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P0C7B7

- ELIC_DICCH

UniProt

P0C7B7 - ELIC_DICCH

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Protein

Cys-loop ligand-gated ion channel

Gene
N/A
Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Mediates cation-selective currents but does not discriminate between different monovalent cations.1 Publication

GO - Molecular functioni

  1. extracellular ligand-gated ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cys-loop ligand-gated ion channel
Alternative name(s):
ELIC
OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Taxonomic identifieri556 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 203203PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Topological domaini225 – 2328CytoplasmicSequence Analysis
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Topological domaini254 – 26310PeriplasmicSequence Analysis
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 30016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Cys-loop ligand-gated ion channelPRO_0000330947Add
BLAST

Interactioni

Subunit structurei

Homopentamer.1 Publication

Protein-protein interaction databases

DIPiDIP-58973N.

Structurei

Secondary structure

1
321
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 2716Combined sources
Turni28 – 314Combined sources
Beta strandi32 – 4312Combined sources
Beta strandi51 – 544Combined sources
Beta strandi56 – 583Combined sources
Helixi60 – 689Combined sources
Beta strandi76 – 783Combined sources
Beta strandi81 – 9414Combined sources
Beta strandi100 – 11112Combined sources
Helixi119 – 1213Combined sources
Beta strandi123 – 13412Combined sources
Beta strandi136 – 14510Combined sources
Turni155 – 1573Combined sources
Beta strandi158 – 1614Combined sources
Beta strandi169 – 1735Combined sources
Helixi178 – 1803Combined sources
Beta strandi186 – 19813Combined sources
Helixi201 – 2066Combined sources
Helixi208 – 21912Combined sources
Turni220 – 2234Combined sources
Helixi227 – 25125Combined sources
Helixi260 – 28223Combined sources
Beta strandi285 – 2906Combined sources
Turni294 – 2985Combined sources
Turni300 – 3023Combined sources
Beta strandi303 – 3053Combined sources
Helixi308 – 3114Combined sources
Beta strandi312 – 3143Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
4TWDX-ray3.20A/B/C/D/E/F/G/H/I/J11-316[»]
4TWFX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
4TWHX-ray3.60A/B/C/D/E/F/G/H/I/J11-316[»]
ProteinModelPortaliP0C7B7.
SMRiP0C7B7. Positions 11-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C7B7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi115 – 1239Cys-loop

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7B7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT
60 70 80 90 100
PGDKPLIVEN TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV
110 120 130 140 150
IYNARFLGSF SNDMDFRLFP FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE
160 170 180 190 200
NIDNEEIDEW WIRKASTHIS DIRYDHLSSV QPNQNEFSRI TVRIDAVRNP
210 220 230 240 250
SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT VVAYAFYTSN
260 270 280 290 300
ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR
310 320
LAFPLGFLAI GCVLVIRGIT L
Length:321
Mass (Da):36,808
Last modified:April 29, 2008 - v1
Checksum:iC532E1C4B657896D
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VL0 X-ray 3.30 A/B/C/D/E/F/G/H/I/J 1-321 [» ]
2YKS X-ray 3.30 A/B/C/D/E/F/G/H/I/J 1-321 [» ]
2YOE X-ray 3.90 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
3ZKR X-ray 3.65 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
4A97 X-ray 3.34 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
4A98 X-ray 3.61 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
4TWD X-ray 3.20 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
4TWF X-ray 3.90 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
4TWH X-ray 3.60 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
ProteinModelPortali P0C7B7.
SMRi P0C7B7. Positions 11-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58973N.

Protein family/group databases

TCDBi 1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P0C7B7.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
[Graphical view ]
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "X-ray structure of a prokaryotic pentameric ligand-gated ion channel."
    Hilf R.J., Dutzler R.
    Nature 452:375-379(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS), FUNCTION, SUBUNIT.

Entry informationi

Entry nameiELIC_DICCH
AccessioniPrimary (citable) accession number: P0C7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3