Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0C6X7 (R1AB_CVHSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Replicase polyprotein 1ab

Short name=pp1ab
Alternative name(s):
ORF1ab polyprotein

Cleaved into the following 15 chains:

  1. Non-structural protein 1
    Short name=nsp1
    Alternative name(s):
    Leader protein
  2. Non-structural protein 2
    Short name=nsp2
    Alternative name(s):
    p65 homolog
  3. Non-structural protein 3
    Short name=nsp3
    EC=3.4.19.12
    EC=3.4.22.69
    Alternative name(s):
    PL2-PRO
    Papain-like proteinase
    Short name=PL-PRO
    SARS coronavirus main proteinase
  4. Non-structural protein 4
    Short name=nsp4
  5. 3C-like proteinase
    Short name=3CL-PRO
    Short name=3CLp
    EC=3.4.22.-
    Alternative name(s):
    nsp5
  6. Non-structural protein 6
    Short name=nsp6
  7. Non-structural protein 7
    Short name=nsp7
  8. Non-structural protein 8
    Short name=nsp8
  9. Non-structural protein 9
    Short name=nsp9
  10. Non-structural protein 10
    Short name=nsp10
    Alternative name(s):
    Growth factor-like peptide
    Short name=GFL
  11. RNA-directed RNA polymerase
    Short name=Pol
    Short name=RdRp
    EC=2.7.7.48
    Alternative name(s):
    nsp12
  12. Helicase
    Short name=Hel
    EC=3.6.4.12
    EC=3.6.4.13
    Alternative name(s):
    nsp13
  13. Exoribonuclease
    Short name=ExoN
    EC=3.1.13.-
    Alternative name(s):
    nsp14
  14. Uridylate-specific endoribonuclease
    EC=3.1.-.-
    Alternative name(s):
    NendoU
    nsp15
  15. Putative 2'-O-methyl transferase
    EC=2.1.1.-
    Alternative name(s):
    nsp16
Gene names
Name:rep
ORF Names:1a-1b
OrganismHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) [Reference proteome]
Taxonomic identifier227859 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]

Protein attributes

Sequence length7073 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products By similarity. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK By similarity. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

Nsp9 is a ssRNA-binding protein. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

Non-structural protein 1: binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response. Ref.30 Ref.31 Ref.32 Ref.34 Ref.35

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Ref.25

ATP + H2O = ADP + phosphate. Ref.25

TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. Ref.25

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.25

Subunit structure

3CL-PRO exists as monomer and homodimer. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer By similarity. Interacts (via N-terminus) with DDX1. Ref.25 Ref.33 Ref.40

Subcellular location

Non-structural protein 3: Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 4: Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 6: Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 7: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.

Non-structural protein 8: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.

Non-structural protein 9: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.

Non-structural protein 10: Host cytoplasmhost perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity.

Helicase: Host endoplasmic reticulum-Golgi intermediate compartment Potential. Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA By similarity.

Uridylate-specific endoribonuclease: Host cytoplasmhost perinuclear region By similarity.

Domain

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane. Ref.25

Post-translational modification

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed By similarity.

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Contains 1 (+)RNA virus helicase ATP-binding domain.

Contains 1 (+)RNA virus helicase C-terminal domain.

Contains 1 CV MBD (coronavirus metal-binding) domain.

Contains 1 Macro domain.

Contains 1 peptidase C16 domain.

Contains 1 peptidase C30 domain.

Contains 1 RdRp catalytic domain.

Caution

Isolates SZ3 and SZ16 have been isolated from Paguma larvata and are described as SARS-like in literature.

Biophysicochemical properties

Kinetic parameters:

The kinetic parameters are studied for the 3C-like proteinase domain. The cleavage takes place at the /.

KM=1.15 mM for peptide TSAVLQ/SGFRK-NH2 Ref.25

KM=0.58 mM for peptide SGVTFQ/GKFKK

KM=1.44 mM for peptide ATVRLQ/AGNAT

pH dependence:

Optimum pH is 7.0 for 3C-like proteinase activity.

Sequence caution

The sequence AAP13440.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAP41036.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAP82975.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAP97881.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAQ01596.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAQ01608.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processActivation of host autophagy by virus
Decay of host mRNAs by virus
Host gene expression shutoff by virus
Host mRNA suppression by virus
Host translation shutoff by virus
Host-virus interaction
Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Inhibition of host ISG15 by virus
Modulation of host ubiquitin pathway by viral deubiquitinase
Modulation of host ubiquitin pathway by virus
Ubl conjugation pathway
Viral immunoevasion
Viral RNA replication
   Cellular componentHost cytoplasm
Host membrane
Membrane
   Coding sequence diversityRibosomal frameshifting
   DomainRepeat
Transmembrane
Transmembrane helix
Zinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
RNA-binding
Zinc
   Molecular functionEndonuclease
Exonuclease
Helicase
Hydrolase
Nuclease
Nucleotidyltransferase
Protease
RNA-directed RNA polymerase
Thiol protease
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA phosphodiester bond hydrolysis, exonucleolytic

Inferred from direct assay Ref.28. Source: GOC

induction by virus of catabolism of host mRNA

Inferred from electronic annotation. Source: UniProtKB-KW

induction by virus of host autophagy

Inferred from electronic annotation. Source: UniProtKB-KW

modulation by virus of host protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host ISG15 activity

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host translation

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host type I interferon-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: InterPro

viral RNA genome replication

Inferred from electronic annotation. Source: InterPro

viral protein processing

Inferred from electronic annotation. Source: InterPro

viral transcription

Inferred from mutant phenotype Ref.28. Source: CACAO

   Cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_function3'-5'-exoribonuclease activity

Inferred from direct assay Ref.28. Source: CACAO

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

helicase activity

Inferred from electronic annotation. Source: UniProtKB-KW

methyltransferase activity

Inferred from electronic annotation. Source: InterPro

omega peptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform Replicase polyprotein 1ab (identifier: P0C6X7-1)

Also known as: pp1ab;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Isoform Replicase polyprotein 1a (identifier: P0C6U8-1)

Also known as: pp1a; ORF1a polyprotein;

