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P0C7H9

- U17L7_HUMAN

UniProt

P0C7H9 - U17L7_HUMAN

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Protein
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
Gene
USP17L7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
Gene namesi
Name:USP17L7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:37180. USP17L7.

Subcellular locationi

Nucleus By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
PRO_0000331649Add
BLAST

Proteomic databases

PaxDbiP0C7H9.
PRIDEiP0C7H9.

Expressioni

Gene expression databases

GenevestigatoriP0C7H9.

Organism-specific databases

HPAiHPA045642.

Interactioni

Protein-protein interaction databases

IntActiP0C7H9. 3 interactions.
STRINGi9606.ENSP00000392249.

Structurei

3D structure databases

ProteinModelPortaliP0C7H9.
SMRiP0C7H9. Positions 50-372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 375296USP
Add
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000144638.
HOVERGENiHBG007129.
InParanoidiP0C7H9.
PhylomeDBiP0C7H9.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C7H9-1 [UniParc]FASTAAdd to Basket

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MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD    50
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY 100
TLPLSNYMLS REDSQTCHLH KCCMFCTMQA HITWALHSPG HVIQPSQVLA 150
AGFHRGEQED AHEFLMFTVD AMKKACLPGH KQLDHHSKDT TLIHQIFGAY 200
WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL VKPKELNGEN 250
AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC 300
RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD 350
DAEVTASGIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD 400
RPATQGELKR DHPCLQVPEL DEHLVERATQ ESTLDHWKFP QEQNKTKPEF 450
NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP EQQSSLLNLS STKPTDQESM 500
NTGTLASLQG STRRSKGNNK HSKRSLLVCQ 530
Length:530
Mass (Da):59,751
Last modified:April 29, 2008 - v1
Checksum:iE748553538E9AFA3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti161 – 1611A → G.
Corresponds to variant rs17815120 [ dbSNP | Ensembl ].
VAR_051526
Natural varianti494 – 4941P → L.
Corresponds to variant rs9694759 [ dbSNP | Ensembl ].
VAR_051527

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC130366 Genomic DNA. No translation available.
RefSeqiNP_001243798.1. NM_001256869.1.
UniGeneiHs.741132.

Genome annotation databases

GeneIDi392197.
KEGGihsa:392197.
UCSCiuc031tag.1. human.

Polymorphism databases

DMDMi187653908.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC130366 Genomic DNA. No translation available.
RefSeqi NP_001243798.1. NM_001256869.1.
UniGenei Hs.741132.

3D structure databases

ProteinModelPortali P0C7H9.
SMRi P0C7H9. Positions 50-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0C7H9. 3 interactions.
STRINGi 9606.ENSP00000392249.

Polymorphism databases

DMDMi 187653908.

Proteomic databases

PaxDbi P0C7H9.
PRIDEi P0C7H9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 392197.
KEGGi hsa:392197.
UCSCi uc031tag.1. human.

Organism-specific databases

CTDi 392197.
GeneCardsi GC08M011990.
HGNCi HGNC:37180. USP17L7.
HPAi HPA045642.
neXtProti NX_P0C7H9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000144638.
HOVERGENi HBG007129.
InParanoidi P0C7H9.
PhylomeDBi P0C7H9.

Miscellaneous databases

GenomeRNAii 392197.
NextBioi 104989.
PROi P0C7H9.

Gene expression databases

Genevestigatori P0C7H9.

Family and domain databases

InterProi IPR006861. HABP4_PAIRBP1-bd.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
    Burrows J.F., McGrattan M.J., Johnston J.A.
    Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  3. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
    Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
    BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiU17L7_HUMAN
AccessioniPrimary (citable) accession number: P0C7H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.
Phe-89 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its catalytic activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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