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Protein

Protein FAM153B

Gene

FAM153B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM153B
Gene namesi
Name:FAM153B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:27323. FAM153B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Protein FAM153BPRO_0000329316Add
BLAST

Proteomic databases

PaxDbiP0C7A2.
PRIDEiP0C7A2.

PTM databases

iPTMnetiP0C7A2.
PhosphoSiteiP0C7A2.

Expressioni

Gene expression databases

BgeeiP0C7A2.
CleanExiHS_FAM153B.
ExpressionAtlasiP0C7A2. baseline and differential.
GenevisibleiP0C7A2. HS.

Organism-specific databases

HPAiHPA042585.
HPA044022.
HPA046691.
HPA052337.
HPA055498.

Structurei

3D structure databases

ProteinModelPortaliP0C7A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM153 family.Curated

Phylogenomic databases

eggNOGiENOG410KIIN. Eukaryota.
ENOG4110Q72. LUCA.
GeneTreeiENSGT00530000064897.
HOGENOMiHOG000015270.
HOVERGENiHBG102425.
InParanoidiP0C7A2.
OrthoDBiEOG7MWGXK.
PhylomeDBiP0C7A2.
TreeFamiTF353284.

Family and domain databases

InterProiIPR023249. FAM153.
[Graphical view]
PANTHERiPTHR40712. PTHR40712. 1 hit.
PfamiPF15722. FAM153. 4 hits.
[Graphical view]
PRINTSiPR02041. PROTEINF153.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C7A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCAYSCCLE VCCGEDEIVY PRMPGESTVC HREREKPITY HWYHWHPGHI
60 70 80 90 100
YPRVASMEDY DEDLVQEASS EDVLGVHMVD KDTERDIEMK RQLRRLRELH
110 120 130 140 150
LYSTWKKYQE AMKTSLGVPQ CERDEGSLGK PLCPPEILSE TLPGSVKKRV
160 170 180 190 200
CFPSEDHLEE FIAEHLPEAS NQSLLTVAHA DTGIQTNGDL EDLEEHGPGQ
210 220 230 240 250
TVSEEATEVH MMEGDPDTLA ELLIRDVLQE LSSYNGEEED PEEVKTSLGV
260 270 280 290 300
PQRGDLEDLE EHVPGQTVSE EATGVHMMQV DPATPAKSDL EDLEEHVPGQ
310 320 330 340 350
TVSEEATGVH MMQVDPATLA KQLEDSTITG SHQQMSASPS SAPAEEATEK
360 370 380
TKVEEEVKTR KPKKKTRKPS KKSRWNVLKC WDIFNIF
Length:387
Mass (Da):43,591
Last modified:April 8, 2008 - v1
Checksum:iE2CA86F4DAC4DBBE
GO
Isoform 2 (identifier: P0C7A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-387: QLEDSTITGS...LKCWDIFNIF → RTYSGIISLFRCEILVL

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):37,996
Checksum:iF685E9884603E725
GO

Sequence cautioni

The sequence AAH28606.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei322 – 38766QLEDS…IFNIF → RTYSGIISLFRCEILVL in isoform 2. 1 PublicationVSP_032916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139491 Genomic DNA. No translation available.
BC028606 mRNA. Translation: AAH28606.1. Different initiation.
UniGeneiHs.368516.

Genome annotation databases

EnsembliENST00000253490; ENSP00000253490; ENSG00000182230. [P0C7A2-1]
UCSCiuc063jwz.1. human. [P0C7A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139491 Genomic DNA. No translation available.
BC028606 mRNA. Translation: AAH28606.1. Different initiation.
UniGeneiHs.368516.

3D structure databases

ProteinModelPortaliP0C7A2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0C7A2.
PhosphoSiteiP0C7A2.

Proteomic databases

PaxDbiP0C7A2.
PRIDEiP0C7A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253490; ENSP00000253490; ENSG00000182230. [P0C7A2-1]
UCSCiuc063jwz.1. human. [P0C7A2-1]

Organism-specific databases

GeneCardsiFAM153B.
HGNCiHGNC:27323. FAM153B.
HPAiHPA042585.
HPA044022.
HPA046691.
HPA052337.
HPA055498.
neXtProtiNX_P0C7A2.
PharmGKBiPA162386580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIIN. Eukaryota.
ENOG4110Q72. LUCA.
GeneTreeiENSGT00530000064897.
HOGENOMiHOG000015270.
HOVERGENiHBG102425.
InParanoidiP0C7A2.
OrthoDBiEOG7MWGXK.
PhylomeDBiP0C7A2.
TreeFamiTF353284.

Miscellaneous databases

ChiTaRSiFAM153B. human.
PROiP0C7A2.

Gene expression databases

BgeeiP0C7A2.
CleanExiHS_FAM153B.
ExpressionAtlasiP0C7A2. baseline and differential.
GenevisibleiP0C7A2. HS.

Family and domain databases

InterProiIPR023249. FAM153.
[Graphical view]
PANTHERiPTHR40712. PTHR40712. 1 hit.
PfamiPF15722. FAM153. 4 hits.
[Graphical view]
PRINTSiPR02041. PROTEINF153.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiF153B_HUMAN
AccessioniPrimary (citable) accession number: P0C7A2
Secondary accession number(s): A8MTI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.