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Protein

Protein BNLF2a

Gene

BNLF2a

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in viral evasion from HLA class I-restricted T-cell immunity. Associates with host TAP1 and TAP2 and prevents TAP-mediated peptide transport and subsequent loading.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BNLF2a
Gene namesi
ORF Names:BNLF2a
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 59HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003824271 – 60Protein BNLF2aAdd BLAST60

Interactioni

Subunit structurei

Interacts with host TAP1 and TAP2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP0C739. 252 interactors.
MINTiMINT-6768342.

Structurei

3D structure databases

SMRiP0C739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lymphocryptovirus BNLF2a family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900026V.

Sequencei

Sequence statusi: Complete.

P0C739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHVLERALL EQQSSACGLP GSSTETRPSH PCPEDPDVSR LRLLLVVLCV
60
LFGLLCLLLI
Length:60
Mass (Da):6,540
Last modified:September 1, 2009 - v1
Checksum:i19EAE809410982EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24812.1.
X01995 Genomic DNA. Translation: CAA26024.1.
EF103557 Genomic DNA. Translation: ABO28739.1.
EF103558 Genomic DNA. Translation: ABO28741.1.
EF110909 Genomic DNA. Translation: ABO28743.1.
EF110910 Genomic DNA. Translation: ABO28745.1.
EF110911 Genomic DNA. Translation: ABO28747.1.
EF110912 Genomic DNA. Translation: ABO28749.1.
AJ507799 Genomic DNA. Translation: CAD53471.1.
RefSeqiYP_401721.1. NC_007605.1.

Genome annotation databases

GeneIDi3783720.
KEGGivg:3783720.

Similar proteinsi

Entry informationi

Entry nameiBNL2A_EBVB9
AccessioniPrimary (citable) accession number: P0C739
Secondary accession number(s): Q04361, Q8AZJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 10, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families