RIESKE.
SUPFAM	SSF56568. AlphaBeta_subunt. 1 hit. SSF50022. Rieske_dom. 1 hit.
TIGRFAMs	TIGR01416. Rieske_proteo. 1 hit.
PROSITE	PS51296. RIESKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UCRIL_HUMAN

Accession

Primary (citable) accession number: P0C7P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.