The sequence of this isoform can be found in the external entry P0C6U8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by conventional translation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180Non-structural protein 1 By similarity
PRO_0000037309
Chain181 – 818638Non-structural protein 2 By similarity
PRO_0000037310
Chain819 – 27401922Non-structural protein 3 By similarity
PRO_0000037311
Chain2741 – 3240500Non-structural protein 4 Potential
PRO_0000283841
Chain3241 – 35463063C-like proteinase By similarity
PRO_0000037312
Chain3547 – 3836290Non-structural protein 6 By similarity
PRO_0000037313
Chain3837 – 391983Non-structural protein 7 By similarity
PRO_0000037314
Chain3920 – 4117198Non-structural protein 8 By similarity
PRO_0000037315
Chain4118 – 4230113Non-structural protein 9 By similarity
PRO_0000037316
Chain4231 – 4369139Non-structural protein 10 By similarity
PRO_0000037317
Chain4370 – 5301932RNA-directed RNA polymerase By similarity
PRO_0000037318
Chain5302 – 5902601Helicase By similarity
PRO_0000037319
Chain5903 – 6429527Exoribonuclease By similarity
PRO_0000037320
Chain6430 – 6775346Uridylate-specific endoribonuclease By similarity
PRO_0000037321
Chain6776 – 7073298Putative 2'-O-methyl transferase By similarity
PRO_0000037322

Regions

Transmembrane2092 – 211221Helical; Potential
Transmembrane2203 – 222321Helical; Potential
Transmembrane2304 – 232421Helical; Potential
Transmembrane2326 – 234621Helical; Potential
Transmembrane2351 – 237121Helical; Potential
Transmembrane2755 – 277521Helical; Potential
Transmembrane2830 – 285021Helical; Potential
Transmembrane2879 – 289921Helical; Potential
Transmembrane2992 – 301221Helical; Potential
Transmembrane3022 – 304221Helical; Potential
Transmembrane3054 – 307421Helical; Potential
Transmembrane3077 – 309721Helical; Potential
Transmembrane3105 – 312521Helical; Potential
Transmembrane3142 – 316221Helical; Potential
Transmembrane3564 – 358421Helical; Potential
Transmembrane3586 – 360621Helical; Potential
Transmembrane3612 – 363221Helical; Potential
Transmembrane3658 – 367821Helical; Potential
Transmembrane3707 – 372721Helical; Potential
Transmembrane3728 – 374821Helical; Potential
Transmembrane3756 – 377621Helical; Potential
Domain1003 – 1169167Macro
Domain1611 – 1875265Peptidase C16
Domain3241 – 3546306Peptidase C30
Domain4981 – 5143163RdRp catalytic
Domain5302 – 538584CV MBD
Domain5558 – 5739182(+)RNA virus helicase ATP-binding
Domain5740 – 5909170(+)RNA virus helicase C-terminal
Zinc finger1729 – 176638C4-type
Zinc finger4304 – 432017
Zinc finger4347 – 436014
Nucleotide binding5583 – 55908ATP By similarity
Region2092 – 2371280HD1
Region2755 – 3162408HD2
Region3564 – 3776213HD3
Compositional bias930 – 100172Glu-rich
Compositional bias2210 – 22134Poly-Leu
Compositional bias3766 – 37694Poly-Cys

Sites

Active site16511For PL-PRO activity By similarity
Active site18121For PL-PRO activity By similarity
Active site32811For 3CL-PRO activity By similarity
Active site33851For 3CL-PRO activity By similarity
Metal binding43041Zinc
Metal binding43071Zinc
Metal binding43131Zinc
Metal binding43201Zinc
Metal binding43471Zinc
Metal binding43501Zinc
Metal binding43581Zinc
Site180 – 1812Cleavage By similarity
Site818 – 8192Cleavage; by PL-PRO By similarity
Site2740 – 27412Cleavage; by PL-PRO By similarity
Site3240 – 32412Cleavage; by 3CL-PRO By similarity
Site3546 – 35472Cleavage; by 3CL-PRO By similarity
Site3836 – 38372Cleavage; by 3CL-PRO By similarity
Site3919 – 39202Cleavage; by 3CL-PRO By similarity
Site4117 – 41182Cleavage; by 3CL-PRO By similarity
Site4230 – 42312Cleavage; by 3CL-PRO By similarity
Site4369 – 43702Cleavage; by 3CL-PRO By similarity
Site5301 – 53022Cleavage; by 3CL-PRO By similarity
Site5902 – 59032Cleavage; by 3CL-PRO By similarity
Site6429 – 64302Cleavage; by 3CL-PRO By similarity
Site6775 – 67762Cleavage; by 3CL-PRO By similarity

Natural variations

Natural variant821G → C in strain: Isolate GD01.
Natural variant1301G → R in strain: Isolate GD01.
Natural variant1381I → T in strain: Isolate SZ16.
Natural variant1811A → V in strain: Isolate Shanghai LY.
Natural variant2251K → Q in strain: Isolate GD01.
Natural variant2491Y → C in strain: Isolate Shanghai LY.
Natural variant3061V → F in strain: Isolate BJ04.
Natural variant5491A → S in strain: Isolate SZ3.
Natural variant7651A → T in strain: Isolate FRA and Isolate Frankfurt-1.
Natural variant8521K → R in strain: Isolate SZ16.
Natural variant10041N → H in strain: Isolate BJ03.
Natural variant10211V → A in strain: Isolate SZ3 and Isolate SZ16.
Natural variant10231I → T in strain: Isolate Shanghai QXC1.
Natural variant11211I → T in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16.
Natural variant11361P → L in strain: Isolate SZ3 and Isolate SZ16.
Natural variant12571K → E in strain: Isolate Shanghai QXC1.
Natural variant13191K → R in strain: Isolate GD01.
Natural variant13291F → S in strain: Isolate GD01.
Natural variant13611T → A in strain: Isolate Shanghai QXC1.
Natural variant13851I → V in strain: Isolate Shanghai QXC1.
Natural variant15381S → T in strain: Isolate GD01.
Natural variant15631M → K in strain: Isolate BJ02.
Natural variant16631L → I in strain: Isolate SZ3 and Isolate SZ16.
Natural variant17621I → L in strain: Isolate BJ03.
Natural variant1776 – 17772QQ → PP in strain: Isolate BJ03.
Natural variant17901E → G in strain: Isolate Shanghai QXC1.
Natural variant18061G → V in strain: Isolate BJ02.
Natural variant19621L → I in strain: Isolate BJ04.
Natural variant21161L → F in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16.
Natural variant22221C → Y in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16.
Natural variant22691L → S in strain: Isolate SZ3 and Isolate SZ16.
Natural variant23261V → A in strain: Isolate Shanghai QXC1.
Natural variant2392 – 23943RNR → CNH in strain: Isolate Shanghai QXC1.
Natural variant24801L → P in strain: Isolate Shanghai QXC1.
Natural variant25521A → V in strain: Isolate Urbani and Isolate Taiwan TC2.
Natural variant25561D → N in strain: Isolate HKU-39849.
Natural variant25641S → P in strain: Isolate GD01.
Natural variant26481N → Y in strain: Isolate Shanghai QXC1.
Natural variant27081S → T in strain: Isolate HKU-39849.
Natural variant27181R → T in strain: Isolate HKU-39849.
Natural variant27461C → W in strain: Isolate SZ3 and Isolate SZ16.
Natural variant27701V → L in strain: Isolate BJ01 and Isolate BJ02.
Natural variant29441T → I in strain: Isolate SIN2500, Isolate GD01 and Isolate GZ50.
Natural variant29711V → A in strain: Isolate GD01 and Isolate SZ16.
Natural variant30201V → A in strain: Isolate Shanghai QXC1.
Natural variant30471V → A in strain: Isolate CUHK-W1, Isolate GD01, Isolate SZ3, Isolate SZ16, Isolate BJ01, Isolate BJ02, Isolate BJ03 and Isolate Shanghai QXC1.
Natural variant30721V → A in strain: Isolate CUHK-W1, Isolate SZ3, Isolate SZ16 and Isolate GD01.
Natural variant31971A → V in strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate Shanghai QXC1.
Natural variant34291Q → P in strain: Isolate BJ02.
Natural variant34881D → E in strain: Isolate BJ04.
Natural variant37171V → A in strain: Isolate Shanghai QXC1.
Natural variant38181N → T in strain: Isolate BJ04.
Natural variant39031D → N in strain: Isolate BJ03.
Natural variant39041I → F in strain: Isolate BJ02.
Natural variant39111M → V in strain: Isolate Shanghai QXC1.
Natural variant40011K → Q in strain: Isolate Shanghai LY.
Natural variant40031T → A in strain: Isolate Shanghai LY.
Natural variant40851I → H in strain: Isolate ZJ01.
Natural variant41141V → A in strain: Isolate Shanghai QXC1.
Natural variant42021V → M in strain: Isolate Shanghai QXC1.
Natural variant42401N → H in strain: Isolate ZJ01.
Natural variant42961E → G in strain: Isolate Shanghai QXC1.
Natural variant4377 – 43782LN → FK in strain: Isolate Shanghai QXC1.
Natural variant44111V → S in strain: Isolate HKU-39849.
Natural variant44591V → I in strain: Isolate Shanghai QXC1.
Natural variant45921V → E in strain: Isolate ZJ01.
Natural variant49101Q → L in strain: Isolate ZJ01.
Natural variant51121D → G in strain: Isolate SZ3.
Natural variant51311A → G in strain: Isolate Taiwan.
Natural variant5134 – 51352CY → VL in strain: Isolate Taiwan.
Natural variant56231L → S in strain: Isolate GD01.
Natural variant57201P → S in strain: Isolate GZ50 and Isolate SIN2500.
Natural variant57441R → C in strain: Isolate ZJ01.
Natural variant57671D → E in strain: Isolate CUHK-W1, Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04, Isolate SIN2500, Isolate GD01, Isolate GZ50, Isolate SZ3, Isolate SZ16 and Isolate Shanghai QXC1.
Natural variant62741T → I in strain: Isolate FRA, Isolate Frankfurt-1 Isolate SIN2677, Isolate SIN2679 and Isolate SIN2748.
Natural variant64741N → S in strain: Isolate Shanghai QXC1.
Natural variant67001M → I in strain: Isolate BJ03.
Natural variant67211C → R in strain: Isolate Shanghai QXC1.
Natural variant67291D → N in strain: Isolate GD01.
Natural variant68401M → L in strain: Isolate BJ02.
Natural variant68621Q → P in strain: Isolate BJ04.
Natural variant68771D → E in strain: Isolate GD01.
Natural variant69101R → K in strain: Isolate SZ3 and Isolate SZ16.
Natural variant69371A → P in strain: Isolate BJ03.
Natural variant69921E → D in strain: Isolate BJ04.
Natural variant70081N → K in strain: Isolate GD01.
Natural variant70241K → Q in strain: Isolate BJ04.

Secondary structure

............................................................................................................................................................................................................................................................................................................................................................................................................................................ 7073
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Replicase polyprotein 1ab (pp1ab) [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: E6504CAFDC36BC09

FASTA7,073790,248
        10         20         30         40         50         60 
MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT CGLVELEKGV 

        70         80         90        100        110        120 
LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS GITLGVLVPH VGETPIAYRN 

       130        140        150        160        170        180 
VLLRKNGNKG AGGHSYGIDL KSYDLGDELG TDPIEDYEQN WNTKHGSGAL RELTRELNGG 

       190        200        210        220        230        240 
AVTRYVDNNF CGPDGYPLDC IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW 

       250        260        270        280        290        300 
FTERSDKSYE HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 

       310        320        330        340        350        360 
RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV IEGPTTCGYL 

       370        380        390        400        410        420 
PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG GRTRCFGGCV FAYVGCYNKR 

       430        440        450        460        470        480 
AYWVPRASAD IGSGHTGITG DNVETLNEDL LEILSRERVN INIVGDFHLN EEVAIILASF 

       490        500        510        520        530        540 
SASTSAFIDT IKSLDYKSFK TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA 

       550        560        570        580        590        600 
AGVIRSIFAR TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY 

       610        620        630        640        650        660 
VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK FLITGVFDIV 

       670        680        690        700        710        720 
KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL RSLNLGEVFI AQSKGLYRQC 

       730        740        750        760        770        780 
IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV LTSEEVVLKN GELEALETPV DSFTNGAIVG 

       790        800        810        820        830        840 
TPVCVNGLML LEIKDKEQYC ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV 

       850        860        870        880        890        900 
RITFELDERV DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE 

       910        920        930        940        950        960 
WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE YGTEDDYQGL 

       970        980        990       1000       1010       1020 
PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE EPVNQFTGYL KLTDNVAIKC 

      1030       1040       1050       1060       1070       1080 
VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA GALNKATNGA MQKESDDYIK LNGPLTVGGS 

      1090       1100       1110       1120       1130       1140 
CLLSGHNLAK KCLHVVGPNL NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL 

      1150       1160       1170       1180       1190       1200 
QVCVQTVRTQ VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK 

      1210       1220       1230       1240       1250       1260 
PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE DMSFLEKDAP 

      1270       1280       1290       1300       1310       1320 
YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE YITTYPGQGC AGYTLEEAKT 

      1330       1340       1350       1360       1370       1380 
ALKKCKSAFY VLPSEAPNAK EEILGTVSWN LREMLAHAEE TRKLMPICMD VRAIMATIQR 

      1390       1400       1410       1420       1430       1440 
KYKGIKIQEG IVDYGVRFFF YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR 

      1450       1460       1470       1480       1490       1500 
CMRSLKAPAV VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG 

      1510       1520       1530       1540       1550       1560 
VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT VDNTNLHTQL 

      1570       1580       1590       1600       1610       1620 
VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS DDTLRSEAFE YYHTLDESFL 

