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Protein

RNA-binding motif protein, Y chromosome, family 1 member D

Gene

RBMY1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Miscellaneous

The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif protein, Y chromosome, family 1 member D
Gene namesi
Name:RBMY1D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:23915. RBMY1D.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi378949.
5940.
PharmGKBiPA134863616.

Polymorphism and mutation databases

BioMutaiRBMY1D.
DMDMi190360153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415381 – 496RNA-binding motif protein, Y chromosome, family 1 member DAdd BLAST496

Proteomic databases

PaxDbiP0C7P1.
PeptideAtlasiP0C7P1.
PRIDEiP0C7P1.

PTM databases

iPTMnetiP0C7P1.
PhosphoSitePlusiP0C7P1.

Expressioni

Tissue specificityi

Testis-specific.

Developmental stagei

Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.

Gene expression databases

BgeeiENSG00000244395.
ExpressionAtlasiP0C7P1. baseline.
GenevisibleiP0C7P1. HS.

Organism-specific databases

HPAiHPA001534.
HPA053147.

Interactioni

Subunit structurei

Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.

Protein-protein interaction databases

STRINGi9606.ENSP00000372124.

Structurei

3D structure databases

ProteinModelPortaliP0C7P1.
SMRiP0C7P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 85RRMPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi254 – 340Arg-richAdd BLAST87

Phylogenomic databases

eggNOGiENOG410J6JX. Eukaryota.
ENOG4111GI6. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiP0C7P1.
OMAiFIGGFNR.
OrthoDBiEOG091G13K0.
PhylomeDBiP0C7P1.
TreeFamiTF331833.

Family and domain databases

InterProiView protein in InterPro
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C7P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF
60 70 80 90 100
AFITFENPAD AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS
110 120 130 140 150
RNRSPSGSLR SARGSRGGTR GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV
160 170 180 190 200
KRGPSSRSGG PPPKKSAPSA VARSNSWMGS QGPMSQRREN YGVPPRRATI
210 220 230 240 250
SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY RDNGHSNRDE
260 270 280 290 300
HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR
310 320 330 340 350
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA
360 370 380 390 400
YRDYGHSSWD EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS
410 420 430 440 450
HGAPPARGPR MSYGGSTCHA YSNTRDRYGR SWESYSSCGD FHYCDREHVC
460 470 480 490
RKDQRNPPSL GRVLPDPREA CGSSSYVASI VDGGESRSEK GDSSRY
Length:496
Mass (Da):55,775
Last modified:June 10, 2008 - v1
Checksum:i46443ED1F5D72C1B
GO
Isoform 2 (identifier: P0C7P1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-363: Missing.

Note: No experimental confirmation available.
Show »
Length:459
Mass (Da):51,283
Checksum:i230B6B80FDD26A09
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056242327 – 363Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007322 Genomic DNA. No translation available.
BC136862 mRNA. Translation: AAI36863.1.
BC144459 mRNA. Translation: AAI44460.1.
CCDSiCCDS35480.1. [P0C7P1-1]
CCDS83521.1. [P0C7P1-2]
RefSeqiNP_001006120.2. NM_001006120.3. [P0C7P1-1]
NP_001307878.1. NM_001320949.1. [P0C7P1-2]
XP_011529788.1. XM_011531486.2. [P0C7P1-1]
UniGeneiHs.380450.

Genome annotation databases

EnsembliENST00000382680; ENSP00000372127; ENSG00000244395. [P0C7P1-1]
ENST00000418956; ENSP00000399181; ENSG00000244395. [P0C7P1-2]
GeneIDi378949.
KEGGihsa:378949.
UCSCiuc004fuu.3. human. [P0C7P1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBY1D_HUMAN
AccessioniPrimary (citable) accession number: P0C7P1
Secondary accession number(s): B7ZMD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM