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Protein

C-type lectin domain family 2 member L

Gene

CLEC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-31646-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member L
Gene namesi
Name:CLEC2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21969. CLEC2L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi154790.
OpenTargetsiENSG00000236279.
PharmGKBiPA142672101.

Polymorphism and mutation databases

BioMutaiCLEC2L.
DMDMi190358747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003393851 – 214C-type lectin domain family 2 member LAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Disulfide bondi128 ↔ 208PROSITE-ProRule annotation
Disulfide bondi187 ↔ 200PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP0C7M8.
PeptideAtlasiP0C7M8.
PRIDEiP0C7M8.

PTM databases

iPTMnetiP0C7M8.
PhosphoSitePlusiP0C7M8.

Expressioni

Gene expression databases

BgeeiENSG00000236279.
CleanExiHS_CLEC2L.
ExpressionAtlasiP0C7M8. baseline and differential.
GenevisibleiP0C7M8. HS.

Organism-specific databases

HPAiHPA045050.

Interactioni

Protein-protein interaction databases

BioGridi127555. 2 interactors.
STRINGi9606.ENSP00000390661.

Structurei

3D structure databases

ProteinModelPortaliP0C7M8.
SMRiP0C7M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 209C-type lectinPROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 33Pro-richAdd BLAST31

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000111783.
HOVERGENiHBG107719.
InParanoidiP0C7M8.
OMAiDCLMTRP.
OrthoDBiEOG091G0MBV.
PhylomeDBiP0C7M8.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAREPPSR ARPPPPLAAR PAPAPAAPRP RSPAEAEARG PEGLLRRSGS
60 70 80 90 100
GYEGSTSWKA ALEDTTTRLL LGAIAVLLFA ILVVMSILAS KGCIKCEAPC
110 120 130 140 150
PEDWLLYGRK CYFFSEEPRD WNTGRQYCHT HEAVLAVIQS QKELEFMFKF
160 170 180 190 200
TRREPWIGLR RVGDEFHWVN GDPFDPDTFT IAGPGECVFV EPTRLVSTEC
210
LMTRPWVCSK MAYT
Length:214
Mass (Da):23,927
Last modified:June 10, 2008 - v1
Checksum:i5D4A8E589C8670C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005531 Genomic DNA. No translation available.
CCDSiCCDS47724.1.
RefSeqiNP_001073980.2. NM_001080511.2.
UniGeneiHs.57806.

Genome annotation databases

EnsembliENST00000422142; ENSP00000390661; ENSG00000236279.
GeneIDi154790.
KEGGihsa:154790.
UCSCiuc010lnd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005531 Genomic DNA. No translation available.
CCDSiCCDS47724.1.
RefSeqiNP_001073980.2. NM_001080511.2.
UniGeneiHs.57806.

3D structure databases

ProteinModelPortaliP0C7M8.
SMRiP0C7M8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127555. 2 interactors.
STRINGi9606.ENSP00000390661.

PTM databases

iPTMnetiP0C7M8.
PhosphoSitePlusiP0C7M8.

Polymorphism and mutation databases

BioMutaiCLEC2L.
DMDMi190358747.

Proteomic databases

PaxDbiP0C7M8.
PeptideAtlasiP0C7M8.
PRIDEiP0C7M8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422142; ENSP00000390661; ENSG00000236279.
GeneIDi154790.
KEGGihsa:154790.
UCSCiuc010lnd.4. human.

Organism-specific databases

CTDi154790.
DisGeNETi154790.
GeneCardsiCLEC2L.
HGNCiHGNC:21969. CLEC2L.
HPAiHPA045050.
neXtProtiNX_P0C7M8.
OpenTargetsiENSG00000236279.
PharmGKBiPA142672101.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000111783.
HOVERGENiHBG107719.
InParanoidiP0C7M8.
OMAiDCLMTRP.
OrthoDBiEOG091G0MBV.
PhylomeDBiP0C7M8.
TreeFamiTF351467.

Enzyme and pathway databases

BioCyciZFISH:G66-31646-MONOMER.

Miscellaneous databases

GenomeRNAii154790.
PROiP0C7M8.

Gene expression databases

BgeeiENSG00000236279.
CleanExiHS_CLEC2L.
ExpressionAtlasiP0C7M8. baseline and differential.
GenevisibleiP0C7M8. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC2L_HUMAN
AccessioniPrimary (citable) accession number: P0C7M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.