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Protein

Acyl-coenzyme A synthetase ACSM4, mitochondrial

Gene

ACSM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).By similarity

Catalytic activityi

ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei455ATPBy similarity1
Binding sitei470ATPBy similarity1
Binding sitei566ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 237ATPBy similarity9
Nucleotide bindingi368 – 373ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-177128 Conjugation of salicylate with glycine

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC:6.2.1.2)
Alternative name(s):
Acyl-CoA synthetase medium-chain family member 4
Gene namesi
Name:ACSM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000215009.5
HGNCiHGNC:32016 ACSM4
MIMi614360 gene
neXtProtiNX_P0C7M7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215009
PharmGKBiPA162375472

Polymorphism and mutation databases

BioMutaiACSM4
DMDMi190358135

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionSequence analysisAdd BLAST22
ChainiPRO_000033938423 – 580Acyl-coenzyme A synthetase ACSM4, mitochondrialAdd BLAST558

Proteomic databases

PaxDbiP0C7M7
PeptideAtlasiP0C7M7
PRIDEiP0C7M7
ProteomicsDBi52346

PTM databases

iPTMnetiP0C7M7
PhosphoSitePlusiP0C7M7

Expressioni

Gene expression databases

BgeeiENSG00000215009
CleanExiHS_ACSM4

Organism-specific databases

HPAiHPA049895

Interactioni

Protein-protein interaction databases

BioGridi131135, 1 interactor
STRINGi9606.ENSP00000382349

Structurei

3D structure databases

ProteinModelPortaliP0C7M7
SMRiP0C7M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00760000119178
HOGENOMiHOG000229982
HOVERGENiHBG053031
InParanoidiP0C7M7
KOiK01896
OMAiLTKPCGL
OrthoDBiEOG091G03NW
PhylomeDBiP0C7M7
TreeFamiTF354287

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C7M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFFRYQTF RFIWLTKPPG RRLHKDHQLW TPLTLADFEA INRCNRPLPK
60 70 80 90 100
NFNFAADVLD QWSQKEKTGE RPANPALWWV NGKGDEVKWS FRELGSLSRK
110 120 130 140 150
AANVLTKPCG LQRGDRLAVI LPRIPEWWLV NVACIRTGII FMPGTIQLTA
160 170 180 190 200
KDILYRLRAS KAKCIVASEE VAPAVESIVL ECPDLKTKLL VSPQSWNGWL
210 220 230 240 250
SFQELFQFAS EEHSCVETGS QEPMTIYFTS GTTGFPKMAQ HSQSSLGIGF
260 270 280 290 300
TLCGRYWLDL KSSDIIWNMS DTGWVKAAIG SVFSSWLCGA CVFVHRMAQF
310 320 330 340 350
DTDTFLDTLT TYPITTLCSP PTVYRMLVQK DLKRYKFKSL RHCLTGGEPL
360 370 380 390 400
NPEVLEQWRV QTGLELYEGY GQTEVGMICA NQKGQEIKPG SMGKGMLPYD
410 420 430 440 450
VQIIDENGNV LPPGKEGEIA LRLKPTRPFC FFSKYVDNPQ KTAATIRGDF
460 470 480 490 500
YVTGDRGVMD SDGYFWFVGR ADDVIISSGY RIGPFEVESA LIEHPAVVES
510 520 530 540 550
AVVSSPDQIR GEVVKAFVVL AAPFKSYNPE KLTLELQDHV KKSTAPYKYP
560 570 580
RKVEFVQELP KTITGKIKRN VLRDQEWRGR
Length:580
Mass (Da):65,703
Last modified:June 10, 2008 - v1
Checksum:i217EF355B93BACC0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061010481R → H. Corresponds to variant dbSNP:rs61584783Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131205 Genomic DNA No translation available.
DY654856 mRNA No translation available.
CCDSiCCDS44825.1
RefSeqiNP_001073923.1, NM_001080454.1
UniGeneiHs.450804

Genome annotation databases

EnsembliENST00000399422; ENSP00000382349; ENSG00000215009
GeneIDi341392
KEGGihsa:341392
UCSCiuc001qsx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACSM4_HUMAN
AccessioniPrimary (citable) accession number: P0C7M7
Secondary accession number(s): A8MTI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 20, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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