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P0C6Z1

- EAR_EBVA8

UniProt

P0C6Z1 - EAR_EBVA8

Protein

Apoptosis regulator BHRF1

Gene

BHRF1

Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. regulation of apoptotic process Source: InterPro

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apoptosis regulator BHRF1
    Alternative name(s):
    Early antigen protein R
    Short name:
    EA-R
    Nuclear antigen
    Gene namesi
    ORF Names:BHRF1
    OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
    Taxonomic identifieri82830 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007639: Genome

    Subcellular locationi

    Host membrane Curated; Single-pass membrane protein Curated. Host mitochondrion
    Note: also observed in the perinuclear region of the cell.By similarity

    GO - Cellular componenti

    1. host cell membrane Source: UniProtKB-SubCell
    2. host cell mitochondrion Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host membrane, Host mitochondrion, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191Apoptosis regulator BHRF1PRO_0000375928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi118 – 1181N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Interacts with isoform 1 of host VRK2; this interaction is involved in protecting cells from apoptosis. Interacts with host PRA1; this interaction seems to modulate BHRF1 anti-apoptotic activity. Interacts with of host BCL2L11 By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-6768790.

    Structurei

    Secondary structure

    1
    191
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1814
    Helixi27 – 359
    Helixi45 – 6016
    Helixi62 – 7514
    Helixi79 – 9113
    Beta strandi92 – 943
    Helixi98 – 11720
    Helixi123 – 13715
    Helixi138 – 1403
    Helixi141 – 1466
    Helixi149 – 1568

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WH6X-ray1.50A1-160[»]
    ProteinModelPortaliP0C6Z1.
    SMRiP0C6Z1. Positions 1-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1818Interaction with host VRK2By similarityAdd
    BLAST
    Regioni89 – 14254Interaction with host VRK2By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi89 – 10921BH1Add
    BLAST
    Motifi142 – 15716BH2Add
    BLAST

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR002475. Bcl2-like.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01258. BH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C6Z1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYSTREILL ALCIRDSRVH GNGTLHPVLE LAARETPLRL SPEDTVVLRY    50
    HVLLEEIIER NSETFTETWN RFITHTEHVD LDFNSVFLEI FHRGDPSLGR 100
    ALAWMAWCMH ACRTLCCNQS TPYYVVDLSV RGMLEASEGL DGWIHQQGGW 150
    STLIEDNIPG SRRFSWTLFL AGLTLSLLVI CSYLFISRGR H 191
    Length:191
    Mass (Da):21,893
    Last modified:May 26, 2009 - v1
    Checksum:i8108BCB94F81DC8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ279927 Genomic DNA. Translation: ABB89223.1.
    RefSeqiYP_001129442.1. NC_009334.1.
    YP_401646.1. NC_007605.1.

    Genome annotation databases

    GeneIDi3783706.
    5176205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ279927 Genomic DNA. Translation: ABB89223.1 .
    RefSeqi YP_001129442.1. NC_009334.1.
    YP_401646.1. NC_007605.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WH6 X-ray 1.50 A 1-160 [» ]
    ProteinModelPortali P0C6Z1.
    SMRi P0C6Z1. Positions 1-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-6768790.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3783706.
    5176205.

    Family and domain databases

    InterProi IPR002475. Bcl2-like.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01258. BH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Epstein-Barr virus type 2 strain AG876."
      Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.
      Virology 350:164-170(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiEAR_EBVA8
    AccessioniPrimary (citable) accession number: P0C6Z1
    Secondary accession number(s): Q777H0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    EA-R is part of the restricted EA-complex.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3