##gff-version 3 P0C6Y4 UniProtKB Chain 1 6781 . . . ID=PRO_0000458147;Note=Replicase polyprotein 1ab P0C6Y4 UniProtKB Chain 1 110 . . . ID=PRO_0000037369;Note=Non-structural protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 111 895 . . . ID=PRO_0000037370;Note=Non-structural protein 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 896 2516 . . . ID=PRO_0000037371;Note=Papain-like protease nsp3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 2517 2997 . . . ID=PRO_0000037372;Note=Non-structural protein 4;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 2998 3299 . . . ID=PRO_0000037373;Note=3C-like proteinase nsp5;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 3300 3579 . . . ID=PRO_0000037374;Note=Non-structural protein 6;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 3580 3662 . . . ID=PRO_0000037375;Note=Non-structural protein 7;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 3663 3857 . . . ID=PRO_0000037376;Note=Non-structural protein 8;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 3858 3965 . . . ID=PRO_0000037377;Note=Viral protein genome-linked nsp9;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 3966 4100 . . . ID=PRO_0000037378;Note=Non-structural protein 10;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 4101 5027 . . . ID=PRO_0000037379;Note=RNA-directed RNA polymerase nsp12;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 5028 5546 . . . ID=PRO_0000037380;Note=Helicase nsp13 P0C6Y4 UniProtKB Chain 5547 6141 . . . ID=PRO_0000037381;Note=Guanine-N7 methyltransferase nsp14;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 6142 6480 . . . ID=PRO_0000037382;Note=Uridylate-specific endoribonuclease nsp15;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Chain 6481 6781 . . . ID=PRO_0000037383;Note=2'-O-methyltransferase nsp16;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Transmembrane 1959 1979 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2022 2042 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2105 2125 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2127 2147 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2150 2170 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2528 2548 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2619 2639 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2654 2674 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2754 2774 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2787 2807 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2814 2834 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 2863 2883 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3336 3356 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3361 3381 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3399 3419 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3431 3451 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3454 3474 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3476 3496 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Transmembrane 3500 3520 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P0C6Y4 UniProtKB Domain 2 109 . . . Note=CoV Nsp1 globular;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01307 P0C6Y4 UniProtKB Domain 112 364 . . . Note=CoV Nsp2 N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01333 P0C6Y4 UniProtKB Domain 383 776 . . . Note=CoV Nsp2 middle;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01334 P0C6Y4 UniProtKB Domain 778 895 . . . Note=CoV Nsp2 C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01335 P0C6Y4 UniProtKB Domain 896 991 . . . Note=Ubiquitin-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6Y4 UniProtKB Domain 1057 1296 . . . Note=Peptidase C16 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Domain 1297 1465 . . . Note=Macro;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00490 P0C6Y4 UniProtKB Domain 1630 1685 . . . Note=Ubiquitin-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 P0C6Y4 UniProtKB Domain 1691 1951 . . . Note=Peptidase C16 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Domain 2038 2102 . . . Note=3Ecto;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6Y4 UniProtKB Domain 2176 2516 . . . Note=CoV Nsp3 Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Domain 2902 2997 . . . Note=Nsp4C;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01291 P0C6Y4 UniProtKB Domain 2998 3299 . . . Note=Peptidase C30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00772 P0C6Y4 UniProtKB Domain 3580 3662 . . . Note=RdRp Nsp7 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01294 P0C6Y4 UniProtKB Domain 3663 3857 . . . Note=RdRp Nsp8 cofactor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01295 P0C6Y4 UniProtKB Domain 3858 3965 . . . Note=Nsp9 ssRNA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01296 P0C6Y4 UniProtKB Domain 3966 4103 . . . Note=ExoN/MTase coactivator;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Domain 4106 4355 . . . Note=NiRAN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01292 P0C6Y4 UniProtKB Domain 4361 4459 . . . Note=Nsp12 Interface;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01344 P0C6Y4 UniProtKB Domain 4460 5027 . . . Note=Nsp12 RNA-dependent RNA polymerase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Domain 4707 4869 . . . Note=RdRp catalytic P0C6Y4 UniProtKB Domain 5028 5140 . . . Note=CV ZBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Domain 5275 5466 . . . Note=(+)RNA virus helicase ATP-binding P0C6Y4 UniProtKB Domain 5467 5636 . . . Note=(+)RNA virus helicase C-terminal P0C6Y4 UniProtKB Domain 5696 5910 . . . Note=ExoN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Domain 5919 6140 . . . Note=N7-MTase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Domain 6142 6202 . . . Note=Nsp15 N-terminal oligomerization;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01305 P0C6Y4 UniProtKB Domain 6203 6320 . . . Note=AV-Nsp11N/CoV-Nsp15M;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01306 P0C6Y4 UniProtKB Domain 6337 6477 . . . Note=NendoU;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 P0C6Y4 UniProtKB Domain 6481 6777 . . . Note=Nidovirus-type SAM-dependent 2'-O-MTase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01300 P0C6Y4 UniProtKB Zinc finger 1162 1193 . . . Note=C4-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Zinc finger 1808 1838 . . . Note=C4-type 2%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Zinc finger 4039 4055 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Zinc finger 4081 4094 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Region 1009 1040 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P0C6Y4 UniProtKB Region 1959 2170 . . . Note=HD1 P0C6Y4 UniProtKB Region 2176 2266 . . . Note=Y1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2180 2193 . . . Note=ZF1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2226 2236 . . . Note=ZF2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2267 2516 . . . Note=CoV-Y;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2267 2356 . . . Note=Y2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2357 2414 . . . Note=Y3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2415 2516 . . . Note=Y4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Region 2528 2883 . . . Note=HD2 P0C6Y4 UniProtKB Region 3336 3520 . . . Note=HD3 P0C6Y4 UniProtKB Region 4462 4676 . . . Note=RdRp Fingers N-ter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Region 4677 4715 . . . Note=RdRp Palm N-ter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Region 4716 4774 . . . Note=RdRp Fingers C-ter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Region 4775 4910 . . . Note=RdRp Palm C-ter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Region 4911 5027 . . . Note=RdRp Thumb;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Region 6031 6045 . . . Note=GpppA-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Active site 1091 1091 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Active site 1239 1239 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Active site 1252 1252 . . . Note=For PL1-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Active site 1729 1729 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Active site 1888 1888 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Active site 1901 1901 . . . Note=For PL2-PRO activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00444 P0C6Y4 UniProtKB Active site 3038 3038 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00772,ECO:0000269|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Active site 3141 3141 . . . Note=For 3CL-PRO activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00772,ECO:0000269|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Active site 4854 4854 . . . Note=For RNA-directed RNA polymerase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Active site 4855 4855 . . . Note=For RNA-directed RNA polymerase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Active site 4856 4856 . . . Note=For RNA-directed RNA polymerase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Active site 5714 5714 . . . Note=For exoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Active site 5716 5716 . . . Note=For exoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Active site 5815 5815 . . . Note=For exoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Active site 5891 5891 . . . Note=For exoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Active site 5896 5896 . . . Note=For exoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Active site 6367 6367 . . . Note=For uridylate-specific endoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 P0C6Y4 UniProtKB Active site 6382 6382 . . . Note=For uridylate-specific endoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 P0C6Y4 UniProtKB Active site 6423 6423 . . . Note=For uridylate-specific endoribonuclease activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01303 P0C6Y4 UniProtKB Active site 6525 6525 . . . Note=For 2'-O-methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01300 P0C6Y4 UniProtKB Active site 6609 6609 . . . Note=For 2'-O-methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01300 P0C6Y4 UniProtKB Active site 6649 6649 . . . Note=For 2'-O-methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01300 P0C6Y4 UniProtKB Active site 6682 6682 . . . Note=For 2'-O-methyltransferase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01300 P0C6Y4 UniProtKB Binding site 59 59 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Binding site 95 95 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Binding site 99 99 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Binding site 102 102 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Binding site 2180 2180 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2185 2185 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2190 2190 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2193 2193 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2226 2226 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2229 2229 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2233 2233 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 2236 2236 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01336 P0C6Y4 UniProtKB Binding site 4039 4039 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4042 4042 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4048 4048 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4055 4055 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4081 4081 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4084 4084 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4092 4092 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4094 4094 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01297 P0C6Y4 UniProtKB Binding site 4390 4390 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01344 P0C6Y4 UniProtKB Binding site 4396 4396 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01344 P0C6Y4 UniProtKB Binding site 4401 4401 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01344 