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Protein

Rhox homeobox family member 2B

Gene

RHOXF2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.1 Publication

Caution

RHOF2 and RHOF2B are arranged in a head-to-head orientation and share high sequence similarity (>99%). They cannot easily be distinguished and are usually analyzed as a single gene.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 193HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • positive regulation of gene expression Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rhox homeobox family member 2B
Gene namesi
Name:RHOXF2BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000203989.4
HGNCiHGNC:33519 RHOXF2B
neXtProtiNX_P0C7M4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203989
PharmGKBiPA162401289

Polymorphism and mutation databases

BioMutaiRHOXF2B
DMDMi190360188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003393711 – 288Rhox homeobox family member 2BAdd BLAST288

Proteomic databases

EPDiP0C7M4
MaxQBiP0C7M4
PaxDbiP0C7M4
PeptideAtlasiP0C7M4
PRIDEiP0C7M4

Expressioni

Tissue specificityi

Expressed in testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells.1 Publication

Developmental stagei

Predominantly expressed in early stage germ cells, type-B spermatogonia and early spermatocytes.1 Publication

Gene expression databases

BgeeiENSG00000203989
CleanExiHS_RHOXF2B
GenevisibleiP0C7M4 HS

Organism-specific databases

HPAiHPA003314

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360455

Structurei

3D structure databases

ProteinModelPortaliP0C7M4
SMRiP0C7M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 195Nuclear localization signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 286Pro-richAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00820000127081
HOGENOMiHOG000154119
HOVERGENiHBG094802
InParanoidiP0C7M4
OMAiQELECIF
OrthoDBiEOG091G0JEY
PhylomeDBiP0C7M4
TreeFamiTF339348

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C7M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP
60 70 80 90 100
EQGTAAGEKL KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGNLEGTSGS
110 120 130 140 150
DGNVEDSDQS EKEPGQQYSR PQGAVGGLEP GNAQQPNVHA FTPLQLQELE
160 170 180 190 200
CIFQREQFPS EFLRRRLARS MNVTELAVQI WFENRRAKWR RHQRALMARN
210 220 230 240 250
MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS SLCFPMPPFP
260 270 280
PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV
Length:288
Mass (Da):31,637
Last modified:June 10, 2008 - v1
Checksum:i50B571B13DB712B9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07830168G → R Found in infertile men; unknown pathological significance; decreased induction of target genes expression. 1 PublicationCorresponds to variant dbSNP:rs781837897Ensembl.1
Natural variantiVAR_078302176L → F Found in infertile men; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs3764830Ensembl.1
Natural variantiVAR_078303227G → R Found in infertile men; unknown pathological significance; decreased induction of target genes expression. 1 Publication1
Natural variantiVAR_078304235D → G Found in infertile men; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs782251394Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590524 mRNA Translation: CAC36517.1
AC005023 Genomic DNA No translation available.
CCDSiCCDS43985.1
RefSeqiNP_001093155.1, NM_001099685.1
UniGeneiHs.196956
Hs.567620

Genome annotation databases

EnsembliENST00000371402; ENSP00000360455; ENSG00000203989
GeneIDi727940
KEGGihsa:727940
UCSCiuc004esj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHF2B_HUMAN
AccessioniPrimary (citable) accession number: P0C7M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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