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P0C701 (RIR2_EBVG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain
EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase 38 kDa subunit
Ribonucleotide reductase small subunit
Gene names
ORF Names:BaRF1
OrganismEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) [Complete proteome]
Taxonomic identifier10376 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Lymphocryptovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit BORF2 (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BNRF1Q665422EBI-2621366,EBI-2621061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Ribonucleoside-diphosphate reductase small chain
PRO_0000375968

Sites

Active site981 By similarity
Metal binding611Iron 1 By similarity
Metal binding911Iron 1 By similarity
Metal binding911Iron 2 By similarity
Metal binding941Iron 1 By similarity
Metal binding1541Iron 2 By similarity
Metal binding1881Iron 2 By similarity
Metal binding1911Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C701 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 473BF0BDFB7F0637

FASTA30234,359
        10         20         30         40         50         60 
MSKLLYVRDH EGFACLTVET HRNRWFAAHI VLTKDCGCLK LLNERDLEFY KFLFTFLAMA 

        70         80         90        100        110        120 
EKLVNFNIDE LVTSFESHDI DHYYTEQKAM ENVHGETYAN ILNMLFDGDR AAMNAYAEAI 

       130        140        150        160        170        180 
MADEALQAKI SWLRDKVAAA VTLPEKILVF LLIEGIFFIS SFYSIALLRV RGLMPGICLA 

       190        200        210        220        230        240 
NNYISRDELL HTRAASLLYN SMTAKADRPR ATWIQELFRT AVEVETAFIE ARGEGVTLVD 

       250        260        270        280        290        300 
VRAIKQFLEA TADRILGDIG QAPLYGTPPP KDCPLTYMTS IKQTNFFEQE SSDYTMLVVD 


DL

« Hide

References

« Hide 'large scale' references
[1]"Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient."
Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H., Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.
J. Virol. 79:15323-15330(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY961628 Genomic DNA. Translation: AAY41106.1.
RefSeqYP_401656.1. NC_007605.1.

3D structure databases

ProteinModelPortalP0C701.
ModBaseSearch...

Protein-protein interaction databases

IntActP0C701. 5 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3783683.

Phylogenomic databases

ProtClustDBCLSP2509600.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_EBVG
AccessionPrimary (citable) accession number: P0C701
Secondary accession number(s): Q777G0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 29, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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