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Protein

Acyl-coenzyme A synthetase ACSM4, mitochondrial

Gene

ACSM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).By similarity

Catalytic activityi

ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei455 – 4551ATPBy similarity
Binding sitei470 – 4701ATPBy similarity
Binding sitei566 – 5661ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2379ATPBy similarity
Nucleotide bindingi368 – 3736ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. butyrate-CoA ligase activity Source: UniProtKB-EC
  3. fatty-acyl-CoA synthase activity Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acyl-CoA metabolic process Source: Ensembl
  2. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_6812. Conjugation of salicylate with glycine.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC:6.2.1.2)
Alternative name(s):
Acyl-CoA synthetase medium-chain family member 4
Gene namesi
Name:ACSM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:32016. ACSM4.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
BLAST
Chaini23 – 580558Acyl-coenzyme A synthetase ACSM4, mitochondrialPRO_0000339384Add
BLAST

Proteomic databases

PaxDbiP0C7M7.
PRIDEiP0C7M7.

PTM databases

PhosphoSiteiP0C7M7.

Expressioni

Gene expression databases

BgeeiP0C7M7.
CleanExiHS_ACSM4.
GenevestigatoriP0C7M7.

Organism-specific databases

HPAiHPA049895.

Structurei

3D structure databases

ProteinModelPortaliP0C7M7.
SMRiP0C7M7. Positions 45-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0365.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiP0C7M7.
KOiK01896.
OMAiIFFRYQT.
OrthoDBiEOG7D85VZ.
PhylomeDBiP0C7M7.
TreeFamiTF354287.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C7M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIFFRYQTF RFIWLTKPPG RRLHKDHQLW TPLTLADFEA INRCNRPLPK
60 70 80 90 100
NFNFAADVLD QWSQKEKTGE RPANPALWWV NGKGDEVKWS FRELGSLSRK
110 120 130 140 150
AANVLTKPCG LQRGDRLAVI LPRIPEWWLV NVACIRTGII FMPGTIQLTA
160 170 180 190 200
KDILYRLRAS KAKCIVASEE VAPAVESIVL ECPDLKTKLL VSPQSWNGWL
210 220 230 240 250
SFQELFQFAS EEHSCVETGS QEPMTIYFTS GTTGFPKMAQ HSQSSLGIGF
260 270 280 290 300
TLCGRYWLDL KSSDIIWNMS DTGWVKAAIG SVFSSWLCGA CVFVHRMAQF
310 320 330 340 350
DTDTFLDTLT TYPITTLCSP PTVYRMLVQK DLKRYKFKSL RHCLTGGEPL
360 370 380 390 400
NPEVLEQWRV QTGLELYEGY GQTEVGMICA NQKGQEIKPG SMGKGMLPYD
410 420 430 440 450
VQIIDENGNV LPPGKEGEIA LRLKPTRPFC FFSKYVDNPQ KTAATIRGDF
460 470 480 490 500
YVTGDRGVMD SDGYFWFVGR ADDVIISSGY RIGPFEVESA LIEHPAVVES
510 520 530 540 550
AVVSSPDQIR GEVVKAFVVL AAPFKSYNPE KLTLELQDHV KKSTAPYKYP
560 570 580
RKVEFVQELP KTITGKIKRN VLRDQEWRGR
Length:580
Mass (Da):65,703
Last modified:June 10, 2008 - v1
Checksum:i217EF355B93BACC0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti481 – 4811R → H.
Corresponds to variant rs61584783 [ dbSNP | Ensembl ].
VAR_061010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131205 Genomic DNA. No translation available.
DY654856 mRNA. No translation available.
CCDSiCCDS44825.1.
RefSeqiNP_001073923.1. NM_001080454.1.
UniGeneiHs.450804.

Genome annotation databases

EnsembliENST00000399422; ENSP00000382349; ENSG00000215009.
GeneIDi341392.
KEGGihsa:341392.
UCSCiuc001qsx.1. human.

Polymorphism databases

DMDMi190358135.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131205 Genomic DNA. No translation available.
DY654856 mRNA. No translation available.
CCDSiCCDS44825.1.
RefSeqiNP_001073923.1. NM_001080454.1.
UniGeneiHs.450804.

3D structure databases

ProteinModelPortaliP0C7M7.
SMRiP0C7M7. Positions 45-578.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP0C7M7.

Polymorphism databases

DMDMi190358135.

Proteomic databases

PaxDbiP0C7M7.
PRIDEiP0C7M7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399422; ENSP00000382349; ENSG00000215009.
GeneIDi341392.
KEGGihsa:341392.
UCSCiuc001qsx.1. human.

Organism-specific databases

CTDi341392.
GeneCardsiGC12P007456.
HGNCiHGNC:32016. ACSM4.
HPAiHPA049895.
MIMi614360. gene.
neXtProtiNX_P0C7M7.
PharmGKBiPA162375472.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0365.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiP0C7M7.
KOiK01896.
OMAiIFFRYQT.
OrthoDBiEOG7D85VZ.
PhylomeDBiP0C7M7.
TreeFamiTF354287.

Enzyme and pathway databases

ReactomeiREACT_6812. Conjugation of salicylate with glycine.

Miscellaneous databases

GenomeRNAii341392.
NextBioi98133.
PROiP0C7M7.
SOURCEiSearch...

Gene expression databases

BgeeiP0C7M7.
CleanExiHS_ACSM4.
GenevestigatoriP0C7M7.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 330-474.
  3. "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."
    Watkins P.A., Maiguel D., Jia Z., Pevsner J.
    J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiACSM4_HUMAN
AccessioniPrimary (citable) accession number: P0C7M7
Secondary accession number(s): A8MTI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.