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Protein

Olfactory receptor 8U9

Gene

OR8U9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8U9
Gene namesi
Name:OR8U9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29166. OR8U9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 567CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9720ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 14325CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 20440ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 23914CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27212ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 30916CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671223.

Polymorphism and mutation databases

DMDMi190359932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 8U9PRO_0000341277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C7N5.

Structurei

3D structure databases

ProteinModelPortaliP0C7N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiP0C7N5.
KOiK04257.
OMAiLMYMVVM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQINCTQVT EFILVGLTDR QELKMPLFVL FLSIYLFTVV GNLGLILLIR
60 70 80 90 100
TDEKLNTPMY FFLSNLAFVD FCYSSVITPK MLGNFLYKQN SISFNACAAQ
110 120 130 140 150
LGCFLAFMTA ECLLLASMAY DRYVAICNPL MYMVVMSPGI CIQLVAAPHS
160 170 180 190 200
YSILVALFHT ILTFRLSYCH SNIVNHFYCD DMPLLRLTCS DTRFKQLWIF
210 220 230 240 250
ACAGIMFISS LLIVFVSYMF IISAILRMHS AEGRQKAFST CGSHMLAVTI
260 270 280 290 300
FYGTLIFMYL QPSSSHALDT DKMASVFYTV IIPMLNPLIY SLQNKEVKEA

LKKIIINKN
Length:309
Mass (Da):35,054
Last modified:June 10, 2008 - v1
Checksum:iA3B36EADA680A15F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW73667.1.
RefSeqiNP_001013375.1. NM_001013357.1.
UniGeneiHs.553618.

Genome annotation databases

GeneIDi504190.
KEGGihsa:504190.
UCSCiuc031yko.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW73667.1.
RefSeqiNP_001013375.1. NM_001013357.1.
UniGeneiHs.553618.

3D structure databases

ProteinModelPortaliP0C7N5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi190359932.

Proteomic databases

PRIDEiP0C7N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504190.
KEGGihsa:504190.
UCSCiuc031yko.1. human.

Organism-specific databases

CTDi504190.
GeneCardsiOR8U9.
HGNCiHGNC:29166. OR8U9.
neXtProtiNX_P0C7N5.
PharmGKBiPA142671223.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiP0C7N5.
KOiK04257.
OMAiLMYMVVM.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii504190.
PROiP0C7N5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR8U9_HUMAN
AccessioniPrimary (citable) accession number: P0C7N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 8, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.