P0C739 (BNL2A_EBVB9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein BNLF2a

Gene names

ORF Names:

BNLF2a

Organism

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) [Reference proteome]

Taxonomic identifier

10377 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Lymphocryptovirus › Epstein-Barr virus (strain GD1)

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in viral evasion from HLA class I-restricted T-cell immunity. Associates with host TAP1 and TAP2 and prevents TAP-mediated peptide transport and subsequent loading. Ref.4
Subunit structure	Interacts with host TAP1 and TAP2. Ref.4
Subcellular location	Host endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the lymphocryptovirus BNLF2a family.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host TAP by virus Inhibition of host adaptive immune response by virus Viral immunoevasion
Cellular component	Host endoplasmic reticulum Host membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	suppression by virus of host TAP complex Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 60	60	Protein BNLF2a		PRO_0000382427
Regions
	Transmembrane	41 – 59	19	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P0C739 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 19EAE809410982EA	FASTA	60	6,540
	10 20 30 40 50 60 MVHVLERALL EQQSSACGLP GSSTETRPSH PCPEDPDVSR LRLLLVVLCV LFGLLCLLLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Modulation of LMP1 protein expression by EBV-encoded microRNAs." Lo A.K., To K.F., Lo K.W., Lung R.W., Hui J.W., Liao G., Hayward S.D. Proc. Natl. Acad. Sci. U.S.A. 104:16164-16169(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 2117 and C666-1.
[2]	"Modulation of latent membrane protein 1 expression in nasopharyngeal carcinoma cells by Epstein-Barr virus encoded miRNAs." Lo A.K.F., Lo K.W., To K.F., Lung R.W.M., Hui J.W.Y., Hayward S.D. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Akata, NPC-21, NPC-56 and NPC-57.
[3]	"DNA sequence and expression of the B95-8 Epstein-Barr virus genome." Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C., Tuffnell P.S., Barrell B.G. Nature 310:207-211(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B95-8.
[4]	"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation." Horst D., van Leeuwen D., Croft N.P., Garstka M.A., Hislop A.D., Kremmer E., Rickinson A.B., Wiertz E.J.H.J., Ressing M.E. J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH HOST TAP1 AND TAP2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01555 Genomic DNA. Translation: CAA24812.1. X01995 Genomic DNA. Translation: CAA26024.1. EF103557 Genomic DNA. Translation: ABO28739.1. EF103558 Genomic DNA. Translation: ABO28741.1. EF110909 Genomic DNA. Translation: ABO28743.1. EF110910 Genomic DNA. Translation: ABO28745.1. EF110911 Genomic DNA. Translation: ABO28747.1. EF110912 Genomic DNA. Translation: ABO28749.1. AJ507799 Genomic DNA. Translation: CAD53471.1.
RefSeq	YP_401721.1. NC_007605.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6768342.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3783720.
Phylogenomic databases
ProtClustDB	CLSP2512942.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

BNL2A_EBVB9

Accession

Primary (citable) accession number: P0C739
Secondary accession number(s): Q04361, Q8AZJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program