      1630       1640       1650       1660       1670       1680 
GRYMSALNHT KKWKFPQVGG LTSIKWADNN CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR 

      1690       1700       1710       1720       1730       1740 
AGDAANFCAL ILAYSNKTVG ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT 

      1750       1760       1770       1780       1790       1800 
GVEAVMYMGT LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC 

      1810       1820       1830       1840       1850       1860 
ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY TTTIKPVSYK 

      1870       1880       1890       1900       1910       1920 
LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA SFDNFKLTCS NTKFADDLNQ 

      1930       1940       1950       1960       1970       1980 
MTGFTKPASR ELSVTFFPDL NGDVVAIDYR HYSASFKKGA KLLHKPIVWH INQATTKTTF 

      1990       2000       2010       2020       2030       2040 
KPNTWCLRCL WSTKPVDTSN SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE 

      2050       2060       2070       2080       2090       2100 
CDVKTTEVVG NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA 

      2110       2120       2130       2140       2150       2160 
THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF TLLFQLCTFT 

      2170       2180       2190       2200       2210       2220 
KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF SKLFTIAMWL LLLSICLGSL 

      2230       2240       2250       2260       2270       2280 
ICVTAAFGVL LSNFGAPSYC NGVRELYLNS SNVTTMDFCE GSFPCSICLS GLDSLDSYPA 

      2290       2300       2310       2320       2330       2340 
LETIQVTISS YKLDLTILGL AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW 

      2350       2360       2370       2380       2390       2400 
LMWFIISIVQ MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC 

      2410       2420       2430       2440       2450       2460 
TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL SLQFKRPINP 

      2470       2480       2490       2500       2510       2520 
TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN LDNLRANNTK GSLPINVIVF 

      2530       2540       2550       2560       2570       2580 
DGKSKCDESA SKSASVYYSQ LMCQPILLLD QALVSDVGDS TEVSVKMFDA YVDTFSATFS 

      2590       2600       2610       2620       2630       2640 
VPMEKLKALV ATAHSELAKG VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL 

      2650       2660       2670       2680       2690       2700 
EVTGDSCNNF MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE 

      2710       2720       2730       2740       2750       2760 
QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM LKATLLCVLA 

      2770       2780       2790       2800       2810       2820 
ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST DDCFANKHAG FDAWFSQRGG 

      2830       2840       2850       2860       2870       2880 
SYKNDKSCPV VAAIITREIG FIVPGLPGTV LRAINGDFLH FLPRVFSAVG NICYTPSKLI 

      2890       2900       2910       2920       2930       2940 
EYSDFATSAC VLAAECTIFK DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ 

      2950       2960       2970       2980       2990       3000 
FPNTYLEGSV RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA 

      3010       3020       3030       3040       3050       3060 
MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE YNHVVAANAL 

      3070       3080       3090       3100       3110       3120 
LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL AHLQWFAMFS PIVPFWITAI 

      3130       3140       3150       3160       3170       3180 
YVFCISLKHC HWFFNNYLRK RVMFNGVTFS TFEEAALCTF LLNKEMYLKL RSETLLPLTQ 

      3190       3200       3210       3220       3230       3240 
YNRYLALYNK YKYFSGALDT TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ 

      3250       3260       3270       3280       3290       3300 
SGFRKMAFPS GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR 

      3310       3320       3330       3340       3350       3360 
KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ TFSVLACYNG 

      3370       3380       3390       3400       3410       3420 
SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC YMHHMELPTG VHAGTDLEGK 

      3430       3440       3450       3460       3470       3480 
FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA AVINGDRWFL NRFTTTLNDF NLVAMKYNYE 

      3490       3500       3510       3520       3530       3540 
PLTQDHVDIL GPLSAQTGIA VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC 

      3550       3560       3570       3580       3590       3600 
SGVTFQGKFK KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA 

      3610       3620       3630       3640       3650       3660 
CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS LSGYRLKDCV 

      3670       3680       3690       3700       3710       3720 
MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY GNALDQAISM WALVISVTSN 

      3730       3740       3750       3760       3770       3780 
YSGVVTTIMF LARAIVFVCV EYYPLLFITG NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY 

      3790       3800       3810       3820       3830       3840 
FRLTLGVYDY LVSTQEFRYM NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS 

      3850       3860       3870       3880       3890       3900 
DVKCTSVVLL SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG 

      3910       3920       3930       3940       3950       3960 
AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS EVVLKKLKKS 

      3970       3980       3990       4000       4010       4020 
LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA KVTSAMQTML FTMLRKLDND 

      4030       4040       4050       4060       4070       4080 
ALNNIINNAR DGCVPLNIIP LTTAAKLMVV VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD 

      4090       4100       4110       4120       4130       4140 
ADSKIVQLSE INMDNSPNLA WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC 

      4150       4160       4170       4180       4190       4200 
TDDNALAYYN NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP 

      4210       4220       4230       4240       4250       4260 
KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA VDPAKAYKDY 

      4270       4280       4290       4300       4310       4320 
LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG ASCCLYCRCH IDHPNPKGFC 

      4330       4340       4350       4360       4370       4380 
DLKGKYVQIP TTCANDPVGF TLRNTVCTVC GMWKGYGCSC DQLREPLMQS ADASTFLNRV 

      4390       4400       4410       4420       4430       4440 
CGVSAARLTP CGTGTSTDVV YRAFDIYNEK VAGFAKFLKT NCCRFQEKDE EGNLLDSYFV 

      4450       4460       4470       4480       4490       4500 
VKRHTMSNYQ HEETIYNLVK DCPAVAVHDF FKFRVDGDMV PHISRQRLTK YTMADLVYAL 

      4510       4520       4530       4540       4550       4560 
RHFDEGNCDT LKEILVTYNC CDDDYFNKKD WYDFVENPDI LRVYANLGER VRQSLLKTVQ 

      4570       4580       4590       4600       4610       4620 
FCDAMRDAGI VGVLTLDNQD LNGNWYDFGD FVQVAPGCGV PIVDSYYSLL MPILTLTRAL 

      4630       4640       4650       4660       4670       4680 
AAESHMDADL AKPLIKWDLL KYDFTEERLC LFDRYFKYWD QTYHPNCINC LDDRCILHCA 

      4690       4700       4710       4720       4730       4740 
NFNVLFSTVF PPTSFGPLVR KIFVDGVPFV VSTGYHFREL GVVHNQDVNL HSSRLSFKEL 

      4750       4760       4770       4780       4790       4800 
LVYAADPAMH AASGNLLLDK RTTCFSVAAL TNNVAFQTVK PGNFNKDFYD FAVSKGFFKE 

