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P0C770

- VSSGP_EBORE

UniProt

P0C770 - VSSGP_EBORE

Protein

Super small secreted glycoprotein

Gene

GP

Organism
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 9 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Super small secreted glycoprotein
    Short name:
    SsGP
    Gene namesi
    Name:GP
    OrganismiReston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
    Taxonomic identifieri129003 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
    Pteropodinae [TaxID: 77225]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000002322: Genome

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 332299Super small secreted glycoproteinPRO_0000391495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi54 – 54InterchainBy similarity
    Disulfide bondi109 ↔ 136By similarity
    Disulfide bondi122 ↔ 148By similarity
    Glycosylationi205 – 2051N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi258 – 2581N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the filoviruses glycoprotein family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR002561. GPC_filovir-type_extra_dom.
    [Graphical view]
    PfamiPF01611. Filo_glycop. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C770-1 [UniParc]FASTAAdd to Basket

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    MGSGYQLLQL PRERFRKTSF LVWVIILFQR AISMPLGIVT NSTLKATEID    50
    QLVCRDKLSS TSQLKSVGLN LEGNGIATDV PSATKRWGFR SGVPPKVVSY 100
    EAGEWAENCY NLEIKKSDGS ECLPLPPDGV RGFPRCRYVH KVQGTGPCPG 150
    DLAFHKNGAF FLYDRLASTV IYRGTTFAEG VIAFLILSEP KKHFWKATPA 200
    HEPVNTTDDS TSYYMTLTLS YEMSNFGGEE SNTLFKVDNH TYVQLDRPHT 250
    PQFLVQLNET LRRNNRLSNS TGRLTWTVDP KIEPDVGEWA FWETKKKLFP 300
    TTSWRKLAFP NSINPHQQLL RSEPGGNCPR KN 332
    Length:332
    Mass (Da):37,496
    Last modified:February 9, 2010 - v1
    Checksum:iD1AFC1BD29D68F35
    GO

    RNA editingi

    Partially edited. RNA editing at this position consists of an insertion of one or two adenine nucleotides. The sequence displayed here is the super small secreted glycoprotein ssGP, derived from the +2A edited RNA. The unedited RNA gives rise to the small secreted glycoprotein sGP (AC Q91DD7), the +1A edited RNA gives rise to the full-length transmembrane glycoprotein GP (AC Q91DD8).

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. No translation available.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050936 Genomic RNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002561. GPC_filovir-type_extra_dom.
    [Graphical view ]
    Pfami PF01611. Filo_glycop. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes."
      Ikegami T., Calaor A.B., Miranda M.E., Niikura M., Saijo M., Kurane I., Yoshikawa Y., Morikawa S.
      Arch. Virol. 146:2021-2027(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVSSGP_EBORE
    AccessioniPrimary (citable) accession number: P0C770
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 9 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3