ID NSP6_ROTBU Reviewed; 98 AA. AC P0C6Z2; DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot. DT 14-APR-2009, sequence version 1. DT 14-DEC-2022, entry version 28. DE RecName: Full=Non-structural protein 6 {ECO:0000255|HAMAP-Rule:MF_04093}; DE Short=NSP6 {ECO:0000255|HAMAP-Rule:MF_04093}; OS Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A). OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes; OC Reovirales; Sedoreoviridae; Rotavirus; Rotavirus A. OX NCBI_TaxID=10934; OH NCBI_TaxID=9913; Bos taurus (Bovine). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=2998051; DOI=10.1016/0042-6822(85)90275-2; RA Ward C.W., Azad A.A., Dyall-Smith M.L.; RT "Structural homologies between RNA gene segments 10 and 11 from UK bovine, RT simian SA11, and human Wa rotaviruses."; RL Virology 144:328-336(1985). RN [2] RP CHARACTERIZATION, AND SUBCELLULAR LOCATION. RX PubMed=17658646; DOI=10.1016/j.virusres.2007.06.011; RA Rainsford E.W., McCrae M.A.; RT "Characterization of the NSP6 protein product of rotavirus gene 11."; RL Virus Res. 130:193-201(2007). CC -!- SUBUNIT: Interacts with NSP2 and NSP5. {ECO:0000255|HAMAP- CC Rule:MF_04093}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04093, CC ECO:0000269|PubMed:17658646}. Host mitochondrion {ECO:0000255|HAMAP- CC Rule:MF_04093}. Note=Found in spherical cytoplasmic structures, called CC viral factories, that appear early after infection and are the site of CC viral replication and packaging. {ECO:0000255|HAMAP-Rule:MF_04093}. CC -!- SIMILARITY: Belongs to the rotavirus A NSP6 family. {ECO:0000255|HAMAP- CC Rule:MF_04093}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; K03385; -; NOT_ANNOTATED_CDS; Genomic_RNA. DR SMR; P0C6Z2; -. DR Proteomes; UP000008657; Genome. DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell. DR HAMAP; MF_04093; ROTA_NSP6; 1. DR InterPro; IPR006950; Rotavirus_NSP6. DR Pfam; PF04866; Rota_NS6; 1. PE 1: Evidence at protein level; KW Host cytoplasm; Host mitochondrion. FT CHAIN 1..98 FT /note="Non-structural protein 6" FT /id="PRO_0000369514" SQ SEQUENCE 98 AA; 11693 MW; C9752DA122E325E5 CRC64; MNHLQQRQLF LENLLVGVNN MFHQMQKRPV NTCCRSLQKI LDHLILLQTI HSPAFRLDQM QLRQMQTLAC LWIHQYNHDH QVTLGAIKWI SPLIKELK //