      4810       4820       4830       4840       4850       4860 
GSSVELKHFF FAQDGNAAIS DYDYYRYNLP TMCDIRQLLF VVEVVDKYFD CYDGGCINAN 

      4870       4880       4890       4900       4910       4920 
QVIVNNLDKS AGFPFNKWGK ARLYYDSMSY EDQDALFAYT KRNVIPTITQ MNLKYAISAK 

      4930       4940       4950       4960       4970       4980 
NRARTVAGVS ICSTMTNRQF HQKLLKSIAA TRGATVVIGT SKFYGGWHNM LKTVYSDVET 

      4990       5000       5010       5020       5030       5040 
PHLMGWDYPK CDRAMPNMLR IMASLVLARK HNTCCNLSHR FYRLANECAQ VLSEMVMCGG 

      5050       5060       5070       5080       5090       5100 
SLYVKPGGTS SGDATTAYAN SVFNICQAVT ANVNALLSTD GNKIADKYVR NLQHRLYECL 

      5110       5120       5130       5140       5150       5160 
YRNRDVDHEF VDEFYAYLRK HFSMMILSDD AVVCYNSNYA AQGLVASIKN FKAVLYYQNN 

      5170       5180       5190       5200       5210       5220 
VFMSEAKCWT ETDLTKGPHE FCSQHTMLVK QGDDYVYLPY PDPSRILGAG CFVDDIVKTD 

      5230       5240       5250       5260       5270       5280 
GTLMIERFVS LAIDAYPLTK HPNQEYADVF HLYLQYIRKL HDELTGHMLD MYSVMLTNDN 

      5290       5300       5310       5320       5330       5340 
TSRYWEPEFY EAMYTPHTVL QAVGACVLCN SQTSLRCGAC IRRPFLCCKC CYDHVISTSH 

      5350       5360       5370       5380       5390       5400 
KLVLSVNPYV CNAPGCDVTD VTQLYLGGMS YYCKSHKPPI SFPLCANGQV FGLYKNTCVG 

      5410       5420       5430       5440       5450       5460 
SDNVTDFNAI ATCDWTNAGD YILANTCTER LKLFAAETLK ATEETFKLSY GIATVREVLS 

      5470       5480       5490       5500       5510       5520 
DRELHLSWEV GKPRPPLNRN YVFTGYRVTK NSKVQIGEYT FEKGDYGDAV VYRGTTTYKL 

      5530       5540       5550       5560       5570       5580 
NVGDYFVLTS HTVMPLSAPT LVPQEHYVRI TGLYPTLNIS DEFSSNVANY QKVGMQKYST 

      5590       5600       5610       5620       5630       5640 
LQGPPGTGKS HFAIGLALYY PSARIVYTAC SHAAVDALCE KALKYLPIDK CSRIIPARAR 

      5650       5660       5670       5680       5690       5700 
VECFDKFKVN STLEQYVFCT VNALPETTAD IVVFDEISMA TNYDLSVVNA RLRAKHYVYI 

      5710       5720       5730       5740       5750       5760 
GDPAQLPAPR TLLTKGTLEP EYFNSVCRLM KTIGPDMFLG TCRRCPAEIV DTVSALVYDN 

      5770       5780       5790       5800       5810       5820 
KLKAHKDKSA QCFKMFYKGV ITHDVSSAIN RPQIGVVREF LTRNPAWRKA VFISPYNSQN 

      5830       5840       5850       5860       5870       5880 
AVASKILGLP TQTVDSSQGS EYDYVIFTQT TETAHSCNVN RFNVAITRAK IGILCIMSDR 

      5890       5900       5910       5920       5930       5940 
DLYDKLQFTS LEIPRRNVAT LQAENVTGLF KDCSKIITGL HPTQAPTHLS VDIKFKTEGL 

      5950       5960       5970       5980       5990       6000 
CVDIPGIPKD MTYRRLISMM GFKMNYQVNG YPNMFITREE AIRHVRAWIG FDVEGCHATR 

      6010       6020       6030       6040       6050       6060 
DAVGTNLPLQ LGFSTGVNLV AVPTGYVDTE NNTEFTRVNA KPPPGDQFKH LIPLMYKGLP 

      6070       6080       6090       6100       6110       6120 
WNVVRIKIVQ MLSDTLKGLS DRVVFVLWAH GFELTSMKYF VKIGPERTCC LCDKRATCFS 

      6130       6140       6150       6160       6170       6180 
TSSDTYACWN HSVGFDYVYN PFMIDVQQWG FTGNLQSNHD QHCQVHGNAH VASCDAIMTR 

      6190       6200       6210       6220       6230       6240 
CLAVHECFVK RVDWSVEYPI IGDELRVNSA CRKVQHMVVK SALLADKFPV LHDIGNPKAI 

      6250       6260       6270       6280       6290       6300 
KCVPQAEVEW KFYDAQPCSD KAYKIEELFY SYATHHDKFT DGVCLFWNCN VDRYPANAIV 

      6310       6320       6330       6340       6350       6360 
CRFDTRVLSN LNLPGCDGGS LYVNKHAFHT PAFDKSAFTN LKQLPFFYYS DSPCESHGKQ 

      6370       6380       6390       6400       6410       6420 
VVSDIDYVPL KSATCITRCN LGGAVCRHHA NEYRQYLDAY NMMISAGFSL WIYKQFDTYN 

      6430       6440       6450       6460       6470       6480 
LWNTFTRLQS LENVAYNVVN KGHFDGHAGE APVSIINNAV YTKVDGIDVE IFENKTTLPV 

      6490       6500       6510       6520       6530       6540 
NVAFELWAKR NIKPVPEIKI LNNLGVDIAA NTVIWDYKRE APAHVSTIGV CTMTDIAKKP 

      6550       6560       6570       6580       6590       6600 
TESACSSLTV LFDGRVEGQV DLFRNARNGV LITEGSVKGL TPSKGPAQAS VNGVTLIGES 

      6610       6620       6630       6640       6650       6660 
VKTQFNYFKK VDGIIQQLPE TYFTQSRDLE DFKPRSQMET DFLELAMDEF IQRYKLEGYA 

      6670       6680       6690       6700       6710       6720 
FEHIVYGDFS HGQLGGLHLM IGLAKRSQDS PLKLEDFIPM DSTVKNYFIT DAQTGSSKCV 

      6730       6740       6750       6760       6770       6780 
CSVIDLLLDD FVEIIKSQDL SVISKVVKVT IDYAEISFML WCKDGHVETF YPKLQASQAW 

      6790       6800       6810       6820       6830       6840 
QPGVAMPNLY KMQRMLLEKC DLQNYGENAV IPKGIMMNVA KYTQLCQYLN TLTLAVPYNM 

      6850       6860       6870       6880       6890       6900 
RVIHFGAGSD KGVAPGTAVL RQWLPTGTLL VDSDLNDFVS DADSTLIGDC ATVHTANKWD 

      6910       6920       6930       6940       6950       6960 
LIISDMYDPR TKHVTKENDS KEGFFTYLCG FIKQKLALGG SIAVKITEHS WNADLYKLMG 

      6970       6980       6990       7000       7010       7020 
HFSWWTAFVT NVNASSSEAF LIGANYLGKP KEQIDGYTMH ANYIFWRNTN PIQLSSYSLF 

      7030       7040       7050       7060       7070 
DMSKFPLKLR GTAVMSLKEN QINDMIYSLL EKGRLIIREN NRVVVSSDIL VNN 

« Hide

Isoform Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [UniParc].

See P0C6U8.

References

[1]"Characterization of a novel coronavirus associated with severe acute respiratory syndrome."
Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R., Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D. expand/collapse author list , Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R., Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J.
Science 300:1394-1399(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Urbani.
[2]"The genome sequence of the SARS-associated coronavirus."
Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H. expand/collapse author list , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
Science 300:1399-1404(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Tor2.
[3]"Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
N. Engl. J. Med. 349:187-188(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
[4]"Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China."
Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L., Luo S.W., Li P.H., Zhang L.J., Guan Y.J., Butt K.M., Wong K.L., Chan K.W., Lim W., Shortridge K.F., Yuen K.Y., Peiris J.S.M., Poon L.L.M.
Science 302:276-278(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate GZ50, Isolate SZ16 and Isolate SZ3.
[5]"The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
Exp. Biol. Med. 228:866-873(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HKU-39849.
[6]"Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection."
Ruan Y., Wei C.L., Ling A.E., Vega V.B., Thoreau H., Se Thoe S.Y., Chia J.-M., Ng P., Chiu K.P., Lim L., Zhang T., Chan K.P., Oon L.E.L., Ng M.L., Leo S.Y., Ng L.F.P., Ren E.C., Stanton L.W., Long P.M., Liu E.T.
Lancet 361:1779-1785(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Sin2500, Isolate Sin2677, Isolate Sin2679, Isolate Sin2748 and Isolate sin2774.
[7]Erratum
Ruan Y., Wei C.L., Ling A.E., Vega V.B., Thoreau H., Se Thoe S.Y., Chia J.-M., Ng P., Chiu K.P., Lim L., Zhang T., Chan K.P., Oon L.E.L., Ng M.L., Leo S.Y., Ng L.F.P., Ren E.C., Stanton L.W., Long P.M., Liu E.T.
Lancet 361:1832-1832(2003)
[8]"Severe acute respiratory syndrome-associated coronavirus genotype and its characterization."
Li L., Wang Z., Lu Y., Bao Q., Chen S., Wu N., Cheng S., Weng J., Zhang Y., Yan J., Mei L., Wang X., Zhu H., Yu Y., Zhang M., Li M., Yao J., Lu Q. expand/collapse author list , Yao P., Bo X., Wo J., Wang S., Hu S.
Chin. Med. J. 116:1288-1292(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate ZJ01.
[9]Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W., Jiang T., Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y., Li X., Lu F. expand/collapse author list , Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L., Deng Y., Dong W., Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H., Li S., Li S., Li W., Li W., Lin W., Liu J., Liu Z., Lu H., Ni P., Qi Q., Sun Y., Tang L., Tong Z., Wang J., Wang X., Wu Q., Xi Y., Xu Z., Yang L., Ye C., Ye J., Zhang B., Zhang F., Zhang J., Zhang X., Zhou J., Yang H.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
[10]"The complete genome of SARS coronavirus clone TW1."
Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TW1.
[11]"Phylogeny of the SARS coronavirus."
Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J.H., Song H.C., Abrignani S., Covacci A., Rappuoli R.
Science 302:1504-1505(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate FRA.
[12]Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S., Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Frankfurt-1.
[13]"Genomic sequence of SARS isolate from the first fatal case in Taiwan."
Yang J.-Y., Lin J.-H., Chiu S.-C., Wang S.-F., Lee S.C., Lin Y.-C., Hsu C.-K., Chen H.-Y., Chang J.G., Chen P.-J., Su I.-J.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TWC.
[14]"Analysis of SARS coronavirus genome in Shanghai isolates."
Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Shanghai QXC1.
[15]Canducci F., Clementi M., Poli G., Vicenzi E.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HSR 1.
[16]Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L., Shih M.-C.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3.
[17]Shu H.Y., Wu K.M., Tsai S.F.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
[18]Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate AS.
[19]Wang Z., Cheng S., Zhang Y.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate ZJ01.
[20]Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-507; 1655-5170 AND 6903-7073.
Strain: Isolate Shanghai LY.
[21]Emery S., Erdman D.D., Peret T.C.T., Ksiazek T.G.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 4993-5127.
Strain: Isolate Vietnam.
[22]"Detection of a novel human coronavirus in a severe acute respiratory syndrome patient in Taiwan."
Lin J.-H., Chiu S.-C., Yang J.-Y., Wang S.-F., Chen H.-Y.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 4993-5136.
Strain: Isolate Taiwan.
[23]"The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases."
Tanner J.A., Watt R.M., Chai Y.-B., Lu L.-Y., Lin M.C., Peiris J.S., Poon L.L.M., Kung H.-F., Huang J.-D.
J. Biol. Chem. 278:39578-39582(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF HELICASE.
[24]"Mechanisms and enzymes involved in SARS coronavirus genome expression."
Thiel V., Ivanov K.A., Putics A., Hertzig T., Schelle B., Bayer S., Weissbrich B., Snijder E.J., Rabenau H., Doerr H.W., Gorbalenya A.E., Ziebuhr J.
J. Gen. Virol. 84:2305-2315(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.
[25]"Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase."
Fan K., Wei P., Feng Q., Chen S., Huang C., Ma L., Lai B., Pei J., Liu Y., Chen J., Lai L.
J. Biol. Chem. 279:1637-1642(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CATALYTIC ACTIVITY OF 3C-LIKE PROTEINASE DOMAIN, SUBUNIT OF 3C-LIKE PROTEINASE DOMAIN, BIOPHYSICOCHEMICAL PROPERTIES OF 3C-LIKE PROTEINASE DOMAIN.
