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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Replicase polyprotein 1ab: Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein.
Host translation inhibitor nsp1: Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.1 Publication
Non-structural protein 2: May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.1 Publication
Papain-like proteinase: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.2 Publications
Non-structural protein 4: Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.1 Publication
Proteinase 3CL-PRO: Ccleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).PROSITE-ProRule annotation1 Publication
Non-structural protein 6: Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.1 Publication
Non-structural protein 7: Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.1 Publication
Non-structural protein 8: Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.1 Publication
Non-structural protein 9: May participate in viral replication by acting as a ssRNA-binding protein.1 Publication
Non-structural protein 10: Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.1 Publication
RNA-directed RNA polymerase: Responsible for replication and transcription of the viral RNA genome.1 Publication
Helicase: Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.2 Publications
Guanine-N7 methyltransferase: Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.3 Publications
Uridylate-specific endoribonuclease: Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
2'-O-methyltransferase: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.Curated2 Publications

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation1 Publication
ATP + H2O = ADP + phosphate.1 Publication
TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.1 Publication
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Kineticsi

The kinetic parameters are studied for the 3C-like proteinase domain. The cleavage takes place at the /.

  1. KM=1.15 mM for peptide TSAVLQ/SGFRK-NH21 Publication
  2. KM=0.58 mM for peptide SGVTFQ/GKFKK1 Publication
  3. KM=1.44 mM for peptide ATVRLQ/AGNAT1 Publication

    pH dependencei

    Optimum pH is 7.0 for 3C-like proteinase activity.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei1651For PL-PRO activityPROSITE-ProRule annotation1
    Active sitei1812For PL-PRO activityPROSITE-ProRule annotation1
    Active sitei3281For 3CL-PRO activityPROSITE-ProRule annotation1
    Active sitei3385For 3CL-PRO activityPROSITE-ProRule annotation1
    Metal bindingi4304Zinc1
    Metal bindingi4307Zinc1
    Metal bindingi4313Zinc1
    Metal bindingi4320Zinc1
    Metal bindingi4347Zinc1
    Metal bindingi4350Zinc1
    Metal bindingi4358Zinc1
    Metal bindingi5306Zinc 1PROSITE-ProRule annotation1
    Metal bindingi5309Zinc 1PROSITE-ProRule annotation1
    Metal bindingi5317Zinc 2PROSITE-ProRule annotation1
    Metal bindingi5320Zinc 1PROSITE-ProRule annotation1
    Metal bindingi5327Zinc 1PROSITE-ProRule annotation1
    Metal bindingi5330Zinc 2PROSITE-ProRule annotation1
    Metal bindingi5334Zinc 2PROSITE-ProRule annotation1
    Metal bindingi5340Zinc 2PROSITE-ProRule annotation1
    Metal bindingi5351Zinc 3PROSITE-ProRule annotation1
    Metal bindingi5356Zinc 3PROSITE-ProRule annotation1
    Metal bindingi5373Zinc 3PROSITE-ProRule annotation1
    Metal bindingi5376Zinc 3PROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
    Zinc fingeri4304 – 4320Add BLAST17
    Zinc fingeri4347 – 4360Add BLAST14
    Nucleotide bindingi5583 – 5590ATPBy similarity8

    GO - Molecular functioni

    • 3'-5'-exoribonuclease activity Source: CACAO
    • ATP binding Source: UniProtKB-KW
    • cysteine-type endopeptidase activity Source: InterPro
    • double-stranded RNA binding Source: UniProtKB
    • endonuclease activity Source: UniProtKB-KW
    • helicase activity Source: UniProtKB
    • Lys48-specific deubiquitinase activity Source: UniProtKB
    • methyltransferase activity Source: UniProtKB-KW
    • mRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
    • mRNA (nucleoside-2'-O-)-methyltransferase activity Source: UniProtKB
    • omega peptidase activity Source: InterPro
    • RNA binding Source: UniProtKB-KW
    • RNA-directed RNA polymerase activity Source: UniProtKB
    • single-stranded RNA binding Source: UniProtKB
    • thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB-EC
    • zinc ion binding Source: InterPro

    GO - Biological processi

    • 7-methylguanosine mRNA capping Source: UniProtKB
    • induction by virus of catabolism of host mRNA Source: UniProtKB-KW
    • induction by virus of host autophagy Source: UniProtKB-KW
    • modulation by virus of host autophagy Source: UniProtKB
    • modulation by virus of host protein ubiquitination Source: UniProtKB
    • mRNA methylation Source: UniProtKB
    • positive regulation of ubiquitin-specific protease activity Source: UniProtKB
    • positive stranded viral RNA replication Source: UniProtKB
    • RNA phosphodiester bond hydrolysis, exonucleolytic Source: UniProtKB
    • suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation Source: UniProtKB
    • suppression by virus of host ISG15 activity Source: UniProtKB
    • suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB
    • suppression by virus of host translation Source: UniProtKB
    • suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB
    • transcription, DNA-templated Source: InterPro
    • transcription, RNA-templated Source: UniProtKB
    • viral protein processing Source: InterPro
    • viral RNA genome replication Source: InterPro
    • viral transcription Source: CACAO
    Complete GO annotation...

    Keywords - Molecular functioni

    Endonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

    Keywords - Biological processi

    Activation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

    Enzyme and pathway databases

    BRENDAi2.7.7.48. 7599.
    3.4.22.B14. 7599.
    3.6.4.12. 7599.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Replicase polyprotein 1ab
    Short name:
    pp1ab
    Alternative name(s):
    ORF1ab polyprotein
    Cleaved into the following 15 chains:
    Alternative name(s):
    Leader protein
    Non-structural protein 2
    Short name:
    nsp2
    Alternative name(s):
    p65 homolog
    Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.69)
    Short name:
    PL-PRO
    Alternative name(s):
    Non-structural protein 3
    Short name:
    nsp3
    PL2-PRO
    SARS coronavirus main proteinase
    Non-structural protein 4
    Short name:
    nsp4
    3C-like proteinase (EC:3.4.22.-)
    Short name:
    3CL-PRO
    Short name:
    3CLp
    Alternative name(s):
    nsp5
    Non-structural protein 6
    Short name:
    nsp6
    Non-structural protein 7
    Short name:
    nsp7
    Non-structural protein 8
    Short name:
    nsp8
    Non-structural protein 9
    Short name:
    nsp9
    Non-structural protein 10
    Short name:
    nsp10
    Alternative name(s):
    Growth factor-like peptide
    Short name:
    GFL
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    Pol
    Short name:
    RdRp
    Alternative name(s):
    nsp12
    Helicase (EC:3.6.4.12, EC:3.6.4.13)
    Short name:
    Hel
    Alternative name(s):
    nsp13
    Alternative name(s):
    nsp14
    Alternative name(s):
    NendoU
    nsp15
    Alternative name(s):
    nsp16
    Gene namesi
    Name:rep
    ORF Names:1a-1b
    OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
    Taxonomic identifieri227859 [NCBI]
    Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Paguma larvata (Masked palm civet) [TaxID: 9675]
    Proteomesi
    • UP000000354 Componenti: Genome

    Subcellular locationi

    Papain-like proteinase :
    Non-structural protein 4 :
    Non-structural protein 7 :
    • Host cytoplasmhost perinuclear region By similarity

    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    Non-structural protein 8 :
    • Host cytoplasmhost perinuclear region By similarity

    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    Non-structural protein 9 :
    • Host cytoplasmhost perinuclear region By similarity

    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    Non-structural protein 10 :
    • Host cytoplasmhost perinuclear region By similarity

    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    Helicase :

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei2092 – 2112HelicalSequence analysisAdd BLAST21
    Transmembranei2203 – 2223HelicalSequence analysisAdd BLAST21
    Transmembranei2304 – 2324HelicalSequence analysisAdd BLAST21
    Transmembranei2326 – 2346HelicalSequence analysisAdd BLAST21
    Transmembranei2351 – 2371HelicalSequence analysisAdd BLAST21
    Transmembranei2755 – 2775HelicalSequence analysisAdd BLAST21
    Transmembranei2830 – 2850HelicalSequence analysisAdd BLAST21
    Transmembranei2879 – 2899HelicalSequence analysisAdd BLAST21
    Transmembranei2992 – 3012HelicalSequence analysisAdd BLAST21
    Transmembranei3022 – 3042HelicalSequence analysisAdd BLAST21
    Transmembranei3054 – 3074HelicalSequence analysisAdd BLAST21
    Transmembranei3077 – 3097HelicalSequence analysisAdd BLAST21
    Transmembranei3105 – 3125HelicalSequence analysisAdd BLAST21
    Transmembranei3142 – 3162HelicalSequence analysisAdd BLAST21
    Transmembranei3564 – 3584HelicalSequence analysisAdd BLAST21
    Transmembranei3586 – 3606HelicalSequence analysisAdd BLAST21
    Transmembranei3612 – 3632HelicalSequence analysisAdd BLAST21
    Transmembranei3658 – 3678HelicalSequence analysisAdd BLAST21
    Transmembranei3707 – 3727HelicalSequence analysisAdd BLAST21
    Transmembranei3728 – 3748HelicalSequence analysisAdd BLAST21
    Transmembranei3756 – 3776HelicalSequence analysisAdd BLAST21

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Host cytoplasm, Host membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi4217G → E: Complete loss of nsp9 dimerization. 1 Publication1
    Mutagenesisi4221G → E: Complete loss of nsp9 dimerization. 1 Publication1

    Chemistry databases

    ChEMBLiCHEMBL5118.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000373091 – 180Host translation inhibitor nsp1By similarityAdd BLAST180
    ChainiPRO_0000037310181 – 818Non-structural protein 2By similarityAdd BLAST638
    ChainiPRO_0000037311819 – 2740Papain-like proteinaseBy similarityAdd BLAST1922
    ChainiPRO_00002838412741 – 3240Non-structural protein 4Sequence analysisAdd BLAST500
    ChainiPRO_00000373123241 – 35463C-like proteinaseBy similarityAdd BLAST306
    ChainiPRO_00000373133547 – 3836Non-structural protein 6By similarityAdd BLAST290
    ChainiPRO_00000373143837 – 3919Non-structural protein 7By similarityAdd BLAST83
    ChainiPRO_00000373153920 – 4117Non-structural protein 8By similarityAdd BLAST198
    ChainiPRO_00000373164118 – 4230Non-structural protein 9By similarityAdd BLAST113
    ChainiPRO_00000373174231 – 4369Non-structural protein 10By similarityAdd BLAST139
    ChainiPRO_00000373184370 – 5301RNA-directed RNA polymeraseBy similarityAdd BLAST932
    ChainiPRO_00000373195302 – 5902HelicaseBy similarityAdd BLAST601
    ChainiPRO_00000373205903 – 6429Guanine-N7 methyltransferaseBy similarityAdd BLAST527
    ChainiPRO_00000373216430 – 6775Uridylate-specific endoribonucleaseBy similarityAdd BLAST346
    ChainiPRO_00000373226776 – 70732'-O-methyltransferaseBy similarityAdd BLAST298

    Post-translational modificationi

    Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sitei180 – 181CleavageBy similarity2
    Sitei818 – 819Cleavage; by PL-PROBy similarity2
    Sitei2740 – 2741Cleavage; by PL-PROBy similarity2
    Sitei3240 – 3241Cleavage; by 3CL-PROBy similarity2
    Sitei3546 – 3547Cleavage; by 3CL-PROBy similarity2
    Sitei3836 – 3837Cleavage; by 3CL-PROBy similarity2
    Sitei3919 – 3920Cleavage; by 3CL-PROBy similarity2
    Sitei4117 – 4118Cleavage; by 3CL-PROBy similarity2
    Sitei4230 – 4231Cleavage; by 3CL-PROBy similarity2
    Sitei4369 – 4370Cleavage; by 3CL-PROBy similarity2
    Sitei5301 – 5302Cleavage; by 3CL-PROBy similarity2
    Sitei5902 – 5903Cleavage; by 3CL-PROBy similarity2
    Sitei6429 – 6430Cleavage; by 3CL-PROBy similarity2
    Sitei6775 – 6776Cleavage; by 3CL-PROBy similarity2

    Proteomic databases

    PRIDEiP0C6X7.

    Interactioni

    Subunit structurei

    Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.8 Publications

    Protein-protein interaction databases

    MINTiMINT-1487760.

    Chemistry databases

    BindingDBiP0C6X7.

    Structurei

    Secondary structure

    17073
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi14 – 20Combined sources7
    Turni23 – 25Combined sources3
    Helixi35 – 48Combined sources14
    Beta strandi51 – 54Combined sources4
    Helixi61 – 63Combined sources3
    Beta strandi68 – 72Combined sources5
    Beta strandi87 – 93Combined sources7
    Turni95 – 98Combined sources4
    Beta strandi99 – 102Combined sources4
    Beta strandi105 – 109Combined sources5
    Beta strandi116 – 123Combined sources8
    Beta strandi827 – 829Combined sources3
    Turni831 – 833Combined sources3
    Beta strandi839 – 841Combined sources3
    Beta strandi848 – 851Combined sources4
    Turni852 – 856Combined sources5
    Beta strandi860 – 862Combined sources3
    Turni869 – 871Combined sources3
    Helixi872 – 882Combined sources11
    Helixi888 – 894Combined sources7
    Helixi898 – 901Combined sources4
    Beta strandi907 – 909Combined sources3
    Beta strandi911 – 915Combined sources5
    Beta strandi918 – 920Combined sources3
    Beta strandi922 – 926Combined sources5
    Beta strandi1013 – 1021Combined sources9
    Helixi1023 – 1030Combined sources8
    Beta strandi1033 – 1038Combined sources6
    Helixi1048 – 1056Combined sources9
    Turni1057 – 1059Combined sources3
    Helixi1060 – 1072Combined sources13
    Beta strandi1080 – 1084Combined sources5
    Turni1086 – 1088Combined sources3
    Beta strandi1090 – 1095Combined sources6
    Helixi1100 – 1102Combined sources3
    Helixi1108 – 1114Combined sources7
    Helixi1115 – 1118Combined sources4
    Beta strandi1119 – 1124Combined sources6
    Helixi1130 – 1132Combined sources3
    Helixi1136 – 1146Combined sources11
    Beta strandi1149 – 1156Combined sources8
    Helixi1158 – 1168Combined sources11
    Beta strandi1345 – 1347Combined sources3
    Helixi1351 – 1361Combined sources11
    Beta strandi1364 – 1368Combined sources5
    Helixi1372 – 1381Combined sources10
    Beta strandi1389 – 1401Combined sources13
    Helixi1407 – 1417Combined sources11
    Beta strandi1421 – 1424Combined sources4
    Beta strandi1426 – 1428Combined sources3
    Helixi1429 – 1431Combined sources3
    Helixi1435 – 1442Combined sources8
    Beta strandi1449 – 1452Combined sources4
    Helixi1457 – 1467Combined sources11
    Beta strandi1544 – 1555Combined sources12
    Beta strandi1557 – 1562Combined sources6
    Helixi1567 – 1571Combined sources5
    Beta strandi1572 – 1576Combined sources5
    Beta strandi1582 – 1584Combined sources3
    Helixi1588 – 1590Combined sources3
    Beta strandi1594 – 1597Combined sources4
    Helixi1602 – 1612Combined sources11
    Helixi1619 – 1630Combined sources12
    Beta strandi1639 – 1642Combined sources4
    Turni1648 – 1650Combined sources3
    Helixi1651 – 1661Combined sources11
    Beta strandi1667 – 1669Combined sources3
    Helixi1670 – 1680Combined sources11
    Helixi1685 – 1694Combined sources10
    Helixi1705 – 1713Combined sources9
    Beta strandi1722 – 1728Combined sources7
    Beta strandi1730 – 1732Combined sources3
    Beta strandi1734 – 1740Combined sources7
    Helixi1742 – 1745Combined sources4
    Beta strandi1746 – 1749Combined sources4
    Helixi1753 – 1758Combined sources6
    Beta strandi1760 – 1763Combined sources4
    Beta strandi1765 – 1785Combined sources21
    Beta strandi1790 – 1793Combined sources4
    Helixi1795 – 1797Combined sources3
    Beta strandi1799 – 1807Combined sources9
    Beta strandi1810 – 1826Combined sources17
    Beta strandi1829 – 1834Combined sources6
    Beta strandi1836 – 1846Combined sources11
    Beta strandi1904 – 1911Combined sources8
    Helixi1912 – 1921Combined sources10
    Beta strandi1929 – 1936Combined sources8
    Beta strandi1942 – 1948Combined sources7
    Helixi1949 – 1951Combined sources3
    Helixi1954 – 1956Combined sources3
    Beta strandi1963 – 1966Combined sources4
    Beta strandi1969 – 1971Combined sources3
    Helixi1977 – 1990Combined sources14
    Helixi3251 – 3254Combined sources4
    Beta strandi3257 – 3262Combined sources6
    Beta strandi3265 – 3272Combined sources8
    Beta strandi3275 – 3279Combined sources5
    Helixi3280 – 3283Combined sources4
    Helixi3286 – 3290Combined sources5
    Helixi3294 – 3299Combined sources6
    Helixi3303 – 3305Combined sources3
    Beta strandi3307 – 3310Combined sources4
    Beta strandi3313 – 3315Combined sources3
    Beta strandi3317 – 3323Combined sources7
    Beta strandi3326 – 3333Combined sources8
    Beta strandi3340 – 3343Combined sources4
    Beta strandi3351 – 3358Combined sources8
    Beta strandi3361 – 3369Combined sources9
    Helixi3379 – 3381Combined sources3
    Beta strandi3388 – 3393Combined sources6
    Beta strandi3396 – 3406Combined sources11
    Turni3408 – 3410Combined sources3
    Beta strandi3412 – 3415Combined sources4
    Beta strandi3421 – 3424Combined sources4
    Beta strandi3427 – 3430Combined sources4
    Helixi3441 – 3453Combined sources13
    Turni3458 – 3460Combined sources3
    Helixi3467 – 3476Combined sources10
    Beta strandi3477 – 3479Combined sources3
    Helixi3484 – 3489Combined sources6
    Helixi3491 – 3497Combined sources7
    Helixi3501 – 3514Combined sources14
    Beta strandi3516 – 3518Combined sources3
    Beta strandi3521 – 3523Combined sources3
    Beta strandi3524 – 3526Combined sources3
    Helixi3533 – 3539Combined sources7
    Turni3540 – 3542Combined sources3
    Helixi3837 – 3855Combined sources19
    Helixi3862 – 3876Combined sources15
    Beta strandi3878 – 3880Combined sources3
    Helixi3881 – 3905Combined sources25
    Helixi3906 – 3909Combined sources4
    Turni3910 – 3912Combined sources3
    Helixi3913 – 3916Combined sources4
    Helixi3922 – 3924Combined sources3
    Helixi3929 – 3946Combined sources18
    Helixi3951 – 3956Combined sources6
    Turni3959 – 3963Combined sources5
    Turni3970 – 3972Combined sources3
    Helixi3973 – 3987Combined sources15
    Helixi3996 – 4017Combined sources22
    Helixi4020 – 4030Combined sources11
    Beta strandi4034 – 4037Combined sources4
    Beta strandi4046 – 4051Combined sources6
    Helixi4054 – 4060Combined sources7
    Beta strandi4065 – 4068Combined sources4
    Beta strandi4071 – 4079Combined sources9
    Helixi4088 – 4090Combined sources3
    Turni4093 – 4095Combined sources3
    Helixi4096 – 4098Combined sources3
    Beta strandi4103 – 4109Combined sources7
    Beta strandi4120 – 4125Combined sources6
    Beta strandi4127 – 4131Combined sources5
    Beta strandi4134 – 4137Combined sources4
    Beta strandi4145 – 4150Combined sources6
    Beta strandi4153 – 4155Combined sources3
    Beta strandi4157 – 4164Combined sources8
    Beta strandi4170 – 4174Combined sources5
    Beta strandi4181 – 4186Combined sources6
    Beta strandi4191 – 4194Combined sources4
    Beta strandi4201 – 4208Combined sources8
    Helixi4213 – 4222Combined sources10
    Helixi4224 – 4227Combined sources4
    Helixi4238 – 4240Combined sources3
    Helixi4243 – 4248Combined sources6
    Beta strandi4250 – 4252Combined sources3
    Helixi4253 – 4262Combined sources10
    Beta strandi4284 – 4288Combined sources5
    Beta strandi4295 – 4300Combined sources6
    Helixi4301 – 4303Combined sources3
    Helixi4305 – 4308Combined sources4
    Beta strandi4314 – 4318Combined sources5
    Beta strandi4325 – 4330Combined sources6
    Helixi4331 – 4333Combined sources3
    Helixi4337 – 4343Combined sources7
    Turni4348 – 4350Combined sources3
    Turni4354 – 4357Combined sources4
    Beta strandi5922 – 5924Combined sources3
    Beta strandi5928 – 5931Combined sources4
    Helixi5933 – 5935Combined sources3
    Beta strandi5955 – 5957Combined sources3
    Helixi5978 – 5983Combined sources6
    Beta strandi5986 – 5997Combined sources12
    Beta strandi6000 – 6002Combined sources3
    Beta strandi6006 – 6016Combined sources11
    Beta strandi6018 – 6020Combined sources3
    Beta strandi6024 – 6028Combined sources5
    Beta strandi6033 – 6037Combined sources5
    Helixi6046 – 6053Combined sources8
    Helixi6054 – 6057Combined sources4
    Helixi6061 – 6076Combined sources16
    Turni6077 – 6079Combined sources3
    Beta strandi6084 – 6089Combined sources6
    Helixi6091 – 6100Combined sources10
    Beta strandi6112 – 6115Combined sources4
    Beta strandi6118 – 6120Combined sources3
    Turni6121 – 6124Combined sources4
    Beta strandi6125 – 6127Combined sources3
    Turni6129 – 6131Combined sources3
    Beta strandi6137 – 6140Combined sources4
    Beta strandi6142 – 6145Combined sources4
    Helixi6146 – 6149Combined sources4
    Helixi6155 – 6162Combined sources8
    Beta strandi6164 – 6166Combined sources3
    Helixi6172 – 6188Combined sources17
    Helixi6204 – 6226Combined sources23
    Beta strandi6229 – 6235Combined sources7
    Beta strandi6242 – 6245Combined sources4
    Beta strandi6247 – 6256Combined sources10
    Beta strandi6263 – 6267Combined sources5
    Helixi6272 – 6275Combined sources4
    Turni6276 – 6278Combined sources3
    Beta strandi6281 – 6288Combined sources8
    Beta strandi6296 – 6303Combined sources8
    Beta strandi6312 – 6314Combined sources3
    Beta strandi6320 – 6322Combined sources3
    Beta strandi6324 – 6326Combined sources3
    Beta strandi6328 – 6330Combined sources3
    Helixi6335 – 6338Combined sources4
    Beta strandi6341 – 6343Combined sources3
    Beta strandi6373 – 6376Combined sources4
    Beta strandi6381 – 6383Combined sources3
    Helixi6387 – 6405Combined sources19
    Beta strandi6408 – 6412Combined sources5
    Helixi6419 – 6425Combined sources7
    Helixi6431 – 6441Combined sources11
    Beta strandi6453 – 6456Combined sources4
    Beta strandi6459 – 6464Combined sources6
    Beta strandi6467 – 6473Combined sources7
    Beta strandi6476 – 6478Combined sources3
    Helixi6480 – 6488Combined sources9
    Beta strandi6493 – 6495Combined sources3
    Helixi6498 – 6503Combined sources6
    Beta strandi6508 – 6513Combined sources6
    Turni6517 – 6520Combined sources4
    Beta strandi6521 – 6530Combined sources10
    Turni6532 – 6534Combined sources3
    Beta strandi6535 – 6539Combined sources5
    Helixi6543 – 6545Combined sources3
    Beta strandi6550 – 6553Combined sources4
    Helixi6559 – 6565Combined sources7
    Beta strandi6567 – 6575Combined sources9
    Beta strandi6589 – 6591Combined sources3
    Beta strandi6594 – 6596Combined sources3
    Beta strandi6599 – 6601Combined sources3
    Beta strandi6606 – 6611Combined sources6
    Beta strandi6614 – 6616Combined sources3
    Helixi6629 – 6631Combined sources3
    Helixi6637 – 6644Combined sources8
    Helixi6647 – 6653Combined sources7
    Helixi6661 – 6664Combined sources4
    Beta strandi6670 – 6673Combined sources4
    Beta strandi6677 – 6679Combined sources3
    Helixi6680 – 6689Combined sources10
    Beta strandi6692 – 6698Combined sources7
    Beta strandi6703 – 6711Combined sources9
    Turni6712 – 6714Combined sources3
    Beta strandi6717 – 6724Combined sources8
    Helixi6728 – 6736Combined sources9
    Beta strandi6741 – 6751Combined sources11
    Beta strandi6754 – 6763Combined sources10
    Beta strandi6766 – 6772Combined sources7
    Helixi6777 – 6780Combined sources4
    Beta strandi6781 – 6785Combined sources5
    Helixi6788 – 6791Combined sources4
    Helixi6817 – 6829Combined sources13
    Beta strandi6841 – 6846Combined sources6
    Helixi6855 – 6863Combined sources9
    Beta strandi6869 – 6876Combined sources8
    Beta strandi6881 – 6888Combined sources8
    Helixi6890 – 6892Combined sources3
    Beta strandi6893 – 6897Combined sources5
    Beta strandi6899 – 6904Combined sources6
    Helixi6924 – 6935Combined sources12
    Beta strandi6936 – 6946Combined sources11
    Beta strandi6948 – 6950Combined sources3
    Helixi6953 – 6959Combined sources7
    Beta strandi6962 – 6970Combined sources9
    Helixi6971 – 6973Combined sources3
    Beta strandi6979 – 6986Combined sources8
    Helixi6996 – 7009Combined sources14
    Helixi7017 – 7020Combined sources4
    Beta strandi7033 – 7035Combined sources3
    Helixi7039 – 7041Combined sources3
    Helixi7044 – 7051Combined sources8
    Beta strandi7055 – 7057Combined sources3
    Beta strandi7065 – 7067Combined sources3

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1O5Smodel-A4745-5301[»]
    1P76model-A3241-3541[»]
    B4225-4231[»]
    1P9Tmodel-A3241-3544[»]
    1PA5model-A3241-3546[»]
    1PUKmodel-A3241-3550[»]
    1Q1Xmodel-A3241-3542[»]
    1Q2WX-ray1.86A/B3241-3544[»]
    1QZ8X-ray2.70A/B4118-4230[»]
    1SXFmodel-A4765-5244[»]
    1UJ1X-ray1.90A/B3241-3546[»]
    1UK2X-ray2.20A/B3241-3546[»]
    1UK3X-ray2.40A/B3241-3546[»]
    1UK4X-ray2.50A/B3241-3546[»]
    1UW7X-ray2.80A4118-4230[»]
    1WOFX-ray2.00A/B3241-3546[»]
    1YSYNMR-A3837-3919[»]
    1Z1IX-ray2.80A3241-3546[»]
    1Z1JX-ray2.80A/B3241-3546[»]
    2A5AX-ray2.08A3241-3546[»]
    2A5IX-ray1.88A3241-3546[»]
    2A5KX-ray2.30A/B3241-3546[»]
    2ACFX-ray1.40A/B/C/D1002-1176[»]
    2AHMX-ray2.40A/B/C/D3837-3919[»]
    E/F/G/H3920-4117[»]
    2AJ5model-A3241-3546[»]
    2ALVX-ray1.90A3241-3543[»]
    2AMDX-ray1.85A/B3241-3546[»]
    2AMQX-ray2.30A/B3241-3546[»]
    2BX3X-ray2.00A3241-3546[»]
    2BX4X-ray2.79A3241-3546[»]
    2C3SX-ray1.90A3241-3546[»]
    2D2DX-ray2.70A/B3241-3546[»]
    2DUCX-ray1.70A/B3241-3546[»]
    2FAVX-ray1.80A/B/C1000-1173[»]
    2FE8X-ray1.85A/B/C1541-1854[»]
    2FYGX-ray1.80A4240-4362[»]
    2G1Fmodel-A/B5302-5877[»]
    2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4378[»]
    2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4378[»]
    2GDTNMR-A13-127[»]
    2GRINMR-A819-930[»]
    2GT7X-ray1.82A/B3241-3546[»]
    2GT8X-ray2.00A3241-3546[»]
    2GTBX-ray2.00A3241-3546[»]
    2GX4X-ray1.93A3241-3546[»]
    2GZ7X-ray1.86A3241-3546[»]
    2GZ8X-ray1.97A3241-3546[»]
    2GZ9X-ray2.17A3241-3546[»]
    2H2ZX-ray1.60A3241-3546[»]
    2H85X-ray2.60A6429-6774[»]
    2HOBX-ray1.95A3241-3546[»]
    2HSXNMR-A13-127[»]
    2IDYNMR-A819-930[»]
    2JZDNMR-A1345-1469[»]
    2JZENMR-A1345-1469[»]
    2JZFNMR-A1331-1469[»]
    2K87NMR-A1884-1998[»]
    2OP9X-ray1.80A/B3241-3541[»]
    2OZKX-ray2.90A/B/C/D6430-6775[»]
    2PWXX-ray2.50A3241-3546[»]
    2Q6GX-ray2.50A/B3241-3546[»]
    2QC2X-ray2.70A/B3241-3546[»]
    2QCYX-ray1.75A3241-3546[»]
    2QIQX-ray1.90A3242-3541[»]
    2RHBX-ray2.80A/B/C/D/E/F6430-6775[»]
    2RNKNMR-A1331-1469[»]
    2V6NX-ray1.98A3241-3546[»]
    2VJ1X-ray2.25A/B3242-3544[»]
    2XYQX-ray2.00A6776-7065[»]
    B4240-4361[»]
    2XYRX-ray2.50A6776-7067[»]
    B4240-4361[»]
    2XYVX-ray2.06A6776-7067[»]
    B4240-4361[»]
    2Z3CX-ray1.79A3241-3546[»]
    2Z3DX-ray2.10A3241-3546[»]
    2Z3EX-ray2.32A3241-3546[»]
    2Z94X-ray1.78A3241-3546[»]
    2Z9GX-ray1.86A3241-3546[»]
    2Z9JX-ray1.95A/B3241-3546[»]
    2Z9KX-ray1.85A/B3241-3546[»]
    2Z9LX-ray2.10A/B3241-3546[»]
    3D62X-ray2.70A3243-3541[»]
    3E9SX-ray2.50A1541-1855[»]
    3EBNX-ray2.40A/B/C/D3429-3546[»]
    3R24X-ray2.00A6776-7073[»]
    B4240-4382[»]
    4TWWX-ray2.42A/B3241-3546[»]
    4TWYX-ray1.60A3241-3546[»]
    4WY3X-ray1.89A3241-3546[»]
    4ZUHX-ray2.39C3235-3245[»]
    5B6OX-ray2.20A/B3241-3556[»]
    5C5NX-ray1.69A3241-3546[»]
    5C5OX-ray1.50A/B3241-3546[»]
    5C8SX-ray3.33A/C4231-4369[»]
    B/D5903-6429[»]
    5C8TX-ray3.20A/C4231-4369[»]
    B/D5903-6429[»]
    5C8UX-ray3.40A/C4231-4369[»]
    B/D5903-6429[»]
    5E6JX-ray2.85A/D1541-1856[»]
    5F22X-ray2.15B3989-4117[»]
    ProteinModelPortaliP0C6X7.
    SMRiP0C6X7.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0C6X7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini1003 – 1169MacroPROSITE-ProRule annotationAdd BLAST167
    Domaini1611 – 1875Peptidase C16PROSITE-ProRule annotationAdd BLAST265
    Domaini3241 – 3546Peptidase C30PROSITE-ProRule annotationAdd BLAST306
    Domaini4981 – 5143RdRp catalyticPROSITE-ProRule annotationAdd BLAST163
    Domaini5302 – 5385CV ZBDPROSITE-ProRule annotationAdd BLAST84
    Domaini5558 – 5739(+)RNA virus helicase ATP-bindingAdd BLAST182
    Domaini5740 – 5909(+)RNA virus helicase C-terminalAdd BLAST170

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni2092 – 2371HD1Add BLAST280
    Regioni2755 – 3162HD2Add BLAST408
    Regioni3564 – 3776HD3Add BLAST213

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi930 – 1001Glu-richAdd BLAST72
    Compositional biasi2210 – 2213Poly-Leu4
    Compositional biasi3766 – 3769Poly-Cys4

    Domaini

    The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

    Sequence similaritiesi

    Contains 1 CV ZBD (coronavirus zinc-binding) domain.PROSITE-ProRule annotation
    Contains 1 Macro domain.PROSITE-ProRule annotation
    Contains 1 peptidase C16 domain.PROSITE-ProRule annotation
    Contains 1 peptidase C30 domain.PROSITE-ProRule annotation
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
    Zinc fingeri4304 – 4320Add BLAST17
    Zinc fingeri4347 – 4360Add BLAST14

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix, Zinc-finger

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR027351. (+)RNA_virus_helicase_core_dom.
    IPR032505. Corona_NSP4_C.
    IPR009461. Coronavirus_NSP16.
    IPR027352. CV_MBD_dom.
    IPR002589. Macro_dom.
    IPR032592. NAR_dom.
    IPR021590. NSP1.
    IPR009466. NSP11.
    IPR024375. Nsp3_coronavir.
    IPR014828. NSP7.
    IPR014829. NSP8.
    IPR014822. NSP9.
    IPR027417. P-loop_NTPase.
    IPR008740. Peptidase_C30.
    IPR013016. Peptidase_C30/C16.
    IPR009003. Peptidase_S1_PA.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009469. RNA_pol_N_coronovir.
    IPR018995. RNA_synth_NSP10_coronavirus.
    IPR029063. SAM-dependent_MTases.
    IPR024358. SARS-CoV_Nsp3_N.
    IPR022733. SARS_polyprot_cleavage.
    IPR014827. Viral_protease.
    [Graphical view]
    PfamiPF16348. Corona_NSP4_C. 1 hit.
    PF06478. Corona_RPol_N. 1 hit.
    PF12379. DUF3655. 1 hit.
    PF01661. Macro. 1 hit.
    PF16251. NAR. 1 hit.
    PF11501. Nsp1. 1 hit.
    PF09401. NSP10. 1 hit.
    PF06471. NSP11. 1 hit.
    PF06460. NSP13. 1 hit.
    PF12124. Nsp3_PL2pro. 1 hit.
    PF08716. nsp7. 1 hit.
    PF08717. nsp8. 1 hit.
    PF08710. nsp9. 1 hit.
    PF05409. Peptidase_C30. 1 hit.
    PF11633. SUD-M. 1 hit.
    PF08715. Viral_protease. 1 hit.
    [Graphical view]
    SMARTiSM00506. A1pp. 1 hit.
    [Graphical view]
    SUPFAMiSSF101816. SSF101816. 1 hit.
    SSF144246. SSF144246. 1 hit.
    SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53335. SSF53335. 1 hit.
    PROSITEiPS51653. CV_ZBD. 1 hit.
    PS51442. M_PRO. 1 hit.
    PS51154. MACRO. 1 hit.
    PS51124. PEPTIDASE_C16. 1 hit.
    PS51657. PSRV_HELICASE. 1 hit.
    PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

    Isoform Replicase polyprotein 1ab (identifier: P0C6X7-1) [UniParc]FASTAAdd to basket
    Also known as: pp1ab

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT
    60 70 80 90 100
    CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS
    110 120 130 140 150
    GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGDELG
    160 170 180 190 200
    TDPIEDYEQN WNTKHGSGAL RELTRELNGG AVTRYVDNNF CGPDGYPLDC
    210 220 230 240 250
    IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW FTERSDKSYE
    260 270 280 290 300
    HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI
    310 320 330 340 350
    RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV
    360 370 380 390 400
    IEGPTTCGYL PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG
    410 420 430 440 450
    GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL
    460 470 480 490 500
    LEILSRERVN INIVGDFHLN EEVAIILASF SASTSAFIDT IKSLDYKSFK
    510 520 530 540 550
    TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA AGVIRSIFAR
    560 570 580 590 600
    TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY
    610 620 630 640 650
    VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK
    660 670 680 690 700
    FLITGVFDIV KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL
    710 720 730 740 750
    RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV
    760 770 780 790 800
    LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCVNGLML LEIKDKEQYC
    810 820 830 840 850
    ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV RITFELDERV
    860 870 880 890 900
    DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE
    910 920 930 940 950
    WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE
    960 970 980 990 1000
    YGTEDDYQGL PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE
    1010 1020 1030 1040 1050
    EPVNQFTGYL KLTDNVAIKC VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA
    1060 1070 1080 1090 1100
    GALNKATNGA MQKESDDYIK LNGPLTVGGS CLLSGHNLAK KCLHVVGPNL
    1110 1120 1130 1140 1150
    NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL QVCVQTVRTQ
    1160 1170 1180 1190 1200
    VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK
    1210 1220 1230 1240 1250
    PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE
    1260 1270 1280 1290 1300
    DMSFLEKDAP YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE
    1310 1320 1330 1340 1350
    YITTYPGQGC AGYTLEEAKT ALKKCKSAFY VLPSEAPNAK EEILGTVSWN
    1360 1370 1380 1390 1400
    LREMLAHAEE TRKLMPICMD VRAIMATIQR KYKGIKIQEG IVDYGVRFFF
    1410 1420 1430 1440 1450
    YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR CMRSLKAPAV
    1460 1470 1480 1490 1500
    VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG
    1510 1520 1530 1540 1550
    VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT
    1560 1570 1580 1590 1600
    VDNTNLHTQL VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS
    1610 1620 1630 1640 1650
    DDTLRSEAFE YYHTLDESFL GRYMSALNHT KKWKFPQVGG LTSIKWADNN
    1660 1670 1680 1690 1700
    CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR AGDAANFCAL ILAYSNKTVG
    1710 1720 1730 1740 1750
    ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT GVEAVMYMGT
    1760 1770 1780 1790 1800
    LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC
    1810 1820 1830 1840 1850
    ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY
    1860 1870 1880 1890 1900
    TTTIKPVSYK LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA
    1910 1920 1930 1940 1950
    SFDNFKLTCS NTKFADDLNQ MTGFTKPASR ELSVTFFPDL NGDVVAIDYR
    1960 1970 1980 1990 2000
    HYSASFKKGA KLLHKPIVWH INQATTKTTF KPNTWCLRCL WSTKPVDTSN
    2010 2020 2030 2040 2050
    SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE CDVKTTEVVG
    2060 2070 2080 2090 2100
    NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA
    2110 2120 2130 2140 2150
    THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF
    2160 2170 2180 2190 2200
    TLLFQLCTFT KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF
    2210 2220 2230 2240 2250
    SKLFTIAMWL LLLSICLGSL ICVTAAFGVL LSNFGAPSYC NGVRELYLNS
    2260 2270 2280 2290 2300
    SNVTTMDFCE GSFPCSICLS GLDSLDSYPA LETIQVTISS YKLDLTILGL
    2310 2320 2330 2340 2350
    AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW LMWFIISIVQ
    2360 2370 2380 2390 2400
    MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC
    2410 2420 2430 2440 2450
    TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL
    2460 2470 2480 2490 2500
    SLQFKRPINP TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN
    2510 2520 2530 2540 2550
    LDNLRANNTK GSLPINVIVF DGKSKCDESA SKSASVYYSQ LMCQPILLLD
    2560 2570 2580 2590 2600
    QALVSDVGDS TEVSVKMFDA YVDTFSATFS VPMEKLKALV ATAHSELAKG
    2610 2620 2630 2640 2650
    VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL EVTGDSCNNF
    2660 2670 2680 2690 2700
    MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE
    2710 2720 2730 2740 2750
    QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM
    2760 2770 2780 2790 2800
    LKATLLCVLA ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST
    2810 2820 2830 2840 2850
    DDCFANKHAG FDAWFSQRGG SYKNDKSCPV VAAIITREIG FIVPGLPGTV
    2860 2870 2880 2890 2900
    LRAINGDFLH FLPRVFSAVG NICYTPSKLI EYSDFATSAC VLAAECTIFK
    2910 2920 2930 2940 2950
    DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ FPNTYLEGSV
    2960 2970 2980 2990 3000
    RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA
    3010 3020 3030 3040 3050
    MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE
    3060 3070 3080 3090 3100
    YNHVVAANAL LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL
    3110 3120 3130 3140 3150
    AHLQWFAMFS PIVPFWITAI YVFCISLKHC HWFFNNYLRK RVMFNGVTFS
    3160 3170 3180 3190 3200
    TFEEAALCTF LLNKEMYLKL RSETLLPLTQ YNRYLALYNK YKYFSGALDT
    3210 3220 3230 3240 3250
    TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ SGFRKMAFPS
    3260 3270 3280 3290 3300
    GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR
    3310 3320 3330 3340 3350
    KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ
    3360 3370 3380 3390 3400
    TFSVLACYNG SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC
    3410 3420 3430 3440 3450
    YMHHMELPTG VHAGTDLEGK FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA
    3460 3470 3480 3490 3500
    AVINGDRWFL NRFTTTLNDF NLVAMKYNYE PLTQDHVDIL GPLSAQTGIA
    3510 3520 3530 3540 3550
    VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC SGVTFQGKFK
    3560 3570 3580 3590 3600
    KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA
    3610 3620 3630 3640 3650
    CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS
    3660 3670 3680 3690 3700
    LSGYRLKDCV MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY
    3710 3720 3730 3740 3750
    GNALDQAISM WALVISVTSN YSGVVTTIMF LARAIVFVCV EYYPLLFITG
    3760 3770 3780 3790 3800
    NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY FRLTLGVYDY LVSTQEFRYM
    3810 3820 3830 3840 3850
    NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS DVKCTSVVLL
    3860 3870 3880 3890 3900
    SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG
    3910 3920 3930 3940 3950
    AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS
    3960 3970 3980 3990 4000
    EVVLKKLKKS LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA
    4010 4020 4030 4040 4050
    KVTSAMQTML FTMLRKLDND ALNNIINNAR DGCVPLNIIP LTTAAKLMVV
    4060 4070 4080 4090 4100
    VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD ADSKIVQLSE INMDNSPNLA
    4110 4120 4130 4140 4150
    WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC TDDNALAYYN
    4160 4170 4180 4190 4200
    NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP
    4210 4220 4230 4240 4250
    KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA
    4260 4270 4280 4290 4300
    VDPAKAYKDY LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG
    4310 4320 4330 4340 4350
    ASCCLYCRCH IDHPNPKGFC DLKGKYVQIP TTCANDPVGF TLRNTVCTVC
    4360 4370 4380 4390 4400
    GMWKGYGCSC DQLREPLMQS ADASTFLNRV CGVSAARLTP CGTGTSTDVV
    4410 4420 4430 4440 4450
    YRAFDIYNEK VAGFAKFLKT NCCRFQEKDE EGNLLDSYFV VKRHTMSNYQ
    4460 4470 4480 4490 4500
    HEETIYNLVK DCPAVAVHDF FKFRVDGDMV PHISRQRLTK YTMADLVYAL
    4510 4520 4530 4540 4550
    RHFDEGNCDT LKEILVTYNC CDDDYFNKKD WYDFVENPDI LRVYANLGER
    4560 4570 4580 4590 4600
    VRQSLLKTVQ FCDAMRDAGI VGVLTLDNQD LNGNWYDFGD FVQVAPGCGV
    4610 4620 4630 4640 4650
    PIVDSYYSLL MPILTLTRAL AAESHMDADL AKPLIKWDLL KYDFTEERLC
    4660 4670 4680 4690 4700
    LFDRYFKYWD QTYHPNCINC LDDRCILHCA NFNVLFSTVF PPTSFGPLVR
    4710 4720 4730 4740 4750
    KIFVDGVPFV VSTGYHFREL GVVHNQDVNL HSSRLSFKEL LVYAADPAMH
    4760 4770 4780 4790 4800
    AASGNLLLDK RTTCFSVAAL TNNVAFQTVK PGNFNKDFYD FAVSKGFFKE
    4810 4820 4830 4840 4850
    GSSVELKHFF FAQDGNAAIS DYDYYRYNLP TMCDIRQLLF VVEVVDKYFD
    4860 4870 4880 4890 4900
    CYDGGCINAN QVIVNNLDKS AGFPFNKWGK ARLYYDSMSY EDQDALFAYT
    4910 4920 4930 4940 4950
    KRNVIPTITQ MNLKYAISAK NRARTVAGVS ICSTMTNRQF HQKLLKSIAA
    4960 4970 4980 4990 5000
    TRGATVVIGT SKFYGGWHNM LKTVYSDVET PHLMGWDYPK CDRAMPNMLR
    5010 5020 5030 5040 5050
    IMASLVLARK HNTCCNLSHR FYRLANECAQ VLSEMVMCGG SLYVKPGGTS
    5060 5070 5080 5090 5100
    SGDATTAYAN SVFNICQAVT ANVNALLSTD GNKIADKYVR NLQHRLYECL
    5110 5120 5130 5140 5150
    YRNRDVDHEF VDEFYAYLRK HFSMMILSDD AVVCYNSNYA AQGLVASIKN
    5160 5170 5180 5190 5200
    FKAVLYYQNN VFMSEAKCWT ETDLTKGPHE FCSQHTMLVK QGDDYVYLPY
    5210 5220 5230 5240 5250
    PDPSRILGAG CFVDDIVKTD GTLMIERFVS LAIDAYPLTK HPNQEYADVF
    5260 5270 5280 5290 5300
    HLYLQYIRKL HDELTGHMLD MYSVMLTNDN TSRYWEPEFY EAMYTPHTVL
    5310 5320 5330 5340 5350
    QAVGACVLCN SQTSLRCGAC IRRPFLCCKC CYDHVISTSH KLVLSVNPYV
    5360 5370 5380 5390 5400
    CNAPGCDVTD VTQLYLGGMS YYCKSHKPPI SFPLCANGQV FGLYKNTCVG
    5410 5420 5430 5440 5450
    SDNVTDFNAI ATCDWTNAGD YILANTCTER LKLFAAETLK ATEETFKLSY
    5460 5470 5480 5490 5500
    GIATVREVLS DRELHLSWEV GKPRPPLNRN YVFTGYRVTK NSKVQIGEYT
    5510 5520 5530 5540 5550
    FEKGDYGDAV VYRGTTTYKL NVGDYFVLTS HTVMPLSAPT LVPQEHYVRI
    5560 5570 5580 5590 5600
    TGLYPTLNIS DEFSSNVANY QKVGMQKYST LQGPPGTGKS HFAIGLALYY
    5610 5620 5630 5640 5650
    PSARIVYTAC SHAAVDALCE KALKYLPIDK CSRIIPARAR VECFDKFKVN
    5660 5670 5680 5690 5700
    STLEQYVFCT VNALPETTAD IVVFDEISMA TNYDLSVVNA RLRAKHYVYI
    5710 5720 5730 5740 5750
    GDPAQLPAPR TLLTKGTLEP EYFNSVCRLM KTIGPDMFLG TCRRCPAEIV
    5760 5770 5780 5790 5800
    DTVSALVYDN KLKAHKDKSA QCFKMFYKGV ITHDVSSAIN RPQIGVVREF
    5810 5820 5830 5840 5850
    LTRNPAWRKA VFISPYNSQN AVASKILGLP TQTVDSSQGS EYDYVIFTQT
    5860 5870 5880 5890 5900
    TETAHSCNVN RFNVAITRAK IGILCIMSDR DLYDKLQFTS LEIPRRNVAT
    5910 5920 5930 5940 5950
    LQAENVTGLF KDCSKIITGL HPTQAPTHLS VDIKFKTEGL CVDIPGIPKD
    5960 5970 5980 5990 6000
    MTYRRLISMM GFKMNYQVNG YPNMFITREE AIRHVRAWIG FDVEGCHATR
    6010 6020 6030 6040 6050
    DAVGTNLPLQ LGFSTGVNLV AVPTGYVDTE NNTEFTRVNA KPPPGDQFKH
    6060 6070 6080 6090 6100
    LIPLMYKGLP WNVVRIKIVQ MLSDTLKGLS DRVVFVLWAH GFELTSMKYF
    6110 6120 6130 6140 6150
    VKIGPERTCC LCDKRATCFS TSSDTYACWN HSVGFDYVYN PFMIDVQQWG
    6160 6170 6180 6190 6200
    FTGNLQSNHD QHCQVHGNAH VASCDAIMTR CLAVHECFVK RVDWSVEYPI
    6210 6220 6230 6240 6250
    IGDELRVNSA CRKVQHMVVK SALLADKFPV LHDIGNPKAI KCVPQAEVEW
    6260 6270 6280 6290 6300
    KFYDAQPCSD KAYKIEELFY SYATHHDKFT DGVCLFWNCN VDRYPANAIV
    6310 6320 6330 6340 6350
    CRFDTRVLSN LNLPGCDGGS LYVNKHAFHT PAFDKSAFTN LKQLPFFYYS
    6360 6370 6380 6390 6400
    DSPCESHGKQ VVSDIDYVPL KSATCITRCN LGGAVCRHHA NEYRQYLDAY
    6410 6420 6430 6440 6450
    NMMISAGFSL WIYKQFDTYN LWNTFTRLQS LENVAYNVVN KGHFDGHAGE
    6460 6470 6480 6490 6500
    APVSIINNAV YTKVDGIDVE IFENKTTLPV NVAFELWAKR NIKPVPEIKI
    6510 6520 6530 6540 6550
    LNNLGVDIAA NTVIWDYKRE APAHVSTIGV CTMTDIAKKP TESACSSLTV
    6560 6570 6580 6590 6600
    LFDGRVEGQV DLFRNARNGV LITEGSVKGL TPSKGPAQAS VNGVTLIGES
    6610 6620 6630 6640 6650
    VKTQFNYFKK VDGIIQQLPE TYFTQSRDLE DFKPRSQMET DFLELAMDEF
    6660 6670 6680 6690 6700
    IQRYKLEGYA FEHIVYGDFS HGQLGGLHLM IGLAKRSQDS PLKLEDFIPM
    6710 6720 6730 6740 6750
    DSTVKNYFIT DAQTGSSKCV CSVIDLLLDD FVEIIKSQDL SVISKVVKVT
    6760 6770 6780 6790 6800
    IDYAEISFML WCKDGHVETF YPKLQASQAW QPGVAMPNLY KMQRMLLEKC
    6810 6820 6830 6840 6850
    DLQNYGENAV IPKGIMMNVA KYTQLCQYLN TLTLAVPYNM RVIHFGAGSD
    6860 6870 6880 6890 6900
    KGVAPGTAVL RQWLPTGTLL VDSDLNDFVS DADSTLIGDC ATVHTANKWD
    6910 6920 6930 6940 6950
    LIISDMYDPR TKHVTKENDS KEGFFTYLCG FIKQKLALGG SIAVKITEHS
    6960 6970 6980 6990 7000
    WNADLYKLMG HFSWWTAFVT NVNASSSEAF LIGANYLGKP KEQIDGYTMH
    7010 7020 7030 7040 7050
    ANYIFWRNTN PIQLSSYSLF DMSKFPLKLR GTAVMSLKEN QINDMIYSLL
    7060 7070
    EKGRLIIREN NRVVVSSDIL VNN
    Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
    Length:7,073
    Mass (Da):790,248
    Last modified:June 10, 2008 - v1
    Checksum:iE6504CAFDC36BC09
    GO
    Isoform Replicase polyprotein 1a (identifier: P0C6U8-1) [UniParc]FASTAAdd to basket
    Also known as: pp1a, ORF1a polyprotein
    The sequence of this isoform can be found in the external entry P0C6U8.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Note: Produced by conventional translation.
    Length:4,382
    Mass (Da):486,373
    GO

    Sequence cautioni

    The sequence AAP13440 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAP41036 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAP82975 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAP97881 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAQ01596 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAQ01608 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural varianti82G → C in strain: Isolate GD01. 1
    Natural varianti130G → R in strain: Isolate GD01. 1
    Natural varianti138I → T in strain: Isolate SZ16. 1
    Natural varianti181A → V in strain: Isolate Shanghai LY. 1
    Natural varianti225K → Q in strain: Isolate GD01. 1
    Natural varianti249Y → C in strain: Isolate Shanghai LY. 1
    Natural varianti306V → F in strain: Isolate BJ04. 1
    Natural varianti549A → S in strain: Isolate SZ3. 1
    Natural varianti765A → T in strain: Isolate FRA and Isolate Frankfurt-1. 1
    Natural varianti852K → R in strain: Isolate SZ16. 1
    Natural varianti1004N → H in strain: Isolate BJ03. 1
    Natural varianti1021V → A in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1023I → T in strain: Isolate Shanghai QXC1. 1
    Natural varianti1121I → T in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1136P → L in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1257K → E in strain: Isolate Shanghai QXC1. 1
    Natural varianti1319K → R in strain: Isolate GD01. 1
    Natural varianti1329F → S in strain: Isolate GD01. 1
    Natural varianti1361T → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti1385I → V in strain: Isolate Shanghai QXC1. 1
    Natural varianti1538S → T in strain: Isolate GD01. 1
    Natural varianti1563M → K in strain: Isolate BJ02. 1
    Natural varianti1663L → I in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1762I → L in strain: Isolate BJ03. 1
    Natural varianti1776 – 1777QQ → PP in strain: Isolate BJ03. 2
    Natural varianti1790E → G in strain: Isolate Shanghai QXC1. 1
    Natural varianti1806G → V in strain: Isolate BJ02. 1
    Natural varianti1962L → I in strain: Isolate BJ04. 1
    Natural varianti2116L → F in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2222C → Y in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2269L → S in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2326V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti2392 – 2394RNR → CNH in strain: Isolate Shanghai QXC1. 3
    Natural varianti2480L → P in strain: Isolate Shanghai QXC1. 1
    Natural varianti2552A → V in strain: Isolate Urbani and Isolate Taiwan TC2. 1
    Natural varianti2556D → N in strain: Isolate HKU-39849. 1
    Natural varianti2564S → P in strain: Isolate GD01. 1
    Natural varianti2648N → Y in strain: Isolate Shanghai QXC1. 1
    Natural varianti2708S → T in strain: Isolate HKU-39849. 1
    Natural varianti2718R → T in strain: Isolate HKU-39849. 1
    Natural varianti2746C → W in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2770V → L in strain: Isolate BJ01 and Isolate BJ02. 1
    Natural varianti2944T → I in strain: Isolate SIN2500, Isolate GD01 and Isolate GZ50. 1
    Natural varianti2971V → A in strain: Isolate GD01 and Isolate SZ16. 1
    Natural varianti3020V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti3047V → A in strain: Isolate CUHK-W1, Isolate GD01, Isolate SZ3, Isolate SZ16, Isolate BJ01, Isolate BJ02, Isolate BJ03 and Isolate Shanghai QXC1. 1
    Natural varianti3072V → A in strain: Isolate CUHK-W1, Isolate SZ3, Isolate SZ16 and Isolate GD01. 1
    Natural varianti3197A → V in strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate Shanghai QXC1. 1
    Natural varianti3429Q → P in strain: Isolate BJ02. 1
    Natural varianti3488D → E in strain: Isolate BJ04. 1
    Natural varianti3717V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti3818N → T in strain: Isolate BJ04. 1
    Natural varianti3903D → N in strain: Isolate BJ03. 1
    Natural varianti3904I → F in strain: Isolate BJ02. 1
    Natural varianti3911M → V in strain: Isolate Shanghai QXC1. 1
    Natural varianti4001K → Q in strain: Isolate Shanghai LY. 1
    Natural varianti4003T → A in strain: Isolate Shanghai LY. 1
    Natural varianti4085I → H in strain: Isolate ZJ01. 1
    Natural varianti4114V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti4202V → M in strain: Isolate Shanghai QXC1. 1
    Natural varianti4240N → H in strain: Isolate ZJ01. 1
    Natural varianti4296E → G in strain: Isolate Shanghai QXC1. 1
    Natural varianti4377 – 4378LN → FK in strain: Isolate Shanghai QXC1. 2
    Natural varianti4411V → S in strain: Isolate HKU-39849. 1
    Natural varianti4459V → I in strain: Isolate Shanghai QXC1. 1
    Natural varianti4592V → E in strain: Isolate ZJ01. 1
    Natural varianti4910Q → L in strain: Isolate ZJ01. 1
    Natural varianti5112D → G in strain: Isolate SZ3. 1
    Natural varianti5131A → G in strain: Isolate Taiwan. 1
    Natural varianti5134 – 5135CY → VL in strain: Isolate Taiwan. 2
    Natural varianti5623L → S in strain: Isolate GD01. 1
    Natural varianti5720P → S in strain: Isolate GZ50 and Isolate SIN2500. 1
    Natural varianti5744R → C in strain: Isolate ZJ01. 1
    Natural varianti5767D → E in strain: Isolate CUHK-W1, Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04, Isolate SIN2500, Isolate GD01, Isolate GZ50, Isolate SZ3, Isolate SZ16 and Isolate Shanghai QXC1. 1
    Natural varianti6274T → I in strain: Isolate FRA, Isolate Frankfurt-1 Isolate SIN2677, Isolate SIN2679 and Isolate SIN2748. 1
    Natural varianti6474N → S in strain: Isolate Shanghai QXC1. 1
    Natural varianti6700M → I in strain: Isolate BJ03. 1
    Natural varianti6721C → R in strain: Isolate Shanghai QXC1. 1
    Natural varianti6729D → N in strain: Isolate GD01. 1
    Natural varianti6840M → L in strain: Isolate BJ02. 1
    Natural varianti6862Q → P in strain: Isolate BJ04. 1
    Natural varianti6877D → E in strain: Isolate GD01. 1
    Natural varianti6910R → K in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti6937A → P in strain: Isolate BJ03. 1
    Natural varianti6992E → D in strain: Isolate BJ04. 1
    Natural varianti7008N → K in strain: Isolate GD01. 1
    Natural varianti7024K → Q in strain: Isolate BJ04. 1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY278741 Genomic RNA. Translation: AAP13442.1.
    AY278741 Genomic RNA. Translation: AAP13440.1. Sequence problems.
    AY274119 Genomic RNA. Translation: AAP41036.1. Sequence problems.
    AY278554 Genomic RNA. Translation: AAP13566.1.
    AY282752 Genomic RNA. Translation: AAP30711.1.
    AY304495 Genomic RNA. No translation available.
    AY304486 Genomic RNA. No translation available.
    AY304488 Genomic RNA. No translation available.
    AY278491 Genomic RNA. No translation available.
    AY283794 Genomic RNA. No translation available.
    AY283795 Genomic RNA. No translation available.
    AY283796 Genomic RNA. No translation available.
    AY283797 Genomic RNA. No translation available.
    AY283798 Genomic RNA. No translation available.
    AY286320 Genomic RNA. Translation: AAP49011.4.
    AY278488 Genomic RNA. Translation: AAP30028.1.
    AY278489 Genomic RNA. Translation: AAP51225.1.
    AY278490 Genomic RNA. No translation available.
    AY279354 Genomic RNA. No translation available.
    AY291451 Genomic RNA. Translation: AAP37015.1.
    AY310120 Genomic RNA. Translation: AAP50483.1.
    AY291315 Genomic RNA. Translation: AAP33696.1.
    AY323977 Genomic RNA. Translation: AAP72973.2.
    AY321118 Genomic RNA. No translation available.
    AY338174 Genomic RNA. Translation: AAQ01594.1.
    AY338174 Genomic RNA. Translation: AAQ01596.1. Sequence problems.
    AY338175 Genomic RNA. Translation: AAQ01606.1.
    AY338175 Genomic RNA. Translation: AAQ01608.1. Sequence problems.
    AY348314 Genomic RNA. Translation: AAP97879.1.
    AY348314 Genomic RNA. Translation: AAP97881.1. Sequence problems.
    AP006557 Genomic RNA. Translation: BAC81346.1.
    AP006558 Genomic RNA. Translation: BAC81360.1.
    AP006559 Genomic RNA. Translation: BAC81374.1.
    AP006560 Genomic RNA. Translation: BAC81388.1.
    AP006561 Genomic RNA. Translation: BAC81402.1.
    AY427439 Genomic RNA. Translation: AAQ94058.1.
    AY322205 Genomic RNA. Translation: AAP82966.1.
    AY322206 Genomic RNA. Translation: AAP82975.1. Sequence problems.
    AY322207 Genomic RNA. Translation: AAP82967.1.
    AY463059 Genomic RNA. Translation: AAP82978.2.
    AY269391 Genomic RNA. Translation: AAP04003.1.
    AY268049 Genomic RNA. Translation: AAP04587.1.
    RefSeqiNP_828849.2. NC_004718.3. [P0C6X7-1]

    Genome annotation databases

    GeneIDi1489680.
    KEGGivg:1489680.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY278741 Genomic RNA. Translation: AAP13442.1.
    AY278741 Genomic RNA. Translation: AAP13440.1. Sequence problems.
    AY274119 Genomic RNA. Translation: AAP41036.1. Sequence problems.
    AY278554 Genomic RNA. Translation: AAP13566.1.
    AY282752 Genomic RNA. Translation: AAP30711.1.
    AY304495 Genomic RNA. No translation available.
    AY304486 Genomic RNA. No translation available.
    AY304488 Genomic RNA. No translation available.
    AY278491 Genomic RNA. No translation available.
    AY283794 Genomic RNA. No translation available.
    AY283795 Genomic RNA. No translation available.
    AY283796 Genomic RNA. No translation available.
    AY283797 Genomic RNA. No translation available.
    AY283798 Genomic RNA. No translation available.
    AY286320 Genomic RNA. Translation: AAP49011.4.
    AY278488 Genomic RNA. Translation: AAP30028.1.
    AY278489 Genomic RNA. Translation: AAP51225.1.
    AY278490 Genomic RNA. No translation available.
    AY279354 Genomic RNA. No translation available.
    AY291451 Genomic RNA. Translation: AAP37015.1.
    AY310120 Genomic RNA. Translation: AAP50483.1.
    AY291315 Genomic RNA. Translation: AAP33696.1.
    AY323977 Genomic RNA. Translation: AAP72973.2.
    AY321118 Genomic RNA. No translation available.
    AY338174 Genomic RNA. Translation: AAQ01594.1.
    AY338174 Genomic RNA. Translation: AAQ01596.1. Sequence problems.
    AY338175 Genomic RNA. Translation: AAQ01606.1.
    AY338175 Genomic RNA. Translation: AAQ01608.1. Sequence problems.
    AY348314 Genomic RNA. Translation: AAP97879.1.
    AY348314 Genomic RNA. Translation: AAP97881.1. Sequence problems.
    AP006557 Genomic RNA. Translation: BAC81346.1.
    AP006558 Genomic RNA. Translation: BAC81360.1.
    AP006559 Genomic RNA. Translation: BAC81374.1.
    AP006560 Genomic RNA. Translation: BAC81388.1.
    AP006561 Genomic RNA. Translation: BAC81402.1.
    AY427439 Genomic RNA. Translation: AAQ94058.1.
    AY322205 Genomic RNA. Translation: AAP82966.1.
    AY322206 Genomic RNA. Translation: AAP82975.1. Sequence problems.
    AY322207 Genomic RNA. Translation: AAP82967.1.
    AY463059 Genomic RNA. Translation: AAP82978.2.
    AY269391 Genomic RNA. Translation: AAP04003.1.
    AY268049 Genomic RNA. Translation: AAP04587.1.
    RefSeqiNP_828849.2. NC_004718.3. [P0C6X7-1]

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1O5Smodel-A4745-5301[»]
    1P76model-A3241-3541[»]
    B4225-4231[»]
    1P9Tmodel-A3241-3544[»]
    1PA5model-A3241-3546[»]
    1PUKmodel-A3241-3550[»]
    1Q1Xmodel-A3241-3542[»]
    1Q2WX-ray1.86A/B3241-3544[»]
    1QZ8X-ray2.70A/B4118-4230[»]
    1SXFmodel-A4765-5244[»]
    1UJ1X-ray1.90A/B3241-3546[»]
    1UK2X-ray2.20A/B3241-3546[»]
    1UK3X-ray2.40A/B3241-3546[»]
    1UK4X-ray2.50A/B3241-3546[»]
    1UW7X-ray2.80A4118-4230[»]
    1WOFX-ray2.00A/B3241-3546[»]
    1YSYNMR-A3837-3919[»]
    1Z1IX-ray2.80A3241-3546[»]
    1Z1JX-ray2.80A/B3241-3546[»]
    2A5AX-ray2.08A3241-3546[»]
    2A5IX-ray1.88A3241-3546[»]
    2A5KX-ray2.30A/B3241-3546[»]
    2ACFX-ray1.40A/B/C/D1002-1176[»]
    2AHMX-ray2.40A/B/C/D3837-3919[»]
    E/F/G/H3920-4117[»]
    2AJ5model-A3241-3546[»]
    2ALVX-ray1.90A3241-3543[»]
    2AMDX-ray1.85A/B3241-3546[»]
    2AMQX-ray2.30A/B3241-3546[»]
    2BX3X-ray2.00A3241-3546[»]
    2BX4X-ray2.79A3241-3546[»]
    2C3SX-ray1.90A3241-3546[»]
    2D2DX-ray2.70A/B3241-3546[»]
    2DUCX-ray1.70A/B3241-3546[»]
    2FAVX-ray1.80A/B/C1000-1173[»]
    2FE8X-ray1.85A/B/C1541-1854[»]
    2FYGX-ray1.80A4240-4362[»]
    2G1Fmodel-A/B5302-5877[»]
    2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4378[»]
    2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4378[»]
    2GDTNMR-A13-127[»]
    2GRINMR-A819-930[»]
    2GT7X-ray1.82A/B3241-3546[»]
    2GT8X-ray2.00A3241-3546[»]
    2GTBX-ray2.00A3241-3546[»]