P0C6Y4 UniProtKB Binding site 4405 4405 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01344 P0C6Y4 UniProtKB Binding site 4582 4582 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Binding site 4737 4737 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Binding site 4740 4740 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Binding site 4741 4741 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01293 P0C6Y4 UniProtKB Binding site 5032 5032 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5035 5035 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5043 5043 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5046 5046 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5053 5053 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5056 5056 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5060 5060 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5066 5066 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5077 5077 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5082 5082 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5099 5099 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5102 5102 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00986 P0C6Y4 UniProtKB Binding site 5310 5317 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Binding site 5831 5831 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5833 5833 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5849 5849 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5852 5852 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5880 5880 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5884 5884 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5887 5887 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5902 5902 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01298 P0C6Y4 UniProtKB Binding site 5954 5960 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Binding site 6069 6069 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Binding site 6086 6086 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Binding site 6097 6097 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Binding site 6100 6100 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01299 P0C6Y4 UniProtKB Site 110 111 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Site 895 896 . . . Note=Cleavage%3B by PL1-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Site 2516 2517 . . . Note=Cleavage%3B by PL2-PRO;Ontology_term=ECO:0000250;evidence=ECO:0000250 P0C6Y4 UniProtKB Site 2997 2998 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 3299 3300 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 3579 3580 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 3662 3663 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 3857 3858 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 3965 3966 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 4100 4101 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 5027 5028 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 5546 5547 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 6141 6142 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Site 6480 6481 . . . Note=Cleavage%3B by 3CL-PRO;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27173881;Dbxref=PMID:27173881 P0C6Y4 UniProtKB Disulfide bond 2054 2080 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6Y4 UniProtKB Disulfide bond 2072 2077 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01337 P0C6Y4 UniProtKB Disulfide bond 3916 3916 . . . Note=Interchain;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Mutagenesis 3916 3916 . . . Note=Complete loss of dimerization. 2.7-fold reduction in ssDNA binding. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Mutagenesis 3952 3959 . . . Note=14-fold reduction in ssDNA binding. GAVLGYIG->EAVLEYIE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29925659;Dbxref=PMID:29925659 P0C6Y4 UniProtKB Mutagenesis 5954 5954 . . . Note=97%25 loss of G-N-7 MTase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32461321;Dbxref=PMID:32461321 P0C6Y4 UniProtKB Mutagenesis 5956 5956 . . . Note=95%25 loss of G-N-7 MTase activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32461321;Dbxref=PMID:32461321 P0C6Y4 UniProtKB Mutagenesis 5958 5959 . . . Note=85%25 loss of G-N-7 MTase activity. PK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32461321;Dbxref=PMID:32461321 P0C6Y4 UniProtKB Mutagenesis 5974 5974 . . . Note=71%25 loss of G-N-7 MTase activity. Higher type I and III interferon response by the host. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32461321;Dbxref=PMID:32461321 P0C6Y4 UniProtKB Mutagenesis 6367 6367 . . . Note=Loss of reduction of the expression levels of host TBK1 and IRF3. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32486349;Dbxref=PMID:32486349 P0C6Y4 UniProtKB Mutagenesis 6382 6382 . . . Note=Loss of reduction of the expression levels of host TBK1 and IRF3. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32486349;Dbxref=PMID:32486349 P0C6Y4 UniProtKB Mutagenesis 6406 6406 . . . Note=No effect on the reduction of the expression levels of host TBK1 and IRF3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32486349;Dbxref=PMID:32486349 P0C6Y4 UniProtKB Mutagenesis 6423 6423 . . . Note=Loss of reduction of the expression levels of host TBK1 and IRF3. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32486349;Dbxref=PMID:32486349 P0C6Y4 UniProtKB Beta strand 3867 3874 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Beta strand 3879 3888 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Beta strand 3893 3903 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Beta strand 3907 3910 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Beta strand 3917 3921 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Beta strand 3925 3930 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Beta strand 3932 3943 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ P0C6Y4 UniProtKB Helix 3948 3958 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIZ