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P0C760 (L_PUUMS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismPuumala virus (strain Sotkamo/V-2969/81) [Complete proteome]
Taxonomic identifier39002 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Protein attributes

Sequence length2156 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-directed RNA polymerase.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the hantavirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21562156RNA-directed RNA polymerase L
PRO_0000379782

Regions

Domain956 – 1142187RdRp catalytic
Compositional bias273 – 2764Poly-Glu
Compositional bias1974 – 200431Asp-rich

Natural variations

Natural variant1571N → D in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural variant14771T → I in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural variant17761R → H in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural variant21331F → L in strain: isolate Sotkamo 2009/WHO Arbovirus collection.

Sequences

Sequence LengthMass (Da)Tools
P0C760 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 3DA19810F1A067F8

FASTA2,156246,999
        10         20         30         40         50         60 
MEKYRDIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN KDREQPIGLV 

        70         80         90        100        110        120 
LLMAGVPNDV IQSMEKRVIP GSPSGQILRS FFKMTPDNYK ITGNLIEFIE VTVTADVARG 

       130        140        150        160        170        180 
VREKILKYQG GLEFIEQLLQ IEAQKGNCQS GFKIKFNVVA VRTDGSNIST QWPSRRNEGV 

       190        200        210        220        230        240 
VQAMRLIQAD INFVREHLIK NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQPLCQPIL 

       250        260        270        280        290        300 
ENLVDYCKNW LGTDHAFAFK EVTGQRVFNV FREEEEIHAS KYGHSRKPRN FLLCQISLQS 

       310        320        330        340        350        360 
PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDHDDII NYYNPRVYFK 

       370        380        390        400        410        420 
PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE LIDSVDVASQ VQHNECSKTI 

       430        440        450        460        470        480 
EKILSDLEVN LGDVANGLDQ PKKTTGVDDI LRKFYDNELV KYLISVIRKT TAWHLGHLLR 

       490        500        510        520        530        540 
DITESLIAHA GLKRSKYWSA HGYACGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDT 

       550        560        570        580        590        600 
DNLDSKAEID GVSWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA 

       610        620        630        640        650        660 
LRSVFAFHFL LSVSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER PFKSALEVYL 

       670        680        690        700        710        720 
YGIIKVLLVS LAQNNKIRFY SRVRLLGLTV DQSTIGASGV YPSLMSRVVY KHYRSLISEA 

       730        740        750        760        770        780 
TTCFFLFEKG LHGNLTEEAK IHLETVEWAR KFREKERELG SYIMEEGYHI QDVLNNQVAV 

       790        800        810        820        830        840 
EQQLFCQEVV ELAAQELNTY LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED 

       850        860        870        880        890        900 
GHLAASVTLI EAIRFLNHSQ NNPTVLELYE QTKKQRAQAR IVRKYQRTEA DRGFFITTLP 

       910        920        930        940        950        960 
TRVRLEIIED YYDAIAKVVP EEYISYGGER KILNIQQALE KALRWASGES EIQSSLGHSI 

       970        980        990       1000       1010       1020 
KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK LKNCVVDALR NIYETDFFIS 

      1030       1040       1050       1060       1070       1080 
RKLHRYIDNM GELSDEVLDF LSFFPNKVSA SIKGNWLQGN LNKCSSLFGA AISLLFKRVW 

      1090       1100       1110       1120       1130       1140 
AKLYPELECF FEFAHHSDDA LFIYGYLEPI DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK 

      1150       1160       1170       1180       1190       1200 
SMFNLHEHIL LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 

      1210       1220       1230       1240       1250       1260 
YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP TAYLKVDRNL 

      1270       1280       1290       1300       1310       1320 
IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK KDNDRYVLGL FKFLMSLSDD 

      1330       1340       1350       1360       1370       1380 
IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL 

      1390       1400       1410       1420       1430       1440 
VYLVRKLNDP SIVTAMTMQS PLQLRFRMQA KQHMKVCKLG GEWVTFREVL AAADAFASEY 

      1450       1460       1470       1480       1490       1500 
RPTLQDMELF QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKERDQTIQ 

      1510       1520       1530       1540       1550       1560 
NPITAVIGYK YASKVDEISD VLDSALHPDS LSTDLQLMRE GVYRELGLDI SQPNVLKKVA 

      1570       1580       1590       1600       1610       1620 
PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK VKPKKEVLKA VSLYGKKEKV 

      1630       1640       1650       1660       1670       1680 
GDLTHLAAMR LCIEVWRWCK ANEQDSVTWL KYLVFENKTL EQWVDLFCSR GVLPIDPEIQ 

      1690       1700       1710       1720       1730       1740 
CLGLLVYDLK GQKGLLQIQA NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA 

      1750       1760       1770       1780       1790       1800 
RLEIFWDKKE YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG 

      1810       1820       1830       1840       1850       1860 
FEWGKPNVPC IVYRNCTLRT GLRVRHPTNK AFSITIQANG FRAMAQLDEE NPRFLLAHAY 

      1870       1880       1890       1900       1910       1920 
HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF MKGLPAAIPP AAYSLIMNKA 

      1930       1940       1950       1960       1970       1980 
KISVDLFMFN ELLALINPQN VLNLDGIEET SEGFTTVSTI SSTQWSEEVS LTLDDSDDDD 

      1990       2000       2010       2020       2030       2040 
DASNLDYTID LDDIDFETID LKEDIEHFLQ DESAYTGDLL IQTEETEVRK LRGMIKILEP 

      2050       2060       2070       2080       2090       2100 
VKLIKSWVSK GLSIDKIYNP VNIILMTRYM SKHYNFQAKQ LSLMDPYDLT EFESVVKGWG 

      2110       2120       2130       2140       2150 
ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSFFSFRHAD ILLKRLFPRD SASSFY 

« Hide

References

[1]"Sequence analysis of the Puumala hantavirus Sotkamo strain L segment."
Piiparinen H., Vapalahti O., Plyusnin A., Vaheri A., Lankinen H.
Virus Res. 51:1-7(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Resequencing of the Puumala virus strain Sotkamo from the WHO Arbovirus collection."
Kurolt I.C., Paessler S., Markotic A.
Virus Genes 45:389-392(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Sotkamo 2009/WHO Arbovirus collection.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z66548 Genomic RNA. No translation available.
HE801635 Genomic RNA. Translation: CCH22849.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP0C760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsTIGR04202. capSnatchArena. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_PUUMS
AccessionPrimary (citable) accession number: P0C760
Secondary accession number(s): I4EPA5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families