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Protein

Phosphohexose mutases

Gene

xanA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in xanthan production.By similarity

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Xanthan biosynthesis protein XanB (xanB)
  2. Phosphohexose mutases (xanA)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97Phosphoserine intermediateBy similarity1
Metal bindingi97Magnesium; via phosphate groupBy similarity1
Metal bindingi237MagnesiumBy similarity1
Metal bindingi239MagnesiumBy similarity1
Metal bindingi241MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processExopolysaccharide synthesis, Lipopolysaccharide biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphohexose mutases
Including the following 2 domains:
Phosphoglucomutase (EC:5.4.2.2)
Short name:
PGM
Alternative name(s):
Glucose phosphomutase
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:xanA
Ordered Locus Names:XCC0626
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001478171 – 448Phosphohexose mutasesAdd BLAST448

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC0626.

Structurei

3D structure databases

ProteinModelPortaliP0C7J2.
SMRiP0C7J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiENOG4107QKV. Bacteria.
COG1109. LUCA.
HOGENOMiHOG000268679.
KOiK15778.
OMAiPTDNGIK.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
InterProiView protein in InterPro
IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
PfamiView protein in Pfam
PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiView protein in PROSITE
PS00710. PGM_PMM. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPAFKAYD IRGRVPDELN EDLARRIGVA LAAQLDQGPV VLGHDVRLAS
60 70 80 90 100
PALQEALSAG LRASGREVID IGLCGTEEVY FQTDHLKAAG GVMVTASHNP
110 120 130 140 150
MDYNGMKLVR EQARPISSDT GLFAIRDTVA ADTAAAGEPT AAEHSRTDKT
160 170 180 190 200
AYLEHLLSYV DRSTLKPLKL VVNAGNGGAG LIVDLLAPHL PFEFVRVFHE
210 220 230 240 250
PDGNFPNGIP NPLLPENRDA TAKAVKEHGA DFGIAWDGDF DRCFFFDHTG
260 270 280 290 300
RFIEGYYLVG LLAQAILAKQ PGGKVVHDPR LTWNTVEMVE DAGGIPVLCK
310 320 330 340 350
SGHAFIKEKM RSENAVYGGE MSAHHYFREF AYADSGMIPW LLIAELVSQS
360 370 380 390 400
GRSLADLVEA RMQKFPCSGE INFKVDDAKA AVARVMAHYG DQSPELDYTD
410 420 430 440
GISADFGQWR FNLRSSNTEP LLRLNVETRG DAALLETRTQ EISNLLRG
Length:448
Mass (Da):48,891
Last modified:May 20, 2008 - v1
Checksum:i44C25C25F6939F5C
GO

Sequence cautioni

The sequence AAM39942 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM39942.1. Different initiation.
RefSeqiNP_636018.1. NC_003902.1.
WP_011035869.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM39942; AAM39942; XCC0626.
GeneIDi999354.
KEGGixcc:XCC0626.
PATRICifig|190485.4.peg.687.

Similar proteinsi

Entry informationi

Entry nameiXANA_XANCP
AccessioniPrimary (citable) accession number: P0C7J2
Secondary accession number(s): P29955
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 27, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families