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Protein

Phosphohexose mutases

Gene

xanA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in xanthan production.By similarity

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Phosphoserine intermediateBy similarity
Metal bindingi97 – 971Magnesium; via phosphate groupBy similarity
Metal bindingi237 – 2371MagnesiumBy similarity
Metal bindingi239 – 2391MagnesiumBy similarity
Metal bindingi241 – 2411MagnesiumBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphoglucomutase activity Source: UniProtKB-EC
  3. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Exopolysaccharide synthesis, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-626-MONOMER.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphohexose mutases
Including the following 2 domains:
Phosphoglucomutase (EC:5.4.2.2)
Short name:
PGM
Alternative name(s):
Glucose phosphomutase
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:xanA
Ordered Locus Names:XCC0626
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Phosphohexose mutasesPRO_0000147817Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC0626.

Structurei

3D structure databases

ProteinModelPortaliP0C7J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000268679.
KOiK15778.
OMAiTSHYQAD.
OrthoDBiEOG6W9X55.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPAFKAYD IRGRVPDELN EDLARRIGVA LAAQLDQGPV VLGHDVRLAS
60 70 80 90 100
PALQEALSAG LRASGREVID IGLCGTEEVY FQTDHLKAAG GVMVTASHNP
110 120 130 140 150
MDYNGMKLVR EQARPISSDT GLFAIRDTVA ADTAAAGEPT AAEHSRTDKT
160 170 180 190 200
AYLEHLLSYV DRSTLKPLKL VVNAGNGGAG LIVDLLAPHL PFEFVRVFHE
210 220 230 240 250
PDGNFPNGIP NPLLPENRDA TAKAVKEHGA DFGIAWDGDF DRCFFFDHTG
260 270 280 290 300
RFIEGYYLVG LLAQAILAKQ PGGKVVHDPR LTWNTVEMVE DAGGIPVLCK
310 320 330 340 350
SGHAFIKEKM RSENAVYGGE MSAHHYFREF AYADSGMIPW LLIAELVSQS
360 370 380 390 400
GRSLADLVEA RMQKFPCSGE INFKVDDAKA AVARVMAHYG DQSPELDYTD
410 420 430 440
GISADFGQWR FNLRSSNTEP LLRLNVETRG DAALLETRTQ EISNLLRG
Length:448
Mass (Da):48,891
Last modified:May 20, 2008 - v1
Checksum:i44C25C25F6939F5C
GO

Sequence cautioni

The sequence AAM39942.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM39942.1. Different initiation.
RefSeqiNP_636018.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM39942; AAM39942; XCC0626.
GeneIDi999354.
KEGGixcc:XCC0626.
PATRICi24071904. VBIXanCam115730_0687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM39942.1. Different initiation.
RefSeqiNP_636018.1. NC_003902.1.

3D structure databases

ProteinModelPortaliP0C7J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190485.XCC0626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM39942; AAM39942; XCC0626.
GeneIDi999354.
KEGGixcc:XCC0626.
PATRICi24071904. VBIXanCam115730_0687.

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000268679.
KOiK15778.
OMAiTSHYQAD.
OrthoDBiEOG6W9X55.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
BioCyciXCAM190485:GIXZ-626-MONOMER.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXANA_XANCP
AccessioniPrimary (citable) accession number: P0C7J2
Secondary accession number(s): P29955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.