Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0C7H9 (U17L7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
Gene names
Name:USP17L7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Nucleus By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP17 subfamily.

Contains 1 USP domain.

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.

Phe-89 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its catalytic activity.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Nucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
PRO_0000331649

Regions

Domain80 – 375296USP

Natural variations

Natural variant1611A → G.
Corresponds to variant rs17815120 [ dbSNP | Ensembl ].
VAR_051526
Natural variant4941P → L.
Corresponds to variant rs9694759 [ dbSNP | Ensembl ].
VAR_051527

Sequences

Sequence LengthMass (Da)Tools
P0C7H9 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: E748553538E9AFA3

FASTA53059,751
        10         20         30         40         50         60 
MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD LCDDLAPVAR 

        70         80         90        100        110        120 
QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY TLPLSNYMLS REDSQTCHLH 

       130        140        150        160        170        180 
KCCMFCTMQA HITWALHSPG HVIQPSQVLA AGFHRGEQED AHEFLMFTVD AMKKACLPGH 

       190        200        210        220        230        240 
KQLDHHSKDT TLIHQIFGAY WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL 

       250        260        270        280        290        300 
VKPKELNGEN AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC 

       310        320        330        340        350        360 
RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASGIT 

       370        380        390        400        410        420 
SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RPATQGELKR DHPCLQVPEL 

       430        440        450        460        470        480 
DEHLVERATQ ESTLDHWKFP QEQNKTKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP 

       490        500        510        520        530 
EQQSSLLNLS STKPTDQESM NTGTLASLQG STRRSKGNNK HSKRSLLVCQ 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
Burrows J.F., McGrattan M.J., Johnston J.A.
Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[3]"Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC130366 Genomic DNA. No translation available.
RefSeqNP_001243798.1. NM_001256869.1.
UniGeneHs.741132.

3D structure databases

ProteinModelPortalP0C7H9.
SMRP0C7H9. Positions 16-396.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0C7H9. 3 interactions.
STRING9606.ENSP00000392249.

Polymorphism databases

DMDM187653908.

Proteomic databases

PaxDbP0C7H9.
PRIDEP0C7H9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID392197.
KEGGhsa:392197.
UCSCuc031tag.1. human.

Organism-specific databases

CTD392197.
GeneCardsGC08M011990.
HGNCHGNC:37180. USP17L7.
HPAHPA045642.
neXtProtNX_P0C7H9.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000144638.
HOVERGENHBG007129.
InParanoidP0C7H9.
PhylomeDBP0C7H9.

Gene expression databases

GenevestigatorP0C7H9.

Family and domain databases

InterProIPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi392197.
NextBio104989.
PROP0C7H9.

Entry information

Entry nameU17L7_HUMAN
AccessionPrimary (citable) accession number: P0C7H9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM