Reviewed, UniProtKB/Swiss-Prot P0C7P1 (RBY1D_HUMAN)

Names and origin

Protein names

Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member D

Gene names

Name:

RBMY1D

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
Subunit structure	Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
Subcellular location	Nucleus.
Tissue specificity	Testis-specific.
Developmental stage	Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.
Miscellaneous	The RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individues, and some of them may represent pseudogenes. The proteins are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	RNA-binding motif protein, Y chromosome, family 1 member D		PRO_0000341538
Regions
	Domain	8 – 85	78	RRM
	Compositional bias	254 – 340	87	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	P0C7P1-1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 46443ED1F5D72C1B	FASTA	496	55,775
	10 20 30 40 50 60 MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 70 80 90 100 110 120 AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR 130 140 150 160 170 180 GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 190 200 210 220 230 240 QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 250 260 270 280 290 300 RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 310 320 330 340 350 360 ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD 370 380 390 400 410 420 EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA 430 440 450 460 470 480 YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI 490 VDGGESRSEK GDSSRY

References

[1]

"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC007322 Genomic DNA. No translation available.
IPI	IPI00215689.
RefSeq	NP_001006120.2.
UniGene	Hs.380450
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P0C7P1.
Genome annotation databases
Ensembl	ENST00000382673; ENSP00000372119; ENSG00000242389; Homo sapiens. [Genome view] ENST00000382677; ENSP00000372124; ENSG00000244395; Homo sapiens. [Genome view] ENST00000382680; ENSP00000372127; ENSG00000244395; Homo sapiens. [Genome view]
GeneID	378949.
KEGG	hsa:378949.
Organism-specific databases
CTD	378949.
GeneCards	GC0YM022435.
HGNC	HGNC:23915. RBMY1D.
HPA	HPA001534.
GenAtlas	Search...
Phylogenomic databases
OMA	QHETYSR
OrthoDB	EOG9RBT61
Gene expression databases
Genevestigator	P0C7P1.
Family and domain databases
InterPro	IPR012677. a_b_plait_nuc_bd. IPR012604. RBM1CTR. IPR000504. RRM_RNP1. IPR015462. Y_Chr_RRM. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
PANTHER	PTHR10432:SF22. Y_Chr_RRM. 1 hit.
Pfam	PF08081. RBM1CTR. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	100875.

Entry information

Entry name

RBY1D_HUMAN

Accession

Primary (citable) accession number: P0C7P1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	November 24, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.