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P0C7B7 (ELIC_DICCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cys-loop ligand-gated ion channel
Alternative name(s):
ELIC
OrganismDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Taxonomic identifier556 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates cation-selective currents but does not discriminate between different monovalent cations. Ref.1

Subunit structure

Homopentamer. Ref.1

Subcellular location

Cell inner membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Cys-loop ligand-gated ion channel
PRO_0000330947

Regions

Topological domain1 – 203203Periplasmic Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 2328Cytoplasmic Potential
Transmembrane233 – 25321Helical; Potential
Topological domain254 – 26310Periplasmic Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 30016Cytoplasmic Potential
Transmembrane301 – 32121Helical; Potential
Motif115 – 1239Cys-loop

Secondary structure

................................................... 321
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C7B7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: C532E1C4B657896D

FASTA32136,808
        10         20         30         40         50         60 
APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT PGDKPLIVEN 

        70         80         90        100        110        120 
TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV IYNARFLGSF SNDMDFRLFP 

       130        140        150        160        170        180 
FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE NIDNEEIDEW WIRKASTHIS DIRYDHLSSV 

       190        200        210        220        230        240 
QPNQNEFSRI TVRIDAVRNP SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT 

       250        260        270        280        290        300 
VVAYAFYTSN ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR 

       310        320 
LAFPLGFLAI GCVLVIRGIT L 

« Hide

References

[1]"X-ray structure of a prokaryotic pentameric ligand-gated ion channel."
Hilf R.J., Dutzler R.
Nature 452:375-379(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS), FUNCTION, SUBUNIT.
+Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
ProteinModelPortalP0C7B7.
SMRP0C7B7. Positions 11-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-58973N.

Protein family/group databases

TCDB1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP0C7B7.

Entry information

Entry nameELIC_DICCH
AccessionPrimary (citable) accession number: P0C7B7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references