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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7

Gene

USP17L7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC19.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
Gene namesi
Name:USP17L7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:37180. USP17L7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiUSP17L7.
DMDMi187653908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7PRO_0000331649Add
BLAST

Proteomic databases

PaxDbiP0C7H9.
PRIDEiP0C7H9.

Expressioni

Organism-specific databases

HPAiHPA045642.

Interactioni

Protein-protein interaction databases

BioGridi134130. 3 interactions.
IntActiP0C7H9. 3 interactions.
STRINGi9606.ENSP00000423115.

Structurei

3D structure databases

ProteinModelPortaliP0C7H9.
SMRiP0C7H9. Positions 50-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 375296USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00790000123004.
HOGENOMiHOG000144638.
HOVERGENiHBG007129.
InParanoidiP0C7H9.
PhylomeDBiP0C7H9.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY
110 120 130 140 150
TLPLSNYMLS REDSQTCHLH KCCMFCTMQA HITWALHSPG HVIQPSQVLA
160 170 180 190 200
AGFHRGEQED AHEFLMFTVD AMKKACLPGH KQLDHHSKDT TLIHQIFGAY
210 220 230 240 250
WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL VKPKELNGEN
260 270 280 290 300
AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC
310 320 330 340 350
RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASGIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RPATQGELKR DHPCLQVPEL DEHLVERATQ ESTLDHWKFP QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP EQQSSLLNLS STKPTDQESM
510 520 530
NTGTLASLQG STRRSKGNNK HSKRSLLVCQ
Length:530
Mass (Da):59,751
Last modified:April 29, 2008 - v1
Checksum:iE748553538E9AFA3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti161 – 1611A → G.
Corresponds to variant rs17815120 [ dbSNP | Ensembl ].
VAR_051526
Natural varianti494 – 4941P → L.
Corresponds to variant rs9694759 [ dbSNP | Ensembl ].
VAR_051527

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130366 Genomic DNA. No translation available.
RefSeqiNP_001243798.1. NM_001256869.1.
UniGeneiHs.741132.

Genome annotation databases

EnsembliENST00000530447; ENSP00000485337; ENSG00000226430.
GeneIDi392197.
KEGGihsa:392197.
UCSCiuc031tag.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130366 Genomic DNA. No translation available.
RefSeqiNP_001243798.1. NM_001256869.1.
UniGeneiHs.741132.

3D structure databases

ProteinModelPortaliP0C7H9.
SMRiP0C7H9. Positions 50-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134130. 3 interactions.
IntActiP0C7H9. 3 interactions.
STRINGi9606.ENSP00000423115.

Protein family/group databases

MEROPSiC19.023.

Polymorphism and mutation databases

BioMutaiUSP17L7.
DMDMi187653908.

Proteomic databases

PaxDbiP0C7H9.
PRIDEiP0C7H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530447; ENSP00000485337; ENSG00000226430.
GeneIDi392197.
KEGGihsa:392197.
UCSCiuc031tag.1. human.

Organism-specific databases

CTDi392197.
GeneCardsiGC08M011990.
HGNCiHGNC:37180. USP17L7.
HPAiHPA045642.
neXtProtiNX_P0C7H9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00790000123004.
HOGENOMiHOG000144638.
HOVERGENiHBG007129.
InParanoidiP0C7H9.
PhylomeDBiP0C7H9.

Miscellaneous databases

GenomeRNAii392197.
NextBioi104989.
PROiP0C7H9.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
    Burrows J.F., McGrattan M.J., Johnston J.A.
    Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  3. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
    Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
    BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiU17L7_HUMAN
AccessioniPrimary (citable) accession number: P0C7H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 24, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated
Phe-89 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.