Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C760

- L_PUUMS

UniProt

P0C760 - L_PUUMS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Puumala virus (strain Sotkamo/V-2969/81)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiPuumala virus (strain Sotkamo/V-2969/81)
Taxonomic identifieri39002 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]
ProteomesiUP000008482: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21562156RNA-directed RNA polymerase LPRO_0000379782Add
BLAST

Proteomic databases

PRIDEiP0C760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi273 – 2764Poly-Glu
Compositional biasi1974 – 200431Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the hantavirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C760-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYRDIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN
60 70 80 90 100
KDREQPIGLV LLMAGVPNDV IQSMEKRVIP GSPSGQILRS FFKMTPDNYK
110 120 130 140 150
ITGNLIEFIE VTVTADVARG VREKILKYQG GLEFIEQLLQ IEAQKGNCQS
160 170 180 190 200
GFKIKFNVVA VRTDGSNIST QWPSRRNEGV VQAMRLIQAD INFVREHLIK
210 220 230 240 250
NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQPLCQPIL ENLVDYCKNW
260 270 280 290 300
LGTDHAFAFK EVTGQRVFNV FREEEEIHAS KYGHSRKPRN FLLCQISLQS
310 320 330 340 350
PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDHDDII
360 370 380 390 400
NYYNPRVYFK PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE
410 420 430 440 450
LIDSVDVASQ VQHNECSKTI EKILSDLEVN LGDVANGLDQ PKKTTGVDDI
460 470 480 490 500
LRKFYDNELV KYLISVIRKT TAWHLGHLLR DITESLIAHA GLKRSKYWSA
510 520 530 540 550
HGYACGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDT DNLDSKAEID
560 570 580 590 600
GVSWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA
610 620 630 640 650
LRSVFAFHFL LSVSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER
660 670 680 690 700
PFKSALEVYL YGIIKVLLVS LAQNNKIRFY SRVRLLGLTV DQSTIGASGV
710 720 730 740 750
YPSLMSRVVY KHYRSLISEA TTCFFLFEKG LHGNLTEEAK IHLETVEWAR
760 770 780 790 800
KFREKERELG SYIMEEGYHI QDVLNNQVAV EQQLFCQEVV ELAAQELNTY
810 820 830 840 850
LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED GHLAASVTLI
860 870 880 890 900
EAIRFLNHSQ NNPTVLELYE QTKKQRAQAR IVRKYQRTEA DRGFFITTLP
910 920 930 940 950
TRVRLEIIED YYDAIAKVVP EEYISYGGER KILNIQQALE KALRWASGES
960 970 980 990 1000
EIQSSLGHSI KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK
1010 1020 1030 1040 1050
LKNCVVDALR NIYETDFFIS RKLHRYIDNM GELSDEVLDF LSFFPNKVSA
1060 1070 1080 1090 1100
SIKGNWLQGN LNKCSSLFGA AISLLFKRVW AKLYPELECF FEFAHHSDDA
1110 1120 1130 1140 1150
LFIYGYLEPI DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK SMFNLHEHIL
1160 1170 1180 1190 1200
LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG
1210 1220 1230 1240 1250
YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP
1260 1270 1280 1290 1300
TAYLKVDRNL IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK
1310 1320 1330 1340 1350
KDNDRYVLGL FKFLMSLSDD IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY
1360 1370 1380 1390 1400
DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL VYLVRKLNDP SIVTAMTMQS
1410 1420 1430 1440 1450
PLQLRFRMQA KQHMKVCKLG GEWVTFREVL AAADAFASEY RPTLQDMELF
1460 1470 1480 1490 1500
QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKERDQTIQ
1510 1520 1530 1540 1550
NPITAVIGYK YASKVDEISD VLDSALHPDS LSTDLQLMRE GVYRELGLDI
1560 1570 1580 1590 1600
SQPNVLKKVA PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK
1610 1620 1630 1640 1650
VKPKKEVLKA VSLYGKKEKV GDLTHLAAMR LCIEVWRWCK ANEQDSVTWL
1660 1670 1680 1690 1700
KYLVFENKTL EQWVDLFCSR GVLPIDPEIQ CLGLLVYDLK GQKGLLQIQA
1710 1720 1730 1740 1750
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA RLEIFWDKKE
1760 1770 1780 1790 1800
YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG
1810 1820 1830 1840 1850
FEWGKPNVPC IVYRNCTLRT GLRVRHPTNK AFSITIQANG FRAMAQLDEE
1860 1870 1880 1890 1900
NPRFLLAHAY HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF
1910 1920 1930 1940 1950
MKGLPAAIPP AAYSLIMNKA KISVDLFMFN ELLALINPQN VLNLDGIEET
1960 1970 1980 1990 2000
SEGFTTVSTI SSTQWSEEVS LTLDDSDDDD DASNLDYTID LDDIDFETID
2010 2020 2030 2040 2050
LKEDIEHFLQ DESAYTGDLL IQTEETEVRK LRGMIKILEP VKLIKSWVSK
2060 2070 2080 2090 2100
GLSIDKIYNP VNIILMTRYM SKHYNFQAKQ LSLMDPYDLT EFESVVKGWG
2110 2120 2130 2140 2150
ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSFFSFRHAD ILLKRLFPRD

SASSFY
Length:2,156
Mass (Da):246,999
Last modified:July 28, 2009 - v1
Checksum:i3DA19810F1A067F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571N → D in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural varianti1477 – 14771T → I in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural varianti1776 – 17761R → H in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural varianti2133 – 21331F → L in strain: isolate Sotkamo 2009/WHO Arbovirus collection.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66548 Genomic RNA. No translation available.
HE801635 Genomic RNA. Translation: CCH22849.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66548 Genomic RNA. No translation available.
HE801635 Genomic RNA. Translation: CCH22849.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P0C760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the Puumala hantavirus Sotkamo strain L segment."
    Piiparinen H., Vapalahti O., Plyusnin A., Vaheri A., Lankinen H.
    Virus Res. 51:1-7(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Resequencing of the Puumala virus strain Sotkamo from the WHO Arbovirus collection."
    Kurolt I.C., Paessler S., Markotic A.
    Virus Genes 45:389-392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Sotkamo 2009/WHO Arbovirus collection.

Entry informationi

Entry nameiL_PUUMS
AccessioniPrimary (citable) accession number: P0C760
Secondary accession number(s): I4EPA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 1, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3