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Protein

Cys-loop ligand-gated ion channel

Gene
N/A
Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates cation-selective currents but does not discriminate between different monovalent cations.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cys-loop ligand-gated ion channel
Alternative name(s):
ELIC
OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Taxonomic identifieri556 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeDickeya

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 203PeriplasmicSequence analysisAdd BLAST203
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 232CytoplasmicSequence analysis8
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 263PeriplasmicSequence analysis10
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 300CytoplasmicSequence analysisAdd BLAST16
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309471 – 321Cys-loop ligand-gated ion channelAdd BLAST321

Interactioni

Subunit structurei

Homopentamer.1 Publication

Protein-protein interaction databases

DIPiDIP-58973N.

Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 27Combined sources16
Turni28 – 31Combined sources4
Beta strandi32 – 44Combined sources13
Beta strandi51 – 54Combined sources4
Beta strandi56 – 59Combined sources4
Helixi61 – 68Combined sources8
Beta strandi76 – 78Combined sources3
Beta strandi81 – 83Combined sources3
Beta strandi86 – 94Combined sources9
Beta strandi98 – 111Combined sources14
Turni117 – 120Combined sources4
Beta strandi123 – 134Combined sources12
Turni137 – 139Combined sources3
Beta strandi140 – 149Combined sources10
Helixi155 – 157Combined sources3
Beta strandi158 – 162Combined sources5
Beta strandi166 – 173Combined sources8
Helixi178 – 180Combined sources3
Beta strandi186 – 198Combined sources13
Helixi201 – 206Combined sources6
Helixi208 – 219Combined sources12
Helixi220 – 223Combined sources4
Helixi227 – 251Combined sources25
Helixi260 – 284Combined sources25
Beta strandi285 – 289Combined sources5
Helixi296 – 298Combined sources3
Helixi302 – 313Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
4TWDX-ray3.20A/B/C/D/E/F/G/H/I/J11-316[»]
4TWFX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
4TWHX-ray3.60A/B/C/D/E/F/G/H/I/J11-316[»]
4YEUX-ray4.60A/B/C/D/E11-199[»]
ProteinModelPortaliP0C7B7.
SMRiP0C7B7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C7B7.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi115 – 123Cys-loop9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT
60 70 80 90 100
PGDKPLIVEN TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV
110 120 130 140 150
IYNARFLGSF SNDMDFRLFP FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE
160 170 180 190 200
NIDNEEIDEW WIRKASTHIS DIRYDHLSSV QPNQNEFSRI TVRIDAVRNP
210 220 230 240 250
SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT VVAYAFYTSN
260 270 280 290 300
ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR
310 320
LAFPLGFLAI GCVLVIRGIT L
Length:321
Mass (Da):36,808
Last modified:April 29, 2008 - v1
Checksum:iC532E1C4B657896D
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
4TWDX-ray3.20A/B/C/D/E/F/G/H/I/J11-316[»]
4TWFX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
4TWHX-ray3.60A/B/C/D/E/F/G/H/I/J11-316[»]
4YEUX-ray4.60A/B/C/D/E11-199[»]
ProteinModelPortaliP0C7B7.
SMRiP0C7B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58973N.

Protein family/group databases

TCDBi1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C7B7.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiELIC_DICCH
AccessioniPrimary (citable) accession number: P0C7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.