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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7

Gene

USP17L7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated
Phe-89 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its catalytic activity.Curated

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiC19.023

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
Gene namesi
Name:USP17L7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000226430.5
HGNCiHGNC:37180 USP17L7
neXtProtiNX_P0C7H9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000226430

Polymorphism and mutation databases

BioMutaiUSP17L7
DMDMi187653908

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316491 – 530Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7Add BLAST530

Proteomic databases

PeptideAtlasiP0C7H9
PRIDEiP0C7H9

Expressioni

Gene expression databases

BgeeiENSG00000226430

Organism-specific databases

HPAiHPA045642

Interactioni

Protein-protein interaction databases

BioGridi1341303 interactors.
IntActiP0C7H9 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0C7H9
SMRiP0C7H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 375USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00890000139343
HOGENOMiHOG000144638
HOVERGENiHBG007129
InParanoidiP0C7H9
OMAiHAGWICH
OrthoDBiEOG091G06D5
PhylomeDBiP0C7H9

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P0C7H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY
110 120 130 140 150
TLPLSNYMLS REDSQTCHLH KCCMFCTMQA HITWALHSPG HVIQPSQVLA
160 170 180 190 200
AGFHRGEQED AHEFLMFTVD AMKKACLPGH KQLDHHSKDT TLIHQIFGAY
210 220 230 240 250
WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL VKPKELNGEN
260 270 280 290 300
AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC
310 320 330 340 350
RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASGIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RPATQGELKR DHPCLQVPEL DEHLVERATQ ESTLDHWKFP QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP EQQSSLLNLS STKPTDQESM
510 520 530
NTGTLASLQG STRRSKGNNK HSKRSLLVCQ
Length:530
Mass (Da):59,751
Last modified:April 29, 2008 - v1
Checksum:iE748553538E9AFA3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051526161A → G. Corresponds to variant dbSNP:rs17815120Ensembl.1
Natural variantiVAR_051527494P → L. Corresponds to variant dbSNP:rs9694759Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130366 Genomic DNA No translation available.
CCDSiCCDS78305.1
RefSeqiNP_001243798.1, NM_001256869.1
UniGeneiHs.741132

Genome annotation databases

EnsembliENST00000530447; ENSP00000485337; ENSG00000226430
GeneIDi392197
KEGGihsa:392197
UCSCiuc031tag.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiU17L7_HUMAN
AccessioniPrimary (citable) accession number: P0C7H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome