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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Avian infectious bronchitis virus (strain Beaudette) (IBV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).By similarity
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.PROSITE-ProRule annotation
The peptide p16 might be involved in the EGF signaling pathway.
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).By similarity
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.By similarity
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation
ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1274For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1437For PL-PRO activityPROSITE-ProRule annotation1
Active sitei2820For 3CL-PRO activity1
Active sitei2922For 3CL-PRO activity1
Metal bindingi4873Zinc 1PROSITE-ProRule annotation1
Metal bindingi4876Zinc 1PROSITE-ProRule annotation1
Metal bindingi4884Zinc 2PROSITE-ProRule annotation1
Metal bindingi4887Zinc 1PROSITE-ProRule annotation1
Metal bindingi4894Zinc 1PROSITE-ProRule annotation1
Metal bindingi4897Zinc 2PROSITE-ProRule annotation1
Metal bindingi4901Zinc 2PROSITE-ProRule annotation1
Metal bindingi4907Zinc 2PROSITE-ProRule annotation1
Metal bindingi4918Zinc 3PROSITE-ProRule annotation1
Metal bindingi4923Zinc 3PROSITE-ProRule annotation1
Metal bindingi4940Zinc 3PROSITE-ProRule annotation1
Metal bindingi4943Zinc 3PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1353 – 1390C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri3858 – 3878By similarityAdd BLAST21
Zinc fingeri3904 – 3917By similarityAdd BLAST14
Nucleotide bindingi5150 – 5157ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Activation of host autophagy by virus, Host-virus interaction, Viral RNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Protein family/group databases

MEROPSiC16.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 14 chains:
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p87
Non-structural protein 3 (EC:3.4.22.-)
Short name:
nsp3
Alternative name(s):
Papain-like proteinase
Short name:
PL-PRO
p195
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
p41
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
p33
Non-structural protein 6
Short name:
nsp6
Alternative name(s):
p34
Non-structural protein 7
Short name:
nsp7
Alternative name(s):
p9
Non-structural protein 8
Short name:
nsp8
Alternative name(s):
p24
Non-structural protein 9
Short name:
nsp9
Alternative name(s):
p10
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
p16
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
p100
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
p68
Exoribonuclease (EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
p58
Alternative name(s):
NendoU
nsp15
p39
Alternative name(s):
nsp16
p35
Gene namesi
Name:rep
ORF Names:1a-1b
OrganismiAvian infectious bronchitis virus (strain Beaudette) (IBV)
Taxonomic identifieri11122 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeGammacoronavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000006717 Componenti: Genome

Subcellular locationi

Non-structural protein 7 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 8 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 9 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 10 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Helicase :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1721 – 1741HelicalSequence analysisAdd BLAST21
Transmembranei1751 – 1771HelicalSequence analysisAdd BLAST21
Transmembranei1844 – 1864HelicalSequence analysisAdd BLAST21
Transmembranei1887 – 1907HelicalSequence analysisAdd BLAST21
Transmembranei2281 – 2301HelicalSequence analysisAdd BLAST21
Transmembranei2560 – 2580HelicalSequence analysisAdd BLAST21
Transmembranei2589 – 2609HelicalSequence analysisAdd BLAST21
Transmembranei2612 – 2632HelicalSequence analysisAdd BLAST21
Transmembranei2644 – 2664HelicalSequence analysisAdd BLAST21
Transmembranei3101 – 3121HelicalSequence analysisAdd BLAST21
Transmembranei3122 – 3142HelicalSequence analysisAdd BLAST21
Transmembranei3152 – 3172HelicalSequence analysisAdd BLAST21
Transmembranei3189 – 3209HelicalSequence analysisAdd BLAST21
Transmembranei3220 – 3240HelicalSequence analysisAdd BLAST21
Transmembranei3258 – 3278HelicalSequence analysisAdd BLAST21
Transmembranei3297 – 3317HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi673G → A: No processing between p87 and p195. 1 Publication1
Mutagenesisi676T → S: No effect. 1 Publication1
Mutagenesisi1274C → S: Complete loss of PL-PRO activity. 1 Publication1
Mutagenesisi1437H → K: Complete loss of PL-PRO activity. 1 Publication1
Mutagenesisi2264A → N: Almost no processing between p195 and peptide HD2. 1 Publication1
Mutagenesisi2265 – 2266Missing : No processing between p195 and peptide HD2. 2
Mutagenesisi2265G → A: No effect. 1 Publication1
Mutagenesisi2265G → N: Almost no processing between p195 and peptide HD2. 1 Publication1
Mutagenesisi2266G → N: No effect. 1 Publication1
Mutagenesisi2820H → K or G: Complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2841E → Q: No effect. 1 Publication1
Mutagenesisi2843E → D, N or Q: No effect. 1 Publication1
Mutagenesisi2922C → A: Complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2922C → S: Partial loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3086Q → E: No processing between 3CL-PRO and p34. 1 Publication1
Mutagenesisi3365Q → E: No effect. 1 Publication1
Mutagenesisi3379Q → E: No processing between p34 and p9. 1 Publication1
Mutagenesisi3462Q → E: No processing between p9 and p24. 1 Publication1
Mutagenesisi3672Q → E: No processing between p24 and p10. 2 Publications1
Mutagenesisi3783Q → E: No processing between p10 and p16. 2 Publications1
Mutagenesisi3928Q → E: No processing between p16 and p100. 1 Publication1
Mutagenesisi4868Q → E: No processing between p100 and p68. 2 Publications1
Mutagenesisi4869S → A or G: No effect. 1 Publication1
Mutagenesisi5468Q → M: No processing between p68 and p58. 1 Publication1
Mutagenesisi5989Q → E: No processing between p58 and p39. 1 Publication1
Mutagenesisi6327Q → E: No processing between p39 and p35. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000374041 – 673Non-structural protein 2Add BLAST673
ChainiPRO_0000037405674 – 2265Non-structural protein 3Add BLAST1592
ChainiPRO_00000374062266 – 2779Non-structural protein 4Add BLAST514
ChainiPRO_00000374072780 – 30863C-like proteinaseAdd BLAST307
ChainiPRO_00000374083087 – 3379Non-structural protein 6Add BLAST293
ChainiPRO_00000374093380 – 3462Non-structural protein 7Add BLAST83
ChainiPRO_00000374103463 – 3672Non-structural protein 8Add BLAST210
ChainiPRO_00000374113673 – 3783Non-structural protein 9Add BLAST111
ChainiPRO_00000374123784 – 3928Non-structural protein 10Add BLAST145
ChainiPRO_00000374133929 – 4868RNA-directed RNA polymeraseAdd BLAST940
ChainiPRO_00000374144869 – 5468HelicaseAdd BLAST600
ChainiPRO_00000374155469 – 5989ExoribonucleaseBy similarityAdd BLAST521
ChainiPRO_00000374165990 – 6327Uridylate-specific endoribonucleaseBy similarityAdd BLAST338
ChainiPRO_00000374176328 – 6629Putative 2'-O-methyl transferaseBy similarityAdd BLAST302

Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity
P41 is N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei673 – 674Cleavage; by PL-PRO2
Sitei2265 – 2266Cleavage; by PL-PRO2
Sitei2779 – 2780Cleavage; by 3CL-PRO2
Sitei3086 – 3087Cleavage; by 3CL-PRO2
Sitei3379 – 3380Cleavage; by 3CL-PRO2
Sitei3462 – 3463Cleavage; by 3CL-PRO2
Sitei3672 – 3673Cleavage; by 3CL-PRO2
Sitei3783 – 3784Cleavage; by 3CL-PRO2
Sitei3928 – 3929Cleavage; by 3CL-PRO2
Sitei4868 – 4869Cleavage; by 3CL-PRO2
Sitei5468 – 5469Cleavage; by 3CL-PRO2
Sitei5989 – 5990Cleavage; by 3CL-PRO2
Sitei6327 – 6328Cleavage; by 3CL-PRO2

Interactioni

Subunit structurei

3CL-PRO exists as monomer and homodimer. The three peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity). Interacts with DDX1 (via C-terminus).By similarity1 Publication

Structurei

Secondary structure

16629
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1015 – 1021Combined sources7
Helixi1023 – 1034Combined sources12
Beta strandi1035 – 1042Combined sources8
Helixi1052 – 1061Combined sources10
Helixi1063 – 1076Combined sources14
Beta strandi1080 – 1084Combined sources5
Beta strandi1091 – 1097Combined sources7
Helixi1107 – 1116Combined sources10
Beta strandi1125 – 1129Combined sources5
Beta strandi1133 – 1135Combined sources3
Turni1136 – 1139Combined sources4
Helixi1140 – 1151Combined sources12
Beta strandi1157 – 1163Combined sources7
Helixi1165 – 1173Combined sources9
Beta strandi1178 – 1188Combined sources11
Beta strandi1190 – 1194Combined sources5
Helixi1200 – 1203Combined sources4
Beta strandi1209 – 1211Combined sources3
Helixi1216 – 1218Combined sources3
Beta strandi1224 – 1226Combined sources3
Helixi1232 – 1235Combined sources4
Turni1236 – 1239Combined sources4
Helixi1242 – 1251Combined sources10
Beta strandi1258 – 1261Combined sources4
Beta strandi1264 – 1267Combined sources4
Turni1271 – 1273Combined sources3
Helixi1274 – 1285Combined sources12
Helixi1294 – 1302Combined sources9
Helixi1307 – 1316Combined sources10
Helixi1327 – 1335Combined sources9
Turni1342 – 1344Combined sources3
Beta strandi1346 – 1353Combined sources8
Beta strandi1356 – 1363Combined sources8
Helixi1364 – 1368Combined sources5
Beta strandi1369 – 1376Combined sources8
Helixi1377 – 1381Combined sources5
Beta strandi1382 – 1386Combined sources5
Turni1388 – 1390Combined sources3
Beta strandi1393 – 1413Combined sources21
Beta strandi1415 – 1418Combined sources4
Beta strandi1424 – 1431Combined sources8
Beta strandi1435 – 1442Combined sources8
Beta strandi1445 – 1447Combined sources3
Beta strandi1458 – 1473Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EJFX-ray1.60A1005-1176[»]
3EKEX-ray2.10A1005-1176[»]
4X2ZX-ray2.15A1174-1483[»]
5BZ0X-ray2.10A1174-1483[»]
ProteinModelPortaliP0C6Y1.
SMRiP0C6Y1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C6Y1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1003 – 1179MacroPROSITE-ProRule annotationAdd BLAST177
Domaini1236 – 1497Peptidase C16PROSITE-ProRule annotationAdd BLAST262
Domaini2780 – 3086Peptidase C30PROSITE-ProRule annotationAdd BLAST307
Domaini4548 – 4710RdRp catalyticPROSITE-ProRule annotationAdd BLAST163
Domaini4869 – 4952CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5125 – 5305(+)RNA virus helicase ATP-bindingAdd BLAST181
Domaini5306 – 5477(+)RNA virus helicase C-terminalAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1721 – 1907HD1Add BLAST187
Regioni2281 – 2664HD2Add BLAST384
Regioni3101 – 3317HD3Add BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Val4
Compositional biasi2570 – 2573Poly-Val4

Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

Sequence similaritiesi

Contains 1 CV ZBD (coronavirus zinc-binding) domain.PROSITE-ProRule annotation
Contains 1 Macro domain.PROSITE-ProRule annotation
Contains 1 peptidase C16 domain.PROSITE-ProRule annotation
Contains 1 peptidase C30 domain.PROSITE-ProRule annotation
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1353 – 1390C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri3858 – 3878By similarityAdd BLAST21
Zinc fingeri3904 – 3917By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027351. (+)RNA_virus_helicase_core_dom.
IPR003593. AAA+_ATPase.
IPR032505. Corona_NSP4_C.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009003. Peptidase_S1_PA.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR029063. SAM-dependent_MTases.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF16348. Corona_NSP4_C. 1 hit.
PF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF00680. RdRP_1. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF08715. Viral_protease. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
SM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51653. CV_ZBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform Replicase polyprotein 1ab (identifier: P0C6Y1-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSLKQGVS PKPRDVILVS KDIPEQLCDA LFFYTSHNPK DYADAFAVRQ
60 70 80 90 100
KFDRSLQTGK QFKFETVCGL FLLKGVDKIT PGVPAKVLKA TSKLADLEDI
110 120 130 140 150
FGVSPLARKY RELLKTACQW SLTVEALDVR AQTLDEIFDP TEILWLQVAA
160 170 180 190 200
KIHVSSMAMR RLVGEVTAKV MDALGSNLSA LFQIVKQQIA RIFQKALAIF
210 220 230 240 250
ENVNELPQRI AALKMAFAKC ARSITVVVVE RTLVVKEFAG TCLASINGAV
260 270 280 290 300
AKFFEELPNG FMGSKIFTTL AFFKEAAVRV VENIPNAPRG TKGFEVVGNA
310 320 330 340 350
KGTQVVVRGM RNDLTLLDQK ADIPVEPEGW SAILDGHLCY VFRSGDRFYA
360 370 380 390 400
APLSGNFALS DVHCCERVVC LSDGVTPEIN DGLILAAIYS SFSVSELVTA
410 420 430 440 450
LKKGEPFKFL GHKFVYAKDA AVSFTLAKAA TIADVLRLFQ SARVIAEDVW
460 470 480 490 500
SSFTEKSFEF WKLAYGKVRN LEEFVKTYVC KAQMSIVILA AVLGEDIWHL
510 520 530 540 550
VSQVIYKLGV LFTKVVDFCD KHWKGFCVQL KRAKLIVTET FCVLKGVAQH
560 570 580 590 600
CFQLLLDAIH SLYKSFKKCA LGRIHGDLLF WKGGVHKIVQ DGDEIWFDAI
610 620 630 640 650
DSVDVEDLGV VQEKSIDFEV CDDVTLPENQ PGHMVQIEDD GKNYMFFRFK
660 670 680 690 700
KDENIYYTPM SQLGAINVVC KAGGKTVTFG ETTVQEIPPP DVVPIKVSIE
710 720 730 740 750
CCGEPWNTIF KKAYKEPIEV DTDLTVEQLL SVIYEKMCDD LKLFPEAPEP
760 770 780 790 800
PPFENVALVD KNGKDLDCIK SCHLIYRDYE SDDDIEEEDA EECDTDSGEA
810 820 830 840 850
EECDTNSECE EEDEDTKVLA LIQDPASIKY PLPLDEDYSV YNGCIVHKDA
860 870 880 890 900
LDVVNLPSGE ETFVVNNCFE GAVKPLPQKV VDVLGDWGEA VDAQEQLCQQ
910 920 930 940 950
EPLQHTFEEP VENSTGSSKT MTEQVVVEDQ ELPVVEQDQD VVVYTPTDLE
960 970 980 990 1000
VAKETAEEVD EFILIFAVPK EEVVSQKDGA QIKQEPIQVV KPQREKKAKK
1010 1020 1030 1040 1050
FKVKPATCEK PKFLEYKTCV GDLTVVIAKA LDEFKEFCIV NAANEHMTHG
1060 1070 1080 1090 1100
SGVAKAIADF CGLDFVEYCE DYVKKHGPQQ RLVTPSFVKG IQCVNNVVGP
1110 1120 1130 1140 1150
RHGDNNLHEK LVAAYKNVLV DGVVNYVVPV LSLGIFGVDF KMSIDAMREA
1160 1170 1180 1190 1200
FEGCTIRVLL FSLSQEHIDY FDVTCKQKTI YLTEDGVKYR SIVLKPGDSL
1210 1220 1230 1240 1250
GQFGQVYAKN KIVFTADDVE DKEILYVPTT DKSILEYYGL DAQKYVIYLQ
1260 1270 1280 1290 1300
TLAQKWNVQY RDNFLILEWR DGNCWISSAI VLLQAAKIRF KGFLTEAWAK
1310 1320 1330 1340 1350
LLGGDPTDFV AWCYASCTAK VGDFSDANWL LANLAEHFDA DYTNAFLKKR
1360 1370 1380 1390 1400
VSCNCGIKSY ELRGLEACIQ PVRATNLLHF KTQYSNCPTC GANNTDEVIE
1410 1420 1430 1440 1450
ASLPYLLLFA TDGPATVDCD EDAVGTVVFV GSTNSGHCYT QAAGQAFDNL
1460 1470 1480 1490 1500
AKDRKFGKKS PYITAMYTRF AFKNETSLPV AKQSKGKSKS VKEDVSNLAT
1510 1520 1530 1540 1550
SSKASFDNLT DFEQWYDSNI YESLKVQESP DNFDKYVSFT TKEDSKLPLT
1560 1570 1580 1590 1600
LKVRGIKSVV DFRSKDGFIY KLTPDTDENS KAPVYYPVLD AISLKAIWVE
1610 1620 1630 1640 1650
GNANFVVGHP NYYSKSLHIP TFWENAENFV KMGDKIGGVT MGLWRAEHLN
1660 1670 1680 1690 1700
KPNLERIFNI AKKAIVGSSV VTTQCGKLIG KAATFIADKV GGGVVRNITD
1710 1720 1730 1740 1750
SIKGLCGITR GHFERKMSPQ FLKTLMFFLF YFLKASVKSV VASYKTVLCK
1760 1770 1780 1790 1800
VVLATLLIVW FVYTSNPVMF TGIRVLDFLF EGSLCGPYKD YGKDSFDVLR
1810 1820 1830 1840 1850
YCADDFICRV CLHDKDSLHL YKHAYSVEQV YKDAASGFIF NWNWLYLVFL
1860 1870 1880 1890 1900
ILFVKPVAGF VIICYCVKYL VLNSTVLQTG VCFLDWFVQT VFSHFNFMGA
1910 1920 1930 1940 1950
GFYFWLFYKI YIQVHHILYC KDVTCEVCKR VARSNRQEVS VVVGGRKQIV
1960 1970 1980 1990 2000
HVYTNSGYNF CKRHNWYCRN CDDYGHQNTF MSPEVAGELS EKLKRHVKPT
2010 2020 2030 2040 2050
AYAYHVVDEA CLVDDFVNLK YKAATPGKDS ASSAVKCFSV TDFLKKAVFL
2060 2070 2080 2090 2100
KEALKCEQIS NDGFIVCNTQ SAHALEEAKN AAIYYAQYLC KPILILDQAL
2110 2120 2130 2140 2150
YEQLVVEPVS KSVIDKVCSI LSSIISVDTA ALNYKAGTLR DALLSITKDE
2160 2170 2180 2190 2200
EAVDMAIFCH NHDVDYTGDG FTNVIPSYGI DTGKLTPRDR GFLINADASI
2210 2220 2230 2240 2250
ANLRVKNAPP VVWKFSELIK LSDSCLKYLI SATVKSGVRF FITKSGAKQV
2260 2270 2280 2290 2300
IACHTQKLLV EKKAGGIVSG TFKCFKSYFK WLLIFYILFT ACCSGYYYME
2310 2320 2330 2340 2350
VSKSFVHPMY DVNSTLHVEG FKVIDKGVLR EIVPEDTCFS NKFVNFDAFW
2360 2370 2380 2390 2400
GRPYDNSRNC PIVTAVIDGD GTVATGVPGF VSWVMDGVMF IHMTQTERKP
2410 2420 2430 2440 2450
WYIPTWFNRE IVGYTQDSII TEGSFYTSIA LFSARCLYLT ASNTPQLYCF
2460 2470 2480 2490 2500
NGDNDAPGAL PFGSIIPHRV YFQPNGVRLI VPQQILHTPY VVKFVSDSYC
2510 2520 2530 2540 2550
RGSVCEYTRP GYCVSLNPQW VLFNDEYTSK PGVFCGSTVR ELMFSMVSTF
2560 2570 2580 2590 2600
FTGVNPNIYM QLATMFLILV VVVLIFAMVI KFQGVFKAYA TTVFITMLVW
2610 2620 2630 2640 2650
VINAFILCVH SYNSVLAVIL LVLYCYASLV TSRNTVIIMH CWLVFTFGLI
2660 2670 2680 2690 2700
VPTWLACCYL GFIIYMYTPL FLWCYGTTKN TRKLYDGNEF VGNYDLAAKS
2710 2720 2730 2740 2750
TFVIRGSEFV KLTNEIGDKF EAYLSAYARL KYYSGTGSEQ DYLQACRAWL
2760 2770 2780 2790 2800
AYALDQYRNS GVEIVYTPPR YSIGVSRLQS GFKKLVSPSS AVEKCIVSVS
2810 2820 2830 2840 2850
YRGNNLNGLW LGDTIYCPRH VLGKFSGDQW NDVLNLANNH EFEVTTQHGV
2860 2870 2880 2890 2900
TLNVVSRRLK GAVLILQTAV ANAETPKYKF IKANCGDSFT IACAYGGTVV
2910 2920 2930 2940 2950
GLYPVTMRSN GTIRASFLAG ACGSVGFNIE KGVVNFFYMH HLELPNALHT
2960 2970 2980 2990 3000
GTDLMGEFYG GYVDEEVAQR VPPDNLVTNN IVAWLYAAII SVKESSFSLP
3010 3020 3030 3040 3050
KWLESTTVSV DDYNKWAGDN GFTPFSTSTA ITKLSAITGV DVCKLLRTIM
3060 3070 3080 3090 3100
VKNSQWGGDP ILGQYNFEDE LTPESVFNQI GGVRLQSSFV RKATSWFWSR
3110 3120 3130 3140 3150
CVLACFLFVL CAIVLFTAVP LKFYVYAAVI LLMAVLFISF TVKHVMAYMD
3160 3170 3180 3190 3200
TFLLPTLITV IIGVCAEVPF IYNTLISQVV IFLSQWYDPV VFDTMVPWMF
3210 3220 3230 3240 3250
LPLVLYTAFK CVQGCYMNSF NTSLLMLYQF VKLGFVIYTS SNTLTAYTEG
3260 3270 3280 3290 3300
NWELFFELVH TTVLANVSSN SLIGLFVFKC AKWMLYYCNA TYLNNYVLMA
3310 3320 3330 3340 3350
VMVNCIGWLC TCYFGLYWWV NKVFGLTLGK YNFKVSVDQY RYMCLHKINP
3360 3370 3380 3390 3400
PKTVWEVFST NILIQGIGGD RVLPIATVQA KLSDVKCTTV VLMQLLTKLN
3410 3420 3430 3440 3450
VEANSKMHVY LVELHNKILA SDDVGECMDN LLGMLITLFC IDSTIDLSEY
3460 3470 3480 3490 3500
CDDILKRSTV LQSVTQEFSH IPSYAEYERA KNLYEKVLVD SKNGGVTQQE
3510 3520 3530 3540 3550
LAAYRKAANI AKSVFDRDLA VQKKLDSMAE RAMTTMYKEA RVTDRRAKLV
3560 3570 3580 3590 3600
SSLHALLFSM LKKIDSEKLN VLFDQASSGV VPLATVPIVC SNKLTLVIPD
3610 3620 3630 3640 3650
PETWVKCVEG VHVTYSTVVW NIDTVIDADG TELHPTSTGS GLTYCISGAN
3660 3670 3680 3690 3700
IAWPLKVNLT RNGHNKVDVV LQNNELMPHG VKTKACVAGV DQAHCSVESK
3710 3720 3730 3740 3750
CYYTNISGNS VVAAITSSNP NLKVASFLNE AGNQIYVDLD PPCKFGMKVG
3760 3770 3780 3790 3800
VKVEVVYLYF IKNTRSIVRG MVLGAISNVV VLQSKGHETE EVDAVGILSL
3810 3820 3830 3840 3850
CSFAVDPADT YCKYVAAGNQ PLGNCVKMLT VHNGSGFAIT SKPSPTPDQD
3860 3870 3880 3890 3900
SYGGASVCLY CRAHIAHPGS VGNLDGRCQF KGSFVQIPTT EKDPVGFCLR
3910 3920 3930 3940 3950
NKVCTVCQCW IGYGCQCDSL RQPKSSVQSV AGASDFDKNY LNRVRGSSEA
3960 3970 3980 3990 4000
RLIPLASGCD PDVVKRAFDV CNKESAGMFQ NLKRNCARFQ ELRDTEDGNL
4010 4020 4030 4040 4050
EYLDSYFVVK QTTPSNYEHE KSCYEDLKSE VTADHDFFVF NKNIYNISRQ
4060 4070 4080 4090 4100
RLTKYTMMDF CYALRHFDPK DCEVLKEILV TYGCIEDYHP KWFEENKDWY
4110 4120 4130 4140 4150
DPIENSKYYV MLAKMGPIVR RALLNAIEFG NLMVEKGYVG VITLDNQDLN
4160 4170 4180 4190 4200
GKFYDFGDFQ KTAPGAGVPV FDTYYSYMMP IIAMTDALAP ERYFEYDVHK
4210 4220 4230 4240 4250
GYKSYDLLKY DYTEEKQELF QKYFKYWDQE YHPNCRDCSD DRCLIHCANF
4260 4270 4280 4290 4300
NILFSTLIPQ TSFGNLCRKV FVDGVPFIAT CGYHSKELGV IMNQDNTMSF
4310 4320 4330 4340 4350
SKMGLSQLMQ FVGDPALLVG TSNNLVDLRT SCFSVCALTS GITHQTVKPG
4360 4370 4380 4390 4400
HFNKDFYDFA EKAGMFKEGS SIPLKHFFYP QTGNAAINDY DYYRYNRPTM
4410 4420 4430 4440 4450
FDICQLLFCL EVTSKYFECY EGGCIPASQV VVNNLDKSAG YPFNKFGKAR
4460 4470 4480 4490 4500
LYYEMSLEEQ DQLFEITKKN VLPTITQMNL KYAISAKNRA RTVAGVSILS
4510 4520 4530 4540 4550
TMTNRQFHQK ILKSIVNTRN ASVVIGTTKF YGGWDNMLRN LIQGVEDPIL
4560 4570 4580 4590 4600
MGWDYPKCDR AMPNLLRIAA SLVLARKHTN CCSWSERIYR LYNECAQVLS
4610 4620 4630 4640 4650
ETVLATGGIY VKPGGTSSGD ATTAYANSVF NIIQATSANV ARLLSVITRD
4660 4670 4680 4690 4700
IVYDNIKSLQ YELYQQVYRR VNFDPAFVEK FYSYLCKNFS LMILSDDGVV
4710 4720 4730 4740 4750
CYNNTLAKQG LVADISGFRE VLYYQNNVFM ADSKCWVEPD LEKGPHEFCS
4760 4770 4780 4790 4800
QHTMLVEVDG EPKYLPYPDP SRILGACVFV DDVDKTEPVA VMERYIALAI
4810 4820 4830 4840 4850
DAYPLVHHEN EEYKKVFFVL LAYIRKLYQE LSQNMLMDYS FVMDIDKGSK
4860 4870 4880 4890 4900
FWEQEFYENM YRAPTTLQSC GVCVVCNSQT ILRCGNCIRK PFLCCKCCYD
4910 4920 4930 4940 4950
HVMHTDHKNV LSINPYICSQ LGCGEADVTK LYLGGMSYFC GNHKPKLSIP
4960 4970 4980 4990 5000
LVSNGTVFGI YRANCAGSEN VDDFNQLATT NWSIVEPYIL ANRCSDSLRR
5010 5020 5030 5040 5050
FAAETVKATE ELHKQQFASA EVREVFSDRE LILSWEPGKT RPPLNRNYVF
5060 5070 5080 5090 5100
TGYHFTRTSK VQLGDFTFEK GEGKDVVYYK ATSTAKLSVG DIFVLTSHNV
5110 5120 5130 5140 5150
VSLVAPTLCP QQTFSRFVNL RPNVMVPECF VNNIPLYHLV GKQKRTTVQG
5160 5170 5180 5190 5200
PPGSGKSHFA IGLAVYFSSA RVVFTACSHA AVDALCEKAF KFLKVDDCTR
5210 5220 5230 5240 5250
IVPQRTTVDC FSKFKANDTG KKYIFSTINA LPEVSCDILL VDEVSMLTNY
5260 5270 5280 5290 5300
ELSFINGKIN YQYVVYVGDP AQLPAPRTLL NGSLSPKDYN VVTNLMVCVK
5310 5320 5330 5340 5350
PDIFLAKCYR CPKEIVDTVS TLVYDGKFIA NNPESRECFK VIVNNGNSDV
5360 5370 5380 5390 5400
GHESGSAYNT TQLEFVKDFV CRNKQWREAI FISPYNAMNQ RAYRMLGLNV
5410 5420 5430 5440 5450
QTVDSSQGSE YDYVIFCVTA DSQHALNINR FNVALTRAKR GILVVMRQRD
5460 5470 5480 5490 5500
ELYSALKFTE LDSETSLQGT GLFKICNKEF SGVHPAYAVT TKALAATYKV
5510 5520 5530 5540 5550
NDELAALVNV EAGSEITYKH LISLLGFKMS VNVEGCHNMF ITRDEAIRNV
5560 5570 5580 5590 5600
RGWVGFDVEA THACGTNIGT NLPFQVGFST GADFVVTPEG LVDTSIGNNF
5610 5620 5630 5640 5650
EPVNSKAPPG EQFNHLRVLF KSAKPWHVIR PRIVQMLADN LCNVSDCVVF
5660 5670 5680 5690 5700
VTWCHGLELT TLRYFVKIGK EQVCSCGSRA TTFNSHTQAY ACWKHCLGFD
5710 5720 5730 5740 5750
FVYNPLLVDI QQWGYSGNLQ FNHDLHCNVH GHAHVASVDA IMTRCLAINN
5760 5770 5780 5790 5800
AFCQDVNWDL TYPHIANEDE VNSSCRYLQR MYLNACVDAL KVNVVYDIGN
5810 5820 5830 5840 5850
PKGIKCVRRG DVNFRFYDKN PIVRNVKQFE YDYNQHKDKF ADGLCMFWNC
5860 5870 5880 5890 5900
NVDCYPDNSL VCRYDTRNLS VFNLPGCNGG SLYVNKHAFY TPKFDRISFR
5910 5920 5930 5940 5950
NLKAMPFFFY DSSPCETIQV DGVAQDLVSL ATKDCITKCN IGGAVCKKHA
5960 5970 5980 5990 6000
QMYAEFVTSY NAAVTAGFTF WVTNKLNPYN LWKSFSALQS IDNIAYNMYK
6010 6020 6030 6040 6050
GGHYDAIAGE MPTVITGDKV FVIDQGVEKA VFVNQTTLPT SVAFELYAKR
6060 6070 6080 6090 6100
NIRTLPNNRI LKGLGVDVTN GFVIWDYANQ TPLYRNTVKV CAYTDIEPNG
6110 6120 6130 6140 6150
LVVLYDDRYG DYQSFLAADN AVLVSTQCYK RYSYVEIPSN LLVQNGMPLK
6160 6170 6180 6190 6200
DGANLYVYKR VNGAFVTLPN TINTQGRSYE TFEPRSDIER DFLAMSEESF
6210 6220 6230 6240 6250
VERYGKDLGL QHILYGEVDK PQLGGLHTVI GMYRLLRANK LNAKSVTNSD
6260 6270 6280 6290 6300
SDVMQNYFVL SDNGSYKQVC TVVDLLLDDF LELLRNILKE YGTNKSKVVT
6310 6320 6330 6340 6350
VSIDYHSINF MTWFEDGSIK TCYPQLQSAW TCGYNMPELY KVQNCVMEPC
6360 6370 6380 6390 6400
NIPNYGVGIT LPSGILMNVA KYTQLCQYLS KTTICVPHNM RVMHFGAGSD
6410 6420 6430 6440 6450
KGVAPGSTVL KQWLPEGTLL VDNDIVDYVS DAHVSVLSDC NKYNTEHKFD
6460 6470 6480 6490 6500
LVISDMYTDN DSKRKHEGVI ANNGNDDVFI YLSSFLRNNL ALGGSFAVKV
6510 6520 6530 6540 6550
TETSWHEVLY DIAQDCAWWT MFCTAVNASS SEAFLIGVNY LGASEKVKVS
6560 6570 6580 6590 6600
GKTLHANYIF WRNCNYLQTS AYSIFDVAKF DLRLKATPVV NLKTEQKTDL
6610 6620
VFNLIKCGKL LVRDVGNTSF TSDSFVCTM
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:6,629
Mass (Da):744,540
Last modified:June 10, 2008 - v1
Checksum:i887FCAF7EA68A270
GO
Isoform Replicase polyprotein 1a (identifier: P0C6V3-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6V3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by conventional translation.
Length:3,951
Mass (Da):441,126
GO

Sequence cautioni

The sequence AAA46223 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA46224 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA70233 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA70234 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAY24431 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAY24432 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti105P → S in strain: Isolate Vero cell-adapted p65. 1
Natural varianti919K → E in strain: Isolate Vero cell-adapted p65. 1
Natural varianti932L → I in strain: Isolate Vero cell-adapted p65. 1
Natural varianti948D → G in strain: Isolate Vero cell-adapted p65. 1
Natural varianti967A → D in strain: Isolate Vero cell-adapted p65. 1
Natural varianti1133L → S in strain: Isolate Vero cell-adapted p65. 1
Natural varianti1388P → S in strain: Isolate Vero cell-adapted p65. 1
Natural varianti1753L → F in strain: Isolate Vero cell-adapted p65. 1
Natural varianti2561Q → H in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3058Missing in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3242N → S in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3409V → A in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3418I → T in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3471 – 3472IP → MT in strain: Isolate Vero cell-adapted p65. 2
Natural varianti3751V → D in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3870S → G in strain: Isolate Vero cell-adapted p65. 1
Natural varianti3935D → G in strain: Isolate Vero cell-adapted p65. 1
Natural varianti5085A → V in strain: Isolate Vero cell-adapted p65. 1
Natural varianti5968F → S in strain: Isolate Vero cell-adapted p65. 1
Natural varianti6221P → L in strain: Isolate Vero cell-adapted p65. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94356 Genomic RNA. Translation: AAA46223.1. Sequence problems.
M94356 Genomic RNA. Translation: AAA46224.1. Sequence problems.
M95169 Genomic RNA. Translation: AAA70233.1. Sequence problems.
M95169 Genomic RNA. Translation: AAA70234.1. Sequence problems.
DQ001339 Genomic RNA. Translation: AAY24431.1. Sequence problems.
DQ001339 Genomic RNA. Translation: AAY24432.1. Sequence problems.
PIRiA33094. VFIHB1.
B33094. VFIHB2.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94356 Genomic RNA. Translation: AAA46223.1. Sequence problems.
M94356 Genomic RNA. Translation: AAA46224.1. Sequence problems.
M95169 Genomic RNA. Translation: AAA70233.1. Sequence problems.
M95169 Genomic RNA. Translation: AAA70234.1. Sequence problems.
DQ001339 Genomic RNA. Translation: AAY24431.1. Sequence problems.
DQ001339 Genomic RNA. Translation: AAY24432.1. Sequence problems.
PIRiA33094. VFIHB1.
B33094. VFIHB2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EJFX-ray1.60A1005-1176[»]
3EKEX-ray2.10A1005-1176[»]
4X2ZX-ray2.15A1174-1483[»]
5BZ0X-ray2.10A1174-1483[»]
ProteinModelPortaliP0C6Y1.
SMRiP0C6Y1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC16.005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C6Y1.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027351. (+)RNA_virus_helicase_core_dom.
IPR003593. AAA+_ATPase.
IPR032505. Corona_NSP4_C.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009003. Peptidase_S1_PA.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR029063. SAM-dependent_MTases.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF16348. Corona_NSP4_C. 1 hit.
PF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF00680. RdRP_1. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF08715. Viral_protease. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
SM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51653. CV_ZBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR1AB_IBVB
AccessioniPrimary (citable) accession number: P0C6Y1
Secondary accession number(s): P26314
, P27920, Q4ZJT1, Q4ZJT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.