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P0C760

- L_PUUMS

UniProt

P0C760 - L_PUUMS

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Puumala virus (strain Sotkamo/V-2969/81)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cap snatching Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
  3. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Cap snatching, Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiPuumala virus (strain Sotkamo/V-2969/81)
Taxonomic identifieri39002 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]
ProteomesiUP000008482: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21562156RNA-directed RNA polymerase L
PRO_0000379782Add
BLAST

Proteomic databases

PRIDEiP0C760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini956 – 1142187RdRp catalytic
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi273 – 2764Poly-Glu
Compositional biasi1974 – 200431Asp-rich
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view]
PIRSFiPIRSF000825. L_HantaV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C760-1 [UniParc]FASTAAdd to Basket

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MEKYRDIHER VKEAVPGETS AVECLDLLDR LYAVRHDVVD QMIKHDWSDN     50
KDREQPIGLV LLMAGVPNDV IQSMEKRVIP GSPSGQILRS FFKMTPDNYK 100
ITGNLIEFIE VTVTADVARG VREKILKYQG GLEFIEQLLQ IEAQKGNCQS 150
GFKIKFNVVA VRTDGSNIST QWPSRRNEGV VQAMRLIQAD INFVREHLIK 200
NDERGALEAM FNLKFHVTGP KVRTFDIPNY RPQPLCQPIL ENLVDYCKNW 250
LGTDHAFAFK EVTGQRVFNV FREEEEIHAS KYGHSRKPRN FLLCQISLQS 300
PYLPSTIASD QYDTRLACSE ILKNYPETPL QLLARDMAYK YITLDHDDII 350
NYYNPRVYFK PTQNIKEPGT FKLNLSNMDP KSKALIDVIS KDSKKGVFGE 400
LIDSVDVASQ VQHNECSKTI EKILSDLEVN LGDVANGLDQ PKKTTGVDDI 450
LRKFYDNELV KYLISVIRKT TAWHLGHLLR DITESLIAHA GLKRSKYWSA 500
HGYACGSVLL CILPSKSLEV AGSFIRFFTV FKEGLGLIDT DNLDSKAEID 550
GVSWCFSKII SLDLNRLLAL NIAFEKSLLA TATWFQYYTE DQGHFPLQHA 600
LRSVFAFHFL LSVSQKMKLC AIFDNLRYLI PAVTSTYSGF EPLIRKFFER 650
PFKSALEVYL YGIIKVLLVS LAQNNKIRFY SRVRLLGLTV DQSTIGASGV 700
YPSLMSRVVY KHYRSLISEA TTCFFLFEKG LHGNLTEEAK IHLETVEWAR 750
KFREKERELG SYIMEEGYHI QDVLNNQVAV EQQLFCQEVV ELAAQELNTY 800
LHAKSQVMAS NIMNKHWDKP YFSQTRNISL KGMSGALQED GHLAASVTLI 850
EAIRFLNHSQ NNPTVLELYE QTKKQRAQAR IVRKYQRTEA DRGFFITTLP 900
TRVRLEIIED YYDAIAKVVP EEYISYGGER KILNIQQALE KALRWASGES 950
EIQSSLGHSI KLKRKLMYVS ADATKWSPGD NSAKFRRFTQ SLYDGLRDDK 1000
LKNCVVDALR NIYETDFFIS RKLHRYIDNM GELSDEVLDF LSFFPNKVSA 1050
SIKGNWLQGN LNKCSSLFGA AISLLFKRVW AKLYPELECF FEFAHHSDDA 1100
LFIYGYLEPI DDGTEWFQYV TQQIQAGNFH WHAVNQEMWK SMFNLHEHIL 1150
LMGSIKISPK KTTVSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG 1200
YFDDLAAAQS RCVKALDMGA CPQLAQLGIV LCTSKVERLY GTAPGMVNNP 1250
TAYLKVDRNL IPIPLGGDGS MSIMELATAG IGMADKNILK NAFITYKHAK 1300
KDNDRYVLGL FKFLMSLSDD IFQHDRLGEF SFVGKVQWKV FTPKSEFEFY 1350
DQYSRKYLEL WSEQHPVYDY IIPRGRDNLL VYLVRKLNDP SIVTAMTMQS 1400
PLQLRFRMQA KQHMKVCKLG GEWVTFREVL AAADAFASEY RPTLQDMELF 1450
QTLVNCTFSK EYAWRDFLNE VQCDVLTTRQ IHRPKVARTF TVKERDQTIQ 1500
NPITAVIGYK YASKVDEISD VLDSALHPDS LSTDLQLMRE GVYRELGLDI 1550
SQPNVLKKVA PLLYKSGKSR IVIVQGNVEG TAESICSYWL KTMSLVKTIK 1600
VKPKKEVLKA VSLYGKKEKV GDLTHLAAMR LCIEVWRWCK ANEQDSVTWL 1650
KYLVFENKTL EQWVDLFCSR GVLPIDPEIQ CLGLLVYDLK GQKGLLQIQA 1700
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGIDCA RLEIFWDKKE 1750
YILETSITQR NVLKILMEEV TKELLRCGMR FKTEQVNSSR SVVLFKTESG 1800
FEWGKPNVPC IVYRNCTLRT GLRVRHPTNK AFSITIQANG FRAMAQLDEE 1850
NPRFLLAHAY HNLKDVRYQA LQAVGNVWFK MTQHKLFINP IISAGLLENF 1900
MKGLPAAIPP AAYSLIMNKA KISVDLFMFN ELLALINPQN VLNLDGIEET 1950
SEGFTTVSTI SSTQWSEEVS LTLDDSDDDD DASNLDYTID LDDIDFETID 2000
LKEDIEHFLQ DESAYTGDLL IQTEETEVRK LRGMIKILEP VKLIKSWVSK 2050
GLSIDKIYNP VNIILMTRYM SKHYNFQAKQ LSLMDPYDLT EFESVVKGWG 2100
ECVKDRFIEL DQEAQRKVTE ERVLPEDVLP DSFFSFRHAD ILLKRLFPRD 2150
SASSFY 2156
Length:2,156
Mass (Da):246,999
Last modified:July 28, 2009 - v1
Checksum:i3DA19810F1A067F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571N → D in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural varianti1477 – 14771T → I in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural varianti1776 – 17761R → H in strain: isolate Sotkamo 2009/WHO Arbovirus collection.
Natural varianti2133 – 21331F → L in strain: isolate Sotkamo 2009/WHO Arbovirus collection.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z66548 Genomic RNA. No translation available.
HE801635 Genomic RNA. Translation: CCH22849.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z66548 Genomic RNA. No translation available.
HE801635 Genomic RNA. Translation: CCH22849.1 .

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi P0C760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR016268. RNA-dir_pol_hantavirus.
IPR024378. RNA-dir_pol_N_hantavirus.
IPR007099. RNA-dir_pol_NSvirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12426. DUF3674. 1 hit.
[Graphical view ]
PIRSFi PIRSF000825. L_HantaV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the Puumala hantavirus Sotkamo strain L segment."
    Piiparinen H., Vapalahti O., Plyusnin A., Vaheri A., Lankinen H.
    Virus Res. 51:1-7(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Resequencing of the Puumala virus strain Sotkamo from the WHO Arbovirus collection."
    Kurolt I.C., Paessler S., Markotic A.
    Virus Genes 45:389-392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Sotkamo 2009/WHO Arbovirus collection.

Entry informationi

Entry nameiL_PUUMS
AccessioniPrimary (citable) accession number: P0C760
Secondary accession number(s): I4EPA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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