P0C7K8 (URE2_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease subunit beta
EC=3.5.1.5

Alternative name(s):
Urea amidohydrolase subunit beta

Gene names

Name:	ureB
Ordered Locus Names:	UU433

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_01954
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_01954
Subunit structure	Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01954.
Sequence similarities	Belongs to the urease beta subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 124	123	Urease subunit beta HAMAP MF_01954		PRO_0000067583

Sequences

	Sequence		Length	Mass (Da)
	P0C7K8 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 743DDE240805F1F5	FASTA	124	13,509
	10 20 30 40 50 60 MSGSSSQFSP GKLVPGAINF ASGEIVMNEG REAKVISIKN TGDRPIQVGS HFHLFEVNSA 70 80 90 100 110 120 LVFFDEKGNE DKERKVAYGR RFDIPSGTAI RFEPGDKKEV SIIDLAGTRE VWGVNGLVNG KLKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli." Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A. J. Bacteriol. 178:647-655(1996) [PubMed: 8550495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27813 / 7 / Serovar 1.
[2]	Erratum Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A. J. Bacteriol. 178:2725-2725(1996) [PubMed: 8626347] [Abstract]
[3]	"Phylogenetic analysis of Ureaplasma urealyticum -- support for the establishment of a new species, Ureaplasma parvum." Kong F., James G., Ma Z., Gordon S., Wang B., Gilbert G.L. Int. J. Syst. Bacteriol. 49:1879-1889(1999) [PubMed: 10555372] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27813 / 7 / Serovar 1, ATCC 27818 / Pi / Serovar 6 and ATCC 33697 / U26 / Serovar 14.
[4]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L40489 Genomic DNA. Translation: AAA89188.2. AF085730 Genomic DNA. Translation: AAD28135.1. AF085731 Genomic DNA. Translation: AAD28138.1. AF085733 Genomic DNA. Translation: AAD28144.1. AF222894 Genomic DNA. Translation: AAF30845.1.
PIR	H82890.
RefSeq	NP_078270.1. NC_002162.1.
3D structure databases
ProteinModelPortal	P0C7K8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876211.
GenomeReviews	Gene locus UU433 in contig AF222894_GR.
KEGG	uur:UU433.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG365918.
OMA	PLSGKRE.
ProtClustDB	CLSK2298935.
Family and domain databases
HAMAP	MF_01954. Urease_beta. [Tree]
InterPro	IPR002019. Urease_beta. [Graphical view]
Gene3D	G3DSA:2.10.150.10. Urease_beta. 1 hit.
KO	K01429.
Pfam	PF00699. Urease_beta. 1 hit. [Graphical view]
SUPFAM	SSF51278. Urease_beta. 1 hit.
TIGRFAMs	TIGR00192. Urease_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URE2_UREPA

Accession

Primary (citable) accession number: P0C7K8
Secondary accession number(s): Q56558

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	November 16, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program