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Protein

Urease subunit alpha

Gene

ureC

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi143 – 1431Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi223 – 2231Nickel 1; via carbamate groupUniRule annotation
Metal bindingi223 – 2231Nickel 2; via carbamate groupUniRule annotation
Binding sitei225 – 2251SubstrateUniRule annotation
Metal bindingi252 – 2521Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi278 – 2781Nickel 2; via tele nitrogenUniRule annotation
Active sitei326 – 3261Proton donorUniRule annotation
Metal bindingi366 – 3661Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciUPAR273119:GHVP-451-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:UU432
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000000423 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Urease subunit alphaPRO_0000067563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei223 – 2231N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi273119.UU432.

Structurei

3D structure databases

ProteinModelPortaliP0C7K7.
SMRiP0C7K7. Positions 1-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKISRKNYS DLYGITTGDS VRLGDTNLWV KVEKDLTTYG EESVFGGGKT
60 70 80 90 100
LREGMGMNST MKLDDKLGNA EVMDLVITNA LIVDYTGIYK ADIGIKNGKI
110 120 130 140 150
AAIGKSGNPH LTDNVDMIVG ISTEISAGEG KIYTAGGLDT HVHWLEPEIV
160 170 180 190 200
PVALDGGITT VIAGGTGMND GTKATTVSPG KFWVKSALQA ADGLSINAGF
210 220 230 240 250
LAKGQGMEDP IFEQIAAGAC GLKIHEDWGA TGNAIDLALT VADKTDVAVA
260 270 280 290 300
IHTDTLNEAG FVEHTIAAMK GRTIHAYHTE GAGGGHAPDI LETVKYAHIL
310 320 330 340 350
PASTNPTIPY TVNTIAEHLD MLMVCHHLNP KVPEDVAFAD SRIRSQTIAA
360 370 380 390 400
EDLLHDMGAI SIMSSDTLAM GRIGEVATRT WQMAHKMKAQ FGSLKGDSEF
410 420 430 440 450
SDNNRVKRYI SKYTINPAIA HGVDSYIGSL EVGKLADIVA WEPKFFGAKP
460 470 480 490 500
YYVVKMGVIA RCVAGDPNAS IPTCEPVIMR DQFGTYGRLL TNTSVSFVSK
510 520 530 540 550
IGLENGIKEE YKLEKELLPV KNCRSVNKKS MKWNSATPNL EVDPQTFDAA
560 570 580 590
VDFNDLENWL EQSASELAKK LKKTSSGKYI LDAEPLTEAP LAQRYFLF
Length:598
Mass (Da):64,545
Last modified:May 20, 2008 - v1
Checksum:i5760DA36AC021424
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001I → L in AAA89189 (PubMed:8550495).Curated
Sequence conflicti244 – 2441K → N in AAD28136 (Ref. 3) Curated
Sequence conflicti244 – 2441K → N in AAD28139 (Ref. 3) Curated
Sequence conflicti355 – 3551H → A in AAA89189 (PubMed:8550495).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40489 Genomic DNA. Translation: AAA89189.2.
AF222894 Genomic DNA. Translation: AAF30844.1.
AF085730 Genomic DNA. Translation: AAD28136.2.
AF085731 Genomic DNA. Translation: AAD28139.2.
AF085733 Genomic DNA. Translation: AAD28145.2.
PIRiG82890.
RefSeqiWP_006688455.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF30844; AAF30844; UU432.
GeneIDi876212.
KEGGiuur:UU432.
PATRICi20534447. VBIUrePar45146_0448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40489 Genomic DNA. Translation: AAA89189.2.
AF222894 Genomic DNA. Translation: AAF30844.1.
AF085730 Genomic DNA. Translation: AAD28136.2.
AF085731 Genomic DNA. Translation: AAD28139.2.
AF085733 Genomic DNA. Translation: AAD28145.2.
PIRiG82890.
RefSeqiWP_006688455.1. NC_002162.1.

3D structure databases

ProteinModelPortaliP0C7K7.
SMRiP0C7K7. Positions 1-552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273119.UU432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF30844; AAF30844; UU432.
GeneIDi876212.
KEGGiuur:UU432.
PATRICi20534447. VBIUrePar45146_0448.

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.
BioCyciUPAR273119:GHVP-451-MONOMER.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE1_UREPA
AccessioniPrimary (citable) accession number: P0C7K7
Secondary accession number(s): Q60058, Q9PQ56, Q9R3U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.