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P0C7P4

- UCRIL_HUMAN

UniProt

P0C7P4 - UCRIL_HUMAN

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Protein
Putative cytochrome b-c1 complex subunit Rieske-like protein 1
Gene
UQCRFS1P1, UQCRFSL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Cofactori

Binds 1 2Fe-2S cluster.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi226 – 2261Iron-sulfur (2Fe-2S) By similarity
Metal bindingi228 – 2281Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Metal bindingi245 – 2451Iron-sulfur (2Fe-2S) By similarity
Metal bindingi248 – 2481Iron-sulfur (2Fe-2S); via pros nitrogen By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquinol-cytochrome-c reductase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative cytochrome b-c1 complex subunit Rieske-like protein 1
    Alternative name(s):
    Ubiquinol-cytochrome c reductase Rieske iron-sulfur subunit pseudogene 1
    Gene namesi
    Synonyms:UQCRFSL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:12588. UQCRFS1P1.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Putative cytochrome b-c1 complex subunit Rieske-like protein 1
    PRO_0000342402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi231 ↔ 247 By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP0C7P4.
    PaxDbiP0C7P4.
    PRIDEiP0C7P4.

    2D gel databases

    UCD-2DPAGEP0C7P4.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C7P4.

    Organism-specific databases

    HPAiHPA041863.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C7P4.
    SMRiP0C7P4. Positions 12-66, 88-283.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini196 – 28186Rieske
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 Rieske domain.

    Phylogenomic databases

    eggNOGiCOG0723.
    HOGENOMiHOG000255193.
    HOVERGENiHBG001040.
    InParanoidiP0C7P4.
    PhylomeDBiP0C7P4.

    Family and domain databases

    Gene3Di1.20.5.270. 1 hit.
    2.102.10.10. 1 hit.
    InterProiIPR011070. Globular_prot_asu/bsu.
    IPR017941. Rieske_2Fe-2S.
    IPR014349. Rieske_Fe-S_prot.
    IPR005805. Rieske_Fe-S_prot_C.
    IPR015248. Ubiqinol_cyt_c_Rdtase_N.
    IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
    IPR004192. Ubiquinol_cyt_Rdtase_TM.
    [Graphical view]
    PANTHERiPTHR10134. PTHR10134. 1 hit.
    PfamiPF00355. Rieske. 1 hit.
    PF09165. Ubiq-Cytc-red_N. 1 hit.
    PF02921. UCR_TM. 1 hit.
    [Graphical view]
    PRINTSiPR00162. RIESKE.
    SUPFAMiSSF50022. SSF50022. 1 hit.
    SSF56568. SSF56568. 1 hit.
    TIGRFAMsiTIGR01416. Rieske_proteo. 1 hit.
    PROSITEiPS51296. RIESKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C7P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQIYTVKEI RSVAARSGPF APVLSATSRG VAGALRPLVQ ATVPATPEQP    50
    VLDLKRPFLS RESLSGQAVR RPLVASVGLN VPASVCYSHT DIKVPDFSEY 100
    RRLEVLDSTK SSRESTEARK GFSYLVTGVT TVGVAYAAKN AVTQFVSSMS 150
    ASADVLALAK IEIKLSDIPE GKNMAFKWRG KPLFVRHRTQ KEIKQEAAVE 200
    LSQLRDPQHD LDRVKKPEWV ILIGVCTHLG CVPIANAGDF GGYYCPCHGS 250
    HYDASGRIRL GPATLNLEVP TYEFTSDDMV IVG 283
    Length:283
    Mass (Da):30,815
    Last modified:July 1, 2008 - v1
    Checksum:i00B1D0656BE89054
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82206 Genomic DNA. No translation available.
    CR592425 mRNA. No translation available.

    Polymorphism databases

    DMDMi193806571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82206 Genomic DNA. No translation available.
    CR592425 mRNA. No translation available.

    3D structure databases

    ProteinModelPortali P0C7P4.
    SMRi P0C7P4. Positions 12-66, 88-283.
    ModBasei Search...

    Polymorphism databases

    DMDMi 193806571.

    2D gel databases

    UCD-2DPAGE P0C7P4.

    Proteomic databases

    MaxQBi P0C7P4.
    PaxDbi P0C7P4.
    PRIDEi P0C7P4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC22P040273.
    HGNCi HGNC:12588. UQCRFS1P1.
    HPAi HPA041863.
    neXtProti NX_P0C7P4.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0723.
    HOGENOMi HOG000255193.
    HOVERGENi HBG001040.
    InParanoidi P0C7P4.
    PhylomeDBi P0C7P4.

    Miscellaneous databases

    PROi P0C7P4.

    Gene expression databases

    Genevestigatori P0C7P4.

    Family and domain databases

    Gene3Di 1.20.5.270. 1 hit.
    2.102.10.10. 1 hit.
    InterProi IPR011070. Globular_prot_asu/bsu.
    IPR017941. Rieske_2Fe-2S.
    IPR014349. Rieske_Fe-S_prot.
    IPR005805. Rieske_Fe-S_prot_C.
    IPR015248. Ubiqinol_cyt_c_Rdtase_N.
    IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
    IPR004192. Ubiquinol_cyt_Rdtase_TM.
    [Graphical view ]
    PANTHERi PTHR10134. PTHR10134. 1 hit.
    Pfami PF00355. Rieske. 1 hit.
    PF09165. Ubiq-Cytc-red_N. 1 hit.
    PF02921. UCR_TM. 1 hit.
    [Graphical view ]
    PRINTSi PR00162. RIESKE.
    SUPFAMi SSF50022. SSF50022. 1 hit.
    SSF56568. SSF56568. 1 hit.
    TIGRFAMsi TIGR01416. Rieske_proteo. 1 hit.
    PROSITEi PS51296. RIESKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-283.
      Tissue: Neuroblastoma.

    Entry informationi

    Entry nameiUCRIL_HUMAN
    AccessioniPrimary (citable) accession number: P0C7P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: May 14, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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