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P0C7H9

- U17L7_HUMAN

UniProt

P0C7H9 - U17L7_HUMAN

Protein

Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7

Gene

USP17L7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
    Gene namesi
    Name:USP17L7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:37180. USP17L7.

    Subcellular locationi

    Nucleus By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7PRO_0000331649Add
    BLAST

    Proteomic databases

    PaxDbiP0C7H9.
    PRIDEiP0C7H9.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C7H9.

    Organism-specific databases

    HPAiHPA045642.

    Interactioni

    Protein-protein interaction databases

    IntActiP0C7H9. 3 interactions.
    STRINGi9606.ENSP00000392249.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C7H9.
    SMRiP0C7H9. Positions 50-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 375296USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP17 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000144638.
    HOVERGENiHBG007129.
    InParanoidiP0C7H9.
    PhylomeDBiP0C7H9.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C7H9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD    50
    LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY 100
    TLPLSNYMLS REDSQTCHLH KCCMFCTMQA HITWALHSPG HVIQPSQVLA 150
    AGFHRGEQED AHEFLMFTVD AMKKACLPGH KQLDHHSKDT TLIHQIFGAY 200
    WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL VKPKELNGEN 250
    AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC 300
    RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD 350
    DAEVTASGIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD 400
    RPATQGELKR DHPCLQVPEL DEHLVERATQ ESTLDHWKFP QEQNKTKPEF 450
    NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP EQQSSLLNLS STKPTDQESM 500
    NTGTLASLQG STRRSKGNNK HSKRSLLVCQ 530
    Length:530
    Mass (Da):59,751
    Last modified:April 29, 2008 - v1
    Checksum:iE748553538E9AFA3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti161 – 1611A → G.
    Corresponds to variant rs17815120 [ dbSNP | Ensembl ].
    VAR_051526
    Natural varianti494 – 4941P → L.
    Corresponds to variant rs9694759 [ dbSNP | Ensembl ].
    VAR_051527

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC130366 Genomic DNA. No translation available.
    RefSeqiNP_001243798.1. NM_001256869.1.
    UniGeneiHs.741132.

    Genome annotation databases

    GeneIDi392197.
    KEGGihsa:392197.
    UCSCiuc031tag.1. human.

    Polymorphism databases

    DMDMi187653908.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC130366 Genomic DNA. No translation available.
    RefSeqi NP_001243798.1. NM_001256869.1.
    UniGenei Hs.741132.

    3D structure databases

    ProteinModelPortali P0C7H9.
    SMRi P0C7H9. Positions 50-372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0C7H9. 3 interactions.
    STRINGi 9606.ENSP00000392249.

    Polymorphism databases

    DMDMi 187653908.

    Proteomic databases

    PaxDbi P0C7H9.
    PRIDEi P0C7H9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 392197.
    KEGGi hsa:392197.
    UCSCi uc031tag.1. human.

    Organism-specific databases

    CTDi 392197.
    GeneCardsi GC08M011990.
    HGNCi HGNC:37180. USP17L7.
    HPAi HPA045642.
    neXtProti NX_P0C7H9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000144638.
    HOVERGENi HBG007129.
    InParanoidi P0C7H9.
    PhylomeDBi P0C7H9.

    Miscellaneous databases

    GenomeRNAii 392197.
    NextBioi 104989.
    PROi P0C7H9.

    Gene expression databases

    Genevestigatori P0C7H9.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
      Burrows J.F., McGrattan M.J., Johnston J.A.
      Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    3. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
      Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
      BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiU17L7_HUMAN
    AccessioniPrimary (citable) accession number: P0C7H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated
    Phe-89 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its catalytic activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3