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Protein

Type-1 glutamine synthetase 2

Gene

glnA2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 glutamine synthetase 2 (EC:6.3.1.2)
Short name:
Type-1 GS 2
Alternative name(s):
Type-1 glutamate--ammonia ligase 2
Gene namesi
Name:glnA2
ORF Names:DDB_G0295755
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0295755. glnA2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Type-1 glutamine synthetase 2PRO_0000330937Add
BLAST

Proteomic databases

PRIDEiP0C7B6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 6059Asn-richAdd
BLAST
Compositional biasi360 – 3634Poly-Leu

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

InParanoidiP0C7B6.
OMAiAFELGHT.
PhylomeDBiP0C7B6.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C7B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLVNKNIF INKNNSLKNF VNNYSTKTNN NNNNIFNKNK NDLKSFSSSS
60 70 80 90 100
KLNNNNNNNN KYEESKLMNA EDLILNQIKI SKSPFVKIAG SDIDGILRGK
110 120 130 140 150
YLDKSKFESS IKKGLGFCSV IFGWDSSDSA YDNVKFTGNH TGYPDMGARP
160 170 180 190 200
DLSTFRTIPW EYDVPLFLMD FIGTNGEPLP ICPRSTLKKV IKKCHEHQFD
210 220 230 240 250
PVQGMEFEWY NYSENNKSLL NKNFSNLEPL SNGMFGYSLL RTSQNSEFMN
260 270 280 290 300
SLAELQGFGV PLEGLHTETG PGVYEAAIRF STALESADRA ILFKHCTKEI
310 320 330 340 350
ASLQGIMASF MAKPFKDLPG CSGHMHQNFN CLKTGKNLFL DESDPNHMSD
360 370 380 390 400
IFKSFVAGQL LLLPEFLPFF APTINSYKRL VDGYWAPTTP TWGMDNRTVA
410 420 430 440 450
LRIIKGGKAT RSEFRVTGSD VNPYISIAAS FAAGLYGVIN KLELKQKPII
460 470 480 490 500
GNSYDLYKKG LVERLPRSLA ESTELLSKSK IAKEYLGEEF VDHFVETRRW
510 520
EYRQFNHQVH KWELERYLEI I
Length:521
Mass (Da):59,201
Last modified:April 29, 2008 - v1
Checksum:iE4E77C3AEB67391A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000135 Genomic DNA. Translation: EEU04062.1.
RefSeqiXP_002649114.1. XM_002649068.1.

Genome annotation databases

EnsemblProtistsiDDB0252590; DDB0252590; DDB_G0295755.
GeneIDi8627058.
KEGGiddi:DDB_G0295755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000135 Genomic DNA. Translation: EEU04062.1.
RefSeqiXP_002649114.1. XM_002649068.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0C7B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0252590; DDB0252590; DDB_G0295755.
GeneIDi8627058.
KEGGiddi:DDB_G0295755.

Organism-specific databases

dictyBaseiDDB_G0295755. glnA2.

Phylogenomic databases

InParanoidiP0C7B6.
OMAiAFELGHT.
PhylomeDBiP0C7B6.

Miscellaneous databases

PROiP0C7B6.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. Bienvenut W.V., Veltman D.M., Insall R.H.
    Submitted (JAN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 88-98; 280-289 AND 468-478, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGLNA2_DICDI
AccessioniPrimary (citable) accession number: P0C7B6
Secondary accession number(s): C7G063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 29, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.