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Protein

Rhox homeobox family member 2B

Gene

RHOXF2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 193HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • positive regulation of gene expression Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rhox homeobox family member 2B
Gene namesi
Name:RHOXF2BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33519. RHOXF2B.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203989.
PharmGKBiPA162401289.

Polymorphism and mutation databases

BioMutaiRHOXF2B.
DMDMi190360188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003393711 – 288Rhox homeobox family member 2BAdd BLAST288

Proteomic databases

EPDiP0C7M4.
MaxQBiP0C7M4.
PaxDbiP0C7M4.
PeptideAtlasiP0C7M4.
PRIDEiP0C7M4.

Expressioni

Tissue specificityi

Expressed in testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells.1 Publication

Developmental stagei

Predominantly expressed in early stage germ cells, type-B spermatogonia and early spermatocytes.1 Publication

Gene expression databases

BgeeiENSG00000203989.
CleanExiHS_RHOXF2B.
GenevisibleiP0C7M4. HS.

Organism-specific databases

HPAiHPA003314.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360455.

Structurei

3D structure databases

ProteinModelPortaliP0C7M4.
SMRiP0C7M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 195Nuclear localization signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 286Pro-richAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00820000127081.
HOGENOMiHOG000154119.
HOVERGENiHBG094802.
InParanoidiP0C7M4.
OMAiQELECIF.
OrthoDBiEOG091G0JEY.
PhylomeDBiP0C7M4.
TreeFamiTF339348.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP
60 70 80 90 100
EQGTAAGEKL KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGNLEGTSGS
110 120 130 140 150
DGNVEDSDQS EKEPGQQYSR PQGAVGGLEP GNAQQPNVHA FTPLQLQELE
160 170 180 190 200
CIFQREQFPS EFLRRRLARS MNVTELAVQI WFENRRAKWR RHQRALMARN
210 220 230 240 250
MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS SLCFPMPPFP
260 270 280
PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV
Length:288
Mass (Da):31,637
Last modified:June 10, 2008 - v1
Checksum:i50B571B13DB712B9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07830168G → R Found in infertile men; unknown pathological significance; decreased induction of target genes expression. 1 PublicationCorresponds to variant dbSNP:rs781837897Ensembl.1
Natural variantiVAR_078302176L → F Found in infertile men; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201815129Ensembl.1
Natural variantiVAR_078303227G → R Found in infertile men; unknown pathological significance; decreased induction of target genes expression. 1 Publication1
Natural variantiVAR_078304235D → G Found in infertile men; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs782251394Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590524 mRNA. Translation: CAC36517.1.
AC005023 Genomic DNA. No translation available.
CCDSiCCDS43985.1.
RefSeqiNP_001093155.1. NM_001099685.1.
UniGeneiHs.196956.
Hs.567620.

Genome annotation databases

EnsembliENST00000371402; ENSP00000360455; ENSG00000203989.
GeneIDi727940.
KEGGihsa:727940.
UCSCiuc004esj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRHF2B_HUMAN
AccessioniPrimary (citable) accession number: P0C7M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

RHOF2 and RHOF2B are arranged in a head-to-head orientation and share high sequence similarity (>99%). They cannot easily be distinguished and are usually analyzed as a single gene.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families