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P0C6Z1

- EAR_EBVA8

UniProt

P0C6Z1 - EAR_EBVA8

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Protein

Apoptosis regulator BHRF1

Gene
BHRF1
Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulator BHRF1
Alternative name(s):
Early antigen protein R
Short name:
EA-R
Nuclear antigen
Gene namesi
ORF Names:BHRF1
OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri82830 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007639: Genome

Subcellular locationi

Host membrane; Single-pass membrane protein Reviewed prediction. Host mitochondrion
Note: also observed in the perinuclear region of the cell By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei166 – 18621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. host cell mitochondrion Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Host mitochondrion, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Apoptosis regulator BHRF1PRO_0000375928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with isoform 1 of host VRK2; this interaction is involved in protecting cells from apoptosis. Interacts with host PRA1; this interaction seems to modulate BHRF1 anti-apoptotic activity. Interacts with of host BCL2L11 By similarity.

Protein-protein interaction databases

MINTiMINT-6768790.

Structurei

Secondary structure

1
191
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1814
Helixi27 – 359
Helixi45 – 6016
Helixi62 – 7514
Helixi79 – 9113
Beta strandi92 – 943
Helixi98 – 11720
Helixi123 – 13715
Helixi138 – 1403
Helixi141 – 1466
Helixi149 – 1568

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WH6X-ray1.50A1-160[»]
ProteinModelPortaliP0C6Z1.
SMRiP0C6Z1. Positions 1-160.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1818Interaction with host VRK2 By similarityAdd
BLAST
Regioni89 – 14254Interaction with host VRK2 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi89 – 10921BH1Add
BLAST
Motifi142 – 15716BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C6Z1-1 [UniParc]FASTAAdd to Basket

« Hide

MAYSTREILL ALCIRDSRVH GNGTLHPVLE LAARETPLRL SPEDTVVLRY    50
HVLLEEIIER NSETFTETWN RFITHTEHVD LDFNSVFLEI FHRGDPSLGR 100
ALAWMAWCMH ACRTLCCNQS TPYYVVDLSV RGMLEASEGL DGWIHQQGGW 150
STLIEDNIPG SRRFSWTLFL AGLTLSLLVI CSYLFISRGR H 191
Length:191
Mass (Da):21,893
Last modified:May 26, 2009 - v1
Checksum:i8108BCB94F81DC8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ279927 Genomic DNA. Translation: ABB89223.1.
RefSeqiYP_001129442.1. NC_009334.1.
YP_401646.1. NC_007605.1.

Genome annotation databases

GeneIDi3783706.
5176205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ279927 Genomic DNA. Translation: ABB89223.1 .
RefSeqi YP_001129442.1. NC_009334.1.
YP_401646.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WH6 X-ray 1.50 A 1-160 [» ]
ProteinModelPortali P0C6Z1.
SMRi P0C6Z1. Positions 1-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-6768790.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3783706.
5176205.

Family and domain databases

InterProi IPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Epstein-Barr virus type 2 strain AG876."
    Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.
    Virology 350:164-170(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiEAR_EBVA8
AccessioniPrimary (citable) accession number: P0C6Z1
Secondary accession number(s): Q777H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

EA-R is part of the restricted EA-complex.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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