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Protein

Non-structural protein V

Gene

P/V

Organism
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi232Zinc 1By similarity1
Metal bindingi251Zinc 1By similarity1
Metal bindingi255Zinc 2By similarity1
Metal bindingi267Zinc 2By similarity1
Metal bindingi269Zinc 2By similarity1
Metal bindingi272Zinc 2By similarity1
Metal bindingi276Zinc 1By similarity1
Metal bindingi279Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF7 by virus, Inhibition of host MDA5 by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein V
Gene namesi
Name:P/V
OrganismiMeasles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri645098 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008699 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003947211 – 299Non-structural protein VAdd BLAST299

Interactioni

Subunit structurei

Interacts with host IFIH1/MDA5 and DHX58/LGP2. Interacts with host TYK2; this interaction inhibits the type I interferon signaling pathway whithout affecting the type II pathway. Interacts with host IRF7; this interaction inhibits IRF7 translocation to the nucleus. Interacts with host CHUK and RELA. Interacts (via C-terminus) with host STAT2.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RELAQ042063EBI-3650423,EBI-73886From a different organism.
STAT2P526304EBI-3650423,EBI-1546963From a different organism.

Protein-protein interaction databases

DIPiDIP-61740N.
IntActiP0C774. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0C774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi213 – 218Poly-Pro6

Sequence similaritiesi

Belongs to the paramyxoviruses V protein family.Curated

Family and domain databases

InterProiIPR024279. Paramyx_V_Zn-bd.
IPR028243. Paramyxo_P/V_N.
[Graphical view]
PfamiPF13825. Paramyxo_PNT. 1 hit.
PF13008. zf-Paramyx-P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQARHVK NGLECIRALK AEPIGSLAVE EAMAAWSEIS DNPGQDRATC
60 70 80 90 100
KEEEAGSSGL SKPCLSAIGS TEGGAPRIRG QGSGESDDDA ETLGIPSRNL
110 120 130 140 150
QASSTGLQCY HVYDHSGEAV KGIQDADSIM VQSGLDGDST LSGGDDESEN
160 170 180 190 200
SDVDIGEPDT EGYAITDRGS APISMGFRAS DVETAEGGEI HELLKLQSRG
210 220 230 240 250
NNFPKLGKTL NVPPPPNPSR ASTSETPIKK GHRREIGLIW NGDRVFIDRW
260 270 280 290
CNPMCSKVTL GTIRARCTCG ECPRVCEQCR TDTGVDTRIW YHNLPEIPE
Length:299
Mass (Da):32,016
Last modified:June 15, 2010 - v1
Checksum:iFEDBD36B65E382D0
GO

RNA editingi

Edited at position 231.
Partially edited. RNA editing at this position consists of an insertion of one guanine nucleotide. The sequence displayed here is the V protein, derived from the edited RNA. The unedited RNA gives rise to the P protein (AC Q9WMB4).

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016162 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016162 Genomic RNA. No translation available.

3D structure databases

ProteinModelPortaliP0C774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61740N.
IntActiP0C774. 3 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR024279. Paramyx_V_Zn-bd.
IPR028243. Paramyxo_P/V_N.
[Graphical view]
PfamiPF13825. Paramyxo_PNT. 1 hit.
PF13008. zf-Paramyx-P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV_MEASC
AccessioniPrimary (citable) accession number: P0C774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.