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Protein

Cys-loop ligand-gated ion channel

Gene
N/A
Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates cation-selective currents but does not discriminate between different monovalent cations.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cys-loop ligand-gated ion channel
Alternative name(s):
ELIC
OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Taxonomic identifieri556 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 203203PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Topological domaini225 – 2328CytoplasmicSequence Analysis
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Topological domaini254 – 26310PeriplasmicSequence Analysis
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 30016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Cys-loop ligand-gated ion channelPRO_0000330947Add
BLAST

Interactioni

Subunit structurei

Homopentamer.1 Publication

Protein-protein interaction databases

DIPiDIP-58973N.

Structurei

Secondary structure

1
321
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 2716Combined sources
Turni28 – 314Combined sources
Beta strandi32 – 4413Combined sources
Beta strandi51 – 544Combined sources
Beta strandi56 – 594Combined sources
Helixi61 – 688Combined sources
Beta strandi76 – 783Combined sources
Beta strandi81 – 833Combined sources
Beta strandi86 – 949Combined sources
Beta strandi98 – 11114Combined sources
Turni117 – 1204Combined sources
Beta strandi123 – 13412Combined sources
Turni137 – 1393Combined sources
Beta strandi140 – 14910Combined sources
Helixi155 – 1573Combined sources
Beta strandi158 – 1625Combined sources
Beta strandi166 – 1738Combined sources
Helixi178 – 1803Combined sources
Beta strandi186 – 19813Combined sources
Helixi201 – 2066Combined sources
Helixi208 – 21912Combined sources
Helixi220 – 2234Combined sources
Helixi227 – 25125Combined sources
Helixi260 – 28425Combined sources
Beta strandi285 – 2895Combined sources
Helixi296 – 2983Combined sources
Helixi302 – 31312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
4TWDX-ray3.20A/B/C/D/E/F/G/H/I/J11-316[»]
4TWFX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
4TWHX-ray3.60A/B/C/D/E/F/G/H/I/J11-316[»]
ProteinModelPortaliP0C7B7.
SMRiP0C7B7. Positions 11-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C7B7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi115 – 1239Cys-loop

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT
60 70 80 90 100
PGDKPLIVEN TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV
110 120 130 140 150
IYNARFLGSF SNDMDFRLFP FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE
160 170 180 190 200
NIDNEEIDEW WIRKASTHIS DIRYDHLSSV QPNQNEFSRI TVRIDAVRNP
210 220 230 240 250
SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT VVAYAFYTSN
260 270 280 290 300
ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR
310 320
LAFPLGFLAI GCVLVIRGIT L
Length:321
Mass (Da):36,808
Last modified:April 29, 2008 - v1
Checksum:iC532E1C4B657896D
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
4TWDX-ray3.20A/B/C/D/E/F/G/H/I/J11-316[»]
4TWFX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
4TWHX-ray3.60A/B/C/D/E/F/G/H/I/J11-316[»]
ProteinModelPortaliP0C7B7.
SMRiP0C7B7. Positions 11-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58973N.

Protein family/group databases

TCDBi1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C7B7.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "X-ray structure of a prokaryotic pentameric ligand-gated ion channel."
    Hilf R.J., Dutzler R.
    Nature 452:375-379(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS), FUNCTION, SUBUNIT.

Entry informationi

Entry nameiELIC_DICCH
AccessioniPrimary (citable) accession number: P0C7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: January 7, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.