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P0C772

- VSSGP_EBOSU

UniProt

P0C772 - VSSGP_EBOSU

Protein

Super small secreted glycoprotein

Gene

GP

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Super small secreted glycoprotein
    Short name:
    SsGP
    Gene namesi
    Name:GP
    OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
    Taxonomic identifieri386033 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
    ProteomesiUP000000277: Genome

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 319287Super small secreted glycoproteinPRO_0000391496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi53 – 53InterchainBy similarity
    Disulfide bondi108 ↔ 135By similarity
    Disulfide bondi121 ↔ 147By similarity
    Glycosylationi204 – 2041N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi268 – 2681N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi123 – 1264Poly-Pro

    Sequence similaritiesi

    Belongs to the filoviruses glycoprotein family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR002561. GPC_filovir-type_extra_dom.
    [Graphical view]
    PfamiPF01611. Filo_glycop. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C772-1 [UniParc]FASTAAdd to Basket

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    MGGLSLLQLP RDKFRKSSFF VWVIILFQKA FSMPLGVVTN STLEVTEIDQ    50
    LVCKDHLAST DQLKSVGLNL EGSGVSTDIP SATKRWGFRS GVPPKVVSYE 100
    AGEWAENCYN LEIKKPDGSE CLPPPPDGVR GFPRCRYVHK AQGTGPCPGD 150
    YAFHKDGAFF LYDRLASTVI YRGVNFAEGV IAFLILAKPK ETFLQSPPIR 200
    EAVNYTENTS SYYATSYLEY EIENFGAQHS TTLFKIDNNT FVRLDRPHTP 250
    QFLFQLNDTI HLHQQLSNTT GRLIWTLDAN INADIGEWAF WENKKKSLRT 300
    TTWRRAVFRS FIAQRDRRR 319
    Length:319
    Mass (Da):36,274
    Last modified:February 9, 2010 - v1
    Checksum:i05B814143DFEC827
    GO

    RNA editingi

    Partially edited. RNA editing at this position consists of an insertion of one or two adenine nucleotides. The sequence displayed here is the super small secreted glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA gives rise to the small secreted glycoprotein sGP (AC Q7T9E0), the +1A edited RNA gives rise to the full-length transmembrane glycoprotein GP (AC Q7T9D9).

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY316199 Genomic RNA. No translation available.
    AY344234 Genomic RNA. No translation available.
    AY729654 Genomic RNA. No translation available.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY316199 Genomic RNA. No translation available.
    AY344234 Genomic RNA. No translation available.
    AY729654 Genomic RNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002561. GPC_filovir-type_extra_dom.
    [Graphical view ]
    Pfami PF01611. Filo_glycop. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels."
      Sanchez A., Lukwiya M., Bausch D., Mahanty S., Sanchez A.J., Wagoner K.D., Rollin P.E.
      J. Virol. 78:10370-10377(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome."
      Towner J.S., Rollin P.E., Bausch D.G., Sanchez A., Crary S.M., Vincent M., Lee W.F., Spiropoulou C.F., Ksiazek T.G., Lukwiya M., Kaducu F., Downing R., Nichol S.T.
      J. Virol. 78:4330-4341(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
      Sanchez A., Rollin P.E.
      Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVSSGP_EBOSU
    AccessioniPrimary (citable) accession number: P0C772
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3