[26]"Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins."
Prentice E., McAuliffe J., Lu X., Subbarao K., Denison M.R.
J. Virol. 78:9977-9986(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.
[27]"Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity."
Harcourt B.H., Jukneliene D., Kanjanahaluethai A., Bechill J., Severson K.M., Smith C.M., Rota P.A., Baker S.C.
J. Virol. 78:13600-13612(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.
Strain: Isolate Urbani.
[28]"Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis."
Minskaia E., Hertzig T., Gorbalenya A.E., Campanacci V., Cambillau C., Canard B., Ziebuhr J.
Proc. Natl. Acad. Sci. U.S.A. 103:5108-5113(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF EXORIBONUCLEASE.
Strain: Isolate Frankfurt-1.
[29]"Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family."
Ricagno S., Egloff M.-P., Ulferts R., Coutard B., Nurizzo D., Campanacci V., Cambillau C., Ziebuhr J., Canard B.
Proc. Natl. Acad. Sci. U.S.A. 103:11892-11897(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ENDONUCLEASE.
[30]"A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus."
Imbert I., Guillemot J.-C., Bourhis J.-M., Bussetta C., Coutard B., Egloff M.-P., Ferron F., Gorbalenya A.E., Canard B.
EMBO J. 25:4933-4942(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF NSP8.
[31]"Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease."
Lindner H.A., Lytvyn V., Qi H., Lachance P., Ziomek E., Menard R.
Arch. Biochem. Biophys. 466:8-14(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF NSP3.
[32]"Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling."
Frieman M., Ratia K., Johnston R.E., Mesecar A.D., Baric R.S.
J. Virol. 83:6689-6705(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF NSP3.
[33]"The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication."
Xu L., Khadijah S., Fang S., Wang L., Tay F.P., Liu D.X.
J. Virol. 84:8571-8583(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DDX1.
[34]"SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage."
Huang C., Lokugamage K.G., Rozovics J.M., Narayanan K., Semler B.L., Makino S.
PLoS Pathog. 7:E1002433-E1002433(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF NSP1.
[35]"Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation."
Lokugamage K.G., Narayanan K., Huang C., Makino S.
J. Virol. 86:13598-13608(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF NSP1.
[36]"Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs."
Anand K., Ziebuhr J., Wadhwani P., Mesters J.R., Hilgenfeld R.
Science 300:1763-1767(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 3241-3540, CHARACTERIZATION.
[37]"Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein."
Campanacci V., Egloff M.-P., Longhi S., Ferron F., Rancurel C., Salomoni A., Durousseau C., Tocque F., Bremond N., Dobbe J.C., Snijder E.J., Canard B., Cambillau C.
Acta Crystallogr. D 59:1628-1631(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 4118-4230 (NSP9).
Strain: Isolate Frankfurt-1.
[38]"The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world."
Egloff M.-P., Ferron F., Campanacci V., Longhi S., Rancurel C., Dutartre H., Snijder E.J., Gorbalenya A.E., Cambillau C., Canard B.
Proc. Natl. Acad. Sci. U.S.A. 101:3792-3796(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 4118-4230.
[39]"The nsp9 replicase protein of SARS-coronavirus, structure and functional insights."
Sutton G., Fry E., Carter L., Sainsbury S., Walter T., Nettleship J., Berrow N., Owens R., Gilbert R., Davidson A., Siddell S., Poon L.L.M., Diprose J., Alderton D., Walsh M., Grimes J.M., Stuart D.I.
Structure 12:341-353(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 4107-4230.
[40]"Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer."
Zhai Y., Sun F., Li X., Pang H., Xu X., Bartlam M., Rao Z.
Nat. Struct. Mol. Biol. 12:980-986(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 3837-4117 AND 3920-4117, INTERACTION OF NSP7 WITH NSP8.
[41]"Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3."
Saikatendu K.S., Joseph J.S., Subramanian V., Clayton T., Griffith M., Moy K., Velasquez J., Neuman B.W., Buchmeier M.J., Stevens R.C., Kuhn P.
Structure 13:1665-1675(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1002-1176.
[42]"Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme."
Ratia K., Saikatendu K.S., Santarsiero B.D., Barretto N., Baker S.C., Stevens R.C., Mesecar A.D.
Proc. Natl. Acad. Sci. U.S.A. 103:5717-5722(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1541-1854.
[43]"Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs."
Joseph J.S., Saikatendu K.S., Subramanian V., Neuman B.W., Brooun A., Griffith M., Moy K., Yadav M.K., Velasquez J., Buchmeier M.J., Stevens R.C., Kuhn P.
J. Virol. 80:7894-7901(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4240-4362.
Strain: Isolate Tor2.
[44]"Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10."
Su D., Lou Z., Sun F., Zhai Y., Yang H., Zhang R., Joachimiak A., Zhang X.C., Bartlam M., Rao Z.
J. Virol. 80:7902-7908(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 4231-4378.
[45]"Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus."
Almeida M.S., Johnson M.A., Herrmann T., Geralt M., Wuthrich K.
J. Virol. 81:3151-3161(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 13-127.
[46]"Crystal structure of Sars coronavirus main proteinase(3CLPRO)."
RIKEN structural genomics initiative (RSGI)
Submitted (JUL-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 3241-3546.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY278741 Genomic RNA. Translation: AAP13442.1.
AY278741 Genomic RNA. Translation: AAP13440.1. Sequence problems.
AY274119 Genomic RNA. Translation: AAP41036.1. Sequence problems.
AY278554 Genomic RNA. Translation: AAP13566.1.
AY282752 Genomic RNA. Translation: AAP30711.1.
AY304495 Genomic RNA. No translation available.
AY304486 Genomic RNA. No translation available.
AY304488 Genomic RNA. No translation available.
AY278491 Genomic RNA. No translation available.
AY283794 Genomic RNA. No translation available.
AY283795 Genomic RNA. No translation available.
AY283796 Genomic RNA. No translation available.
AY283797 Genomic RNA. No translation available.
AY283798 Genomic RNA. No translation available.
AY286320 Genomic RNA. Translation: AAP49011.4.
AY278488 Genomic RNA. Translation: AAP30028.1.
AY278489 Genomic RNA. Translation: AAP51225.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37015.1.
AY310120 Genomic RNA. Translation: AAP50483.1.
AY291315 Genomic RNA. Translation: AAP33696.1.
AY323977 Genomic RNA. Translation: AAP72973.2.
AY321118 Genomic RNA. No translation available.
AY338174 Genomic RNA. Translation: AAQ01594.1.
AY338174 Genomic RNA. Translation: AAQ01596.1. Sequence problems.
AY338175 Genomic RNA. Translation: AAQ01606.1.
AY338175 Genomic RNA. Translation: AAQ01608.1. Sequence problems.
AY348314 Genomic RNA. Translation: AAP97879.1.
AY348314 Genomic RNA. Translation: AAP97881.1. Sequence problems.
AP006557 Genomic RNA. Translation: BAC81346.1.
AP006558 Genomic RNA. Translation: BAC81360.1.
AP006559 Genomic RNA. Translation: BAC81374.1.
AP006560 Genomic RNA. Translation: BAC81388.1.
AP006561 Genomic RNA. Translation: BAC81402.1.
AY427439 Genomic RNA. Translation: AAQ94058.1.
AY322205 Genomic RNA. Translation: AAP82966.1.
AY322206 Genomic RNA. Translation: AAP82975.1. Sequence problems.
AY322207 Genomic RNA. Translation: AAP82967.1.
AY463059 Genomic RNA. Translation: AAP82978.2.
AY269391 Genomic RNA. Translation: AAP04003.1.
AY268049 Genomic RNA. Translation: AAP04587.1.
RefSeqNP_828849.2. NC_004718.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1O5Smodel-A4745-5301[»]
1P76model-A3241-3541[»]
B4225-4231[»]
1P9Tmodel-A3241-3544[»]
1PA5model-A3241-3546[»]
1PUKmodel-A3241-3550[»]
1Q1Xmodel-A3241-3542[»]
1Q2WX-ray1.86A/B3241-3544[»]
1QZ8X-ray2.70A/B4118-4230[»]
1SXFmodel-A4765-5244[»]
1UJ1X-ray1.90A/B3241-3546[»]
1UK2X-ray2.20A/B3241-3546[»]
1UK3X-ray2.40A/B3241-3546[»]
1UK4X-ray2.50A/B3241-3546[»]
1UW7X-ray2.80A4118-4230[»]
1WOFX-ray2.00A/B3241-3546[»]
1YSYNMR-A3837-3919[»]
1Z1IX-ray2.80A3241-3546[»]
1Z1JX-ray2.80A/B3241-3546[»]
2A5AX-ray2.08A3241-3546[»]
2A5IX-ray1.88A3241-3546[»]
2A5KX-ray2.30A/B3241-3546[»]
2ACFX-ray1.40A/B/C/D1002-1176[»]
2AHMX-ray2.40A/B/C/D3837-3919[»]
E/F/G/H3920-4117[»]
2AJ5model-A3241-3546[»]
2ALVX-ray1.90A3241-3543[»]
2AMDX-ray1.85A/B3241-3546[»]
2AMQX-ray2.30A/B3241-3546[»]
2BX3X-ray2.00A3241-3546[»]
2BX4X-ray2.79A3241-3546[»]
2C3SX-ray1.90A3241-3546[»]
2D2DX-ray2.70A/B3241-3546[»]
2DUCX-ray1.70A/B3241-3546[»]
2FAVX-ray1.80A/B/C1000-1173[»]
2FE8X-ray1.85A/B/C1541-1854[»]
2FYGX-ray1.80A4240-4362[»]
2G1Fmodel-A/B5302-5877[»]
2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4378[»]
2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4378[»]
2GDTNMR-A13-127[»]
2GRINMR-A819-930[»]
2GT7X-ray1.82A/B3241-3546[»]
2GT8X-ray2.00A3241-3546[»]
2GTBX-ray2.00A3241-3546[»]
2GX4X-ray1.93A3241-3546[»]
2GZ7X-ray1.86A3241-3546[»]
2GZ8X-ray1.97A3241-3546[»]
2GZ9X-ray2.17A3241-3546[»]
2H2ZX-ray1.60A3241-3546[»]
2H85X-ray2.60A6429-6774[»]
2HOBX-ray1.95A3241-3546[»]
2HSXNMR-A13-127[»]
2IDYNMR-A819-930[»]
2JZDNMR-A1345-1469[»]
2JZENMR-A1345-1469[»]
2JZFNMR-A1331-1469[»]
2K87NMR-A1884-1998[»]
2OP9X-ray1.80A/B3241-3541[»]
2OZKX-ray2.90A/B/C/D6430-6775[»]
2PWXX-ray2.50A3241-3546[»]
2Q6GX-ray2.50A/B3241-3546[»]
2QC2X-ray2.70A/B3241-3546[»]
2QCYX-ray1.75A3241-3546[»]
2QIQX-ray1.90A3242-3541[»]
2RHBX-ray2.80A/B/C/D/E/F6430-6775[»]
2RNKNMR-A1331-1469[»]
2V6NX-ray1.98A3241-3546[»]
2VJ1X-ray2.25A/B3242-3544[»]
2XYQX-ray2.00A6776-7065[»]
B4240-4361[»]
2XYRX-ray2.50A6776-7067[»]
B4240-4361[»]
2XYVX-ray2.06A6776-7067[»]
B4240-4361[»]
2YY4X-ray2.20A/B3241-3556[»]
2Z3CX-ray1.79A3241-3546[»]
2Z3DX-ray2.10A3241-3546[»]
2Z3EX-ray2.32A3241-3546[»]
2Z94X-ray1.78A3241-3546[»]
2Z9GX-ray1.86A3241-3546[»]
2Z9JX-ray1.95A/B3241-3546[»]
2Z9KX-ray1.85A/B3241-3546[»]
2Z9LX-ray2.10A/B3241-3546[»]
3D62X-ray2.70A3243-3541[»]
3E9SX-ray2.50A1541-1855[»]
3EBNX-ray2.40A/B/C/D3429-3546[»]
3R24X-ray2.00A6776-7073[»]
B4240-4378[»]
ProteinModelPortalP0C6X7.
SMRP0C6X7. Positions 13-127, 819-930, 1002-1176, 1331-1469, 1541-1854, 3241-3546, 3837-3910, 3921-4111, 4118-4230, 4240-4362, 6430-6773.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1487760.

Chemistry

BindingDBP0C6X7.
ChEMBLCHEMBL5118.

Proteomic databases

PRIDEP0C6X7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489680.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027351. (+)RNA_virus_helicase_core_dom.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR021590. NSP1.
IPR009466. NSP11.
IPR024375. Nsp3_coronavir.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR024358. SARS-CoV_Nsp3_N.
IPR022733. SARS_polyprot_cleavage.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view]
PfamPF06478. Corona_RPol_N. 1 hit.
PF12379. DUF3655. 1 hit.
PF01661. Macro. 1 hit.
PF11501. Nsp1. 1 hit.
PF09401. NSP10. 1 hit.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF12124. Nsp3_PL2pro. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF00680. RdRP_1. 1 hit.
PF11633. SUD-M. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF08715. Viral_protease. 1 hit.
[Graphical view]
SUPFAMSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS51653. CV_MBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0C6X7.

Entry information

Entry nameR1AB_CVHSA
AccessionPrimary (citable) accession number: P0C6X7
Secondary accession number(s): P59641 expand/collapse secondary AC list , Q6WGN0, Q7T697, Q808C0, Q80BV7, Q80BV8, Q80E51
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references