Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apoptosis regulator BHRF1

Gene

BHRF1

Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulator BHRF1
Alternative name(s):
Early antigen protein R
Short name:
EA-R
Nuclear antigen
Gene namesi
ORF Names:BHRF1
OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri82830 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007639 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Host mitochondrion, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003759281 – 191Apoptosis regulator BHRF1Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi118N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with isoform 1 of host VRK2; this interaction is involved in protecting cells from apoptosis. Interacts with host PRA1; this interaction seems to modulate BHRF1 anti-apoptotic activity. Interacts with of host BCL2L11 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-6768790.

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi27 – 35Combined sources9
Helixi45 – 60Combined sources16
Helixi62 – 75Combined sources14
Helixi79 – 91Combined sources13
Beta strandi92 – 94Combined sources3
Helixi98 – 117Combined sources20
Helixi123 – 137Combined sources15
Helixi138 – 140Combined sources3
Helixi141 – 146Combined sources6
Helixi149 – 156Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WH6X-ray1.50A1-160[»]
4OYDX-ray1.80A/C2-158[»]
ProteinModelPortaliP0C6Z1.
SMRiP0C6Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 18Interaction with host VRK2By similarityAdd BLAST18
Regioni89 – 142Interaction with host VRK2By similarityAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 109BH1Add BLAST21
Motifi142 – 157BH2Add BLAST16

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19463.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C6Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYSTREILL ALCIRDSRVH GNGTLHPVLE LAARETPLRL SPEDTVVLRY
60 70 80 90 100
HVLLEEIIER NSETFTETWN RFITHTEHVD LDFNSVFLEI FHRGDPSLGR
110 120 130 140 150
ALAWMAWCMH ACRTLCCNQS TPYYVVDLSV RGMLEASEGL DGWIHQQGGW
160 170 180 190
STLIEDNIPG SRRFSWTLFL AGLTLSLLVI CSYLFISRGR H
Length:191
Mass (Da):21,893
Last modified:May 26, 2009 - v1
Checksum:i8108BCB94F81DC8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279927 Genomic DNA. Translation: ABB89223.1.
RefSeqiYP_001129442.1. NC_009334.1.
YP_401646.1. NC_007605.1.

Genome annotation databases

GeneIDi3783706.
5176205.
KEGGivg:3783706.
vg:5176205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279927 Genomic DNA. Translation: ABB89223.1.
RefSeqiYP_001129442.1. NC_009334.1.
YP_401646.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WH6X-ray1.50A1-160[»]
4OYDX-ray1.80A/C2-158[»]
ProteinModelPortaliP0C6Z1.
SMRiP0C6Z1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-6768790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783706.
5176205.
KEGGivg:3783706.
vg:5176205.

Phylogenomic databases

KOiK19463.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAR_EBVA8
AccessioniPrimary (citable) accession number: P0C6Z1
Secondary accession number(s): Q777H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: November 30, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

EA-R is part of the restricted EA-complex.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.