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P0C6Z1 (EAR_EBVA8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apoptosis regulator BHRF1
Alternative name(s):
Early antigen protein R
Short name=EA-R
Nuclear antigen
Gene names
ORF Names:BHRF1
OrganismEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) [Reference proteome]
Taxonomic identifier82830 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell By similarity.

Subunit structure

Interacts with isoform 1of host VRK2; this interaction is involved in protecting cells from apoptosis. Interacts with host PRA1; this interaction seems to modulate BHRF1 anti-apoptotic activity. Interacts with of host BCL2L11 By similarity.

Subcellular location

Host membrane; Single-pass membrane protein Potential. Host mitochondrion. Note: also observed in the perinuclear region of the cell By similarity.

Miscellaneous

EA-R is part of the restricted EA-complex.

Sequence similarities

Belongs to the Bcl-2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Apoptosis regulator BHRF1
PRO_0000375928

Regions

Transmembrane166 – 18621Helical; Potential
Region1 – 1818Interaction with host VRK2 By similarity
Region89 – 14254Interaction with host VRK2 By similarity
Motif89 – 10921BH1
Motif142 – 15716BH2

Amino acid modifications

Glycosylation221N-linked (GlcNAc...); by host Potential
Glycosylation1181N-linked (GlcNAc...); by host Potential

Secondary structure

.................... 191
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C6Z1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 8108BCB94F81DC8B

FASTA19121,893
        10         20         30         40         50         60 
MAYSTREILL ALCIRDSRVH GNGTLHPVLE LAARETPLRL SPEDTVVLRY HVLLEEIIER 

        70         80         90        100        110        120 
NSETFTETWN RFITHTEHVD LDFNSVFLEI FHRGDPSLGR ALAWMAWCMH ACRTLCCNQS 

       130        140        150        160        170        180 
TPYYVVDLSV RGMLEASEGL DGWIHQQGGW STLIEDNIPG SRRFSWTLFL AGLTLSLLVI 

       190 
CSYLFISRGR H 

« Hide

References

[1]"The genome of Epstein-Barr virus type 2 strain AG876."
Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.
Virology 350:164-170(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ279927 Genomic DNA. Translation: ABB89223.1.
RefSeqYP_001129442.1. NC_009334.1.
YP_401646.1. NC_007605.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WH6X-ray1.50A1-160[»]
ProteinModelPortalP0C6Z1.
SMRP0C6Z1. Positions 1-160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-6768790.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3783706.
5176205.

Phylogenomic databases

ProtClustDBCLSP2512081.

Family and domain databases

InterProIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PfamPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEAR_EBVA8
AccessionPrimary (citable) accession number: P0C6Z1
Secondary accession number(s): Q777H0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references