P0C7K9 (URE3_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease subunit gamma
EC=3.5.1.5

Alternative name(s):
Urea amidohydrolase subunit gamma

Gene names

Name:	ureA
Ordered Locus Names:	UU434

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_00739
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_00739
Subunit structure	Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00739.
Sequence similarities	Belongs to the urease gamma subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	urea metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Urease subunit gamma HAMAP MF_00739		PRO_0000098056

Sequences

	Sequence		Length	Mass (Da)
	P0C7K9 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: CEA69997E1979F16	FASTA	101	11,219
	10 20 30 40 50 60 MNLSLREVQK LLITVAADVA RRRLARGLKL NYSEAVALIT DHVMEGARDG KLVADLMQSA 70 80 90 100 REVLRVDQVM EGVDTMVSII QVEVTFPDGT KLVSVHDPIY K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli." Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A. J. Bacteriol. 178:647-655(1996) [PubMed: 8550495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27813 / 7 / Serovar 1.
[2]	Erratum Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A. J. Bacteriol. 178:2725-2725(1996) [PubMed: 8626347] [Abstract]
[3]	"Phylogenetic analysis of Ureaplasma urealyticum -- support for the establishment of a new species, Ureaplasma parvum." Kong F., James G., Ma Z., Gordon S., Wang B., Gilbert G.L. Int. J. Syst. Bacteriol. 49:1879-1889(1999) [PubMed: 10555372] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27813 / 7 / Serovar 1, ATCC 27818 / Pi / Serovar 6 and ATCC 33697 / U26 / Serovar 14.
[4]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L40489 Genomic DNA. Translation: AAA89187.1. AF085730 Genomic DNA. Translation: AAD28134.2. AF085731 Genomic DNA. Translation: AAD28137.2. AF085733 Genomic DNA. Translation: AAD28143.2. AF222894 Genomic DNA. Translation: AAF30846.1.
PIR	A82891.
RefSeq	NP_078271.1. NC_002162.1.
3D structure databases
ProteinModelPortal	P0C7K9.
SMR	P0C7K9. Positions 1-99.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876210.
GenomeReviews	Gene locus UU434 in contig AF222894_GR.
KEGG	uur:UU434.
PATRIC	20534451. VBIUrePar45146_0450.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG286300.
OMA	YPEAVAY.
ProtClustDB	PRK13241.
Family and domain databases
HAMAP	MF_00739. Urease_gamma. [Tree]
InterPro	IPR002026. Urease_gamma/gamma-beta_su. IPR012010. Urease_gamma_su. [Graphical view]
Gene3D	G3DSA:3.30.280.10. Urease_gamma_reg. 1 hit.
KO	K01430.
Pfam	PF00547. Urease_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF001223. Urease_gamma. 1 hit.
ProDom	PD002319. Urease_gamma_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54111. Urease_gamma_reg. 1 hit.
TIGRFAMs	TIGR00193. Urease_gam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URE3_UREPA

Accession

Primary (citable) accession number: P0C7K9
Secondary accession number(s): Q56557, Q9R2X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program