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Protein

Cytosolic endo-beta-N-acetylglucosaminidase

Gene

ENGASE

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.

Catalytic activityi

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

GO - Molecular functioni

  • beta-N-acetylglucosaminidase activity Source: AgBase
  • hydrolase activity Source: AgBase
  • mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  • catabolism by organism of cell wall peptidoglycan in other organism Source: AgBase

Keywordsi

Molecular functionGlycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
Short name:
ENGase
Gene namesi
Name:ENGASE
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288691 – 728Cytosolic endo-beta-N-acetylglucosaminidaseAdd BLAST728

Proteomic databases

PaxDbiP0C7A1
PRIDEiP0C7A1

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019265

Structurei

3D structure databases

ProteinModelPortaliP0C7A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 381BRCTAdd BLAST95

Sequence similaritiesi

Belongs to the glycosyl hydrolase 85 family.Curated

Phylogenomic databases

eggNOGiKOG2331 Eukaryota
COG4724 LUCA
HOGENOMiHOG000082678
HOVERGENiHBG107848
InParanoidiP0C7A1
PhylomeDBiP0C7A1

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR032979 ENGase
IPR008979 Galactose-bd-like_sf
IPR005201 Glyco_hydro_85
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR13246 PTHR13246, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF03644 Glyco_hydro_85, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

P0C7A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSQSVMLEL REQDEVWVRL YKGERENAVF SDEYDTYITF SGHLINFQPA
60 70 80 90 100
AEPLGTTVLH AAVDTRPQPA RYFDTGTTEP VSFFLSGLEE LLAWHPSSDD
110 120 130 140 150
EFNVCAVPLA QRQPPLHSRR PRTLLCHDMR GGYLEDRFIQ GSATRNPYVF
160 170 180 190 200
YHWRYVDIFV YFSHHTVTIP PVCWTNAAHR NGVPVLGTFI TEWADGEKLC
210 220 230 240 250
EAFLAGGEDA YRAVSHQLAR IAQHYRFDGW LINIENALSA AAVGNLSPFL
260 270 280 290 300
RHLTAEVHGA VPGGLVIWYD SILESGTLRW QNELNQQNRV FFDACDGLFV
310 320 330 340 350
NYNWKEEHLE RTRELAGQRH ADVYIGVDVF ARGDVVGGGF DTNKSLSLIR
360 370 380 390 400
KHGLSAAIFA PGWVYKHLGE ENFLLNEDKF WGLLEDYLPT HSICTLPLAT
410 420 430 440 450
SFSVGMGTGM FLAGKEEEAG PWYNLSAQEI QPLYPERRGW LSTSCCLQDA
460 470 480 490 500
WCGGSSLRVQ GTIPPGEERV AIRLSLWVDL GSSGFSLSIC GTLASGPHRD
510 520 530 540 550
DFTVALELTT WHSSRCHDGT VTVLPSEDEP HGRHHPHLLP APPPALSRML
560 570 580 590 600
AACSHGAQGW TSRCYEQELR GCSLRDLSLL VSRQQASPQE TSFSCLLGEL
610 620 630 640 650
RVLDAGSMAA SPPQVQSLTA SQLWWQDGPS AEQLSLSLTL RWAFPPGRAA
660 670 680 690 700
CFRVLSQGAR CHRAQPAQPQ LLGLAHGCQY RAVGLAVPRP APGQSCQLEL
710 720
LVEPVLPSEL PVGPERWGRL LLVYSEPA
Length:728
Mass (Da):80,889
Last modified:April 8, 2008 - v1
Checksum:iCAA311512C095918
GO

Similar proteinsi

Entry informationi

Entry nameiENASE_CHICK
AccessioniPrimary (citable) accession number: P0C7A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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