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Protein

Envelope glycoprotein N

Gene

gN

Organism
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein NUniRule annotation
Gene namesi
Name:gNUniRule annotation
ORF Names:BLRF1
OrganismiEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10376 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007641 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host Golgi apparatushost trans-Golgi network UniRule annotation

  • Note: When coexpressed with gM, localizes in the host trans-Golgi network.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 69Virion surfaceUniRule annotationAdd BLAST37
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Topological domaini91 – 102IntravirionUniRule annotationAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32UniRule annotationAdd BLAST32
ChainiPRO_000037595233 – 102Envelope glycoprotein NUniRule annotationAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55Interchain (with gM)UniRule annotation

Post-translational modificationi

O-glycosylated. Contains alpha 2,6-sialic acid residues.By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex.UniRule annotation

Protein-protein interaction databases

BioGridi971758. 1 interactor.
IntActiP0C6Z4. 3 interactors.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein N family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

HAMAPiMF_04037. HSV_GN. 1 hit.
InterProiIPR005211. Herpes_glycoprotein_N.
[Graphical view]
PfamiPF03554. Herpes_UL73. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVLRKPFA KAVPLLFLAA TWLLTGVLPA GASSPTNAAA ASLTEAQDQF
60 70 80 90 100
YSYTCNADTF SPSLTSFASI WALLTLVLVI IASAIYLMYV CFNKFVNTLL

TD
Length:102
Mass (Da):10,944
Last modified:May 26, 2009 - v1
Checksum:iDF40CC9B30B060B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY961628 Genomic DNA. Translation: AAY41114.1.
RefSeqiYP_401665.1. NC_007605.1.

Genome annotation databases

GeneIDi3783716.
KEGGivg:3783716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY961628 Genomic DNA. Translation: AAY41114.1.
RefSeqiYP_401665.1. NC_007605.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971758. 1 interactor.
IntActiP0C6Z4. 3 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783716.
KEGGivg:3783716.

Family and domain databases

HAMAPiMF_04037. HSV_GN. 1 hit.
InterProiIPR005211. Herpes_glycoprotein_N.
[Graphical view]
PfamiPF03554. Herpes_UL73. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGN_EBVG
AccessioniPrimary (citable) accession number: P0C6Z4
Secondary accession number(s): Q777F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: November 30, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.