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P0C7B7

- ELIC_DICCH

UniProt

P0C7B7 - ELIC_DICCH

Protein

Cys-loop ligand-gated ion channel

Gene
N/A
Organism
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Mediates cation-selective currents but does not discriminate between different monovalent cations.1 Publication

    GO - Molecular functioni

    1. extracellular ligand-gated ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cys-loop ligand-gated ion channel
    Alternative name(s):
    ELIC
    OrganismiDickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi)
    Taxonomic identifieri556 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Cys-loop ligand-gated ion channelPRO_0000330947Add
    BLAST

    Interactioni

    Subunit structurei

    Homopentamer.1 Publication

    Protein-protein interaction databases

    DIPiDIP-58973N.

    Structurei

    Secondary structure

    1
    321
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 2716
    Turni28 – 314
    Beta strandi32 – 4312
    Beta strandi51 – 544
    Beta strandi56 – 583
    Helixi60 – 689
    Beta strandi76 – 783
    Beta strandi81 – 9414
    Beta strandi100 – 11112
    Helixi119 – 1213
    Beta strandi123 – 13412
    Beta strandi136 – 14510
    Turni155 – 1573
    Beta strandi158 – 1614
    Beta strandi169 – 1735
    Helixi178 – 1803
    Beta strandi186 – 19813
    Helixi201 – 2066
    Helixi208 – 21912
    Turni220 – 2234
    Helixi227 – 25125
    Helixi260 – 28223
    Beta strandi285 – 2906
    Turni294 – 2985
    Turni300 – 3023
    Beta strandi303 – 3053
    Helixi308 – 3114
    Beta strandi312 – 3143

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VL0X-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
    2YKSX-ray3.30A/B/C/D/E/F/G/H/I/J1-321[»]
    2YOEX-ray3.90A/B/C/D/E/F/G/H/I/J11-316[»]
    3ZKRX-ray3.65A/B/C/D/E/F/G/H/I/J11-316[»]
    4A97X-ray3.34A/B/C/D/E/F/G/H/I/J11-316[»]
    4A98X-ray3.61A/B/C/D/E/F/G/H/I/J11-316[»]
    ProteinModelPortaliP0C7B7.
    SMRiP0C7B7. Positions 11-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0C7B7.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 203203PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 2328CytoplasmicSequence Analysis
    Topological domaini254 – 26310PeriplasmicSequence Analysis
    Topological domaini285 – 30016CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi115 – 1239Cys-loop

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0C7B7-1 [UniParc]FASTAAdd to Basket

    « Hide

    APADNAADAR PVDVSVSIFI NKIYGVNTLE QTYKVDGYIV AQWTGKPRKT    50
    PGDKPLIVEN TQIERWINNG LWVPALEFIN VVGSPDTGNK RLMLFPDGRV 100
    IYNARFLGSF SNDMDFRLFP FDRQQFVLEL EPFSYNNQQL RFSDIQVYTE 150
    NIDNEEIDEW WIRKASTHIS DIRYDHLSSV QPNQNEFSRI TVRIDAVRNP 200
    SYYLWSFILP LGLIIAASWS VFWLESFSER LQTSFTLMLT VVAYAFYTSN 250
    ILPRLPYTTV IDQMIIAGYG SIFAAILLII FAHHRQAMGV EDDLLIQRCR 300
    LAFPLGFLAI GCVLVIRGIT L 321
    Length:321
    Mass (Da):36,808
    Last modified:April 29, 2008 - v1
    Checksum:iC532E1C4B657896D
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VL0 X-ray 3.30 A/B/C/D/E/F/G/H/I/J 1-321 [» ]
    2YKS X-ray 3.30 A/B/C/D/E/F/G/H/I/J 1-321 [» ]
    2YOE X-ray 3.90 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
    3ZKR X-ray 3.65 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
    4A97 X-ray 3.34 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
    4A98 X-ray 3.61 A/B/C/D/E/F/G/H/I/J 11-316 [» ]
    ProteinModelPortali P0C7B7.
    SMRi P0C7B7. Positions 11-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-58973N.

    Protein family/group databases

    TCDBi 1.A.9.9.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P0C7B7.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "X-ray structure of a prokaryotic pentameric ligand-gated ion channel."
      Hilf R.J., Dutzler R.
      Nature 452:375-379(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS), FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiELIC_DICCH
    AccessioniPrimary (citable) accession number: P0C7B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3